Article
Engineering, Biomedical
Ying Zhang, Cong Wang, Weishuo Li, Wei Tian, Chunming Tang, Lingjing Xue, Ziming Lin, Guilai Liu, Dongfei Liu, Ying Zhou, Qianqian Wang, Xu Wang, Lutz Birnbaumer, Yong Yang, Xianjing Li, Caoyun Ju, Can Zhang
Summary: The study proposes a general CTC intervention strategy based on neutrophil cyto-pharmaceuticals to suppress CTC colonization and metastasis formation, offering a new perspective for understanding the mechanism of CTC colonization and suggesting targeted intervention as a meaningful treatment for tumor metastasis.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Biomedical
Pei Pan, Xue Dong, Ying Chen, Jing-Jie Ye, Yun-Xia Sun, Xian-Zheng Zhang
Summary: This study developed a hybrid nanoplatform combining radiosensitization and enhanced antitumor immune response. The platform utilized a high-Z element to produce reactive oxygen species (ROS) and induce immunogenic death in cancer cells under X-ray irradiation. Furthermore, the fusion of tumor cell and bacterial membranes amplified the immune response. The synergistic therapy achieved significant tumor inhibition and has potential as a clinical alternative treatment.
Review
Chemistry, Multidisciplinary
Neda Khosravi, Elham Pishavar, Behzad Baradaran, Fatemeh Oroojalian, Ahad Mokhtarzadeh
Summary: Nanomedicine research has made significant progress, but encounters obstacles such as low drug concentration and rapid drug elimination. Stem cell membranes and stem cell-derived exosomes have emerged as promising therapeutic carriers. Combining synthetic nanoparticles with stem cell membranes enhances drug delivery. Utilizing stem cell-derived exosome membranes improves the therapeutic capability of engineered drug delivery vehicles.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Immunology
Chao Wang, Minghua Cao, Xiaoli Jiang, Yudi Yao, Zhuoqi Liu, Daya Luo
Summary: Research suggests that the macrophage balance fraction (MBF) is an effective indicator of the balance of tumor associated macrophages, reflecting the degree of immunosuppression and metastatic ability of breast cancer. Different MBF environments can impact the migration and invasion ability of breast cancer cells, and breast cancer-derived exosomes may play a role in the mechanism of MBF changes in breast cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Hyunjong Lee, Kwon Joong Na, Hongyoon Choi
Summary: This study analyzed transcriptomic profiles of metastatic breast cancer and found variable enrichment patterns of immune cells in metastatic lesions, highlighting the importance of considering the tumor immune microenvironment for precise immuno-oncology treatments.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Lingling Zhu, Xianzhe Yu, Ting Cao, Hanyu Deng, Xiaojun Tang, Qing Lin, Qinghua Zhou
Summary: Metastasis is the leading cause of cancer-related death and current treatments have limited efficacy. Nanobiomaterials, including immune cell membrane-based nanocarriers, have shown promise in overcoming the limitations of conventional therapies. This review explores the impact of immune cells on tumor metastasis and highlights the potential of immune cell membrane-based nanocarriers in improving therapeutic efficacy against cancer metastases. However, there are still challenges that need to be addressed for clinical translation.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Medicine, General & Internal
Chengjun Zhu, Jing Xu, Jinyu Sun, Shiyun Cui, Yue Sun, Tao Yu, Cenzhu Wang, Tianyao Wang, Yufeng Wu, Feng Ju, Jiafeng Yao, Kai Liu, Wenwen Zhang, Xiaoxiang Guan
Summary: This study investigates the association between circulating tumor cells (CTCs) and breast cancer metastasis. The results show that CTC enumeration is significantly associated with liver metastasis in breast cancer patients, and CTCs >= 5 are a risk factor for tumor metastasis. Furthermore, high CTC levels may be associated with an increased risk of liver metastasis in patients with metastatic breast cancer.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Indira Sigdel, Niraj Gupta, Fairuz Faizee, Vishwa M. Khare, Amit K. Tiwari, Yuan Tang
Summary: The article highlights the high mortality rate of breast cancer due to metastasis, emphasizing the urgent need for better models to understand and prevent this process. Microfluidic approaches offer the ability to mimic cellular microenvironments and monitor interactions in real-time, showing great potential in advancing our mechanistic understanding of breast cancer metastasis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Evgeniya S. Grigoryeva, Luibov A. Tashireva, Olga E. Savelieva, Marina V. Zavyalova, Nataliya O. Popova, Gleb A. Kuznetsov, Elena S. Andryuhova, Vladimir M. Perelmuter
Summary: In this study, we investigated the expression of integrins beta 3, beta 4, and alpha V beta 5 on exosomes and tumor cells, and their association with distant metastasis in breast cancer patients. We found that exosomal integrin beta 4 was associated with lung metastasis, while integrin beta 3 was not evaluable due to its rarity in brain metastasis. Exosomal integrin alpha V beta 5 showed no association with liver metastasis. Furthermore, integrin beta 4 in the primary tumor was associated with liver metastasis, and beta 4+ tumor cells in liver metastasis patients showed increased expression of E-cadherin+ and CD44+CD24- cells compared to patients with lung or no distant metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Qian Xie, Bin Li, Jialong Fan, Jiahao Liang, Sai Jiang, Yan Qin, Ling Jiang, Jiao Cui, Xiaoping Nie, Shaoqiu Sun, Bin Liu, Wei Wang
Summary: Breast cancer is a global threat to women's health and has a poor prognosis. Panaxytriol (PA), a phytoconstituent isolated from Panax japonicus, has shown inhibitory effects on APE1 activity, a key enzyme in breast cancer development. To enhance the therapeutic efficacy of PA, Prussian blue nanoparticles with dopamine surface modification were used in combination with the photodynamic agent indocyanine green. The hybrid-cell membrane camouflage of the nano-delivery system improved solubility and targeting ability. In vivo studies on nude mice demonstrated that this biomimetic formulation effectively inhibited breast cancer growth through cell proliferation inhibition and apoptosis induction. Comprehensive therapy combining PA and nanomaterials may be an effective strategy for treating breast cancer.
MATERIALS & DESIGN
(2022)
Review
Biochemistry & Molecular Biology
Huidan Luo, Bin Yi
Summary: Exosomes, as nanoscale membrane vesicles, are important for cell communication and can serve as non-invasive liquid biopsy biomarkers in nasopharyngeal carcinoma. They play a role in regulating physiological processes of the tumor and have implications in cell growth, angiogenesis, metastasis, immunosuppression, radiation resistance, and chemotherapy resistance in NPC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Engineering, Biomedical
Chunxiang Feng, Zhiyong Xiong, Cheng Wang, Wen Xiao, Haibing Xiao, Kairu Xie, Ke Chen, Huageng Liang, Xiaoping Zhang, Hongmei Yang
Summary: The novel exosome-based drug delivery system designed in this study effectively degrades high molecular weight hyaluronan and modifies the immune microenvironment, reducing tumor cell metastasis.
BIOACTIVE MATERIALS
(2021)
Article
Biochemical Research Methods
Xiaofu Weng, Dan Wei, Zhangru Yang, Wen Pang, Kai Pang, Bobo Gu, Xunbin Wei
Summary: Photodynamic therapy (PDT) can effectively reduce metastasis by minimizing circulating tumor cells (CTCs) after treatment, and compared with traditional surgery, PDT provides minimal invasion and targeted therapy for breast cancer.
BIOMEDICAL OPTICS EXPRESS
(2021)
Review
Oncology
Lucas E. L. Terceiro, Chidalu A. Edechi, Nnamdi M. Ikeogu, Barbara E. Nickel, Sabine Hombach-Klonisch, Tanveer Sharif, Etienne Leygue, Yvonne Myal
Summary: The tumor microenvironment is crucial in the development and metastasis of various cancers, including breast cancer. Interactions between breast cancer cells and neighboring cells regulate metastasis through cell-to-cell contact or the release of signaling factors. Exosomes and circulating tumor cells also play roles in breast cancer metastasis. Markers associated with stromal cells in the breast tumor environment have potential to predict patient survival and guide treatment, while advancements in technology may lead to more effective therapies for breast cancer patients.
Article
Engineering, Environmental
Ying Yin, Wei Tang, Xiaoyue Ma, Lin Tang, Yu Zhang, Meng Yang, Fangfang Hu, Guanglin Li, Yazhou Wang
Summary: This study presents an effective approach for treating malignant glioma based on neutrophil-macrophage hybrid membrane coating nanotechnology. The biomimetic nanoparticle can overcome the blood-brain barrier and target glioma, showing high therapeutic efficacy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Biomedical
Yixin Sun, Simeng Wang, Yaqi Li, Danping Wang, Yu Zhang, Haotian Zhang, Hongrui Lei, Xiaohong Liu, Jin Sun, Bingjun Sun, Zhonggui He
Summary: Prodrug-based nanoassemblies, combining prodrug technology and nanocarriers, show great promise in cancer treatment. The chemical structure of prodrugs is closely related to their antitumor efficacy and safety, and the relationship between them needs further exploration.
ACTA BIOMATERIALIA
(2023)
Article
Medicine, Research & Experimental
Chutong Tian, Jin Sun, Mingyang Zhang, Chunlin Guo, Yifan Miao, Zhonggui He
Summary: In this study, a lipophilic disulfide-bridged linoleic prodrug (PTX-S-S-LA) was synthesized and efficiently incorporated into a self-microemulsifying drug delivery system (SMEDDS) to facilitate the oral absorption of paclitaxel (PTX). The prodrug SMEDDS showed higher drug loading efficiency and stability compared to parent PTX, and significantly increased drug partition in the intestinal micellar aqueous phase. Moreover, SMEDDS enhanced gastrointestinal biological adhesion and lymphatic transport, resulting in improved antitumor efficiency without significant gastrointestinal toxicity. Overall, the combination of PTX-S-S-LA and SMEDDS provides a promising approach for effective oral delivery of PTX.
MOLECULAR PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Xiaoyuan Fan, Kaiyuan Wang, Qi Lu, Yutong Lu, Jin Sun
Summary: Immunotherapy aims to activate the immune system to treat cancer, but its effectiveness in clinical applications is still limited. Cell-based drug delivery systems have the potential to enhance the efficacy of cancer immunotherapy and play important roles.
Article
Chemistry, Multidisciplinary
Hao Ye, Kaiyuan Wang, Jian Zhao, Qi Lu, Menglin Wang, Bingjun Sun, Yang Shen, Hongchen Liu, Salvador Pane, Xiang-Zhong Chen, Zhonggui He, Jin Sun
Summary: The use of Golgi apparatus-Pd-l1 (-/-) exosome hybrid membrane coated nanoparticles (GENPs) can significantly reduce the secretion of PD-L1, leading to reduced tumor relapse rates. GENPs accumulate in tumors and disrupt PD-L1 production and exosome release through induction of intracellular events. Furthermore, they can mimic exosomes to activate T cells and promote systemic immune responses.
Article
Chemistry, Multidisciplinary
Roger Sanchis-Gual, Hao Ye, Towa Ueno, Fabian C. Landers, Lukas Hertle, Siyu Deng, Andrea Veciana, Yanming Xia, Carlos Franco, Hongsoo Choi, Josep Puigmarti-Luis, Bradley J. Nelson, Xiang-Zhong Chen, Salvador Pane
Summary: The past decade has witnessed a rise in the development of small-scale magnetic robots for biomedical applications. However, many of the designs reported have biocompatibility concerns. This study introduces a strategy to fabricate biocompatible and degradable microrobots using polyvinyl alcohol (PVA)-based magnetic hydrogel. The PVA-based magnetic microrobots, with different morphologies and tunable stability, can be used for targeted drug and cell delivery due to their high mobility, tunable stability, and high biocompatibility.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Medicine, Research & Experimental
Ximing Zhang, Fangxue Zhao, Jing Feng, Cong Chen, Zhonggui He, Mengchi Sun, Jin Sun
Summary: In this study, an ionizable PTX prodrug (PTXP) was designed to achieve remote loading of liposomal formulations. Compared to marketable PTX liposomes, PTXP liposomes showed higher loading efficiency and encapsulation efficiency, as well as demonstrated stability, prolonged circulation time, high tumor site accumulation, potent anti-tumor effects, and safety in vitro and in vivo.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Marija Vukomanovic, Lea Gazvoda, Mario Kurtjak, Marjeta Macek-Krzmanc, Matjaz Spreitzer, Qiao Tang, Jiang Wu, Hao Ye, Xiangzhong Chen, Michele Mattera, Josep Puigmarti-Luis, Salvador Vidal Pane
Summary: Poly-L-lactide (PLLA) has the potential to be used as a biocompatible, biodegradable, and implantable piezoelectric material for mimicking biophysical processes. By modifying PLLA with a small amount of crystalline filler particles, the piezoelectricity of PLLA can be increased and provide a larger voltage output during ultrasound-assisted activation. The films also show low ability to produce reactive oxygen species (ROS) and increase local temperature during interactions with ultrasound.
Article
Multidisciplinary Sciences
Kaiyuan Wang, Yang Li, Xia Wang, Zhijun Zhang, Liping Cao, Xiaoyuan Fan, Bin Wan, Fengxiang Liu, Xuanbo Zhang, Zhonggui He, Yingtang Zhou, Dong Wang, Jin Sun, Xiaoyuan Chen
Summary: Gas-based therapy using virus-mimicking hollow mesoporous tetrasulfide-doped organosilica as a nano-adjuvant shows potential for enhancing anti-tumor immune response in preclinical breast cancer models. The gas nanoadjuvant achieves tumor-specific drug release, promotes photodynamic therapy, and produces H2S and CO as gas immunoadjuvants to activate the cGAS-STING pathway. This approach potentiates photoimmunotherapy of poorly immunogenic breast tumors.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Yi-fan Miao, Qing Ye, Ming-yang Zhang, Lin Gao, Xi-yan Wang, Wen-xin Zhong, Zi-xuan Wang, Zhong-gui He, Chu-tong Tian, Jin Sun
Summary: Due to the serious side effects of intravenous Taxol, the development of an oral chemotherapeutic strategy for paclitaxel (PTX) delivery is highly anticipated. This study explores a series of triglyceride-mimetic prodrugs of PTX with different fatty acid structures to enhance oral antitumor effect and guide the design of similar prodrugs. The results show that the length of fatty acids plays a significant role in in vitro intestinal digestion behavior, lymph transport efficiency, and plasma pharmacokinetics, while the degree of unsaturation has a negligible impact. These findings provide a theoretical basis for the rational design of TG-like PTX prodrugs.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Wei Zhong, Rongjian Hu, Shuai Zhou, Jianhua Xu, Kaiyuan Wang, Bowen Yao, Ranhua Xiong, Jiajun Fu
Summary: In this study, a self-adaptive dressing was developed by coating a quaternary ammonium salt-based hydrogel with cellulose sulfate as dynamic layers to solve the problems of cytotoxicity and adhesive deterioration. The dressing exhibited excellent wound sealing and hemostasis performance and achieved optimal disinfection and epithelium regeneration by responding to the changing acidity of the wound environment.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Hongyan Zhang, Liying Chen, Yue Zhao, Ningchao Luo, Jingbin Shi, Shujun Xu, Lisha Ma, Menglin Wang, Mancang Gu, Chaofeng Mu, Yang Xiong
Summary: Cancer-associated fibroblasts (CAFs) play a significant role in promoting an immunosuppressive microenvironment in triple-negative breast cancer (TNBC), leading to the failure of immunotherapy. This study focuses on using a polymeric nanoparticle called LPPR to target and inhibit CAFs, thus reshaping the tumor microenvironment to enhance the effect of immune checkpoint blockade therapy in TNBC.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Cell Biology
Ziyue Wang, Shenwu Zhang, Zhiqiang Kong, Songhao Li, Jin Sun, Ying Zheng, Zhonggui He, Hao Ye, Cong Luo
Summary: Solid tumors are complex evolving systems, and self-adaptive synthetic therapeutics are needed to overcome the challenges they pose. However, accurate targeting and destruction of hypoxic niches limit complete tumor eradication.
CELL REPORTS MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Menglin Wang, Benoit Rousseau, Kunyu Qiu, Guannan Huang, Yu Zhang, Hang Su, Christine Le Bihan-Benjamin, Ines Khati, Oliver Artz, Michael B. Foote, Yung-Yi Cheng, Kuo-Hsiung Lee, Michael Z. Miao, Yue Sun, Philippe-Jean Bousquet, Marc Hilmi, Elise Dumas, Anne-Sophie Hamy, Fabien Reyal, Lin Lin, Paul M. Armistead, Wantong Song, Ava Vargason, Janelle C. Arthur, Yun Liu, Jianfeng Guo, Xuefei Zhou, Juliane Nguyen, Yongqun He, Jenny P. -Y. Ting, Aaron C. Anselmo, Leaf Huang
Summary: Research has shown that the tumor microbiota can influence cancer progression. Targeting anaerobic bacteria with pre-resection antibiotics significantly improves disease-free survival in colorectal cancer patients. By designing an antibiotic encapsulated in liposomes, tumor-associated bacteria can be eliminated without disrupting the gut microbiome, leading to enhanced anti-tumoral immunity and potential interventions in microbiome-immunotherapy.
NATURE BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Kaiyuan Wang, Xuanbo Zhang, Hao Ye, Xia Wang, Zhijin Fan, Qi Lu, Songhao Li, Jian Zhao, Shunzhe Zheng, Zhonggui He, Qianqian Ni, Xiaoyuan Chen, Jin Sun
Summary: Cytokine therapy for cancer immunotherapy is a promising strategy, but limited by the wide distribution of cytokine receptors, systemic immune activation, and short half-life of cytokines. In this study, a biomimetic nanovaccine was developed to selectively target IL-15 to antigen-specific T cells, reducing off-target toxicity and improving therapeutic efficacy.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.