Article
Biochemistry & Molecular Biology
Kimberly Barber, Patricia Mendonca, Jasmine A. Evans, Karam F. A. Soliman
Summary: Chronic oxidative stress and inflammation play a role in neurodegenerative diseases. Natural compounds, such as cardamonin, have been investigated for their ability to protect cells from oxidative stress. This study found that cardamonin has antioxidant and anti-inflammatory effects on LPS-activated BV-2 microglial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jung-Eun Park, Yea-Hyun Leem, Jin-Sun Park, Do-Yeon Kim, Jihee Lee Kang, Hee-Sun Kim
Summary: This study examined the anti-inflammatory and neuroprotective effects of GTS-21, a selective alpha 7 nicotinic acetylcholine receptor (alpha 7 nAChR) agonist, in neuroinflammation and Parkinson's disease (PD) mouse models. GTS-21 inhibited inflammation by reducing the expression of pro-inflammatory cytokines and activating anti-inflammatory signaling pathways. It also showed neuroprotective properties by reducing microglial activation and protecting dopaminergic neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Entomology
Hyun Seok Yun, Jisun Oh, Ji Sun Lim, Hyo Jung Kim, Jong-Sang Kim
Summary: This study compared the anti-inflammatory effects of wasp venom from the yellow-legged hornet (Vespa velutina) with bee venom on BV-2 murine microglial cells. The results showed that wasp venom effectively suppressed LPS-induced inflammation in microglial cells by inhibiting the NF-kappa B-mediated signaling pathway.
Article
Clinical Neurology
Tianyuan Wang, Huandi Weng, Hongji Zhou, Zecheng Yang, Zhongyou Tian, Biao Xi, Yalan Li
Summary: This study aimed to investigate the protective effects and mechanisms of action of esketamine in postoperative depression (POD). The results showed that esketamine can significantly improve depression-like symptoms caused by anesthesia and surgery, and restore synaptogenesis in the medial prefrontal cortex (mPFC) that had been perturbed by inflammation. The anti-inflammatory effects of esketamine may be mediated by the BDNF/TrkB signaling pathway.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Pharmacology & Pharmacy
Young-Sun Lee, Deepak Prasad Gupta, Sung Hee Park, Hyun-Jeong Yang, Gyun Jee Song
Summary: The study found that DMF can inhibit nitric oxide and proinflammatory cytokine production in microglia, induce microglial switching to the M2 state, increase the expression levels of autophagy markers such as LC3 and ATG7, and promote the formation of autophagosomes. These results suggest that DMF induces autophagy in microglia and its anti-inflammatory effects are partially mediated through an autophagy-dependent pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Yue Guo, Peng Zhang, Haosen Zhao, Chang Xu, Sen Lin, Xifan Mei, He Tian
Summary: In this study, melatonin was found to promote the beneficial polarization of microglia from pro-inflammatory to anti-inflammation, decrease ROS activity, and restore mitochondrial metabolism. Melatonin may have therapeutic potential for neuroinflammation-related neurological disorders, such as spinal cord injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Giovanni Pallio, Angela D'Ascola, Luigi Cardia, Federica Mannino, Alessandra Bitto, Letteria Minutoli, Giacomo Picciolo, Violetta Squadrito, Natasha Irrera, Francesco Squadrito, Domenica Altavilla
Summary: Metaxalone may have antioxidant and anti-inflammatory effects, with potential for treating neurological disorders associated with neuroinflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Manuela Leri, Marzia Vasarri, Federica Carnemolla, Francesco Oriente, Serena Cabaro, Maria Stio, Donatella Degl'Innocenti, Massimo Stefani, Monica Bucciantini
Summary: In Alzheimer's disease, microglia become chronically inflammatory and neurotoxic. Genetic variants of molecules like TREM2 increase the risk of developing AD. This study explored the protective effects of extra virgin olive oil polyphenols on neuronal and microglial cells, finding that they reduce pro-inflammatory cytokines, activate the anti-inflammatory pathway, and enhance microglial activity. These findings offer important insights into the mechanisms by which olive polyphenols alleviate neuroinflammation and neuronal impairment.
Article
Neurosciences
Mohamed H. Yousef, Mohamed Salama, Hassan A. N. El-Fawal, Anwar Abdelnaser
Summary: This study aims to explore the therapeutic utility of GSK3 inhibition in multimodal disease modification and emphasizes the difference in therapeutic value between selective isoform inhibition. The results reveal that GSK3 beta-selective inhibition has superior anti-inflammatory and anti-oxidative efficacy compared to GSK3 alpha-selective and non-selective pan-inhibition.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Elena Grao-Cruces, Maria C. Millan-Linares, Maria E. Martin-Rubio, Rocio Toscano, Sergio Barrientos-Trigo, Beatriz Bermudez, Sergio Montserrat-de la Paz
Summary: High-density lipoproteins (HDLs) are important for brain health in the central nervous system, but their functions may be compromised in obese patients. Obesity-related metabolic disturbances can reverse the antioxidant and anti-inflammatory properties of HDLs in microglial cells, leading to higher pro-inflammatory cytokine production.
Article
Polymer Science
Serra Falih Makttoof Alyousufi, Masoud Homayouni Tabrizi, Parichehreh Yaghmaei
Summary: In this study, liposomes containing Urolithin (Uro) B were designed and their antioxidant and anti-tumor properties were examined. The results showed that the nanoliposomes had suitable size and dispersion, effectively inhibited free radicals, and induced cell death in lung cancer cells by regulating related genes. These findings suggest the potential of Uro B-nanoliposomes in clinical applications against lung cancer.
Review
Cell Biology
Feng Xue, Heng Du
Summary: Mutations in the TREM2 gene are associated with the development of sporadic AD, but the exact role of TREM2 in the pathogenesis of AD is still unclear. Studies on AD mouse model transcriptomics can help understand the impact of TREM2 on the balance of pro- and anti-inflammatory microglial activations, potentially leading to the development of TREM2-targeted strategies for prevention and treatment of this neurodegenerative disorder.
Review
Chemistry, Medicinal
Emad H. M. Hassanein, Mostafa S. Abd El-Maksoud, Islam M. Ibrahim, Esraa K. Abd-alhameed, Hanan S. Althagafy, Nesma M. Mohamed, Samir A. Ross
Summary: Galangin, a naturally occurring flavonoid, has many biological activities including anti-inflammatory effects. Its mechanism of action involves suppressing p38 MAPK, NF-kB, and NLRP3 signaling pathways, which has been confirmed by molecular docking. Clinical translational research is needed to determine if galangin can be used as a safe natural source of anti-inflammatory medication for humans.
PHYTOTHERAPY RESEARCH
(2023)
Article
Oncology
Ting Li, Yun Xin Zhai, Tianyi Zheng, Bing Xu
Summary: In this study, neferine was found to suppress the activation of microglia and attenuate neuroinflammation, providing potential therapeutic options for Parkinson's disease.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Multidisciplinary Sciences
Lauren Mifflin, Zhirui Hu, Connor Dufort, Cynthia C. Hession, Alec J. Walker, Kongyan Niu, Hong Zhu, Nan Liu, Jun S. Liu, Joshua Z. Levin, Beth Stevens, Junying Yuan, Chengyu Zou
Summary: The study identifies a subclass of microglia, termed RIPK1-Regulated Inflammatory Microglia (RRIMs), in mouse models of ALS. RRIMs show significant up-regulation of proinflammatory pathways, are highly regulated by TNF alpha signaling, and their prevalence can be suppressed by inhibiting RIPK1 activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.