Review
Biochemistry & Molecular Biology
Dumitru Constantin-Teodosiu, Despina Constantin
Summary: Muscle fatigue can decrease the capacity of muscles to complete tasks over time, with short-lasting fatigue often caused by overtraining, undertraining, or physical injury, while persistent and severe fatigue may be associated with pathological states or chronic exposure to certain substances.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Yuntian Shen, Ming Li, Kexin Wang, Guangdong Qi, Hua Liu, Wei Wang, Yanan Ji, Mengyuan Chang, Chunyan Deng, Feng Xu, Mi Shen, Hualin Sun
Summary: Diabetes mellitus is a chronic disease that can lead to complications such as kidney disease, cardiovascular disease, neuropathy, and skeletal muscle atrophy. Understanding the molecular regulatory mechanisms of diabetic muscular atrophy is important in developing new treatment strategies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lauren Jun, Megan Robinson, Thangiah Geetha, Tom L. L. Broderick, Jeganathan Ramesh Babu
Summary: Skeletal muscle atrophy is a prevalent issue in numerous pathological conditions and has significant implications for the health of society, particularly older adults. The detrimental effects of muscle atrophy include functional disability, increased fracture risk, decreased metabolic rate, and reduced bone density. This review article focuses on the prevalence and mechanisms of skeletal muscle atrophy, with particular emphasis on high-fat, high-sugar diets, obesity, and diabetes, as well as other conditions such as sarcopenia, Alzheimer's disease, cancer cachexia, and heart failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Geriatrics & Gerontology
Kate T. Murphy, Gordon S. Lynch
Summary: There is increasing evidence that neurodegenerative disorders, such as Parkinsonian syndromes, are associated with impaired skeletal muscle health, leading to wasting and weakness. However, the concept of skeletal muscle health has been understudied and is an important area that needs attention. This review focuses on the changes in skeletal muscle health in Parkinson's disease and two atypical Parkinsonian syndromes, multiple system atrophy and progressive supranuclear palsy, and discusses potential pharmacological interventions. It also highlights the need for personalized interventions and early diagnosis to preserve muscle health and improve quality of life for patients with these syndromes.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Biochemistry & Molecular Biology
Zhaolu Wang, Jinjin Yang, Xiaohui Sun, Xi Sun, Gongshe Yang, Xin'e Shi
Summary: Skeletal muscle plays a crucial role in physical activities, metabolism, and energy balance, but its homeostasis is challenged by various factors such as injury, aging, and obesity. Exosomes, a type of extracellular vesicles, have emerged as important mediators in intercellular communication and hold great potential for treating skeletal muscle diseases. This review outlines recent research progress in exosomal isolation, characterization, mechanism of action, and highlights advancements in exosomes derived from different organs and tissues, as well as engineered exosomes, which have the ability to regulate the physiological and pathological development of skeletal muscle. These advancements enhance our understanding of muscle formation and diseases, and the utilization of engineered exosomes as nanocarriers with advanced biomolecule design methodologies offers innovative therapeutic perspectives for muscle diseases.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Review
Pharmacology & Pharmacy
Kexin Wang, Qingyuan Liu, Mingyu Tang, Guangdong Qi, Chong Qiu, Yan Huang, Weiran Yu, Wei Wang, Hualin Sun, Xuejun Ni, Yuntian Shen, Xingxing Fang
Summary: Chronic kidney disease (CKD) is a high-risk chronic catabolic disease with high morbidity and mortality. CKD is accompanied by many complications, leading to a poor quality of life and even threatening the life of patients. Muscle atrophy is a common complication of CKD.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jinjoo Kim, Youngmo Yang, Eunwon Choi, Sumin Lee, Jiyoung Choi
Summary: This study investigates the effects of C-peptides on muscle atrophy and provides evidence that C-peptides can mitigate muscle weight reduction and preserve muscle function. The findings suggest the potential therapeutic application of C-peptides in treating diabetic muscular dystrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Yukun Liu, Dongfang Wang, Tianyu Li, Ligang Xu, Zhanfei Li, Xiangjun Bai, Manli Tang, Yuchang Wang
Summary: Septic myopathy, also known as ICU acquired weakness, is a clinical symptom of sepsis patients, characterized by muscle weakness and muscular atrophy, which affects respiratory and motor systems, reduces quality of life, and even threatens survival. Melatonin, a hormone secreted by the pineal gland, has multiple biological functions such as anti-inflammatory, antioxidant, and mitochondrial protection, and may play a role in the repair and regeneration of skeletal muscle atrophy in septic myopathy. This article critically discusses and reviews the effects of melatonin on sepsis and skeletal muscle depletion based on previous research results.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Geriatrics & Gerontology
Wei Chen, Yushi Chen, Yuxi Liu, Xinxia Wang
Summary: Autophagy is a physiological process that plays a crucial role in degrading cellular components and regulating cellular structure. It has been found to have various mechanisms and functions in muscle regeneration, including influencing the fate of muscle stem cells and regulating muscle cell functions. Understanding the role and mechanism of autophagy in muscle regeneration can lead to the development of more effective therapeutic strategies.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Physiology
Joseph J. Bass, Edward J. O. Hardy, Thomas B. Inns, Daniel J. Wilkinson, Mathew Piasecki, Robert H. Morris, Abi Spicer, Craig Sale, Ken Smith, Philip J. Atherton, Bethan E. Phillips
Summary: This study aimed to develop an experimental paradigm to investigate muscles with different susceptibility to atrophy, with the hope of uncovering central mechanisms. Results showed that after immobilization, there were differences in muscle volume and thickness between the tibialis anterior (TA) and medial gastrocnemius (MG) muscles, providing valuable insights into mechanisms of disuse atrophy.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Lin Yin, Na Li, Weihua Jia, Nuoqi Wang, Meidai Liang, Xiuying Yang, Guanhua Du
Summary: Skeletal muscle is crucial for various bodily functions, but pathological issues can lead to muscle wasting and atrophy, characterized by weakness and reduced mass. While exercise is effective, it is not universally applicable, highlighting the need for further research into treatment options.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Nutrition & Dietetics
Anna G. Beaudry, Michelle L. Law
Summary: Cancer cachexia is a syndrome of bodily wasting and functional decline. Nutritional support, particularly amino acid supplementation, is important in managing cachexia. Leucine has been found to increase protein synthesis and decrease degradation. Current research suggests that a leucine-rich diet can attenuate cachexia symptoms, but further studies are needed to explore its effects on protein turnover, immune response, and tumor growth.
Article
Neurosciences
Joseph J. Bass, Abid A. Kazi, Colleen S. Deane, Asif Nakhuda, Stephen P. Ashcroft, Matthew S. Brook, Daniel J. Wilkinson, Bethan E. Phillips, Andrew Philp, Janelle Tarum, Fawzi Kadi, Ditte Andersen, Amadeo Munoz Garcia, Ken Smith, Iain J. Gallagher, Nathaniel J. Szewczyk, Mark E. Cleasby, Philip J. Atherton
Summary: Reduced vitamin D receptor (VDR) expression leads to skeletal muscle atrophy through the induction of autophagy, without affecting muscle protein synthesis or anabolic signaling. VDR knockdown impairs mitochondrial function and myogenic regulation, highlighting its crucial role in maintaining muscle mass and limiting autophagy. These findings suggest a fundamental regulatory role of VDR in myogenesis and muscle mass regulation.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Review
Pharmacology & Pharmacy
Wei Wang, Ming Li, Zehao Chen, Lai Xu, Mengyuan Chang, Kexin Wang, Chunyan Deng, Yun Gu, Songlin Zhou, Yuntian Shen, Feng Tao, Hualin Sun
Summary: Pathophysiological changes of skeletal muscle can cause muscle atrophy and dysfunction, greatly affecting quality of life. Extracellular vesicles (EVs) are involved in the pathophysiological processes of skeletal muscle. EVs play a role in skeletal muscle growth, regeneration, and atrophy by delivering bioactive molecules. EVs have potential as biomarkers and therapeutic carriers for skeletal muscle diseases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Elisa Duranti, Chiara Villa
Summary: ALS is a fatal disease characterized by the loss of motor neurons, leading to muscle damage and paralysis. Muscle research plays a crucial role in understanding the molecular mechanisms and developing treatments for this disease.
Article
Biochemical Research Methods
Larissa Stebounova, Scott M. Ebert, Logan T. Murry, Christopher M. Adams, Daryl J. Murry
JOURNAL OF CHROMATOGRAPHIC SCIENCE
(2018)
Article
Neurosciences
David C. Hughes, George R. Marcotte, Leslie M. Baehr, Daniel W. D. West, Andrea G. Marshall, Scott M. Ebert, Arik Davidyan, Christopher M. Adams, Sue C. Bodine, Keith Baar
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Clinical Neurology
Asma Al-Zougbi, Katherine D. Mathews, Amal Shibli-Rahhal
Article
Biochemistry & Molecular Biology
Jordan D. Fuqua, Caleb P. Mere, Ana Kronemberger, Jay Blomme, Dam Bae, Kristen D. Turner, Matthew P. Harris, Estevao Scudese, Mitchell Edwards, Scott M. Ebert, Luis G. O. de Sousa, Sue C. Bodine, Ling Yang, Christopher M. Adams, Vitor A. Lira
Article
Physiology
Scott M. Ebert, Jason M. Dierdorff, David K. Meyerholz, Steven A. Bullard, Asma Al-Zougbi, Austin D. DeLau, Kristin C. Tomcheck, Zachary P. Skopec, George R. Marcotte, Sue C. Bodine, Christopher M. Adams
JOURNAL OF APPLIED PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Scott M. Ebert, Steven A. Bullard, Nathan Basisty, George R. Marcotte, Zachary P. Skopec, Jason M. Dierdorff, Asma Al-Zougbi, Kristin C. Tomcheck, Austin D. DeLau, Jacob A. Rathmacher, Sue C. Bodine, Birgit Schilling, Christopher M. Adams
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Immunology
Adeline Rosu, Najla El Hachem, Francesca Rapino, Kevin Rouault-Pierre, Joseph Jorssen, Joan Somja, Eve Ramery, Marc Thiry, Laurent Nguyen, Maarten Jacquemyn, Dirk Daelemans, Christopher M. Adams, Dominique Bonnet, Alain Chariot, Pierre Close, Fabrice Bureau, Christophe J. Desmet
Summary: The study reveals the crucial role of tRNA anticodon modifications in hematopoiesis, with Elp3 deficiency causing bone marrow failure and activating a p53-dependent checkpoint resembling amino acid deprivation response, ultimately promoting the development of cancer.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Cell Biology
Zheng Fan, Guillermo Turiel, Raphaela Ardicoglu, Moheb Ghobrial, Evi Masschelein, Tea Kocijan, Jing Zhang, Ge Tan, Gillian Fitzgerald, Tatiane Gorski, Abdiel Alvarado-Diaz, Paola Gilardoni, Christopher M. Adams, Bart Ghesquiere, Katrien De Bock
Summary: The study suggests that there are two populations of muscle endothelial cells characterized by differential expression of ATF3/4, with red ATF3/4(+) mECs being more angiogenic compared to white ATF3/4(low) mECs. Mechanistically, ATF3/4 in mECs control genes involved in amino acid uptake and metabolism, metabolically priming red mECs for angiogenesis. Deletion of Atf4 in ECs was found to impair exercise-induced angiogenesis.
Review
Nutrition & Dietetics
Scott M. Ebert, Blake B. Rasmussen, Andrew R. Judge, Sarah M. Judge, Lars Larsson, Ronald C. Wek, Tracy G. Anthony, George R. Marcotte, Matthew J. Miller, Mark A. Yorek, Adrian Vella, Elena Volpi, Jennifer Stern, Matthew D. Strub, Zachary Ryan, John J. Talley, Christopher M. Adams
Summary: Activating transcription factor 4 (ATF4) is a multifunctional protein that regulates transcription and is involved in various cellular responses. Most of our knowledge about ATF4 comes from studies conducted in cultured cells, with limited understanding of its in vivo role. This review provides an overview of the basic biology of ATF4 and focuses on its role in mammalian skeletal muscle fibers.
JOURNAL OF NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Xiaoding Wang, Guangyu Zhang, Subhajit Dasgupta, Erica L. Niewold, Chao Li, Qinfeng Li, Xiang Luo, Lin Tan, Anwarul Ferdous, Philip L. Lorenzi, Beverly A. Rothermel, Thomas G. Gillette, Christopher M. Adams, Philipp E. Scherer, Joseph A. Hill, Zhao Wang
Summary: ATF4 plays a critical role in heart failure induced by pressure overload, governing the production of NADPH in both the cytosol and mitochondria. This finding provides important insights for further research on the molecular mechanisms of the heart in response to oxidative stress.
CIRCULATION RESEARCH
(2022)
Article
Biochemical Research Methods
Nathan Basisty, Nicholas Shulman, Cameron Wehrfritz, Alexandra N. Marsh, Samah Shah, Jacob Rose, Scott Ebert, Matthew Miller, Dao-Fu Dai, Peter S. Rabinovitch, Christopher M. Adams, Michael J. MacCoss, Brendan MacLean, Birgit Schilling
Summary: In this study, a new computational tool, TurnoveR, was developed to accurately calculate protein turnover rates and integrated into the Skyline proteomics software. The computational pipeline of TurnoveR replicated previous study results and is expected to facilitate the broader application of protein turnover analysis in various relevant areas.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Medicine, Research & Experimental
George R. Marcotte, Matthew J. Miller, Hawley E. Kunz, Zachary C. Ryan, Matthew D. Strub, Patrick M. Vanderboom, Carrie J. Heppelmann, Sarah Chau, Zachary D. Von Ruff, Sean P. Kilroe, Andrew T. Mckeen, Jason M. Dierdorff, Jennifer I. Stern, Karl A. Nath, Chad E. Grueter, Vitor A. Lira, Andrew R. Judge, Blake B. Rasmussen, K. Sreekumaran Nair, Ian R. Lanza, Scott M. Ebert, Christopher M. Adams
Summary: The expression of GADD45A in skeletal muscle is associated with mitochondrial loss, atrophy, and weakness. These findings provide new insights for identifying therapeutic targets for human muscle weakness.
Article
Biochemistry & Molecular Biology
Renata Oliveira Pereira, Satya M. Tadinada, Frederick M. Zasadny, Karen Jesus Oliveira, Karla Maria Pereira Pires, Angela Olvera, Jennifer Jeffers, Rhonda Souvenir, Rose Mcglauflin, Alec Seei, Trevor Funari, Hiromi Sesaki, Matthew J. Potthoff, Christopher M. Adams, Ethan J. Anderson, E. Dale Abel
