DOT1L: a key target in normal chromatin remodelling and in mixed-lineage leukaemia treatment
出版年份 2019 全文链接
标题
DOT1L: a key target in normal chromatin remodelling and in mixed-lineage leukaemia treatment
作者
关键词
-
出版物
Epigenetics
Volume -, Issue -, Pages 1-15
出版商
Informa UK Limited
发表日期
2019-12-03
DOI
10.1080/15592294.2019.1699991
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness
- (2019) Vijayalakshmi Kari et al. Clinical Epigenetics
- Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells
- (2019) Giovanni Nassa et al. Science Advances
- Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase
- (2019) Cathy J. Anderson et al. Cell Reports
- The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection
- (2019) Xiangyu Chen et al. Cellular & Molecular Immunology
- Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L‐dose dependency in HDAC1‐deficient thymic lymphoma
- (2019) Hanneke Vlaming et al. EMBO JOURNAL
- The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia
- (2018) Eytan M. Stein et al. BLOOD
- Structural and functional analysis of the DOT1L–AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis
- (2018) Heng Zhang et al. GENES & DEVELOPMENT
- The protective role of DOT1L in UV-induced melanomagenesis
- (2018) Bo Zhu et al. Nature Communications
- Lung Cancer Therapy Targeting Histone Methylation: Opportunities and Challenges
- (2018) Yuchen Chen et al. Computational and Structural Biotechnology Journal
- Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy
- (2018) Subhankar Biswas et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Peptidomimetics for Targeting Protein–Protein Interactions between DOT1L and MLL Oncofusion Proteins AF9 and ENL
- (2018) Lei Du et al. ACS Medicinal Chemistry Letters
- Cooperative gene activation by AF4 and DOT1L drives MLL-rearranged leukemia
- (2017) Hiroshi Okuda et al. JOURNAL OF CLINICAL INVESTIGATION
- The MLL recombinome of acute leukemias in 2017
- (2017) C Meyer et al. LEUKEMIA
- Mechanisms of Pinometostat (EPZ-5676) Treatment–Emergent Resistance in MLL -Rearranged Leukemia
- (2017) Carly T. Campbell et al. MOLECULAR CANCER THERAPEUTICS
- The histone demethylase KDM3A regulates the transcriptional program of the androgen receptor in prostate cancer cells
- (2017) Stephen Wilson et al. Oncotarget
- DOT1L as a therapeutic target for the treatment of DNMT3A -mutant acute myeloid leukemia
- (2016) Rachel E. Rau et al. BLOOD
- Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays
- (2016) Shijie Chen et al. Journal of Chemical Information and Modeling
- Functional interdependence of BRD4 and DOT1L in MLL leukemia
- (2016) Omer Gilan et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach
- (2016) Chao Chen et al. ACS Medicinal Chemistry Letters
- ‘Acute myeloid leukemia: a comprehensive review and 2016 update’
- (2016) I De Kouchkovsky et al. Blood Cancer Journal
- Functional interdependence of BRD4 and DOT1L in MLL leukemia
- (2016) Omer Gilan et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond
- (2015) Chun-Wei Chen et al. EXPERIMENTAL HEMATOLOGY
- Exploring drug delivery for the DOT1L inhibitor pinometostat (EPZ-5676): Subcutaneous administration as an alternative to continuous IV infusion, in the pursuit of an epigenetic target
- (2015) Nigel J. Waters et al. JOURNAL OF CONTROLLED RELEASE
- Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor
- (2014) Aravind Basavapathruni et al. BIOPHARMACEUTICS & DRUG DISPOSITION
- Functional characterisation of different MLL fusion proteins by using inducible Sleeping Beauty vectors
- (2014) K. Wächter et al. CANCER LETTERS
- AF9 YEATS Domain Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation
- (2014) Yuanyuan Li et al. CELL
- DOT1L-HES6 fusion drives androgen independent growth in prostate cancer
- (2014) M. Annala et al. EMBO Molecular Medicine
- Survival of Adults with Acute Lymphoblastic Leukemia in Germany and the United States
- (2014) Dianne Pulte et al. PLoS One
- DOT1L Inhibition Sensitizes MLL-Rearranged AML to Chemotherapy
- (2014) Wei Liu et al. PLoS One
- Direct interactions promote eviction of the Sir3 heterochromatin protein by the SWI/SNF chromatin remodeling enzyme
- (2014) Benjamin J. Manning et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1
- (2013) Kyle D. Konze et al. ACS Chemical Biology
- Bromo-deaza-SAH: A potent and selective DOT1L inhibitor
- (2013) Wenyu Yu et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
- (2013) S. R. Daigle et al. BLOOD
- Chromatin Remodeling at DNA Double-Strand Breaks
- (2013) Brendan D. Price et al. CELL
- Protein arginine methylation of non-histone proteins and its role in diseases
- (2013) Han Wei et al. CELL CYCLE
- Promoter histone H3K27 methylation in the control of IGF2 imprinting in human tumor cell lines
- (2013) Tao Li et al. HUMAN MOLECULAR GENETICS
- A Medicinal Chemistry Perspective for Targeting Histone H3 Lysine-79 Methyltransferase DOT1L
- (2013) Justin L. Anglin et al. JOURNAL OF MEDICINAL CHEMISTRY
- The MLL recombinome of acute leukemias in 2013
- (2013) C Meyer et al. LEUKEMIA
- Histone H4 Lysine 20 methylation: key player in epigenetic regulation of genomic integrity
- (2013) S. Jorgensen et al. NUCLEIC ACIDS RESEARCH
- Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations
- (2013) Hong Wu et al. PLoS One
- Epigenetics in Saccharomyces cerevisiae
- (2013) M. Grunstein et al. Cold Spring Harbor Perspectives in Biology
- ATM Release at Resected Double-Strand Breaks Provides Heterochromatin Reconstitution to Facilitate Homologous Recombination
- (2013) Verena Geuting et al. PLoS Genetics
- S-Adenosyl-Methionine-Dependent Methyltransferases: Highly Versatile Enzymes in Biocatalysis, Biosynthesis and Other Biotechnological Applications
- (2012) Anna-Winona Struck et al. CHEMBIOCHEM
- Bat3 facilitates H3K79 dimethylation by DOT1L and promotes DNA damage-induced 53BP1 foci at G1/G2 cell-cycle phases
- (2012) Timothy P Wakeman et al. EMBO JOURNAL
- The N676D and G697R mutations in the kinase domain of FLT3 confer resistance to the inhibitor AC220
- (2012) D. Pauwels et al. HAEMATOLOGICA
- Mutations of FLT3/ITD confer resistance to multiple tyrosine kinase inhibitors
- (2012) A B Williams et al. LEUKEMIA
- Histone Lysine Methylation Dynamics: Establishment, Regulation, and Biological Impact
- (2012) Joshua C. Black et al. MOLECULAR CELL
- A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
- (2012) Sarah K Knutson et al. Nature Chemical Biology
- Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation
- (2012) W. Qi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
- (2012) Wenyu Yu et al. Nature Communications
- Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation
- (2011) S. Y. Jo et al. BLOOD
- DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis
- (2011) A. T. Nguyen et al. BLOOD
- Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
- (2011) Scott R. Daigle et al. CANCER CELL
- Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker
- (2011) Masashi Takawa et al. CANCER SCIENCE
- Essential role of DOT1L in maintaining normal adult hematopoiesis
- (2011) Anh T Nguyen et al. CELL RESEARCH
- Deficiency of H3K79 Histone Methyltransferase Dot1-like Protein (DOT1L) Inhibits Cell Proliferation
- (2011) Wootae Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Histone Methyltransferase SETD3 Regulates Muscle Differentiation
- (2011) Gwang Hyeon Eom et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies
- (2011) Yuan Yao et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The heterogeneity of pediatric MLL-rearranged acute myeloid leukemia
- (2011) B V Balgobind et al. LEUKEMIA
- Dot1 and Histone H3K79 Methylation in Natural Telomeric and HM Silencing
- (2011) Yoh-Hei Takahashi et al. MOLECULAR CELL
- A Common Telomeric Gene Silencing Assay Is Affected by Nucleotide Metabolism
- (2011) Marlies P. Rossmann et al. MOLECULAR CELL
- Catalytic Mechanism Investigation of Lysine-Specific Demethylase 1 (LSD1): A Computational Study
- (2011) Xiangqian Kong et al. PLoS One
- The AF4{middle dot}MLL fusion protein is capable of inducing ALL in mice without requirement of MLL{middle dot}AF4
- (2010) A. Bursen et al. BLOOD
- MLL-AF9-Induced Leukemogenesis Requires Coexpression of the Wild-Type Mll Allele
- (2010) Austin T. Thiel et al. CANCER CELL
- Outcome after relapse of acute lymphoblastic leukemia in adult patients included in four consecutive risk-adapted trials by the PETHEMA Study Group
- (2010) A. Oriol et al. HAEMATOLOGICA
- Overexpression ofgrappaencoding a histone methyltransferase enhances stress resistance inDrosophila
- (2009) Olivier List et al. HEREDITAS
- Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation
- (2008) Ali Shilatifard CURRENT OPINION IN CELL BIOLOGY
- Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia
- (2008) M. G. Guenther et al. GENES & DEVELOPMENT
- DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells
- (2008) D. J. Steger et al. MOLECULAR AND CELLULAR BIOLOGY
- Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation
- (2008) Robert K. McGinty et al. NATURE
- Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states
- (2008) Floor Frederiks et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer
- (2008) S. Varambally et al. SCIENCE
- The Histone H3K79 Methyltransferase Dot1L Is Essential for Mammalian Development and Heterochromatin Structure
- (2008) Brendan Jones et al. PLoS Genetics
- Chronic Myeloid Leukemia Stem Cells
- (2008) C. H. Jamieson Hematology-American Society of Hematology Education Program
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