Reproducibility of academic preclinical translational research: lessons from the development of Hedgehog pathway inhibitors to treat cancer

Statins Synergize with Hedgehog Pathway Inhibitors for Treatment of Medulloblastoma

(2018) Renata E. Gordon et al.   CLINICAL CANCER RESEARCH

Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61

(2018) Andrea Calcaterra et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Noncanonical hedgehog pathway activation through SRF–MKL1 promotes drug resistance in basal cell carcinomas

(2018) Ramon J Whitson et al.   NATURE MEDICINE

Non-canonical activation of hedgehog in prostate cancer cells mediated by the interaction of transcriptionally active androgen receptor proteins with Gli3

(2018) Na Li et al.   ONCOGENE

Antitumor Activity of Intratumoral Ethanol Injection in an Orthotopic Pancreatic Cancer Cell Mouse Xenograft Model

(2018) Wen-Ying Zhang et al.   Gastroenterology Research and Practice

The whole-genome landscape of medulloblastoma subtypes

(2017) Paul A. Northcott et al.   NATURE

Phase I study of oral sonidegib (LDE225) in pediatric brain and solid tumors and a phase II study in children and adults with relapsed medulloblastoma

(2017) Mark W Kieran et al.   NEURO-ONCOLOGY

Consensus and controversies regarding the treatment of rhabdomyosarcoma

(2017) Scott C. Borinstein et al.   PEDIATRIC BLOOD & CANCER

A dual mechanism of activation of the Sonic Hedgehog pathway in anaplastic thyroid cancer: crosstalk with RAS-BRAF-MEK pathway and ligand secretion by tumor stroma

(2017) Alessia Parascandolo et al.   Oncotarget

Irreversible growth plate fusions in children with medulloblastoma treated with a targeted hedgehog pathway inhibitor

(2017) Giles W. Robinson et al.   Oncotarget

Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells

(2017) Joseph L. Regan et al.   Cell Reports

Hedgehog Pathway Inhibition Hampers Sphere and Holoclone Formation in Rhabdomyosarcoma

(2017) Ana Almazán-Moga et al.   Stem Cells International

Pharmacodynamic study of the oral hedgehog pathway inhibitor, vismodegib, in patients with metastatic castration-resistant prostate cancer

(2016) Benjamin L. Maughan et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

PTEN Signaling in the Postnatal Perivascular Progenitor Niche Drives Medulloblastoma Formation

(2016) Guo Zhu et al.   CANCER RESEARCH

Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling

(2016) Pengxiang Huang et al.   CELL

Structural basis of Smoothened regulation by its extracellular domains

(2016) Eamon F. X. Byrne et al.   NATURE

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma

(2016) Ximena Bonilla et al.   NATURE GENETICS

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling

(2016) Giovanni Luchetti et al.   eLife

Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma

(2015) Scott X. Atwood et al.   CANCER CELL

Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma

(2015) Hayley J. Sharpe et al.   CANCER CELL

RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors

(2015) X. Zhao et al.   CANCER RESEARCH

Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer

(2015) Daniel V.T. Catenacci et al.   JOURNAL OF CLINICAL ONCOLOGY

Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog–Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032

(2015) Giles W. Robinson et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeting hedgehog signaling reduces self-renewal in embryonal rhabdomyosarcoma

(2015) S Satheesha et al.   ONCOGENE

Hedgehog Inhibitors in Rhabdomyosarcoma: A Comparison of Four Compounds and Responsiveness of Four Cell Lines

(2015) Rosalie Ridzewski et al.   Frontiers in Oncology

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma

(2014) E. J. Kim et al.   CLINICAL CANCER RESEARCH

Ptch2 mediates the Shh response in Ptch1-/- cells

(2014) A. C. Alfaro et al.   DEVELOPMENT

Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumorsin vitroandin vivoby targeting overexpressed Gli1

(2014) Kornelius Kerl et al.   INTERNATIONAL JOURNAL OF CANCER

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

(2014) C. Bettegowda et al.   Science Translational Medicine

PTEN Loss Mitigates the Response of Medulloblastoma to Hedgehog Pathway Inhibition

(2013) C. Metcalfe et al.   CANCER RESEARCH

Phase I Study of Vismodegib in Children with Recurrent or Refractory Medulloblastoma: A Pediatric Brain Tumor Consortium Study

(2013) A. Gajjar et al.   CLINICAL CANCER RESEARCH

Distinct cellular origin and genetic requirement of Hedgehog-Gli in postnatal rhabdomyosarcoma genesis

(2013) M Rajurkar et al.   ONCOGENE

A Phase II, Randomized, Placebo-Controlled Study of Vismodegib as Maintenance Therapy in Patients with Ovarian Cancer in Second or Third Complete Remission

(2012) S. B. Kaye et al.   CLINICAL CANCER RESEARCH

A Randomized Phase II Trial of Vismodegib versus Placebo with FOLFOX or FOLFIRI and Bevacizumab in Patients with Previously Untreated Metastatic Colorectal Cancer

(2012) J. Berlin et al.   CLINICAL CANCER RESEARCH

A statin-regulated microRNA represses human c-Myc expression and function

(2012) Apana A. L. Takwi et al.   EMBO Molecular Medicine

Off-Target Function of the Sonic Hedgehog Inhibitor Cyclopamine in Mediating Apoptosis via Nitric Oxide-Dependent Neutral Sphingomyelinase 2/Ceramide Induction

(2012) M. Meyers-Needham et al.   MOLECULAR CANCER THERAPEUTICS

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma

(2012) Aleksandar Sekulic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular subgroups of medulloblastoma: the current consensus

(2011) Michael D. Taylor et al.   ACTA NEUROPATHOLOGICA

Targeting Superficial or Nodular Basal Cell Carcinoma with Topically Formulated Small Molecule Inhibitor of Smoothened

(2011) T. Tang et al.   CLINICAL CANCER RESEARCH

Topical Treatment of Basal Cell Carcinomas in Nevoid Basal Cell Carcinoma Syndrome with a Smoothened Inhibitor

(2011) Hans Skvara et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: A report from the Children's Oncology Group

(2011) Joseph G. Pressey et al.   PEDIATRIC BLOOD & CANCER

PTHrP Treatment Fails to Rescue Bone Defects Caused by Hedgehog Pathway Inhibition in Young Mice

(2011) Jillian L. Brechbiel et al.   TOXICOLOGIC PATHOLOGY

Mouse models and mouse supermodels

(2010) Tom Curran   EMBO Molecular Medicine

Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway

(2010) Elspeth M. Beauchamp et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway

(2010) Zainab Jagani et al.   NATURE MEDICINE

Heterozygosity for Pten Promotes Tumorigenesis in a Mouse Model of Medulloblastoma

(2010) Robert C. Castellino et al.   PLoS One

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

(2010) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genetic Landscape of the Childhood Cancer Medulloblastoma

(2010) D. W. Parsons et al.   SCIENCE

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

(2010) S. Buonamici et al.   Science Translational Medicine

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

(2009) Frédéric Varnat et al.   EMBO Molecular Medicine

Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)

(2009) Martin R. Tremblay et al.   JOURNAL OF MEDICINAL CHEMISTRY

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

(2009) Charles M. Rudin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma

(2009) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

(2009) R. L. Yauch et al.   SCIENCE

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Transient Inhibition of the Hedgehog Pathway in Young Mice Causes Permanent Defects in Bone Structure

(2008) Hiromichi Kimura et al.   CANCER CELL

A paracrine requirement for hedgehog signalling in cancer

(2008) Robert L. Yauch et al.   NATURE

Methylation of PTCH1, the Patched-1 gene, in a panel of primary medulloblastomas

(2007) Joel I. Pritchard et al.   CANCER GENETICS AND CYTOGENETICS

Cyclopamine treatment of full-blownHh/Ptch-associated RMS partially inhibits Hh/Ptch signaling, but not tumor growth

(2007) Ines Ecke et al.   MOLECULAR CARCINOGENESIS