Transposon Insertion Mutagenesis in Mice for Modeling Human Cancers: Critical Insights Gained and New Opportunities

PiggyBac transposon tools for recessive screening identify B-cell lymphoma drivers in mice

(2019) Julia Weber et al.   Nature Communications

Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors

(2019) Pauline J. Beckmann et al.   CANCER RESEARCH

Insertional mutagenesis using the Sleeping Beauty transposon system identifies drivers of erythroleukemia in mice

(2019) Keith R. Loeb et al.   Scientific Reports

Src-Dependent DBL Family Members Drive Resistance to Vemurafenib in Human Melanoma

(2019) Charlotte R. Feddersen et al.   CANCER RESEARCH

Ambra1 Modulates the Sensitivity of Breast Cancer Cells to Epirubicin by Regulating Autophagy via ATG12

(2018) Wei-liang Sun et al.   CANCER SCIENCE

Genetic and clonal dissection of osteosarcoma progression and lung metastasis

(2018) Huaiyuan Xu et al.   INTERNATIONAL JOURNAL OF CANCER

Efficacy of Larotrectinib in TRK Fusion–Positive Cancers in Adults and Children

(2018) Alexander Drilon et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis

(2018) Safiyyah Ziyad et al.   Cell Reports

Transcriptomics and Transposon Mutagenesis Identify Multiple Mechanisms of Resistance to the FGFR Inhibitor AZD4547

(2018) Sjors M. Kas et al.   CANCER RESEARCH

Evaluating the landscape of gene cooperativity with receptor tyrosine kinases in liver tumorigenesis using transposon-mediated mutagenesis

(2018) Yannan Fan et al.   JOURNAL OF HEPATOLOGY

Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma

(2018) Eric P. Rahrmann et al.   MOLECULAR CANCER RESEARCH

Molecular profiling of nonalcoholic fatty liver disease-associated hepatocellular carcinoma using SB transposon mutagenesis

(2018) Takahiro Kodama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of RALY promotes migration and predicts poor prognosis in hepatocellular carcinoma

(2018) Zebin Zhu et al.   Cancer Management and Research

A functional genomics approach to identify pathways of drug resistance in medulloblastoma

(2018) Kelsey C. Bertrand et al.   Acta Neuropathologica Communications

RNA binding protein RALY promotes Protein Arginine Methyltransferase 1 alternatively spliced isoform v2 relative expression and metastatic potential in breast cancer cells

(2017) Emma Bondy-Chorney et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis

(2017) Tim Wartewig et al.   NATURE

Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma

(2017) Sjors M Kas et al.   NATURE GENETICS

A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes

(2017) Jorge de la Rosa et al.   NATURE GENETICS

Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf−/−mouse model

(2017) Emilie A. Chapeau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transposon mutagenesis identifies chromatin modifiers cooperating withRasin thyroid tumorigenesis and detectsATXN7as a cancer gene

(2017) Cristina Montero-Conde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for stratification

(2017) Liming Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

piggyBacmediates efficient in vivo CRISPR library screening for tumorigenesis in mice

(2017) Chunlong Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Transposon Screen Identifies Loss of Primary Cilia as a Mechanism of Resistance to SMO Inhibitors

(2017) Xuesong Zhao et al.   Cancer Discovery

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

(2016) Dominik Sturm et al.   CELL

Transposon mutagenesis identifies candidate genes that cooperate with loss of transforming growth factor-beta signaling in mouse intestinal neoplasms

(2016) Shelli M. Morris et al.   INTERNATIONAL JOURNAL OF CANCER

shRNA-mediated AMBRA1 knockdown reduces the cisplatin-induced autophagy and sensitizes ovarian cancer cells to cisplatin

(2016) Xiaoyan Li et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Analyzing tumor heterogeneity and driver genes in single myeloid leukemia cells with SBCapSeq

(2016) Karen M Mann et al.   NATURE BIOTECHNOLOGY

Sleeping Beautytransposon mutagenesis identifies genes that cooperate with mutantSmad4in gastric cancer development

(2016) Haruna Takeda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transposon mutagenesis identifies genes that cooperate with mutant Pten in breast cancer progression

(2016) Roberto Rangel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sleeping Beautyscreen revealsPpargactivation in metastatic prostate cancer

(2016) Imran Ahmad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FOXR2 contributes to cell proliferation and malignancy in human hepatocellular carcinoma

(2016) Xiao Wang et al.   TUMOR BIOLOGY

Ambra1 in autophagy and apoptosis: Implications for cell survival and chemotherapy resistance

(2016) WEI-LIANG SUN   Oncology Letters

Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application

(2016) Young Kwang Chae et al.   Oncotarget

Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation

(2016) Jianqiang Wu et al.   Cell Reports

Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5 +/− leukemia

(2015) Louise van der Weyden et al.   BMC CANCER

A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression

(2015) George Giotopoulos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Global burden of cancer attributable to high body-mass index in 2012: a population-based study

(2015) Melina Arnold et al.   LANCET ONCOLOGY

Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor

(2015) C. Dorr et al.   MOLECULAR CANCER RESEARCH

Transposon mutagenesis identifies genetic drivers of BrafV600E melanoma

(2015) Michael B Mann et al.   NATURE GENETICS

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

(2015) Branden S Moriarity et al.   NATURE GENETICS

Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression

(2015) Haruna Takeda et al.   NATURE GENETICS

Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia

(2015) L M Heltemes-Harris et al.   ONCOGENE

BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model

(2015) Daniele Perna et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice

(2015) Julia Weber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High expression of FOXR2 in breast cancer correlates with poor prognosis

(2015) Haiping Song et al.   TUMOR BIOLOGY

Identification of FoxR2 as an Oncogene in Medulloblastoma

(2014) Hideto Koso et al.   CANCER RESEARCH

Interplay between the immune system and adipose tissue in obesity

(2014) Mark A Exley et al.   JOURNAL OF ENDOCRINOLOGY

Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults

(2014) Krishnan Bhaskaran et al.   LANCET

A conditional piggyBac transposition system for genetic screening in mice identifies oncogenic networks in pancreatic cancer

(2014) Roland Rad et al.   NATURE GENETICS

Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes

(2014) Mark D M Leiserson et al.   NATURE GENETICS

The Candidate Cancer Gene Database: a database of cancer driver genes from forward genetic screens in mice

(2014) Kenneth L. Abbott et al.   NUCLEIC ACIDS RESEARCH

Genetic Signature of Histiocytic Sarcoma Revealed by a Sleeping Beauty Transposon Genetic Screen in Mice

(2014) Raha A. Been et al.   PLoS One

Sleeping Beauty Mouse Models Identify Candidate Genes Involved in Gliomagenesis

(2014) Irina Vyazunova et al.   PLoS One

The landscape of kinase fusions in cancer

(2014) Nicolas Stransky et al.   Nature Communications

Kinase fusions are frequent in Spitz tumours and spitzoid melanomas

(2014) Thomas Wiesner et al.   Nature Communications

TRKing Down an Old Oncogene in a New Era of Targeted Therapy

(2014) Aria Vaishnavi et al.   Cancer Discovery

A Sleeping Beauty screen reveals NF-kB activation in CLL mouse model

(2013) N. Zanesi et al.   BLOOD

Adaptive Immunity Does Not Strongly Suppress Spontaneous Tumors in a Sleeping Beauty Model of Cancer

(2013) L. M. Rogers et al.   JOURNAL OF IMMUNOLOGY

Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model

(2013) Emilie A Bard-Chapeau et al.   NATURE GENETICS

Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis

(2013) Eric P Rahrmann et al.   NATURE GENETICS

Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer

(2013) Aria Vaishnavi et al.   NATURE MEDICINE

Clonal Expansion Analysis of Transposon Insertions by High-Throughput Sequencing Identifies Candidate Cancer Genes in a PiggyBac Mutagenesis Screen

(2013) Roland H. Friedel et al.   PLoS One

Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia

(2013) J. Z. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups

(2013) L. A. Genovesi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low-copy piggyBac transposon mutagenesis in mice identifies genes driving melanoma

(2013) T. K. Ni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a neuronal transcription factor network involved in medulloblastoma development

(2013) Maria Łastowska et al.   Acta Neuropathologica Communications

Obesity in Cancer Survival

(2012) Niyati Parekh et al.   Annual Review of Nutrition

Loss of Rassf1a Synergizes with Deregulated Runx2 Signaling in Tumorigenesis

(2012) L. van der Weyden et al.   CANCER RESEARCH

Sex bias occurrence of hepatocellular carcinoma in Poly7 molecular subclass is associated withEGFR

(2012) Vincent W. Keng et al.   HEPATOLOGY

Adipocyte-derived endotrophin promotes malignant tumor progression

(2012) Jiyoung Park et al.   JOURNAL OF CLINICAL INVESTIGATION

A Transposon-Based Analysis of Gene Mutations Related to Skin Cancer Development

(2012) Rita M. Quintana et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The role of BRAF V600 mutation in melanoma

(2012) Paolo A Ascierto et al.   Journal of Translational Medicine

Increased tumorigenesis associated with loss of the tumor suppressor gene Cadm1

(2012) Louise van der Weyden et al.   Molecular Cancer

Clonal selection drives genetic divergence of metastatic medulloblastoma

(2012) Xiaochong Wu et al.   NATURE

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

(2012) Pedro A. Pérez-Mancera et al.   NATURE

Transposon-mediated BAC transgenesis in human ES cells

(2012) Maria Rostovskaya et al.   NUCLEIC ACIDS RESEARCH

Jdp2 downregulates Trp53 transcription to promote leukaemogenesis in the context of Trp53 heterozygosity

(2012) L van der Weyden et al.   ONCOGENE

Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells

(2012) H. Koso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma

(2012) K. M. Mann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer

(2012) K. A. O'Donnell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling the evolution of ETV6-RUNX1-induced B-cell precursor acute lymphoblastic leukemia in mice

(2011) L. van der Weyden et al.   BLOOD

Cell of origin strongly influences genetic selection in a mouse model of T-ALL

(2011) K. E. Berquam-Vrieze et al.   BLOOD

In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma

(2011) Florian A. Karreth et al.   CELL

Paracrine and Endocrine Effects of Adipose Tissue on Cancer Development and Progression

(2011) Jiyoung Park et al.   ENDOCRINE REVIEWS

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

Impact of Body Mass Index on Survival After Colorectal Cancer Diagnosis: The Cancer Prevention Study-II Nutrition Cohort

(2011) Peter T. Campbell et al.   JOURNAL OF CLINICAL ONCOLOGY

NONO and RALY proteins are required for YB-1 oxaliplatin induced resistance in colon adenocarcinoma cell lines

(2011) Serges P Tsofack et al.   Molecular Cancer

Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice

(2011) George S Vassiliou et al.   NATURE GENETICS

Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis

(2011) H Nikki March et al.   NATURE GENETICS

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis

(2011) T. K. Starr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sleeping Beauty–Mediated Somatic Mutagenesis Implicates CSF1 in the Formation of High-Grade Astrocytomas

(2010) Aaron M. Bender et al.   CANCER RESEARCH

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

(2010) Ramin Nazarian et al.   NATURE

PiggyBac Transposon Mutagenesis: A Tool for Cancer Gene Discovery in Mice

(2010) R. Rad et al.   SCIENCE

Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity

(2010) Roger H. Unger et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Identification of PDE4D as a Proliferation Promoting Factor in Prostate Cancer Using a Sleeping Beauty Transposon-Based Somatic Mutagenesis Screen

(2009) E. P. Rahrmann et al.   CANCER RESEARCH

Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

(2009) L. S. Collier et al.   CANCER RESEARCH

A Modified Sleeping Beauty Transposon System That Can Be Used to Model a Wide Variety of Human Cancers in Mice

(2009) A. J. Dupuy et al.   CANCER RESEARCH

A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma

(2009) Vincent W Keng et al.   NATURE BIOTECHNOLOGY

A Transposon-Based Genetic Screen in Mice Identifies Genes Altered in Colorectal Cancer

(2009) T. K. Starr et al.   SCIENCE

Medulloblastoma Can Be Initiated by Deletion of Patched in Lineage-Restricted Progenitors or Stem Cells

(2008) Zeng-Jie Yang et al.   CANCER CELL

Transposition of the vertebrate Tol2 transposable element in Drosophila melanogaster

(2008) Akihiro Urasaki et al.   GENE

Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

(2008) Andrew G Renehan et al.   LANCET

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Bacteriophage Mu integration in yeast and mammalian genomes

(2008) Anja O. Paatero et al.   NUCLEIC ACIDS RESEARCH

Chromosomal transposition of PiggyBac in mouse embryonic stem cells

(2008) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA