期刊
NATURE GENETICS
卷 46, 期 1, 页码 24-+出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ng.2847
关键词
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资金
- Biomedical Research Council
- Agency for Science, Technology and Research, Singapore
- Cancer Prevention Research Institute of Texas (CPRIT)
- Wellcome Trust
- Cancer Research UK
- Cancer Research UK [13031] Funding Source: researchfish
The most common risk factor for developing hepatocellular carcinoma (HCC) is chronic infection with hepatitis B virus (HBV). To better understand the evolutionary forces driving HCC, we performed a near-saturating transposon mutagenesis screen in a mouse HBV model of HCC. This screen identified 21 candidate early stage drivers and a very large number (2,860) of candidate later stage drivers that were enriched for genes that are mutated, deregulated or functioning in signaling pathways important for human HCC, with a striking 1,199 genes being linked to cellular metabolic processes. Our study provides a comprehensive overview of the genetic landscape of HCC.
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