Enhanced processivity of Dnmt1 by monoubiquitinated histone H3

Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation

(2018) Tao Li et al.   NUCLEIC ACIDS RESEARCH

Critical Role of the UBL Domain in Stimulating the E3 Ubiquitin Ligase Activity of UHRF1 toward Chromatin

(2018) Benjamin M. Foster et al.   MOLECULAR CELL

Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1

(2018) Yingfeng Li et al.   NATURE

RFTS-dependent negative regulation of Dnmt1 by nucleosome structure and histone tails

(2017) Yuichi Mishima et al.   FEBS Journal

DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation

(2017) Martha Smets et al.   HUMAN MOLECULAR GENETICS

Synthesis of ubiquitylated histone H3 using a thiirane linker for chemical ligation

(2017) Toru Kawakami et al.   JOURNAL OF PEPTIDE SCIENCE

Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance

(2017) Satoshi Ishiyama et al.   MOLECULAR CELL

Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation

(2017) Luna Yamaguchi et al.   Scientific Reports

Identification of a methylation profile for DNMT1-associated autosomal dominant cerebellar ataxia, deafness, and narcolepsy

(2016) Kristin D. Kernohan et al.   Clinical Epigenetics

DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination

(2015) Weihua Qin et al.   CELL RESEARCH

Regulation of maintenance DNA methylation via histone ubiquitylation

(2015) Atsuya Nishiyama et al.   JOURNAL OF BIOCHEMISTRY

Crystal Structure of Human DNA Methyltransferase 1

(2015) Zhi-Min Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation

(2015) Jingdong Cheng et al.   Nature Communications

Dual Functions of the RFTS Domain of Dnmt1 in Replication-Coupled DNA Methylation and in Protection of the Genome from Aberrant Methylation

(2015) Ronald Garingalao Garvilles et al.   PLoS One

The UHRF1 Protein Stimulates the Activity and Specificity of the Maintenance DNA Methyltransferase DNMT1 by an Allosteric Mechanism

(2013) Pavel Bashtrykov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA Methyltransferase Dnmt1 Directly Interacts with the SET and RING Finger-associated (SRA) Domain of the Multifunctional Protein Uhrf1 to Facilitate Accession of the Catalytic Center to Hemi-methylated DNA

(2013) Ahmet Can Berkyurek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication

(2013) Atsuya Nishiyama et al.   NATURE

DNMT1-interacting RNAs block gene-specific DNA methylation

(2013) Annalisa Di Ruscio et al.   NATURE

Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy

(2012) Juliane Winkelmann et al.   HUMAN MOLECULAR GENETICS

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Structure-Based Mechanistic Insights into DNMT1-Mediated Maintenance DNA Methylation

(2012) J. Song et al.   SCIENCE

Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss

(2011) Christopher J Klein et al.   NATURE GENETICS

Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1)

(2011) K. Takeshita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclin-dependent kinase-like 5 binds and phosphorylates DNA methyltransferase 1

(2008) Isamu Kameshita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism

(2008) Kyohei Arita et al.   NATURE