期刊
EUROPEAN HEART JOURNAL
卷 42, 期 12, 页码 1170-1177出版社
OXFORD UNIV PRESS
DOI: 10.1093/eurheartj/ehaa953
关键词
Alcohol consumption; Atrial fibrillation; Epidemiology; Biomarkers
资金
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme [648131]
- European Union's Horizon 2020 research and innovation programme [847770]
- German Center for Cardiovascular Research (DZHK e. V.) [81Z1710103]
- German Ministry of Research and Education [BMBF 01ZX1408A]
- ERACoSysMed3 [031L0239]
- European Union Seventh Framework Programme (FP7/2007-2013) [HEALTH-F2-2011, 278913]
- European Union Seventh Framework Programme project ENGAGE [HEALTH-F42007-2014113]
- European Union Seventh Framework Programme project CHANCES [HEALTH-F3-2010-242244]
- Medical Research Council London [G0601463, 80983]
- National Institute for Health and Welfare, Finland (THL)
- Finnish Foundation for Cardiovascular Research and the Academy of Finland [139635]
- Emil Aaltonen Foundation
- Paavo Nurmi Foundation
- Finnish Medical Foundation
- Academy of Finland [321351]
- Norr county council
- Vasterbotten county council
- Vasterbotten county council (ALF)
- Swedish Heart and Lung Foundation
- Ministero della Salute, Italy. Bando Ricerca Finalizzata 2018 [RF-2018-12367074]
- MRC [G0601463] Funding Source: UKRI
This study found that even modest alcohol intake (1.2 drinks/day) was associated with an increased risk of atrial fibrillation, which needs to be considered in atrial fibrillation prevention.
Aims There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of alcohol intake in European cohorts. Methods and results In a community-based pooled cohort, we followed 107 845 individuals for the association between alcohol consumption, including types of alcohol and drinking patterns, and incident AF. We collected information on classical cardiovascular risk factors and incident heart failure (HF) and measured the biomarkers N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin I. The median age of individuals was 47.8 years, 48.3% were men. The median alcohol consumption was 3 g/day. N = 5854 individuals developed AF (median follow-up time: 13.9 years). In a sex- and cohort-stratified Cox regression analysis alcohol consumption was non-linearly and positively associated with incident AF. The hazard ratio for one drink (12 g) per day was 1.16, 95% CI 1.11-1.22, P < 0.001. Associations were similar across types of alcohol. In contrast, alcohol consumption at lower doses was associated with reduced risk of incident HF. The association between alcohol consumption and incident AF was neither fully explained by cardiac biomarker concentrations nor by the occurrence of HF. Conclusions In contrast to other cardiovascular diseases such as HF, even modest habitual alcohol intake of 1.2 drinks/day was associated with an increased risk of AF, which needs to be considered in AF prevention.
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