Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation

Exploiting the balance between life and death: Targeted cancer therapy and “oncogenic shock”

(2010) Sreenath V. Sharma et al.   BIOCHEMICAL PHARMACOLOGY

Early mammalian erythropoiesis requires the Dot1L methyltransferase

(2010) Y. Feng et al.   BLOOD

The AF4{middle dot}MLL fusion protein is capable of inducing ALL in mice without requirement of MLL{middle dot}AF4

(2010) A. Bursen et al.   BLOOD

Histone H3 Lysine 79 Methyltransferase Dot1 Is Required for Immortalization by MLL Oncogenes

(2010) M.-J. Chang et al.   CANCER RESEARCH

MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia

(2010) Sara C. Monroe et al.   EXPERIMENTAL HEMATOLOGY

Targeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development

(2010) Evan R Barry et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

(2010) M. Mohan et al.   GENES & DEVELOPMENT

The leukemogenic AF4–MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures

(2010) A Benedikt et al.   LEUKEMIA

Histone modification levels are predictive for gene expression

(2010) R. Karlic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular biology of mixed lineage leukemia

(2009) R. K. Slany   HAEMATOLOGICA

New insights to the MLL recombinome of acute leukemias

(2009) C Meyer et al.   LEUKEMIA

ES Cell Cycle Progression and Differentiation Require the Action of the Histone Methyltransferase Dot1L

(2009) Evan R. Barry et al.   STEM CELLS

Misguided Transcriptional Elongation Causes Mixed Lineage Leukemia

(2009) Dorothee Mueller et al.   PLOS BIOLOGY

The PHD fingers of MLL block MLL fusion protein-mediated transformation

(2008) A. G. Muntean et al.   BLOOD

Menin regulates the function of hematopoietic stem cells and lymphoid progenitors

(2008) I. Maillard et al.   BLOOD

H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias

(2008) Andrei V. Krivtsov et al.   CANCER CELL

DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells

(2008) D. J. Steger et al.   MOLECULAR AND CELLULAR BIOLOGY

The Histone H3K79 Methyltransferase Dot1L Is Essential for Mammalian Development and Heterochromatin Structure

(2008) Brendan Jones et al.   PLoS Genetics