Article
Pharmacology & Pharmacy
Jinxian Wu, Shanyong Wang, Shanshan Liu, Fang Liu, Feifan Zhou
Summary: This study developed a self-assembly nanoparticle using glycated chitosan for synergistic treatment of triple-negative breast cancer. The nanoparticle enabled direct elimination of primary tumors and suppression of distant tumors, while enhancing tumor immunogenicity and infiltration of CD8(+) T cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chanju Lee, Soyoung Kim, Chanmi Jeong, Inhee Cho, Juyeon Jo, Ik-Hwan Han, Hyunsu Bae
Summary: The study suggests that targeting M2-like tumor-associated macrophages (TAMs) could be a potential therapeutic strategy for inhibiting breast cancer metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Quanyuan Wan, Zihua Zeng, Jianjun Qi, Zhenghu Chen, Xiaohui Liu, Youli Zu
Summary: The study demonstrates the effectiveness of targeted chemotherapy for triple-negative breast cancer using a DNA nanoparticle to deliver doxorubicin to cancer cells, showing promising results in vitro and in animal experiments while potentially reducing side effects for patients.
Article
Chemistry, Multidisciplinary
Qiang Wu, Zhuoyuan Li, Xin Zhou, Zhewei Wei, Sami Ramadan, Yunsheng Xu, Lizhou Xu, Danyang Li
Summary: A multifunctional nanodrug system based on iron-based ternary chalcogenide nanoparticles, combining photothermal therapy, ferrotherapy, and immunotherapy, has shown great potential for the treatment of TNBC.
Article
Immunology
Qin Zhou, Jiawei Xu, Yan Xu, Shaokun Sun, Jian Chen
Summary: The study found that low ICAM1 expression may be related to immune escape, leading to poor treatment response and a worse prognosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Yifeng Cao, Chuyang Chen, Yi Tao, Weifeng Lin, Ping Wang
Summary: Triple-negative breast cancer (TNBC) is characterized by extensive tumor heterogeneity at both the pathologic and molecular levels, leading to increased mortality of patients due to accelerated aggressiveness and terrible metastasis. Hindered by the negative expression of certain receptors, targeted therapy has been challenging, but the higher immune response in TNBC compared to other breast cancer types makes it suitable for immunotherapy.
Article
Engineering, Environmental
Xiuhong Guan, Jiesong Li, Jiali Cai, Shihui Huang, Hong Liu, Sheng Wang, Xiaoyong Zhang, Yi Sun, Hongyan Liu, Guoxi Xie, Zhiyong Wang
Summary: Triple-negative breast cancer lacks sufficient biomarkers to guide the benefits of immunotherapy; a theranostic nanocomposite with dual imaging modality and chemical phototherapeutic capacity has been developed for breast cancer cell inhibition, promoting imaging-guided phototherapy.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biophysics
Jingmou Yu, Liangliang Wang, Yun Ling, Xin Xiao, Juntao Gong, Hongguang Jin, Jing Xu, Pu Chen, Xin Xie, Lei Zhang
Summary: In this study, novel polymeric nanoparticles targeting dual receptors and responding to reducing conditions for drug release were developed for the treatment of triple-negative breast cancer. The bioresponsive drug release of the nanoparticles was demonstrated, and it was found that they effectively targeted specific receptors both in vitro and in vivo. The nanoparticles showed higher cytotoxicity and cellular uptake compared to unmodified drug-containing micelles, and they exhibited the strongest suppression of tumor growth in a mouse model. These findings suggest that amphiphilic nanoparticles can serve as a targeted and intelligent delivery vehicle for triple-negative breast cancer therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Oncology
Xuewei Bai, Yanmei Zhou, Qiushi Lin, Chiung-Kuei Huang, Songhua Zhang, Rolf Carlson, Hossein Ghanbari, Bei Sun, Jack R. Wands, Xiaoqun Dong
Summary: Triple negative breast cancer (TNBC) is a more aggressive subtype with a poorer prognosis than others. This study shows that targeting the aspartate beta-hydroxylase (ASPH) network may enhance the efficacy of Doxorubicin (DOX) therapy in TNBC by promoting immunogenic cell death and suppressing tumor growth and metastases.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Man Luo, Afu Fu, Renfei Wu, Na Wei, Kai Song, Sierin Lim, Kathy Qian
Summary: Resistance to doxorubicin remains a challenge in breast cancer treatment, especially for triple negative breast cancer. A study found that high levels of glucose-6-phosphate dehydrogenase (G6PD) may contribute to the resistance of breast cancer cells to doxorubicin-induced oxidative stress. Inhibiting G6PD could be a potential strategy to treat doxorubicin-resistant breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Zitong Zhao, Lei Fang, Ping Xiao, Xiangshi Sun, Lei Zhou, Xiaochen Liu, Jue Wang, Guanru Wang, Haiqiang Cao, Pengcheng Zhang, Yanyan Jiang, Dangge Wang, Yaping Li
Summary: In this study, walking dead TNBC cells were developed by conjugating anti-PD-1 and doxorubicin-loaded liposomes onto cell corpses for temporal chemo-immunotherapy against lung metastasis. The walking dead TNBC cells improved drug accumulation and local retention in the lungs, reprogrammed the lung microenvironment, and prolonged overall survival in mice with lung metastasis.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
In Seon Jeon, Jae Do Yoo, Smriti Gurung, Minseong Kim, Chanju Lee, Eun Jung Park, Rang-Woon Park, Byungheon Lee, Soyoun Kim
Summary: The use of ferritin nanocages displaying PD-L1pep1 shows potential as an effective immunotherapy by specifically targeting PD-L1 expressed on cancer cells and restoring T cell activities. In a mouse model, these nanocages demonstrated antitumor activity and were more potent when encapsulating the chemotherapeutic drug doxorubicin compared to a monoclonal antibody against PD-L1. This suggests that ferritin nanocages could be a promising immunotherapeutic nanomedicine for solid tumors.
Article
Biochemistry & Molecular Biology
Rui Li, Yiming Zhou, Yijia Liu, Xingpeng Jiang, Wenlong Zeng, Zhuoran Gong, Gang Zheng, Desheng Sun, Zhifei Dai
Summary: In this study, a targeted silicon phthalocyanine was synthesized and modified to achieve high accumulation in TNBC cells. In vitro experiments showed significant apoptosis of tumor cells with the targeted silicon phthalocyanine, while the non-targeted photosensitizer exhibited no such effect. This study indicates that the targeted silicon phthalocyanine has great potential for TPDT treatment of TNBC.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Biophysics
E. V. Dukhopelnykov, Yu. N. Blyzniuk, A. A. Skuratovska, E. G. Bereznyak, N. A. Gladkovskaya
Summary: This study investigated the interaction between superparamagnetic iron oxide nanoparticles (SPIONs) and doxorubicin (DOX) and DNA. The results showed that the nanoparticles do not interact with DNA, but can load a large number of DOX molecules. At high DNA concentrations, almost all DOX molecules bind to DNA.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Oncology
Elie Marcheteau, Thomas Farge, Michael Peres, Guillaume Labrousse, Julie Tenet, Stephanie Delmas, Maud Chusseau, Raphaelle Duprez-Paumier, Camille Franchet, Florence Dalenc, Caroline Imbert, Justine Noujarede, Celine Colacios, Herve Prats, Florence Cabon, Bruno Segui
Summary: TSP1 plays a crucial role in TNBC by influencing TILs content and immunotherapy efficacy, making it a potential therapeutic target in combination with immunotherapy for TNBC treatment.
Article
Engineering, Biomedical
Tin-Yo Yen, Zachary R. Stephen, Guanyou Lin, Qingxin Mu, Mike Jeon, Stela Untoro, Parker Welsh, Miqin Zhang
ADVANCED HEALTHCARE MATERIALS
(2019)
Article
Materials Science, Multidisciplinary
Qingxin Mu, Guanyou Lin, Zachary R. Stephen, Seokhwan Chung, Hui Wang, Victoria K. Patton, Rachel N. Gebhart, Miqin Zhang
Review
Chemistry, Multidisciplinary
Guanyou Lin, Richard A. Revia, Miqin Zhang
Summary: Cancer is a genetic disease caused by the accumulation of gene mutations in a cellular subpopulation, and gene therapy has shown potential to be the ultimate solution for treating cancer. Utilizing nanoscale inorganic carriers for delivering nucleic acids has demonstrated promising results in small-animal models, providing effective and safe treatment for oncological diseases.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Guanyou Lin, Jianxi Huang, Mengyuan Zhang, Shanshan Chen, Miqin Zhang
Summary: This study reports the development of a novel nanoparticle formulation (NP-Chi-xPEI) that can safely and effectively deliver DNA into breast cancer cells for successful transfection. The NP-Chi-xPEI nanoparticle shows high transfection efficiency and low cytotoxicity, making it a potential reliable vehicle for DNA delivery to breast cancer cells.
Article
Chemistry, Analytical
Zhiyong Wei, Qingxin Mu, Hui Wang, Guanyou Lin, Miqin Zhang
Summary: The assessment of biodegradability of nanomaterials is crucial for understanding interactions with biological systems and determining potential applications. A study on carbon-based biconcave nanodisks (CBBNs) reveals significant degradation in biological systems, making them suitable for biomedical use.
Review
Chemistry, Multidisciplinary
Guanyou Lin, Miqin Zhang
Summary: The potential of theranostic nanoparticles in tumor treatment is widely recognized due to their ability to integrate multifaceted functionalities into a single nanosystem. These nanoparticles typically consist of an inorganic core for imaging and therapeutic functions, bioinert coatings for improved biocompatibility, controlled drug-loading-release modules, and targeting ligands for specific cell uptake. The design and assembly of these functionalities require sophisticated molecular design and precise execution. Ligand chemistry plays a decisive role in translating theoretical designs into functionalized theranostic nanoparticles. This Account reviews the properties and utilities of capping ligands, drug-loading ligands, and targeting ligands in theranostic nanoparticles.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yuanzhang Tang, Yang Zhou, Guanyou Lin, Miqin Zhang
Summary: Human-induced pluripotent stem cells (hiPSCs) cultured in 3D matrices can benefit from improved cell penetration and pluripotency maintenance by modifying the scaffold with hiPSCs conditioned medium (CM). This study demonstrates that CM treatment promotes uniform cell adhesion and distribution, enhances pluripotency markers, and upregulates genes associated with pluripotency. The results highlight the importance of CM treated scaffolds in maintaining the primitive and undifferentiated phenotype of hiPSCs in 3D matrices.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Jianxi Huang, Guanyou Lin, Taylor Juenke, Seokhwan Chung, Nicholas Lai, Tianxin Zhang, Tianyi Zhang, Miqin Zhang
Summary: This study introduces a novel approach using iron oxide nanoparticles for safe and efficient mRNA delivery to hard-to-transfect cancer cells. The developed nanoparticles showed enhanced cellular internalization of mRNA, easy mRNA release, and minimal cytotoxicity, suggesting great promise for mRNA therapy against hard-to-transfect cancers.
Article
Microbiology
Kayla Hogan, Sai Paul, Guanyou Lin, Jay Fuerte-Stone, Evgeni V. Sokurenko, Wendy E. Thomas
Summary: Bacterial adhesion is influenced by bacterial transport and the interactions between bacterial adhesins and surface receptors. Gravity sedimentation causes bacteria to concentrate on lower surfaces, and initial bacterial attachment may be inhibited by shear due to mass transport effects. A conceptual framework and theory are provided to predict the impact of sedimentation on adhesion between and within adhesive regions in flow, and to normalize bacterial binding level under experimental set-ups.
Article
Materials Science, Biomaterials
Guanyou Lin, Qingxin Mu, Richard Revia, Zachary Stephen, Mike Jeon, Miqin Zhang
Summary: The development of a highly specific apoptosis labeling nanoparticle (IONP-Neu-PSA) with a magnetic iron oxide core conjugated with PSA as a tumor targeting ligand shows promise for prolonged in vivo apoptosis imaging. The nanoparticle demonstrated minimal cytotoxicity, high labeling specificity, and prolonged tracking ability in tracking apoptotic tumors for two weeks under near-IR imaging. Additionally, it possesses T-2 contrast enhancing properties that may enable apoptosis detection by MRI, making it a versatile tool for cancer treatment monitoring and pathological research.
BIOMATERIALS SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Kui Wang, Forrest M. Kievit, Peter A. Chiarelli, Zachary R. Stephen, Guanyou Lin, John R. Silber, Richard G. Ellenbogen, Miqin Zhang
Summary: The study introduces the development of iron oxide nanoparticles for targeted delivery of small interfering RNAs to suppress the TMZ-resistance gene in treating GBMs. This approach leads to increased apoptosis of GBM stem-like cells, reduced tumor growth, and significantly prolonged survival compared to conventional treatment with TMZ alone, offering promising outcomes for GBM patients.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Materials Science, Biomaterials
Mike Jeon, Guanyou Lin, Zachary R. Stephen, Josey E. Vechey, Manjot Singh, Richard Revia, Amy Hauck Newman, Diana Martinez, Miqin Zhang
BIOMATERIALS SCIENCE
(2020)
Article
Chemistry, Physical
Hui Wang, Richard Revia, Qingxin Mu, Guanyou Lin, Charles Yen, Miqin Zhang
NANOSCALE HORIZONS
(2020)
Article
Pharmacology & Pharmacy
Mike Jeon, Guanyou Lin, Zachary R. Stephen, Frances L. Kato, Miqin Zhang
ADVANCED THERAPEUTICS
(2019)