Molecular pathogenesis of H5 highly pathogenic avian influenza: the role of the haemagglutinin cleavage site motif

Emergence of a Highly Pathogenic Avian Influenza Virus from a Low-Pathogenic Progenitor

(2014) I. Monne et al.   JOURNAL OF VIROLOGY

Airborne Transmission of Highly Pathogenic H7N1 Influenza Virus in Ferrets

(2014) T. C. Sutton et al.   JOURNAL OF VIROLOGY

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

(2014) Marco Biasini et al.   NUCLEIC ACIDS RESEARCH

Sampling Strategies and Biodiversity of Influenza A Subtypes in Wild Birds

(2014) Sarah H. Olson et al.   PLoS One

H5N1 infection causes rapid mortality and high cytokine levels in chickens compared to ducks

(2014) Simon Burggraaf et al.   VIRUS RESEARCH

Characterization of a Novel Influenza Virus in Cattle and Swine: Proposal for a New Genus in the Orthomyxoviridae Family

(2014) B. M. Hause et al.   mBio

Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2013)

(2013) M. J. Adams et al.   ARCHIVES OF VIROLOGY

Differences in highly pathogenic avian influenza viral pathogenesis and associated early inflammatory response in chickens and ducks

(2013) J. B. W. J. Cornelissen et al.   AVIAN PATHOLOGY

Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice

(2013) Nicolas Tchitchek et al.   BMC Systems Biology

The pathobiology of two Indonesian H5N1 avian influenza viruses representing different clade 2.1 sublineages in chickens and ducks

(2013) Hendra Wibawa et al.   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

Clinical symptoms, immune factors, and molecular characteristics of an adult male in Shenzhen, China infected with influenza virus H5N1

(2013) Chunli Wu et al.   JOURNAL OF MEDICAL VIROLOGY

A Single Amino Acid at the Hemagglutinin Cleavage Site Contributes to the Pathogenicity but Not the Transmission of Egyptian Highly Pathogenic H5N1 Influenza Virus in Chickens

(2013) S.-W. Yoon et al.   JOURNAL OF VIROLOGY

Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus

(2013) Rongbao Gao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Excessive Cytokine Response to Rapid Proliferation of Highly Pathogenic Avian Influenza Viruses Leads to Fatal Systemic Capillary Leakage in Chickens

(2013) Saya Kuribayashi et al.   PLoS One

Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins

(2013) N. S. Heaton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The highly pathogenic H7N3 avian influenza strain from July 2012 in Mexico acquired an extended cleavage site through recombination with host 28S rRNA

(2013) Sebastian Maurer-Stroh et al.   Virology Journal

New World Bats Harbor Diverse Influenza A Viruses

(2013) Suxiang Tong et al.   PLoS Pathogens

Respiratory tract versus cloacal sampling of migratory ducks for influenza A viruses: are both ends relevant?

(2012) Scott Krauss et al.   Influenza and Other Respiratory Viruses

Influenza Research Database: an integrated bioinformatics resource for influenza research and surveillance

(2012) R. Burke Squires et al.   Influenza and Other Respiratory Viruses

A Single Amino Acid at the Hemagglutinin Cleavage Site Contributes to the Pathogenicity and Neurovirulence of H5N1 Influenza Virus in Mice

(2012) Y. Zhang et al.   JOURNAL OF VIROLOGY

The Multibasic Cleavage Site in H5N1 Virus Is Critical for Systemic Spread along the Olfactory and Hematogenous Routes in Ferrets

(2012) E. J. A. Schrauwen et al.   JOURNAL OF VIROLOGY

Viral Quasispecies Evolution

(2012) E. Domingo et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Role of Position 627 of PB2 and the Multibasic Cleavage Site of the Hemagglutinin in the Virulence of H5N1 Avian Influenza Virus in Chickens and Ducks

(2012) Karel A. Schat et al.   PLoS One

A distinct lineage of influenza A virus from bats

(2012) S. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Avian influenza virus hemagglutinins H2, H4, H8, and H14 support a highly pathogenic phenotype

(2012) J. Veits et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Benefits and Risks of Influenza Research: Lessons Learned

(2012) A. S. Fauci et al.   SCIENCE

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets

(2012) S. Herfst et al.   SCIENCE

Role of host cellular proteases in the pathogenesis of influenza and influenza-induced multiple organ failure

(2011) Hiroshi Kido et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

(2011) John R. Teijaro et al.   CELL

Insertion of a multibasic cleavage site in the haemagglutinin of human influenza H3N2 virus does not increase pathogenicity in ferrets

(2011) E. J. A. Schrauwen et al.   JOURNAL OF GENERAL VIROLOGY

Highly Pathogenic (H5N1) Avian Influenza Induces an Inflammatory T Helper Type 1 Cytokine Response in the Chicken

(2011) Adam J. Karpala et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Human Pulmonary Microvascular Endothelial Cells Support Productive Replication of Highly Pathogenic Avian Influenza Viruses: Possible Involvement in the Pathogenesis of Human H5N1 Virus Infection

(2011) H. Zeng et al.   JOURNAL OF VIROLOGY

The Multibasic Cleavage Site of the Hemagglutinin of Highly Pathogenic A/Vietnam/1203/2004 (H5N1) Avian Influenza Virus Acts as a Virulence Factor in a Host-Specific Manner in Mammals

(2011) A. L. Suguitan et al.   JOURNAL OF VIROLOGY

Improvement of H5N1 influenza vaccine viruses: Influence of internal gene segments of avian and human origin on production and hemagglutinin content

(2011) Marion Abt et al.   VACCINE

H9N2 influenza virus acquires intravenous pathogenicity on the introduction of a pair of di-basic amino acid residues at the cleavage site of the hemagglutinin and consecutive passages in chickens

(2011) Kosuke Soda et al.   Virology Journal

Persistence of Avian Influenza Virus (H5N1) in Feathers Detached from Bodies of Infected Domestic Ducks

(2010) Y. Yamamoto et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Pathobiological characterization of low-pathogenicity H5 avian influenza viruses of diverse origins in chickens, ducks and turkeys

(2010) S. P. S. Pillai et al.   ARCHIVES OF VIROLOGY

Amino acids adjacent to the haemagglutinin cleavage site are relevant for virulence of avian influenza viruses of subtype H5

(2010) S. Gohrbandt et al.   JOURNAL OF GENERAL VIROLOGY

H5N1 Virus Activates Signaling Pathways in Human Endothelial Cells Resulting in a Specific Imbalanced Inflammatory Response

(2010) D. Viemann et al.   JOURNAL OF IMMUNOLOGY

Highly Pathogenic H5N1 Influenza Viruses Carry Virulence Determinants beyond the Polybasic Hemagglutinin Cleavage Site

(2010) Jessica Bogs et al.   PLoS One

Infection studies with two highly pathogenic avian influenza strains (Vietnamese and Indonesian) in Pekin ducks (Anas platyrhynchos), with particular reference to clinical disease, tissue tropism and viral shedding

(2009) John Bingham et al.   AVIAN PATHOLOGY

Acquisition of a Polybasic Hemagglutinin Cleavage Site by a Low-Pathogenic Avian Influenza Virus Is Not Sufficient for Immediate Transformation into a Highly Pathogenic Strain

(2009) O. Stech et al.   JOURNAL OF VIROLOGY

Protein structure homology modeling using SWISS-MODEL workspace

(2009) Lorenza Bordoli et al.   Nature Protocols

The influence of the multi-basic cleavage site of the H5 hemagglutinin on the attenuation, immunogenicity and efficacy of a live attenuated influenza A H5N1 cold-adapted vaccine virus

(2009) Amorsolo L. Suguitan et al.   VIROLOGY

Cleavage mechanism of the H5N1 hemagglutinin by trypsin and furin

(2008) X.-L. Guo et al.   AMINO ACIDS

Pathology of Specific-Pathogen-Free Chickens Inoculated with H5N1 Avian Influenza Viruses Isolated in Japan in 2004

(2008) Kikuyasu Nakamura et al.   AVIAN DISEASES

Source of High Pathogenicity of an Avian Influenza Virus H5N1: Why H5 Is Better Cleaved by Furin

(2008) Panita Decha et al.   BIOPHYSICAL JOURNAL

Substrate Cleavage Analysis of Furin and Related Proprotein Convertases

(2008) Albert G. Remacle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The H5N1 Influenza Variant Fujian-Like Hemagglutinin Selected Following Vaccination Exhibits a Compromised Furin Cleavage

(2008) Antonella Pasquato et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Sampling for low-pathogenic avian influenza A virus in wild Mallard ducks: Oropharyngeal versus cloacal swabbing

(2008) Patrik Ellström et al.   VACCINE

H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice

(2008) Lucy A. Perrone et al.   PLoS Pathogens