Article
Immunology
Krystal D. Kao, Helmut Grasberger, Mohamad El-Zaatari
Summary: Gastric myeloid-derived suppressor cells (MDSCs) are a population that expands during gastric pre-neoplastic and neoplastic development. S100a8 is identified as a pan-specific marker for this population, and the subset S100a8(+)Cxcr2(+) plays a role in regulating gastric immunopathology and lipid peroxidation.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Oncology
James R. Goldenring
Summary: Intestinal-type gastric cancer can arise from precancerous metaplastic lineages, specifically from spasmolytic polypeptide-expressing metaplasia (SPEM) cells. A recent study identified an activating Kras(G12D) mutation in SPEM cells, which propagated into adenomatous and cancerous lesions, suggesting that SPEM lineages can serve as a direct precursor for dysplasia and intestinal-type gastric cancer.
JOURNAL OF PATHOLOGY
(2023)
Article
Immunology
Xiaodan Xiang, Yaping Wu, Hongwei Li, Cun Li, Lu Yan, Qian Li
Summary: Helicobacter pylori infection promotes SLFN4(+) MDSC differentiation by inducing secretion of IFN-alpha from pDCs, through activating the TLR9-MyD88-IRF7 pathway. IFN-alpha induces SLFN4 transcription by binding to the Slfn4 promoter.
INFECTION AND IMMUNITY
(2021)
Article
Immunology
Stefanie Dietz, Julian Schwarz, Ana Velic, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez, Nicolas Casadei, Alexander Marme, Christian F. Poets, Christian Gille, Natascha Koestlin-Gille
Summary: In this study, the impact of the murine MHC class Ib molecule Qa-2 on pregnancy outcome was analyzed. Lack of Qa-2 led to intrauterine growth restriction and increased abortion rates, accompanied by disturbed trophoblast invasion, altered spiral artery remodeling, and protein aggregation in trophoblast cells indicating a preeclampsia-like phenotype. Furthermore, lack of Qa-2 caused imbalanced immunological adaptation to pregnancy, with altered immune cell and especially T-cell homeostasis. Application of sHLA-G reduced abortion rates in Qa-2 deficient mice by inducing MDSC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Shannon Esher Righi, Amanda J. Harriett, Elizabeth A. Lilly, Paul L. Fidel Jr, Mairi C. Noverr
Summary: Immunization with low-virulence Candida species can protect against polymicrobial intra-abdominal infections by suppressing lethal inflammation, which is mediated by Gr-1(+) polymorphonuclear leukocytes with features resembling myeloid-derived suppressor cells (MDSCs) and the production of IL-10.
Article
Immunology
Chiel van Geffen, Astrid Deissler, Sandra Beer-Hammer, Bernd Nuernberg, Rupert Handgretinger, Harald Renz, Dominik Hartl, Saeed Kolahian
Summary: The study suggests that MDSCs play a role in lung diseases like asthma through the EP4 pathway, showing that EP4-primed MDSCs can dampen airway inflammation by modulating arginase-1 and nitric oxide synthase-2.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Maria Iglesias-Escudero, David San Segundo, David Merino-Fernandez, Victor M. Mora-Cuesta, Patricia Lamadrid, Marta Alonso-Pena, Sandra Raso, David Iturbe, Sonia Fernandez-Rozas, Jose Cifrian, Marcos Lopez-Hoyos
Summary: Lung transplantation is a primary treatment for end-stage lung diseases, but long-term survival is limited. The study explores the dysregulation of immune mechanisms and the role of myeloid-derived suppressor cells (MDSCs) in promoting graft tolerance. The results suggest that increased frequencies of Mo-MDSCs after acute cellular rejection may be associated with the development of chronic lung allograft dysfunction (CLAD).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Ellis Tibbs, Xuefang Cao
Summary: This paper addresses the controversy surrounding the expression of GzmB by murine MDSCs. The authors conducted experiments to investigate this question and found that MDSCs under stringent developmental processes do not express GzmB. Additionally, the GzmB protein detected in the MDSC culture was attributed to T cells or natural killer cells present in the bone marrow culture. The authors further strengthened their findings by genetically deleting GzmB from the myeloid lineage and assessing tumor burden, finding no significant difference compared to the control group. Therefore, this paper proposes alternative theories that align with the known understanding of GzmB expression and secretion.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Immunology
Tengfei Xiao, Ping Zhang, Tongbao Feng, Kefeng Lu, Xiaoyan Wang, Siyuan Zhou, Yetao Qiang
Summary: Ulcerative colitis (UC) is a precancerous disease caused by a combination of genetic susceptibility, environmental factors, and microbiota dysbiosis. Butyrate has been shown to alleviate DSS-induced colitis by inhibiting proinflammatory mediators and synergistically regulating with MDSCs through CCR9 recruitment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Junfeng Zhang, Yunsheng Zhang, Zhiya Yang, Dalei Cheng, Hui Zhang, Li Wei, Chen Liu, Fenglian Yan, Chunxia Li, Guanjun Dong, Changying Wang, Dongmei Shi, Huabao Xiong
Summary: Although psoriasis is characterized as a T cell-mediated inflammatory disease, the role of myeloid cells in the development of psoriasis is not fully understood. This study found that the expression of the anti-inflammatory cytokine interleukin-35 (IL-35) was increased in patients with psoriasis, along with an increase in myeloid-derived suppressor cells (MDSCs). IL-35 reduced the number of MDSCs and ameliorated psoriasis. IL-35 also reduced the expression of inducible nitric oxide synthase in MDSCs. Overall, IL-35 may play a critical role in regulating iNOS-expressing MDSCs in psoriasis, suggesting IL-35 as a potential therapeutic strategy for psoriasis and other cutaneous inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Deepali K. Bhat, Purevdorj B. Olkhanud, Arunakumar Gangaplara, Fayaz Seifuddin, Mehdi Pirooznia, Angelique Biancotto, Giovanna Fantoni, Corinne Pittman, Berline Francis, Pradeep K. Dagur, Ankit Saxena, J. Philip McCoy, Ruth M. Pfeiffer, Courtney D. Fitzhugh
Summary: Haploidentical hematopoietic stem cell transplantation is an effective treatment for sickle cell disease, but rejection remains a challenge. This study identified specific cytokines and immune cells associated with graft rejection and engraftment, highlighting the importance of donor myeloid chimerism for successful transplantation. Further research is needed to validate these findings and explore their potential clinical implications.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Samantha L. Tucker, Demba Sarr, Balazs Rada
Summary: Cystic Fibrosis is a genetic disease that causes chronic lung inflammation and infections, leading to high mortality rates. Immune system disruption in CF results in impaired immune responses, chronic infections with pathogens, and alterations in T cell and neutrophil functions. The role of P. aeruginosa and gMDSCs in T cell suppression and immune evasion in CF remains a subject of ongoing research.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Xi Liu, Zhiyuan Ma, Zilin Deng, Zhiqiang Yi, Biguang Tuo, Taolang Li, Xuemei Liu
Summary: This review focuses on the origin, models, and regulatory mechanisms of spasmolytic polypeptide-expressing metaplasia (SPEM) and its role in the development of gastric mucosal injury. The study finds that SPEM arises mainly from the trans-differentiation of mature chief cells, mucous neck cells, or isthmic stem cells, and it participates in the regulation of gastric mucosal injury. The authors hope to provide new prospects for the prevention and treatment of gastric mucosal diseases through understanding cell differentiation and transformation.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Review
Oncology
Zhaonian Hao, Ruyuan Li, Yuanyuan Wang, Shuangying Li, Zhenya Hong, Zhiqiang Han
Summary: MDSC play vital roles in cancer microenvironment, influencing the responses to immunotherapies and prognosis of cancer patients. Therefore, proposing MDSC-inhibiting strategies becomes crucial in the field of cancer immunotherapies.
BIOMARKER RESEARCH
(2021)
Review
Immunology
Hui Zhang, Qi-Wei Li, Yuan-Yuan Li, Xue Tang, Ling Gu, Han-Min Liu
Summary: Pulmonary hypertension (PH) is characterized by increased pulmonary vascular resistance and pressure, and the relationship between myeloid-derived suppressor cells (MDSCs) and PH has been studied. MDSCs are a group of cells that can suppress T-cell responses and potentially exacerbate the development of diseases. Understanding the relationship between MDSCs and PH can help identify potential therapeutic targets for the treatment of PH.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Hematology
Morgan Salmon, Basil Schaheen, Michael Spinosa, William Montgomery, Nicolas H. Pope, John P. Davis, William F. Johnston, Ashish K. Sharma, Gary K. Owens, Juanita L. Merchant, Zendra E. Zehner, Gilbert R. Upchurch, Gorav Ailawadi
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2019)
Letter
Gastroenterology & Hepatology
Tenghao Zheng, Shanti Eswaran, Amanda L. Photenhauer, Juanita L. Merchant, William D. Chey, Mauro D'Amato
Review
Biochemistry & Molecular Biology
Filipe M. Cerqueira, Amanda L. Photenhauer, Rebecca M. Pollet, Haley A. Brown, Nicole M. Koropatkin
TRENDS IN MICROBIOLOGY
(2020)
Article
Gastroenterology & Hepatology
Lin Ding, Qian Li, Jayati Chakrabarti, Andres Munoz, Emmanuelle Faure-Kumar, Ramon Ocadiz-Ruiz, Nataliya Razumilava, Guiying Zhang, Michael H. Hayes, Ricky A. Sontz, Zoe Elena Mendoza, Swapna Mahurkar, Joel K. Greenson, Guillermo Perez-Perez, Nguyen Thi Hong Hanh, Yana Zavros, Linda C. Samuelson, Dimitrios Iliopoulos, Juanita L. Merchant
Article
Oncology
Jennifer A. Jimenez, April A. Apfelbaum, Allegra G. Hawkins, Laurie K. Svoboda, Abhijay Kumar, Ramon Ocadiz Ruiz, Alessandra X. Garcia, Elena Haarer, Zeribe C. Nwosu, Joshua Bradin, Trupta Purohit, Dong Chen, Tomasz Cierpicki, Jolanta Grembecka, Costas A. Lyssiotis, Elizabeth R. Lawlor
Summary: Ewing sarcomas are driven by EWS-ETS fusions, with EWS-FLI1 being the most common fusion gene. Both EWS-FLI1 and menin regulate serine biosynthesis by modulating ATF4, a stress-response gene. Inhibition of EWS-FLI1 or menin leads to loss of ATF4 and downregulation of serine synthesis pathway genes.
MOLECULAR CANCER RESEARCH
(2021)
Article
Microbiology
Mark T. Anderson, Aric N. Brown, Ali Pirani, Sara N. Smith, Amanda L. Photenhauer, Yuang Sun, Evan S. Snitkin, Michael A. Bachman, Harry L. T. Mobley
Summary: Bloodstream infections, caused by Gram-negative species, are a significant public health burden due to high mortality rates and treatment costs. A study characterizing infection kinetics and bacterial replication rates of six common pathogens in a murine model revealed different colonization abilities in major organs. While some species replicated rapidly in the liver or kidney, others were steadily cleared from targeted organs during infection, highlighting the complex dynamics of bacterial replication and immune-mediated clearance. Insights from this study may aid in developing strategies to combat bloodstream infections in the future.
Article
Biochemistry & Molecular Biology
Filipe M. Cerqueira, Amanda L. Photenhauer, Heidi L. Doden, Aric N. Brown, Ahmed M. Abdel-Hamid, Sarah Morais, Edward A. Bayer, Zdzislaw Wawrzak, Isaac Cann, Jason M. Ridlon, Jesse B. Hopkins, Nicole M. Koropatkin
Summary: Researchers performed a structure-function analysis of Sas20 and found that it has two distinct starch-binding domains that facilitate the degradation of resistant starch in the human gut by Ruminococcus bromii.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Feiran Li, Fanghua Li, Russell Urie, Elizabeth Bealer, Ramon Ocadiz Ruiz, Eiji Saito, Ali Turan, Esma Yolcu, Haval Shirwan, Lonnie D. Shea
Summary: The direct modulation of T cell responses is a promising therapeutic strategy to modulate undesired immune responses. This study demonstrated the design of membrane-coated nanoparticles (MCNPs) that can directly interact and modulate T cells. The engineered MCNPs showed the ability to promote antigen-specific responses, activate T cells, and induce apoptosis. In summary, MCNPs represent a tunable platform to directly interact with and modulate T cell responses.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Multidisciplinary Sciences
Jing Wang, Ramon Ocadiz-Ruiz, Matthew S. S. Hall, Grace G. G. Bushnell, Sophia M. M. Orbach, Joseph T. T. Decker, Ravi M. M. Raghani, Yining Zhang, Aaron H. H. Morris, Jacqueline S. S. Jeruss, Lonnie D. D. Shea
Summary: 3D scaffolds can mimic the microenvironment of primary tumors and metastatic organs, providing a platform to study the roles of neutrophils in regulating lung metastasis. The study reveals that neutrophils play multifaceted roles in attracting lung-tropic circulating tumor cells and establishing immune environments that direct different fates of cancer cells.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Oncology
Jing Wang, Ramon Ocadiz-Ruiz, Matthew Hall, Grace Bushnell, Sophia Orbach, Joseph Decker, Ravi Raghani, Yining Zhang, Aaron Morris, Jacqueline Jeruss, Lonnie Shea
Meeting Abstract
Gastroenterology & Hepatology
Karen Rico, Sulaiman Sheriff, David C. Metz, Julie Starr, Bryson W. Katona, Juanita L. Merchant
Meeting Abstract
Gastroenterology & Hepatology
Akash Gupta, Ramon Ocadiz-Ruiz, Durga Attili, Michael K. Dame, Elaine Brady, D. K. Turgeon, Juanita L. Merchant
Meeting Abstract
Gastroenterology & Hepatology
Lin Ding, Qian Li, Andres Munoz, Milena Saqui-Salces, Juanita L. Merchant
Meeting Abstract
Gastroenterology & Hepatology
Lin Ding, Qian Li, Andres Munoz, Yana Zavros, Emmanuelle Faure, Dimitrios Iliopoulos, Jayati Chakrabarti, Juanita L. Merchant
Article
Gastroenterology & Hepatology
Nataliya Razumilava, Junya Shiota, Nureen H. Mohamad Zaki, Ramon Ocadiz-Ruiz, Christine M. Cieslak, Kais Zakharia, Benjamin L. Allen, Gregory J. Gores, Linda C. Samuelson, Juanita L. Merchant
HEPATOLOGY COMMUNICATIONS
(2019)