Trypsin Treatment Unlocks Barrier for Zoonotic Bat Coronavirus Infection

Development of a Broadly Accessible Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine Platform

(2018) Sudhakar Agnihothram et al.   JOURNAL OF VIROLOGY

Discovery of Novel Bat Coronaviruses in South China That Use the Same Receptor as Middle East Respiratory Syndrome Coronavirus

(2018) Chu-Ming Luo et al.   JOURNAL OF VIROLOGY

Viral metagenomics, protein structure, and reverse genetics: Key strategies for investigating coronaviruses

(2018) Bryan A. Johnson et al.   VIROLOGY

MERS-CoV: Understanding the Latest Human Coronavirus Threat

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Lysosomal proteases are a determinant of coronavirus tropism

(2018) Yuan Zheng et al.   JOURNAL OF VIROLOGY

Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin

(2018) Peng Zhou et al.   NATURE

Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein

(2018) Hannah Kleine-Weber et al.   Scientific Reports

One Health, emerging infectious diseases and wildlife: two decades of progress?

(2017) Andrew A. Cunningham et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen

(2017) Jesper Pallesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein

(2017) Wentao Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice

(2017) Kun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

(2017) Timothy P. Sheahan et al.   Science Translational Medicine

AIDS, Avian flu, SARS, MERS, Ebola, Zika… what next?

(2017) Leslie A. Reperant et al.   VACCINE

Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome Coronavirus

(2017) S. J. Anthony et al.   mBio

The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases

(2017) James T. Earnest et al.   PLoS Pathogens

Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus

(2017) Jie Zhou et al.   Science Advances

Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1 Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response

(2016) Lei-Ping Zeng et al.   JOURNAL OF VIROLOGY

Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism

(2016) Jung-Eun Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARS-like WIV1-CoV poised for human emergence

(2016) Vineet D. Menachery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation and Characterization of Porcine Deltacoronavirus from Pigs with Diarrhea in the United States

(2015) Hui Hu et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus

(2015) Yang Yang et al.   JOURNAL OF VIROLOGY

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

(2015) Vineet D Menachery et al.   NATURE MEDICINE

Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus

(2015) Davide Corti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular pathogenesis of H5 highly pathogenic avian influenza: the role of the haemagglutinin cleavage site motif

(2015) Jasmina M. Luczo et al.   REVIEWS IN MEDICAL VIROLOGY

Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis

(2015) Jean Kaoru Millet et al.   VIRUS RESEARCH

Proteolytic Activation of the Porcine Epidemic Diarrhea Coronavirus Spike Fusion Protein by Trypsin in Cell Culture

(2014) Oliver Wicht et al.   JOURNAL OF VIROLOGY

Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus

(2014) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Mouse Model for Betacoronavirus Subgroup 2c Using a Bat Coronavirus Strain HKU5 Variant

(2014) S. Agnihothram et al.   mBio

MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-  treatment

(2013) A. H. de Wilde et al.   JOURNAL OF GENERAL VIROLOGY

Evaluation of Serologic and Antigenic Relationships Between Middle Eastern Respiratory Syndrome Coronavirus and Other Coronaviruses to Develop Vaccine Platforms for the Rapid Response to Emerging Coronaviruses

(2013) Sudhakar Agnihothram et al.   JOURNAL OF INFECTIOUS DISEASES

Release of Severe Acute Respiratory Syndrome Coronavirus Nuclear Import Block Enhances Host Transcription in Human Lung Cells

(2013) A. C. Sims et al.   JOURNAL OF VIROLOGY

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

(2013) Xing-Yi Ge et al.   NATURE

Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus

(2013) T. Scobey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering a Replication-Competent, Propagation-Defective Middle East Respiratory Syndrome Coronavirus as a Vaccine Candidate

(2013) F. Almazan et al.   mBio

Evidence Supporting a Zoonotic Origin of Human Coronavirus Strain NL63

(2012) J. Huynh et al.   JOURNAL OF VIROLOGY

Prediction and prevention of the next pandemic zoonosis

(2012) Stephen S Morse et al.   LANCET

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Porcine epidemic diarrhoea virus: a comprehensive review of molecular epidemiology, diagnosis, and vaccines

(2012) Daesub Song et al.   VIRUS GENES

Proteomic Identification of Protease Cleavage Sites Characterizes Prime and Non-prime Specificity of Cysteine Cathepsins B, L, and S

(2011) Martin L. Biniossek et al.   JOURNAL OF PROTEOME RESEARCH

A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

(2011) M. Bolles et al.   JOURNAL OF VIROLOGY

Successful Vaccination Strategies That Protect Aged Mice from Lethal Challenge from Influenza Virus and Heterologous Severe Acute Respiratory Syndrome Coronavirus

(2010) T. Sheahan et al.   JOURNAL OF VIROLOGY

Early Upregulation of Acute Respiratory Distress Syndrome-Associated Cytokines Promotes Lethal Disease in an Aged-Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Infection

(2009) B. Rockx et al.   JOURNAL OF VIROLOGY

Recombination, Reservoirs, and the Modular Spike: Mechanisms of Coronavirus Cross-Species Transmission

(2009) R. L. Graham et al.   JOURNAL OF VIROLOGY

Coronaviruses post-SARS: update on replication and pathogenesis

(2009) Stanley Perlman et al.   NATURE REVIEWS MICROBIOLOGY

Human airway epithelial cell culture to identify new respiratory viruses: Coronavirus NL63 as a model

(2008) Bridget S. Banach et al.   JOURNAL OF VIROLOGICAL METHODS

Pathways of Cross-Species Transmission of Synthetically Reconstructed Zoonotic Severe Acute Respiratory Syndrome Coronavirus

(2008) T. Sheahan et al.   JOURNAL OF VIROLOGY

Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice

(2008) M. M. Becker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium

(2007) Amy C. Sims et al.   VIRUS RESEARCH