Neuroprotective Effects of Pomegranate Juice against Parkinson’s Disease and Presence of Ellagitannins-Derived Metabolite—Urolithin A—In the Brain

Induction of Autophagy and Activation of SIRT-1 Deacetylation Mechanisms Mediate Neuroprotection by the Pomegranate Metabolite Urolithin A in BV2 Microglia and Differentiated 3D Human Neural Progenitor Cells

(2019) Ravikanth Velagapudi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Neuroprotective Effects of Thymol, a Dietary Monoterpene Against Dopaminergic Neurodegeneration in Rotenone-Induced Rat Model of Parkinson’s Disease

(2019) Hayate Javed et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Urolithin A‐activated autophagy but not mitophagy protects against ischemic neuronal injury by inhibiting ER stress in vitro and in vivo

(2019) Anil Ahsan et al.   CNS Neuroscience & Therapeutics

Predictors of Residue and Airway Invasion in Parkinson’s Disease

(2019) James A. Curtis et al.   DYSPHAGIA

Lycopodium Attenuates Loss of Dopaminergic Neurons by Suppressing Oxidative Stress and Neuroinflammation in a Rat Model of Parkinson’s Disease

(2019) Richard L. Jayaraj et al.   MOLECULES

Polyphenol Microbial Metabolites Exhibit Gut and Blood–Brain Barrier Permeability and Protect Murine Microglia against LPS-Induced Inflammation

(2019) Shelby L. Johnson et al.   Metabolites

Hypoxia‐inducible factor 1 alpha and nuclear‐related receptor 1 as targets for neuroprotection by albendazole in a rat rotenone model of Parkinson's disease

(2019) Esraa A. Kandil et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Maternal pomegranate juice attenuates maternal inflammation–induced fetal brain injury by inhibition of apoptosis, neuronal nitric oxide synthase, and NF-κB in a rat model

(2018) Yuval Ginsberg et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Punicalagin ameliorates the elevation of plasma homocysteine, amyloid-β, TNF-α and apoptosis by advocating antioxidants and modulating apoptotic mediator proteins in brain

(2018) Mohammed A. El-Missiry et al.   BIOMEDICINE & PHARMACOTHERAPY

Neuroprotective effect of agmatine (decarboxylated l-arginine) against oxidative stress and neuroinflammation in rotenone model of Parkinson’s disease

(2018) E K El-Sayed et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Damage to dopaminergic neurons by oxidative stress in Parkinson's disease (Review)

(2018) Ji‑Dong Guo et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Improved neuroprotective effect of resveratrol nanoparticles as evinced by abrogation of rotenone-induced behavioral deficits and oxidative and mitochondrial dysfunctions in rat model of Parkinson’s disease

(2018) Suresh Palle et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia

(2018) Gyeongjin Lee et al.   PHYTOMEDICINE

Polyphenols in Parkinson’s Disease: A Systematic Review of In Vivo Studies

(2018) Małgorzata Kujawska et al.   Nutrients

New Perspectives on Roles of Alpha-Synuclein in Parkinson’s Disease

(2018) Guoxin Zhang et al.   Frontiers in Aging Neuroscience

Bougainvillea spectabilis flowers extract protects against the rotenone-induced toxicity

(2017) Omar M.E. Abdel-Salam et al.   Asian Pacific Journal of Tropical Medicine

Mechanistic Investigations of the Mitochondrial Complex I Inhibitor Rotenone in the Context of Pharmacological and Safety Evaluation

(2017) Sabrina Heinz et al.   Scientific Reports

Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments

(2017) Panchanan Maiti et al.   Translational Neurodegeneration

Resveratrol supplementation confers neuroprotection in cortical brain tissue of nonhuman primates fed a high-fat/sucrose diet

(2016) Michel Bernier et al.   Aging-US

Neuroprotective Effects of Bioavailable Polyphenol-Derived Metabolites against Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells

(2016) Antonio González-Sarrías et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Vanillin Attenuated Behavioural Impairments, Neurochemical Deficts, Oxidative Stress and Apoptosis Against Rotenone Induced Rat Model of Parkinson’s Disease

(2016) Chinnasamy Dhanalakshmi et al.   NEUROCHEMICAL RESEARCH

Aquaporin-4 deficiency diminishes the differential degeneration of midbrain dopaminergic neurons in experimental Parkinson’s disease

(2016) Ji Zhang et al.   NEUROSCIENCE LETTERS

Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-β Peptide in Mice

(2016) Maressa Caldeira Morzelle et al.   PLoS One

Degeneration of Dopaminergic Neurons Due to Metabolic Alterations and Parkinson’s Disease

(2016) Juhyun Song et al.   Frontiers in Aging Neuroscience

Pomegranate extract decreases oxidative stress and alleviates mitochondrial impairment by activating AMPK-Nrf2 in hypothalamic paraventricular nucleus of spontaneously hypertensive rats

(2016) Wenyan Sun et al.   Scientific Reports

Pomegranate’s Neuroprotective Effects against Alzheimer’s Disease Are Mediated by Urolithins, Its Ellagitannin-Gut Microbial Derived Metabolites

(2015) Tao Yuan et al.   ACS Chemical Neuroscience

Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism

(2015) Ching-Chi Chiu et al.   EXPERIMENTAL NEUROLOGY

Curcumin ameliorates dopaminergic neuronal oxidative damage via activation of the Akt/Nrf2 pathway

(2015) QUNLI CUI et al.   Molecular Medicine Reports

Anti-oxidant polydatin (piceid) protects against substantia nigral motor degeneration in multiple rodent models of Parkinson’s disease

(2015) Yupin Chen et al.   Molecular Neurodegeneration

Determination of Phenolic Compounds and Antioxidant Activity in Leaves from Wild Rubus L. Species

(2015) Jan Oszmiański et al.   MOLECULES

Long-term (15 mo) dietary supplementation with pomegranates from Oman attenuates cognitive and behavioral deficits in a transgenic mice model of Alzheimer's disease

(2015) Selvaraju Subash et al.   NUTRITION

Neuroprotective potential of ferulic acid in the rotenone model of Parkinson’s disease

(2015) Emdadul Haque et al.   Drug Design Development and Therapy

Long-Term Dietary Supplementation of Pomegranates, Figs and Dates Alleviate Neuroinflammation in a Transgenic Mouse Model of Alzheimer’s Disease

(2015) Musthafa Mohamed Essa et al.   PLoS One

Pomegranate Extract Modulates Processing of Amyloid-β Precursor Proteinin an Aged Alzheimer’s Disease Animal Model

(2014) A Ahmed et al.   Current Alzheimer Research

Neuroprotective Effect of Punicalagin against Cerebral Ischemia Reperfusion-induced Oxidative Brain Injury in Rats

(2014) Lavanya Yaidikar et al.   Journal of Stroke & Cerebrovascular Diseases

Pomegranate extract protects against cerebral ischemia/reperfusion injury and preserves brain DNA integrity in rats

(2014) Maha A.E. Ahmed et al.   LIFE SCIENCES

Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients

(2014) María A. Nuñez-Sánchez et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Modulatory effects of sodium salicylate on the factors affecting protein aggregation during rotenone induced Parkinson’s disease pathology

(2014) Poonam Thakur et al.   NEUROCHEMISTRY INTERNATIONAL

Pomegranate phenolics inhibit formation of advanced glycation endproducts by scavenging reactive carbonyl species

(2014) Weixi Liu et al.   Food & Function

Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints

(2013) Susan Y. Bookheimer et al.   Evidence-based Complementary and Alternative Medicine

Chemical guide parameters for Punica granatum cv. ‘Mollar’ fruit juices processed at industrial scale

(2013) Salud Vegara et al.   FOOD CHEMISTRY

Pomegranate Polyphenols and Extract Inhibit Nuclear Factor of Activated T-Cell Activity and Microglial Activation In Vitro and in a Transgenic Mouse Model of Alzheimer Disease

(2013) Lalida Rojanathammanee et al.   JOURNAL OF NUTRITION

Alda-1 reduces cerebral ischemia/reperfusion injury in rat through clearance of reactive aldehydes

(2013) Si-Hai Fu et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in Parkinson's disease

(2013) Victor Tapias et al.   NEUROBIOLOGY OF AGING

Chronic exposure to rotenone, a dopaminergic toxin, results in peripheral neuropathy associated with dopaminergic damage

(2013) Zbigniew K. Binienda et al.   NEUROSCIENCE LETTERS

Ameliorative effect of Sida cordifolia in rotenone induced oxidative stress model of Parkinson's disease

(2013) Navneet Khurana et al.   NEUROTOXICOLOGY

Beneficial Effect of Vitamin E in Rotenone Induced Model of PD: Behavioural, Neurochemical and Biochemical Study

(2013) Neha Sharma et al.   Experimental Neurobiology

Attenuation of KBrO3-Induced Renal and Hepatic Toxicity By Cloudy Apple Juice In Rat

(2012) Małgorzata Kujawska et al.   PHYTOTHERAPY RESEARCH

Antiglycative and neuroprotective activity of colon-derived polyphenol catabolites

(2011) Elena Verzelloni et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Acetyl-l-carnitine and α-lipoic acid affect rotenone-induced damage in nigral dopaminergic neurons of rat brain, implication for Parkinson's disease therapy

(2011) Sawsan A. Zaitone et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Antioxidant status in rats after long-term intake of anthocyanins and ellagitannins from blackberries

(2010) Neuza MA Hassimotto et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

A highly reproducible rotenone model of Parkinson's disease

(2009) Jason R. Cannon et al.   NEUROBIOLOGY OF DISEASE

Parkinson-Linked Genes and Toxins That Affect Neuronal Cell Death Through the Bcl-2 Family

(2008) Douglas W. Ethell et al.   ANTIOXIDANTS & REDOX SIGNALING