标题
Metabolomic tools used in marine natural product drug discovery
作者
关键词
-
出版物
Expert Opinion on Drug Discovery
Volume -, Issue -, Pages 1-24
出版商
Informa UK Limited
发表日期
2020-02-06
DOI
10.1080/17460441.2020.1722636
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Mapping the Surface Microbiome and Metabolome of Brown Seaweed Fucus vesiculosus by Amplicon Sequencing, Integrated Metabolomics and Imaging Techniques
- (2019) Delphine Parrot et al. Scientific Reports
- Application of metabolomics and molecular networking in investigating the chemical profile and antitrypanosomal activity of British bluebells (Hyacinthoides non-scripta)
- (2019) Dotsha J. Raheem et al. Scientific Reports
- Isolation of a Novel Flavanonol and an Alkylresorcinol with Highly Potent Anti-Trypanosomal Activity from Libyan propolis
- (2019) Weam Siheri et al. MOLECULES
- Mass spectrometry-based metabolomics of volatiles as a new tool for understanding aroma and flavour chemistry in processed food products
- (2019) Carmen Diez-Simon et al. Metabolomics
- Novel applications of mass spectrometry-based metabolomics in herbal medicines and its active ingredients: Current evidence
- (2019) Xi-Jun Wang et al. MASS SPECTROMETRY REVIEWS
- Revelation of the metabolic pathway of hederacoside C using an innovative data analysis strategy for dynamic multiclass biotransformation experiments
- (2019) Laura Peeters et al. JOURNAL OF CHROMATOGRAPHY A
- Advancing untargeted metabolomics using data-independent acquisition mass spectrometry technology
- (2019) Ruohong Wang et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Metabolomics-guided isolation of anti-trypanosomal compounds from endophytic fungi of the mangrove plant Avicennia lanata
- (2019) Noor Wini Mazlan et al. CURRENT MEDICINAL CHEMISTRY
- Bioactive Compounds Isolated from Marine-Derived Microbes in China: 2009–2018
- (2019) Weiwei Sun et al. Marine Drugs
- Rapid Metabolome and Bioactivity Profiling of Fungi Associated with the Leaf and Rhizosphere of the Baltic Seagrass Zostera marina
- (2019) Lars-Erik Petersen et al. Marine Drugs
- NMR-Based Metabolomics in Metal-Based Drug Research
- (2019) Federica De Castro et al. MOLECULES
- NMR Spectroscopy for Metabolomics Research
- (2019) Abdul-Hamid Emwas et al. Metabolites
- Marine Natural Products: A Source of Novel Anticancer Drugs
- (2019) Shaden A. M. Khalifa et al. Marine Drugs
- Gas chromatography-mass spectrometry-based analytical strategies for fatty acid analysis in biological samples
- (2019) Huai-Hsuan Chiu et al. JOURNAL OF FOOD AND DRUG ANALYSIS
- Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts
- (2019) Xiaoju Dou et al. Marine Drugs
- High-throughput metabolomics by 1D NMR
- (2018) Alessia Vignoli et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Evaluation of metabolic changes induced by polyphenols in the crayfish Astacus leptodactylus by metabolomics using Fourier transformed infrared spectroscopy
- (2018) Maria Grazia Volpe et al. JOURNAL OF BIOSCIENCES
- Ascidian Toxins with Potential for Drug Development
- (2018) Dianne Watters Marine Drugs
- Parallel lives of symbionts and hosts: chemical mutualism in marine animals
- (2018) Maho Morita et al. NATURAL PRODUCT REPORTS
- Nuclear magnetic resonance (NMR)-based metabolomics for cancer research
- (2018) Renuka Ranjan et al. NMR IN BIOMEDICINE
- Metabolomics data fusion between near infrared spectroscopy and high-resolution mass spectrometry: A synergetic approach to boost performance or induce confusion
- (2018) Shengyun Dai et al. TALANTA
- Application of NMR metabolomics to search for human disease biomarkers in blood
- (2018) Zikuan Song et al. CLINICAL CHEMISTRY AND LABORATORY MEDICINE
- Metabolic and Biosynthetic Diversity in Marine Myxobacteria
- (2018) Katja Gemperlein et al. Marine Drugs
- Marine Natural Products in Medicinal Chemistry
- (2018) Carlos Jiménez ACS Medicinal Chemistry Letters
- Streptomyces as a Prominent Resource of Future Anti-MRSA Drugs
- (2018) Hefa Mangzira Kemung et al. Frontiers in Microbiology
- Molecular Networking-Based Metabolome and Bioactivity Analyses of Marine-Adapted Fungi Co-cultivated With Phytopathogens
- (2018) Ernest Oppong-Danquah et al. Frontiers in Microbiology
- Accelerating Metabolite Identification in Natural Product Research: Toward an Ideal Combination of Liquid Chromatography–High-Resolution Tandem Mass Spectrometry and NMR Profiling, in Silico Databases, and Chemometrics
- (2018) Jean-Luc Wolfender et al. ANALYTICAL CHEMISTRY
- Filtering the NMR Spectra of Complex Mixtures through Polymer-Mediated Paramagnetic Spin Relaxation
- (2018) Juan Correa et al. CHEMISTRY-A EUROPEAN JOURNAL
- The potentiality of NMR-based metabolomics in food science and food authentication assessment
- (2018) Roberto Consonni et al. MAGNETIC RESONANCE IN CHEMISTRY
- Sterol and Sphingoid Glycoconjugates from Microalgae
- (2018) Valentin Stonik et al. Marine Drugs
- Variations in Microbial Diversity and Metabolite Profiles of the Tropical Marine Sponge Xestospongia muta with Season and Depth
- (2018) Marcela Villegas-Plazas et al. MICROBIAL ECOLOGY
- Fradiamine A, a new siderophore from the deep-sea actinomycete Streptomyces fradiae MM456M-mF7
- (2017) Yasuhiro Takehana et al. JOURNAL OF ANTIBIOTICS
- Integrating Molecular Networking and Biological Assays To Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium
- (2017) C. Benjamin Naman et al. JOURNAL OF NATURAL PRODUCTS
- Discovery of C-Glycosylpyranonaphthoquinones in Streptomyces sp. MBT76 by a Combined NMR-Based Metabolomics and Bioinformatics Workflow
- (2017) Changsheng Wu et al. JOURNAL OF NATURAL PRODUCTS
- Upregulation and Identification of Antibiotic Activity of a Marine-Derived Streptomyces sp. via Co-Cultures with Human Pathogens
- (2017) Anne Sung et al. Marine Drugs
- Cytotoxic Natural Products from Marine Sponge-Derived Microorganisms
- (2017) Huawei Zhang et al. Marine Drugs
- Isolation of Petrocidin A, a New Cytotoxic Cyclic Dipeptide from the Marine Sponge-Derived Bacterium Streptomyces sp. SBT348
- (2017) Cheng Cheng et al. Marine Drugs
- Metabolomics of Ulva lactuca Linnaeus (Chlorophyta) exposed to oil fuels: Fourier transform infrared spectroscopy and multivariate analysis as tools for metabolic fingerprint
- (2017) Fernanda Kokowicz Pilatti et al. MARINE POLLUTION BULLETIN
- HMDB 4.0: the human metabolome database for 2018
- (2017) David S Wishart et al. NUCLEIC ACIDS RESEARCH
- Metabolomics-Coupled Functional Pharmacology of Chlorophyll Compounds Isolated From the Leaves of Ficus Exasperata Vahl (Moraceae) Provides Novel Pathways on Myometrial Activity
- (2017) Enitome E. Bafor et al. Reproductive Sciences
- Microbiome and metabolome data integration provides insight into health and disease
- (2017) Michael Shaffer et al. Translational Research
- Molecular Networking As a Drug Discovery, Drug Metabolism, and Precision Medicine Strategy
- (2017) Robert A. Quinn et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Marine Actinobacteria as a source of compounds for phytopathogen control: An integrative metabolic-profiling / bioactivity and taxonomical approach
- (2017) Luz A. Betancur et al. PLoS One
- New natural products identified by combined genomics-metabolomics profiling of marine Streptomyces sp. MP131-18
- (2017) Constanze Paulus et al. Scientific Reports
- Molecular identification in metabolomics using infrared ion spectroscopy
- (2017) Jonathan Martens et al. Scientific Reports
- Optimization of LC-Orbitrap-HRMS acquisition and MZmine 2 data processing for nontarget screening of environmental samples using design of experiments
- (2016) Meng Hu et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Automated Detection of Natural Halogenated Compounds from LC-MS Profiles–Application to the Isolation of Bioactive Chlorinated Compounds from Marine-Derived Fungi
- (2016) Catherine Roullier et al. ANALYTICAL CHEMISTRY
- Untargeted Metabolomics To Ascertain Antibiotic Modes of Action
- (2016) Isabel M. Vincent et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Discovery of pentangular polyphenols hexaricins A–C from marine Streptosporangium sp. CGMCC 4.7309 by genome mining
- (2016) Jun Tian et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Stress-driven discovery of a cryptic antibiotic produced by Streptomyces sp. WU20 from Kueishantao hydrothermal vent with an integrated metabolomics strategy
- (2016) Yutong Shi et al. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
- Metabolomics study on the antitumor effect of marine natural compound flexibilide in HCT-116 colon cancer cell line
- (2016) Dan Gao et al. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
- Training in metabolomics research. II. Processing and statistical analysis of metabolomics data, metabolite identification, pathway analysis, applications of metabolomics and its future
- (2016) Stephen Barnes et al. JOURNAL OF MASS SPECTROMETRY
- Biochemometrics for Natural Products Research: Comparison of Data Analysis Approaches and Application to Identification of Bioactive Compounds
- (2016) Joshua J. Kellogg et al. JOURNAL OF NATURAL PRODUCTS
- Natural Products as Sources of New Drugs from 1981 to 2014
- (2016) David J. Newman et al. JOURNAL OF NATURAL PRODUCTS
- Time Dependency of Chemodiversity and Biosynthetic Pathways: An LC-MS Metabolomic Study of Marine-Sourced Penicillium
- (2016) Catherine Roullier et al. Marine Drugs
- Emerging applications of metabolomics in drug discovery and precision medicine
- (2016) David S. Wishart NATURE REVIEWS DRUG DISCOVERY
- Toward Understanding Myometrial Regulation: Metabolomic Investigation Reveals New Pathways of Oxytocin and Ritodrine Activity on the Myometrium
- (2016) Enitome E. Bafor et al. Reproductive Sciences
- Galaxy-M: a Galaxy workflow for processing and analyzing direct infusion and liquid chromatography mass spectrometry-based metabolomics data
- (2016) Robert L. Davidson et al. GigaScience
- Spatial Molecular Architecture of the Microbial Community of a Peltigera Lichen
- (2016) Neha Garg et al. mSystems
- Mass-Up: an all-in-one open software application for MALDI-TOF mass spectrometry knowledge discovery
- (2015) H. López-Fernández et al. BMC BIOINFORMATICS
- Current approaches and challenges for the metabolite profiling of complex natural extracts
- (2015) Jean-Luc Wolfender et al. JOURNAL OF CHROMATOGRAPHY A
- Metabolomics-Driven Discovery of a Prenylated Isatin Antibiotic Produced by Streptomyces Species MBT28
- (2015) Changsheng Wu et al. JOURNAL OF NATURAL PRODUCTS
- Investigation of Interspecies Interactions within Marine Micromonosporaceae Using an Improved Co-Culture Approach
- (2015) Navid Adnani et al. Marine Drugs
- LC-MS-Based Metabolomics Study of Marine Bacterial Secondary Metabolite and Antibiotic Production in Salinispora arenicola
- (2015) Utpal Bose et al. Marine Drugs
- Taxonomy, Physiology, and Natural Products of Actinobacteria
- (2015) Essaid Ait Barka et al. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
- The re-emergence of natural products for drug discovery in the genomics era
- (2015) Alan L. Harvey et al. NATURE REVIEWS DRUG DISCOVERY
- Biodiversity, Anti-Trypanosomal Activity Screening, and Metabolomic Profiling of Actinomycetes Isolated from Mediterranean Sponges
- (2015) Cheng Cheng et al. PLoS One
- MET-COFEA: A Liquid Chromatography/Mass Spectrometry Data Processing Platform for Metabolite Compound Feature Extraction and Annotation
- (2014) Wenchao Zhang et al. ANALYTICAL CHEMISTRY
- Forazoline A: Marine-Derived Polyketide with Antifungal In Vivo Efficacy
- (2014) Thomas P. Wyche et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The utility of metabolomics in natural product and biomarker characterization
- (2014) Daniel G. Cox et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- An R package to analyse LC/MS metabolomic data: MAIT (Metabolite Automatic Identification Toolkit)
- (2014) Francesc Fernández-Albert et al. BIOINFORMATICS
- Effects of salinity on antibiotic production in sponge-derivedSalinisporaactinobacteria
- (2014) Y.K. Ng et al. JOURNAL OF APPLIED MICROBIOLOGY
- Exploring the diversity and metabolic potential of actinomycetes from temperate marine sediments from Newfoundland, Canada
- (2014) K. R. Duncan et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Importance of Purity Evaluation and the Potential of Quantitative 1H NMR as a Purity Assay
- (2014) Guido F. Pauli et al. JOURNAL OF MEDICINAL CHEMISTRY
- The Current State of Drug Discovery and a Potential Role for NMR Metabolomics
- (2014) Robert Powers JOURNAL OF MEDICINAL CHEMISTRY
- Infrared-metabolomics approach in detecting changes inAndrographis paniculatametabolites due to different harvesting ages and times
- (2014) Nur A'thifah Yusof et al. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
- Dereplication Strategies for Targeted Isolation of New Antitrypanosomal Actinosporins A and B from a Marine Sponge Associated-Actinokineospora sp. EG49
- (2014) Usama Abdelmohsen et al. Marine Drugs
- Metabolomic Tools for Secondary Metabolite Discovery from Marine Microbial Symbionts
- (2014) Lynsey Macintyre et al. Marine Drugs
- Metabolomic Profiling and Genomic Study of a Marine Sponge-Associated Streptomyces sp.
- (2014) Christina Viegelmann et al. Marine Drugs
- Marketed Marine Natural Products in the Pharmaceutical and Cosmeceutical Industries: Tips for Success
- (2014) Ana Martins et al. Marine Drugs
- Marine natural products
- (2014) John W. Blunt et al. NATURAL PRODUCT REPORTS
- Discovering the Recondite Secondary Metabolome Spectrum of Salinispora Species: A Study of Inter-Species Diversity
- (2014) Utpal Bose et al. PLoS One
- Infrared biospectroscopy for a fast qualitative evaluation of sample preparation in metabolomics
- (2014) Julia Kuligowski et al. TALANTA
- Development of a New Benzophenone–Diketopiperazine-Type Potent Antimicrotubule Agent Possessing a 2-Pyridine Structure
- (2014) Yoshiki Hayashi et al. ACS Medicinal Chemistry Letters
- A New-Class Antibacterial—Almost. Lessons in Drug Discovery and Development: A Critical Analysis of More than 50 Years of Effort toward ATPase Inhibitors of DNA Gyrase and Topoisomerase IV
- (2014) Gregory S. Bisacchi et al. ACS Infectious Diseases
- Multivariate statistical models of metabolomic data reveals different metabolite distribution patterns in isonitrosoacetophenone-elicited Nicotiana tabacum and Sorghum bicolor cells
- (2014) Ntakadzeni E Madala et al. SpringerPlus
- Integrated Metabolomics Approach Facilitates Discovery of an Unpredicted Natural Product Suite from Streptomyces coelicolor M145
- (2013) Ashley M. Sidebottom et al. ACS Chemical Biology
- Chemical dereplication of marine actinomycetes by liquid chromatography–high resolution mass spectrometry profiling and statistical analysis
- (2013) David Forner et al. ANALYTICA CHIMICA ACTA
- Antibiotics in the clinical pipeline in 2013
- (2013) Mark S Butler et al. JOURNAL OF ANTIBIOTICS
- Molecular Networking as a Dereplication Strategy
- (2013) Jane Y. Yang et al. JOURNAL OF NATURAL PRODUCTS
- Functional Metabolomics Uncovers Metabolic Alterations Associated to Severe Oxidative Stress in MCF7 Breast Cancer Cells Exposed to Ascididemin
- (2013) Daniel Morvan Marine Drugs
- Looking back into the future: 30 years of metabolomics at TNO
- (2013) Jan van der Greef et al. MASS SPECTROMETRY REVIEWS
- Mass spectrometry and NMR spectroscopy: modern high-end detectors for high resolution separation techniques – state of the art in natural product HPLC-MS, HPLC-NMR, and CE-MS hyphenations
- (2013) Christoph Seger et al. NATURAL PRODUCT REPORTS
- Marine Sediment-Derived Streptomyces Bacteria from British Columbia, Canada Are a Promising Microbiota Resource for the Discovery of Antimicrobial Natural Products
- (2013) Doralyn S. Dalisay et al. PLoS One
- STATISTICAL METHODS FOR THE ANALYSIS OF HIGH-THROUGHPUT METABOLOMICS DATA
- (2013) Jörg Bartel et al. Computational and Structural Biotechnology Journal
- Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology
- (2012) William H. Gerwick et al. CHEMISTRY & BIOLOGY
- Structural Analysis of Cytochrome P450 105N1 Involved in the Biosynthesis of the Zincophore, Coelibactin
- (2012) Bin Zhao et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Quantitative 1H NMR. Development and Potential of an Analytical Method: An Update
- (2012) Guido F. Pauli et al. JOURNAL OF NATURAL PRODUCTS
- Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010
- (2012) David J. Newman et al. JOURNAL OF NATURAL PRODUCTS
- Mass spectral molecular networking of living microbial colonies
- (2012) J. Watrous et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modern analytical techniques in metabolomics analysis
- (2011) Aihua Zhang et al. ANALYST
- MetSign: A Computational Platform for High-Resolution Mass Spectrometry-Based Metabolomics
- (2011) Xiaoli Wei et al. ANALYTICAL CHEMISTRY
- PeakML/mzMatch: A File Format, Java Library, R Library, and Tool-Chain for Mass Spectrometry Data Analysis
- (2011) Richard A. Scheltema et al. ANALYTICAL CHEMISTRY
- Brentuximab Vedotin (SGN-35)
- (2011) J. Katz et al. CLINICAL CANCER RESEARCH
- Marine natural products: a new wave of drugs?
- (2011) Rana Montaser et al. Future Medicinal Chemistry
- Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis
- (2011) S. Kitani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Natural Products and Their Biological Targets: Proteomic and Metabolomic Labeling Strategies
- (2010) Thomas Böttcher et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Biochemical disorders induced by cytotoxic marine natural products in breast cancer cells as revealed by proton NMR spectroscopy-based metabolomics
- (2010) Mathilde Bayet-Robert et al. BIOCHEMICAL PHARMACOLOGY
- MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data
- (2010) Tomáš Pluskal et al. BMC BIOINFORMATICS
- Biologically active secondary metabolites from marine cyanobacteria
- (2010) Joshawna K Nunnery et al. CURRENT OPINION IN BIOTECHNOLOGY
- Ziconotide for treatment of severe chronic pain
- (2010) Achim Schmidtko et al. LANCET
- A Review of Trabectedin (ET-743): A Unique Mechanism of Action
- (2010) Maurizio D'Incalci et al. MOLECULAR CANCER THERAPEUTICS
- NMR methods for unravelling the spectra of complex mixtures
- (2010) Ramon Novoa-Carballal et al. NATURAL PRODUCT REPORTS
- Strategies for the Discovery of New Natural Products by Genome Mining
- (2009) Malek Zerikly et al. CHEMBIOCHEM
- Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research
- (2009) Augustin Scalbert et al. Metabolomics
- Development of Yondelis® (trabectedin, ET-743). A semisynthetic process solves the supply problem
- (2009) Carmen Cuevas et al. NATURAL PRODUCT REPORTS
- Design and synthesis of vidarabine prodrugs as antiviral agents
- (2008) Wei Shen et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative and inhibitor of tubulin polymerization, given weekly to advanced solid tumor patients for 3 weeks
- (2008) Nobuyuki Yamamoto et al. CANCER SCIENCE
- Applications of Metabolomics in Drug Discovery and Development
- (2008) David S Wishart Drugs in research & development
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