Article
Cardiac & Cardiovascular Systems
Qi Jiang, Dingxin Qin, Ling Yang, Yongping Lin, Lishang Zhai, Yuli Zhang, Gang Yang, Kexin Wang, Debing Tong, Xintao Li, Zijun Chen, Kai Huang, Tianhong Yu, Xue Xiang, Chang Cui, Cheng Cai, Jiaojiao Shi, Mingfang Li, Minglong Chen
Summary: The study provides strong evidence that high Lp(a) increases the risk of AF. No other lipid components were causally associated with AF, CES, or HF, except for a marginal association between triglycerides and HF.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Medicine, General & Internal
Sehoon Park, Soojin Lee, Yaerim Kim, Semin Cho, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Soryoung Lee, Eue-Keun Choi, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Summary: The study found that a genetic predisposition for AF is significantly associated with lower gray matter volume but not with white matter volume. The total effect of AF on gray matter volume may be mediated by ischemic stroke.
Article
Cardiac & Cardiovascular Systems
Weiqi Chen, Xueli Cai, Hongyi Yan, Yuesong Pan
Summary: Using Mendelian randomization, this study found that genetically predicted OSA has a causal effect on an increased risk of atrial fibrillation. The results were consistent across various sensitivity analyses.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Genetics & Heredity
Milad Nazarzadeh, Ana-Catarina Pinho-Gomes, Zeinab Bidel, Dexter Canoy, Abbas Dehghan, Karl Smith Byrne, Derrick A. Bennett, George Davey Smith, Kazem Rahimi
Summary: The effect of elevated blood pressure on the risk of atrial fibrillation is likely causal, indicating that blood pressure-lowering treatment may be effective in preventing atrial fibrillation. However, average effects hide clinically important variations, with a more pronounced effect in individuals with high genetic susceptibility risk for atrial fibrillation.
Article
Cardiac & Cardiovascular Systems
Guihong Liu, Tao Chen, Xin Zhang, Binbin Hu, Huashan Shi
Summary: The aim of this study was to investigate the direct causal effect of atrial fibrillation (AF) on pulmonary embolism (PE). Using a Mendelian randomization approach, no evidence was found to suggest an association between genetically predicted AF and risk of PE. These findings do not support a causal role of AF in the development of PE.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Review
Endocrinology & Metabolism
Mingjian Shi, Ali M. Manouchehri, Christian M. Shaffer, Nataraja Sarma Vaitinadin, Jacklyn N. Hellwege, Joe-Elie Salem, Lea K. Davis, Jill H. Simmons, Dan M. Roden, M. Benjamin Shoemaker, Jane F. Ferguson, Jonathan D. Mosley
Summary: Genetic predisposition to lower TSH levels is associated with increased risk of atrial fibrillation through mechanisms mediated in part by taller stature. Understanding these genetic mechanisms could lead to improved targeted therapies to mitigate AF risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Tao Cheng, Huan Wang, Yuanhui Hu
Summary: The study investigated the causal relationship between blood metabolites and atrial fibrillation (AF) using Mendelian randomization analysis. Two metabolites, tryptophan betaine and uridine, were found to be causally related to AF. These findings provide new insights into the pathogenesis of AF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Ya-fang Gao, Tian-yu Jin, Yan Chen, Ya-hui Ding
Summary: This study used Mendelian randomization (MR) analysis to investigate the causal genetic relationships between atrial fibrillation (AF) and vascular dementia (VaD). The results showed that there were no significant genetic relationships between AF and VaD risk, as well as between VaD and AF risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaoyu Zhang, Biyan Wang, Tao Geng, Di Liu, Qiuyue Tian, Xiaoni Meng, Qiaoyun Zhang, Mengyang Jiang, Yiqiang Zhang, Manshu Song, Wei Wang, Youxin Wang, Baoguo Wang
Summary: This MR study provides no clear evidence that COVID-19 is causally associated with the risk of AF.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Rohin K. Reddy, Maddalena Ardissino, Fu Siong Ng
Summary: This study conducted Mendelian randomization and found that type 2 diabetes (T2D) is causally associated with atrial fibrillation (AF), with mediation through systolic blood pressure. The findings suggest that besides glycemic control, reducing systolic blood pressure may provide specific benefits for AF risk in patients with T2D.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Mingxiao Li, Chao Jiang, Yiwei Lai, Yufeng Wang, Manlin Zhao, Sitong Li, Xiaodong Peng, Liu He, Xueyuan Guo, Songnan Li, Nian Liu, Chenxi Jiang, Ribo Tang, Caihua Sang, Deyong Long, Xin Du, Jianzeng Dong, Changsheng Ma
Summary: This study provides evidence supporting the causal effect of atrial fibrillation (AF) on overall dementia and vascular dementia, with ischemic stroke and low cardiac output potentially mediating this association.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Yuntao Feng, Xuebo Liu, Hongwei Tan
Summary: A recent study found a link between immune responses and atrial fibrillation (AF), but it is unclear whether the immune response is a cause or consequence of AF. Using a genetic prediction method, this study discovered a causal relationship between peripheral immune cell counts and AF, particularly in lymphocytes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Xingang Sun, Yunlong Lu, Zhen Wang, Qiqi Wang, Liangrong Zheng
Summary: The study found no causal association between plasma Hcy levels and AF based on Mendelian randomization analyses, suggesting that genetically elevated Hcy levels do not increase the risk of AF. The results were consistent across different methods and sensitivity analyses, indicating the robustness of the findings.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Georgios Georgiopoulos, Georgios Ntritsos, Kimon Stamatelopoulos, Costas Tsioufis, Alberto Aimo, Stefano Masi, Evangelos Evangelou
Summary: Observational studies have shown that elevated blood pressure is the leading risk factor for atrial fibrillation, and this study used Mendelian randomization to investigate the potential causal relationship between blood pressure levels and AF risk. The results suggest that there is a likely causal association between increased blood pressure levels and the risk of developing AF, and optimal blood pressure control might be an important therapeutic target for AF prevention independently from other risk factors.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Qin Wang, Tom G. Richardson, Eleanor Sanderson, Matthew J. Tudball, Mika Ala-Korpela, George Davey Smith, Michael Holmes
Summary: This study used Mendelian randomization analysis to evaluate the causes and consequences of atrial fibrillation (AF). The results showed that body mass index, height, systolic blood pressure, and genetic liability to coronary artery disease are independent causal risk factors for AF. Additionally, several proteins were identified as having therapeutic potential for AF.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Nutrition & Dietetics
Mi Ma, Hong Zhi, Shengyi Yang, Evan Yi-Wen Yu, Lina Wang
Summary: This study used a two-sample Mendelian randomization (TSMR) study to investigate the potential causal relationship between body mass index (BMI) and the risk of atrial fibrillation (AF). The results showed that higher BMI causally increased the risk of AF, suggesting that controlling BMI and obesity can help prevent AF.