标题
Transforming growth factor–β in tissue fibrosis
作者
关键词
-
出版物
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 217, Issue 3, Pages -
出版商
Rockefeller University Press
发表日期
2020-02-20
DOI
10.1084/jem.20190103
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- LMO7 is a Negative Feedback Regulator of TGF-β Signaling and Fibrosis
- (2019) Yi Xie et al. CIRCULATION
- Cadherin-11–mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-β
- (2019) Monika Lodyga et al. Science Signaling
- A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation
- (2019) Carlos M. Minutti et al. IMMUNITY
- Mechanical regulation of myofibroblast phenoconversion and collagen contraction
- (2019) Boris Hinz et al. EXPERIMENTAL CELL RESEARCH
- Protective Effects of Activated Myofibroblasts in the Pressure-Overloaded Myocardium Are Mediated Through Smad-Dependent Activation of a Matrix-Preserving Program
- (2019) Ilaria Russo et al. CIRCULATION RESEARCH
- Fibroblast Primary Cilia are Required for Cardiac Fibrosis
- (2019) Elisa Villalobos et al. CIRCULATION
- Macrophage Smad3 Protects the Infarcted Heart, Stimulating Phagocytosis and Regulating Inflammation
- (2019) Bijun Chen et al. CIRCULATION RESEARCH
- ADAMTS16 activates latent TGF-β, accentuating fibrosis and dysfunction of the pressure-overloaded heart
- (2019) Yufeng Yao et al. CARDIOVASCULAR RESEARCH
- Distinct roles of myofibroblast-specific Smad2 and Smad3 signaling in repair and remodeling of the infarcted heart
- (2019) Shuaibo Huang et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Inhibition of hyperglycolysis in mesothelial cells prevents peritoneal fibrosis
- (2019) Meijun Si et al. Science Translational Medicine
- Hexokinase 2 couples glycolysis with the profibrotic actions of TGF-β
- (2019) Xueqian Yin et al. Science Signaling
- Increased macrophage-derived SPARC precedes collagen deposition in myocardial fibrosis
- (2018) Lindsay T. McDonald et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Cardiac fibroblast-specific p38α MAP kinase promotes cardiac hypertrophy via a putative paracrine interleukin-6 signaling mechanism
- (2018) Sumia A. Bageghni et al. FASEB JOURNAL
- The fibronectin ED-A domain enhances recruitment of latent TGF-β-binding protein-1 to the fibroblast matrix
- (2018) Franco Klingberg et al. JOURNAL OF CELL SCIENCE
- Thrombospondin-1 regulation of latent TGF-β activation: A therapeutic target for fibrotic disease
- (2018) Joanne E. Murphy-Ullrich et al. MATRIX BIOLOGY
- Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities
- (2018) Nikolaos G. Frangogiannis MOLECULAR ASPECTS OF MEDICINE
- PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production
- (2018) Lindsay J. Celada et al. Science Translational Medicine
- AMPK Activation Regulates LTBP4-Dependent TGF-β1 Secretion by Pro-inflammatory Macrophages and Controls Fibrosis in Duchenne Muscular Dystrophy
- (2018) Gaëtan Juban et al. Cell Reports
- Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis
- (2017) Ying Wei et al. JOURNAL OF CLINICAL INVESTIGATION
- Fibroblast-specific TGF-β–Smad2/3 signaling underlies cardiac fibrosis
- (2017) Hadi Khalil et al. JOURNAL OF CLINICAL INVESTIGATION
- Th1 effector T cells selectively orchestrate cardiac fibrosis in nonischemic heart failure
- (2017) Tania Nevers et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Endothelial cell-specific activation of transforming growth factor-β signaling in mice induces cutaneous, visceral, and microvascular fibrosis
- (2017) Peter J Wermuth et al. LABORATORY INVESTIGATION
- IL11 is a crucial determinant of cardiovascular fibrosis
- (2017) Sebastian Schafer et al. NATURE
- ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis
- (2017) David Lagares et al. NATURE MEDICINE
- Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis
- (2017) Zhongwei Cao et al. Science Translational Medicine
- Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and Infection
- (2017) Shomyseh Sanjabi et al. Cold Spring Harbor Perspectives in Biology
- Targeting TGF-β Signaling for Therapeutic Gain
- (2017) Rosemary J. Akhurst Cold Spring Harbor Perspectives in Biology
- Opposing Actions of Fibroblast and Cardiomyocyte Smad3 Signaling in the Infarcted Myocardium
- (2017) Ping Kong et al. CIRCULATION
- Infarct Fibroblasts Do Not Derive From Bone Marrow Lineages
- (2017) Thomas Moore-Morris et al. CIRCULATION RESEARCH
- Stretch-induced Activation of Transforming Growth Factor-β1in Pulmonary Fibrosis
- (2016) Aaron R. Froese et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Overexpression of the short endoglin isoform reduces renal fibrosis and inflammation after unilateral ureteral obstruction
- (2016) José M. Muñoz-Félix et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Myofibroblasts
- (2016) Boris Hinz EXPERIMENTAL EYE RESEARCH
- Macrophages in Tissue Repair, Regeneration, and Fibrosis
- (2016) Thomas A. Wynn et al. IMMUNITY
- Anti–TGF-β1 Antibody Therapy in Patients with Diabetic Nephropathy
- (2016) James Voelker et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Transforming growth factor beta (TGF-β) isoforms in wound healing and fibrosis
- (2016) Michael K. Lichtman et al. WOUND REPAIR AND REGENERATION
- Signaling Receptors for TGF-β Family Members
- (2016) Carl-Henrik Heldin et al. Cold Spring Harbor Perspectives in Biology
- Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins
- (2016) Ian B. Robertson et al. Cold Spring Harbor Perspectives in Biology
- Genetic lineage tracing defines myofibroblast origin and function in the injured heart
- (2016) Onur Kanisicak et al. Nature Communications
- SnoN as a novel negative regulator of TGF-β/Smad signaling: a target for tailoring organ fibrosis
- (2015) Matthew R. Zeglinski et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Simvastatin alleviates cardiac fibrosis induced by infarction via up-regulation of TGF-β receptor III expression
- (2015) Fei Sun et al. BRITISH JOURNAL OF PHARMACOLOGY
- Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis
- (2015) Rafael Kramann et al. Cell Stem Cell
- Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients
- (2015) Lisa M. Rice et al. JOURNAL OF CLINICAL INVESTIGATION
- Genetic Analysis of Connective Tissue Growth Factor as an Effector of Transforming Growth Factor β Signaling and Cardiac Remodeling
- (2015) Federica Accornero et al. MOLECULAR AND CELLULAR BIOLOGY
- TβRIII independently binds type I and type II TGF-β receptors to inhibit TGF-β signaling
- (2015) Keren Tazat et al. MOLECULAR BIOLOGY OF THE CELL
- Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis
- (2015) Katrin Palumbo-Zerr et al. NATURE MEDICINE
- ALK1 heterozygosity increases extracellular matrix protein expression, proliferation and migration in fibroblasts
- (2014) José M. Muñoz-Félix et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Developmental Heterogeneity of Cardiac Fibroblasts Does Not Predict Pathological Proliferation and Activation
- (2014) Shah R. Ali et al. CIRCULATION RESEARCH
- Resident fibroblast lineages mediate pressure overload–induced cardiac fibrosis
- (2014) Thomas Moore-Morris et al. JOURNAL OF CLINICAL INVESTIGATION
- CD44 Is Critically Involved in Infarct Healing by Regulating the Inflammatory and Fibrotic Response
- (2014) P. Huebener et al. JOURNAL OF IMMUNOLOGY
- TGF-β1, but Not Bone Morphogenetic Proteins, Activates Smad1/5 Pathway in Primary Human Macrophages and Induces Expression of Proatherogenic Genes
- (2014) Dinara Nurgazieva et al. JOURNAL OF IMMUNOLOGY
- Attenuated development of cardiac fibrosis in left ventricular pressure overload by SM16, an orally active inhibitor of ALK5
- (2014) Kristin V.T. Engebretsen et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Curtailing Endothelial TGF- Signaling Is Sufficient to Reduce Endothelial-Mesenchymal Transition and Fibrosis in CKD
- (2014) S. Xavier et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Molecular mechanisms of epithelial–mesenchymal transition
- (2014) Samy Lamouille et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Transforming growth factor β—at the centre of systemic sclerosis
- (2014) Robert Lafyatis Nature Reviews Rheumatology
- Phenotypical Differences in Connective Tissue Cells Emerging from Microvascular Pericytes in Response to Overexpression of PDGF-B and TGF-β1 in Normal Skin in Vivo
- (2013) Alejandro Rodriguez et al. AMERICAN JOURNAL OF PATHOLOGY
- TGF-β Activation and Function in Immunity
- (2013) Mark A. Travis et al. Annual Review of Immunology
- Thrombospondin-1 Induction in the Diabetic Myocardium Stabilizes the Cardiac Matrix in Addition to Promoting Vascular Rarefaction Through Angiopoietin-2 Upregulation
- (2013) Carlos Gonzalez-Quesada et al. CIRCULATION RESEARCH
- C-C motif chemokine receptor 9 positive macrophages activate hepatic stellate cells and promote liver fibrosis in mice
- (2013) Po-sung Chu et al. HEPATOLOGY
- Glucocorticoids Recruit Tgfbr3 and Smad1 to Shift Transforming Growth Factor-β Signaling from the Tgfbr1/Smad2/3 Axis to the Acvrl1/Smad1 Axis in Lung Fibroblasts
- (2013) Julian T. Schwartze et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TAK1 Is Required for Dermal Wound Healing and Homeostasis
- (2013) Fen Guo et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Heterozygous disruption of activin receptor–like kinase 1 is associated with increased renal fibrosis in a mouse model of obstructive nephropathy
- (2013) José M. Muñoz-Félix et al. KIDNEY INTERNATIONAL
- Endoglin Haploinsufficiency Promotes Fibroblast Accumulation during Wound Healing through Akt Activation
- (2013) Miguel Pericacho et al. PLoS One
- LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1
- (2013) Shuyu Ren et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transforming Growth Factor β-1 Stimulates Profibrotic Epithelial Signaling to Activate Pericyte-Myofibroblast Transition in Obstructive Kidney Fibrosis
- (2012) Ching-Fang Wu et al. AMERICAN JOURNAL OF PATHOLOGY
- BAMBI (BMP and activin membrane-bound inhibitor) protects the murine heart from pressure-overload biomechanical stress by restraining TGF-β signaling
- (2012) Ana V. Villar et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Reduced Endoglin Activity Limits Cardiac Fibrosis and Improves Survival in Heart Failure
- (2012) Navin K. Kapur et al. CIRCULATION
- The myofibroblast matrix: implications for tissue repair and fibrosis
- (2012) Franco Klingberg et al. JOURNAL OF PATHOLOGY
- Lineage tracing and genetic ablation of ADAM12+ perivascular cells identify a major source of profibrotic cells during acute tissue injury
- (2012) Sophie Dulauroy et al. NATURE MEDICINE
- Matricellular Proteins in Cardiac Adaptation and Disease
- (2012) Nikolaos G. Frangogiannis PHYSIOLOGICAL REVIEWS
- Platelet-Derived Growth Factor–Producing CD4+Foxp3+Regulatory T Lymphocytes Promote Lung Fibrosis
- (2011) Sandra Lo Re et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Platelet TGF- 1 contributions to plasma TGF- 1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload
- (2011) A. Meyer et al. BLOOD
- Exploring anti-TGF-β therapies in cancer and fibrosis
- (2011) Lukas J. A. C. Hawinkels et al. GROWTH FACTORS
- Protease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta
- (2011) Katia Bourd-Boittin et al. HEPATOLOGY
- Endogenous Thrombospondin 1 Protects the Pressure-Overloaded Myocardium by Modulating Fibroblast Phenotype and Matrix Metabolism
- (2011) Ying Xia et al. HYPERTENSION
- Hyaluronan Facilitates Transforming Growth Factor-β1-dependent Proliferation via CD44 and Epidermal Growth Factor Receptor Interaction
- (2011) Soma Meran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Binding of Anti-SSA Antibodies to Apoptotic Fetal Cardiocytes Stimulates Urokinase Plasminogen Activator (uPA)/uPA Receptor-Dependent Activation of TGF-β and Potentiates Fibrosis
- (2011) Paraskevi Briassouli et al. JOURNAL OF IMMUNOLOGY
- Transforming growth factor-beta type 1 receptor (ALK5) and Smad proteins mediate TIMP-1 and collagen synthesis in experimental intestinal fibrosis
- (2011) Carlos Medina et al. JOURNAL OF PATHOLOGY
- Transforming growth factor-β3 regulates assembly of a non-fibrotic matrix in a 3D corneal model
- (2011) D. Karamichos et al. Journal of Tissue Engineering and Regenerative Medicine
- A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis
- (2011) Howard Trachtman et al. KIDNEY INTERNATIONAL
- Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition
- (2011) J. R. Rock et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Discovery and development of avotermin (recombinant human transforming growth factor beta 3): A new class of prophylactic therapeutic for the improvement of scarring
- (2011) Nick L. Occleston et al. WOUND REPAIR AND REGENERATION
- Inhibition of type III TGF-β receptor aggravates lung fibrotic process
- (2010) Ji-Yeon Ahn et al. BIOMEDICINE & PHARMACOTHERAPY
- Thrombospondin-1 is not the major activator of TGF- 1 in thrombopoietin-induced myelofibrosis
- (2010) S. Evrard et al. BLOOD
- Smad3 Signaling Critically Regulates Fibroblast Phenotype and Function in Healing Myocardial Infarction
- (2010) Marcin Dobaczewski et al. CIRCULATION RESEARCH
- Integrin–TGF-β crosstalk in fibrosis, cancer and wound healing
- (2010) Coert Margadant et al. EMBO REPORTS
- Smad7 Inhibits Transforming Growth Factor-β Family Type I Receptors through Two Distinct Modes of Interaction
- (2010) Yuto Kamiya et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-β signaling in hepatic stellate cells
- (2010) Sheng Cao et al. JOURNAL OF CLINICAL INVESTIGATION
- Endothelial–Mesenchymal Transition in Bleomycin-Induced Pulmonary Fibrosis
- (2009) Naozumi Hashimoto et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Human BAMBI Cooperates with Smad7 to Inhibit Transforming Growth Factor-β Signaling
- (2009) Xiaohua Yan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Distribution of TGF-β isoforms and signaling intermediates in corneal fibrotic wound repair
- (2009) Man-IL Huh et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- The Role of Toll-Like Receptor 2 in Inflammation and Fibrosis during Progressive Renal Injury
- (2009) Jaklien C. Leemans et al. PLoS One
- SM16, an Orally Active TGF-β Type I Receptor Inhibitor Prevents Myofibroblast Induction and Vascular Fibrosis in the Rat Carotid Injury Model
- (2008) Kai Fu et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Integrins and the activation of latent transforming growth factor β1 – An intimate relationship
- (2008) P WIPFF et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- Hyaluronan Facilitates Transforming Growth Factor-β1-mediated Fibroblast Proliferation
- (2008) Soma Meran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Progressive pulmonary fibrosis is mediated by TGF-β isoform 1 but not TGF-β3
- (2007) Kjetil Ask et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started