Article
Cardiac & Cardiovascular Systems
Becker M. Al-Khayatt, Justin D. Salciccioli, Dominic C. Marshall, Andrew D. Krahn, Joseph Shalhoub, Markus B. Sikkel
Summary: The incidence and mortality of atrial fibrillation across Europe did not show a general trend from 1990 to 2017, with unique patterns observed for some nations. Higher mortality rates were observed in wealthier countries, with women experiencing worse outcomes and increasing disparities over time.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Aniqa B. Alam, Pamela L. Lutsey, Lin Y. Chen, Richard F. MacLehose, Iris Y. Shao, Alvaro Alonso
Summary: This study identified several risk factors for dementia in patients with atrial fibrillation (AF), including frailty, cognitive impairment, mood disorders, schizophrenia, and substance abuse. Among cardiometabolic conditions, only stroke and diabetes mellitus were associated with a small increase in dementia risk.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Adrian D. Elliott, Melissa E. Middeldorp, Isabelle C. Van Gelder, Christine M. Albert, Prashanthan Sanders
Summary: The global prevalence of atrial fibrillation (AF) has significantly increased over the past three decades to approximately 60 million cases. Various risk factors, including lifestyle choices, can modify the lifetime risk of AF. This review provides evidence on the epidemiology of AF, both non-modifiable and modifiable risk factors, and strategies for primary and secondary prevention. It also discusses potential interventions to reduce the frequency and severity of subsequent AF episodes and proposes strategies and global policy changes for the prevention and management of AF.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Dora Csengeri, Ngoc-Anh Sprunker, Augusto Di Castelnuovo, Teemu Niiranen, Julie Kk Vishram-Nielsen, Simona Costanzo, Stefan Soderberg, Steen M. Jensen, Erkki Vartiainen, Maria Benedetta Donati, Christina Magnussen, Stephan Camen, Francesco Gianfagna, Maja-Lisa Lochen, Frank Kee, Jukka Kontto, Ellisiv B. Mathiesen, Wolfgang Koenig, Blankenberg Stefan, Giovanni de Gaetano, Torben Jorgensen, Kari Kuulasmaa, Tanja Zeller, Veikko Salomaa, Licia Iacoviello, Renate B. Schnabel
Summary: This study found that even modest alcohol intake (1.2 drinks/day) was associated with an increased risk of atrial fibrillation, which needs to be considered in atrial fibrillation prevention.
EUROPEAN HEART JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Guohao Wu, Jingguo Wu, Qin Lu, Yunjiu Cheng, Weiyi Mei
Summary: Through a systematic review of 101 studies, it was found that obesity, increased body mass index, smoking history, diabetes mellitus, and hypertension are associated with an increased risk of atrial fibrillation (AF), whereas dyslipidemia is not related to AF risk in the general population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel J. Philipson, Florian Rader, Robert J. Siegel
Summary: Atrial fibrillation is a common arrhythmia in hypertrophic cardiomyopathy, leading to complications such as heart failure and thrombosis in patients. Accurate risk assessment and treatment are crucial for managing this condition effectively.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Jelle C. L. Himmelreich, Ralf E. Harskamp, Bastiaan Geelhoed, Saverio Virdone, Wim A. M. Lucassen, Ron T. Gansevoort, Michiel Rienstra
Summary: The study validated multiple risk models and scores for predicting atrial fibrillation (AF) risk in young individuals. The results showed that multivariable models had limited additional discriminatory value over age alone, suggesting that the selection strategy for primary AF screening should not be expanded to younger individuals.
Review
Medicine, Research & Experimental
Lindsay J. Young, Steve Antwi-Boasiako, Joel Ferrall, Loren E. Wold, Peter J. Mohler, Mona El Refaey
Summary: This article reviews the tissue and cellular pathways of atrial fibrillation, explores the role of genetic and environmental risk factors in atrial fibrillation susceptibility, and provides the latest information on the potential link between SARS-CoV-2 and human atrial fibrillation. Improved understanding of the mechanisms underlying atrial fibrillation holds promise in preventative care and early diagnostics, as well as introducing novel targeted therapies for attenuating atrial fibrillation progression and maintenance.
Review
Cardiac & Cardiovascular Systems
James N. Kiage, Sheharyar Minhas, David Hana, Nadim Khouzam, Amir Khouzam, Rajesh Kabra
Summary: Pregnancy leads to cardiovascular changes increasing the risk of atrial fibrillation in women. Multiparity is associated with an increased risk of atrial fibrillation in a dose-response relationship, suggesting the need for further studies to elucidate this association.
CURRENT PROBLEMS IN CARDIOLOGY
(2021)
Article
Nutrition & Dietetics
Shengyi Yang, Rupak Pudasaini, Hong Zhi, Lina Wang
Summary: The results of univariable and multivariable Mendelian randomization analysis suggest that there is no significant association between blood lipids and the risk of atrial fibrillation.
Article
Veterinary Sciences
Carlo Guglielmini, Carlotta Valente, Giovanni Romito, Chiara Mazzoldi, Marco Baron Toaldo, Marlos Goncalves Sousa, Marcela Wolf, Tamyris Beluque, Oriol Domenech, Valentina Patata, Francesco Porciello, Paolo Ferrari, Domenico Caivano, Barbara Contiero, Helen Poser
Summary: The aim of this study was to identify risk factors for the development of atrial fibrillation in dogs with an echocardiographic diagnosis of dilated cardiomyopathy (DCM). The results showed that increased left atrial diameter and presence of right atrial enlargement were significant predictors of atrial fibrillation development.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Hasan K. Siddiqi, Manickavasagar Vinayagamoorthy, Baris Gencer, Chee Ng, Julie Pester, Nancy R. Cook, I-Min Lee, Julie Buring, JoAnn E. Manson, Christine M. Albert
Summary: This study examines sex differences in atrial fibrillation (AF) incidence in a contemporary cohort without prevalent cardiovascular disease (CVD). It suggests that after controlling for height and/or body size, women without CVD at baseline were at higher risk for AF than men.
Article
Cardiac & Cardiovascular Systems
Shaan Khurshid, Samuel Friedman, Christopher Reeder, Paolo Di Achille, Nathaniel Diamant, Pulkit Singh, Lia X. Harrington, Xin Wang, Mostafa A. Al-Alusi, Gopal Sarma, Andrea S. Foulkes, Patrick T. Ellinor, Christopher D. Anderson, Jennifer E. Ho, Anthony A. Philippakis, Puneet Batra, Steven A. Lubitz
Summary: The AI-based analysis of 12-lead ECGs has a similar predictive usefulness as a clinical risk factor model for incident AF, and the two approaches can complement each other.
Article
Cardiac & Cardiovascular Systems
Tanja Charlotte Frederiksen, Morten Krogh Christiansen, Emelia J. Benjamin, Kim Overvad, Anja Olsen, Mette K. Andersen, Torben Hansen, Niels Grarup, Henrik Kjaerulf Jensen, Christina C. Dahm
Summary: This study aimed to assess the interaction between lifestyle and genetics on the risk of atrial fibrillation (AF). The findings showed that regardless of genetic risk, a worse lifestyle was associated with higher incidence rates of AF.
Article
Environmental Sciences
Jesse D. Thacher, Aslak H. Poulsen, Ulla A. Hvidtfeldt, Ole Raaschou-Nielsen, Matthias Ketzel, Steen S. Jensen, Jorgen Brandt, Victor H. Valencia, Thomas Muenzel, Mette Sorensen
Summary: Transportation noise is found to be associated with a small increase in AF risk, especially for exposure at the least exposed facade.
ENVIRONMENTAL RESEARCH
(2022)
Letter
Medicine, General & Internal
Raymond Ngai Chiu Chan, Robert Ngai Fung Chan, Oscar Hou In Chou, Gary Tse, Sharen Lee
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Beizheng Xu, Yueying Wang, Gary Tse, Jiayi Chen, Guangping Li, Panagiotis Korantzopoulos, Tong Liu
Summary: This systematic review and meta-analysis found that radiation therapy (RT) may increase the acute and long-term risks for patients with cardiac implantable electronic devices (CIEDs) such as pacemakers and implantable cardioverter-defibrillators. The risk of device malfunction was higher for implantable cardioverter-defibrillator (ICD) than pacemakers, and higher with radiation using beam energy ≥ 10 MV and neutron-generating RT. Risk stratification is needed for patients with cancer receiving RT and have CIEDs.
Review
Cell Biology
Daiqi Liu, Xuyao Han, Zhiwei Zhang, Gary Tse, Qingmiao Shao, Tong Liu
Summary: Heat shock proteins (HSPs) are protective proteins that play a role in cell stress response. They have been found to protect cells and organs, especially the cardiovascular system, against harmful conditions. Recent research has focused on the role of HSPs in the remodeling of atrial fibrillation (AF), a common arrhythmia that can be life-threatening.
Article
Endocrinology & Metabolism
Carlin Chang, Jiandong Zhou, Oscar Hou In Chou, Justin Chan, Keith Sai Kit Leung, Teddy Tai Loy Lee, Wing Tak Wong, Abraham Ka Chung Wai, Tong Liu, Qingpeng Zhang, Sharen Lee, Gary Tse
Summary: This study evaluated the predictive value of neutrophil-to-lymphocyte ratio (NLR) for ischemic stroke and atrial fibrillation (AF) in patients with type 2 diabetes mellitus. The results showed that NLR was significantly associated with an increased risk of new-onset ischemic stroke and AF. NLR had predictive value for ischemic stroke but lower predictive value for AF in Chinese type 2 diabetes patients.
ENDOCRINOLOGY DIABETES & METABOLISM
(2023)
Article
Oncology
Jeffrey Shi Kai Chan, Yan Hiu Athena Lee, Jeremy Man Ho Hui, Kang Liu, Edward Christopher Dee, Kenrick Ng, Tong Liu, Gary Tse, Chi Fai Ng
Summary: Our study examined the impact of cardiovascular comorbidities on adverse cardiovascular outcomes in prostate cancer patients treated with androgen deprivation therapy (ADT). We analyzed data from Hong Kong patients with prostate cancer who received ADT and found that the presence of heart failure, myocardial infarction, arrhythmia, or a combination of these comorbidities was associated with increased cardiovascular risks. The number of major cardiovascular comorbidities had a prognostic impact, indicating its importance over the specific type of comorbidity.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Cardiac & Cardiovascular Systems
Ying Liu, Yi Zheng, Gary Tse, George Bazoukis, Konstantinos Letsas, Christos Goudis, Panagiotis Korantzopoulos, Guangping Li, Tong Liu
Summary: This systematic review and meta-analysis aimed to explore the relationship between sick sinus syndrome (SSS) and atrial fibrillation (AF) and compare different therapy strategies for patients with SSS and AF. Results showed that SSS was associated with a higher risk of new-onset AF. Catheter ablation was found to be more effective than pacemaker therapy in reducing the risk of AF recurrence, AF progression, mortality, stroke, and heart failure hospitalization. Different pacing strategies for SSS were also compared, with VVI/VVIR showing a higher risk of new-onset AF compared to DDD/DDDR. AAI/AAIR had a higher risk of all-cause mortality but a lower risk of cardiac death compared to DDD/DDDR. Right atrial septum pacing showed similar risks of new-onset AF or AF recurrence compared to right atrial appendage pacing. The meta-analysis emphasized the importance of avoiding high ventricular pacing percentages in SSS patients to reduce AF burden and mortality.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Hematology
Xiaogang Zhu, Zhenhua Wang, Markus W. Ferrari, Katharina Ferrari-Kuehne, David H. Hsi, Gary Tse, Quanzhong Zhou, Haifeng Liang, Yuhui Zhang, Jian Zhang
Summary: Infective endocarditis (IE) carries a high risk of vascular complications, which are correlated with increased mortality. The use of anticoagulation in IE patients remains controversial and challenging. An appropriate anticoagulation strategy is crucial for improving outcomes and requires a good understanding of the indication, timing, and regimen of anticoagulation in IE.
THROMBOSIS RESEARCH
(2023)
Article
Medicine, Research & Experimental
Jeffrey Shi Kai Chan, Dawnie Ho Hei Lau, Emma King, Leonardo Roever, Tong Liu, Yuki Ka Ling Shum, Kenrick Ng, Edward Christopher Dee, Ana Ciobanu, George Bazoukis, Elham Mahmoudi, Danish Iltaf Satti, Kamalan Jeevaratnam, Adrian Baranchuk, Gary Tse, Cardiovasc Analyt Grp
Summary: This article introduces a virtual international medical research mentoring organization, which has successfully trained 63 members from 14 different countries in academic medicine through the use of virtual platforms and multi-level mentoring approach. The members have published over 100 peer-reviewed research and review articles and won 13 research prizes. This accessible and distributed model is viable and efficient, catering to the needs of contemporary healthcare, and others should consider building similar models to improve medical research mentoring globally.
Article
Cardiac & Cardiovascular Systems
Xiaoyan Liu, Lidong Huang, Gary Tse, Tong Liu, Jingjin Che
Summary: This study retrospectively analyzed the efficacy and safety of LCZ696 in patients with CHF and ESRD on dialysis. The results showed that LCZ696 treatment group had significantly lower rate of HF rehospitalization, delayed occurrence of HF rehospitalization, and longer survival time. Therefore, LCZ696 is effective and safe in CHF patients with ESRD on dialysis.
CLINICAL CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sharen Lee, Cheuk To Skylar Chung, Danny Radford, Oscar Hou In Chou, Teddy Tai Loy Lee, Zita Man Wai Ng, Leonardo Roever, Rajesh Rajan, George Bazoukis, Konstantinos P. P. Letsas, Shaoying Zeng, Fang Zhou Liu, Wing Tak Wong, Tong Liu, Gary Tse
Summary: This study found that there are differences in health care resource utilization and costs between patients with Brugada syndrome (BrS) and congenital long QT syndrome (LQTS). BrS patients have lower total costs but higher costs for Accident and Emergency (A & E) and general outpatient services, while they have lower costs for inpatient stay and specialist outpatient services compared to LQTS patients.
CLINICAL CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Gary Tse, Quinncy Lee, Oscar Hou In Chou, Cheuk To Chung, Sharen Lee, Jeffrey Shi Kai Chan, Guoliang Li, Narinder Kaur, Leonardo Roever, Haipeng Liu, Tong Liu, Jiandong Zhou
Summary: Routinely collected electronic health records (EHRs) data provide valuable information for epidemiological studies, and the use of big data and artificial intelligence (AI) has rapidly increased in Hong Kong since 2015. The advantages of big data include generalizability, simultaneous determination of multiple outcomes, ease of cross-validation, analysis of numerous variables, analysis of static and dynamic variables, capturing non-linear and latent interactions, and enhancing prediction models with AI approaches.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Bonn Lee, Charlotte Edling, Shiraz Ahmad, Fiona E. N. Lebeau, Gary Tse, Kamalan Jeevaratnam
Summary: This study reviewed clinical and non-clinical literature on cardiovascular disease risks, electrocardiograms, neurocardiac lesions in Parkinson's disease, and fundamental electrophysiological studies. Pathological evidence suggests that the hearts of Parkinson's disease patients may undergo alpha-synucleinopathy. Future research is needed to integrate cardiac electrophysiology and pathological alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Jonathan V. V. Mui, Lifang Li, Oscar Hou In Chou, Nida Azfar, Athena Lee, Jeremy Hui, Sharen Lee, Gary Tse, Jiandong Zhou
Summary: This study investigated the risk of new onset depression in patients with type 2 diabetes mellitus using sodium-glucose co-transporter 2 inhibitors (SGLT2Is) compared to dipeptidyl peptidase 4 inhibitors (DPP4Is). The findings suggest that SGLT2I use is associated with a significantly lower risk of depression compared to DPP4I use in these patients.
ACTA DIABETOLOGICA
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Ronald Nam, Gary Tse
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Oncology
Yan Hiu Athena Lee, Jeremy Man Ho Hui, Chi Ho Leung, Christopher Tze Wei Tsang, Kyle Hui, Pias Tang, Jeffrey Shi Kai Chan, Edward Christopher Dee, Kenrick Ng, Sean McBride, Paul L. Nguyen, Gary Tse, Chi Fai Ng
Summary: This study compared the risks of major adverse cardiovascular events (MACE) between enzalutamide and abiraterone in prostate cancer patients, and found that enzalutamide users had lower cardiovascular risks.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
