标题
PI3K in stemness regulation: from development to cancer
作者
关键词
-
出版物
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 48, Issue 1, Pages 301-315
出版商
Portland Press Ltd.
发表日期
2020-02-03
DOI
10.1042/bst20190778
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Cracking the context-specific PI3K signaling code
- (2020) Ralitsa R. Madsen et al. Science Signaling
- Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition
- (2019) Yoko Katsuno et al. Science Signaling
- PI3K isoforms in cell signalling and vesicle trafficking
- (2019) Benoit Bilanges et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Correction: The induction of core pluripotency master regulators in cancers defines poor clinical outcomes and treatment resistance
- (2019) A. C. Hepburn et al. ONCOGENE
- Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner
- (2019) Ralitsa R. Madsen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cell cycle dynamics of human pluripotent stem cells primed for differentiation
- (2019) Anna Shcherbina et al. STEM CELLS
- The H1047R PIK3CA oncogene induces a senescence-like state, pleiotropy and acute HSP90 dependency in HER2+ mammary epithelial cells
- (2019) Anindita Chakrabarty et al. CARCINOGENESIS
- The role of insulin as a key regulator of seeding, proliferation, and mRNA transcription of human pluripotent stem cells
- (2019) Mohammad Shahbazi et al. Stem Cell Research & Therapy
- Mouse Models for Exploring the Biological Consequences and Clinical Significance of PIK3CA Mutations
- (2019) Camilla B. Mitchell et al. Biomolecules
- Mutationally-activated PI3’-kinase-α promotes de-differentiation of lung tumors initiated by the BRAFV600E oncoprotein kinase
- (2019) J Edward van Veen et al. eLife
- Distinct roles of PIK3CA in the enrichment and maintenance of cancer stem cells in head and neck squamous cell carcinoma
- (2019) Xi Chen et al. Molecular Oncology
- PIK3CA Cooperates with KRAS to Promote MYC Activity and Tumorigenesis via the Bromodomain Protein BRD9
- (2019) Catherine M. Bell et al. Cancers
- Spatial and temporal control of NODAL signaling
- (2018) Caroline S Hill CURRENT OPINION IN CELL BIOLOGY
- mTOR signaling in stem and progenitor cells
- (2018) Delong Meng et al. DEVELOPMENT
- Pluripotency Deconstructed
- (2018) Masaki Kinoshita et al. DEVELOPMENT GROWTH & DIFFERENTIATION
- Defining essential genes for human pluripotent stem cells by CRISPR–Cas9 screening in haploid cells
- (2018) Atilgan Yilmaz et al. NATURE CELL BIOLOGY
- The functions and regulation of the PTEN tumour suppressor: new modes and prospects
- (2018) Yu-Ru Lee et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Encoding Growth Factor Identity in the Temporal Dynamics of FOXO3 under the Combinatorial Control of ERK and AKT Kinases
- (2018) Somponnat Sampattavanich et al. Cell Systems
- Identification of the tumour transition states occurring during EMT
- (2018) Ievgenia Pastushenko et al. NATURE
- Cancer-Associated PIK3CA Mutations in Overgrowth Disorders
- (2018) Ralitsa R. Madsen et al. TRENDS IN MOLECULAR MEDICINE
- A high-avidity biosensor reveals plasma membrane PI(3,4)P2 is predominantly a class I PI3K signaling product
- (2018) Brady D. Goulden et al. JOURNAL OF CELL BIOLOGY
- Oncogenic activation of PI3K induces progenitor cell differentiation to suppress epidermal growth
- (2018) Zhe Ying et al. NATURE CELL BIOLOGY
- T-ALL leukemia stem cell 'stemness' is epigenetically controlled by the master regulator SPI1
- (2018) Haichuan Zhu et al. eLife
- Insulin Receptor Isoforms in Physiology and Disease: An Updated View
- (2017) Antonino Belfiore et al. ENDOCRINE REVIEWS
- Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids
- (2017) Pamela Riemer et al. JOURNAL OF CELL BIOLOGY
- PTEN Regulates PI(3,4)P 2 Signaling Downstream of Class I PI3K
- (2017) Mouhannad Malek et al. MOLECULAR CELL
- The impact of cellular metabolism on chromatin dynamics and epigenetics
- (2017) Michael A. Reid et al. NATURE CELL BIOLOGY
- EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
- (2017) Tsukasa Shibue et al. Nature Reviews Clinical Oncology
- A pathology atlas of the human cancer transcriptome
- (2017) Mathias Uhlen et al. SCIENCE
- TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α
- (2017) Anahita Hamidi et al. Science Signaling
- Pentraxin-3 is a PI3K signaling target that promotes stem cell–like traits in basal-like breast cancers
- (2017) Clémence Thomas et al. Science Signaling
- Understanding the mTOR signaling pathway via mathematical modeling
- (2017) Nurgazy Sulaimanov et al. Wiley Interdisciplinary Reviews-Systems Biology and Medicine
- TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α
- (2017) Anahita Hamidi et al. Science Signaling
- Pentraxin-3 is a PI3K signaling target that promotes stem cell–like traits in basal-like breast cancers
- (2017) Clémence Thomas et al. Science Signaling
- Cancer Stem Cells: Basic Concepts and Therapeutic Implications
- (2016) Dany Nassar et al. Annual Review of Pathology-Mechanisms of Disease
- Emerging evidence of signalling roles for PI(3,4)P2 in Class I and II PI3K-regulated pathways
- (2016) P. T. Hawkins et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Stem Cells: A Renaissance in Human Biology Research
- (2016) Jun Wu et al. CELL
- Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination
- (2016) Jason S. L. Yu et al. DEVELOPMENT
- Mapping growth-factor-modulated Akt signaling dynamics
- (2016) Sean M. Gross et al. JOURNAL OF CELL SCIENCE
- Overexpression of PIK3CA in murine head and neck epithelium drives tumor invasion and metastasis through PDK1 and enhanced TGFβ signaling
- (2016) L Du et al. ONCOGENE
- TGF-β upregulates the translation of USP15 via the PI3K/AKT pathway to promote p53 stability
- (2016) W-T Liu et al. ONCOGENE
- Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans
- (2016) Sandra D. Castillo et al. Science Translational Medicine
- The complexities and versatility of the RAS-to-ERK signalling system in normal and cancer cells
- (2016) Dirk Fey et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression
- (2016) Esther Castellano et al. Nature Communications
- A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity
- (2016) Luca Fagnocchi et al. Nature Communications
- Conditional Loss of Pten in Myogenic Progenitors Leads to Postnatal Skeletal Muscle Hypertrophy but Age-Dependent Exhaustion of Satellite Cells
- (2016) Feng Yue et al. Cell Reports
- A Multi-Lineage Screen Reveals mTORC1 Inhibition Enhances Human Pluripotent Stem Cell Mesendoderm and Blood Progenitor Production
- (2016) Emanuel Joseph Paul Nazareth et al. Stem Cell Reports
- Glycolysis-Mediated Changes in Acetyl-CoA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells
- (2015) Arieh Moussaieff et al. Cell Metabolism
- ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway
- (2015) Lena Ho et al. Cell Stem Cell
- Dynamic Pluripotent Stem Cell States and Their Applications
- (2015) Jun Wu et al. Cell Stem Cell
- Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity
- (2015) Alexandra Van Keymeulen et al. NATURE
- PIK3CAH1047R induces multipotency and multi-lineage mammary tumours
- (2015) Shany Koren et al. NATURE
- The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors
- (2015) Erine H. Budi et al. Science Signaling
- PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation
- (2015) Jason S. L. Yu et al. Nature Communications
- The insulin response integrates increased TGF-β signaling through Akt-induced enhancement of cell surface delivery of TGF-β receptors
- (2015) Erine H. Budi et al. Science Signaling
- Targeting cancer's weaknesses (not its strengths): Therapeutic strategies suggested by the atavistic model
- (2014) Charles H. Lineweaver et al. BIOESSAYS
- Regulatory interactions maintaining self-renewal of human embryonic stem cells as revealed through a systems analysis of PI3K/AKT pathway
- (2014) Shibin Mathew et al. BIOINFORMATICS
- Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation
- (2014) Joyce V. Lee et al. Cell Metabolism
- Regulatory Principles of Pluripotency: From the Ground State Up
- (2014) Jamie A. Hackett et al. Cell Stem Cell
- Quantitative analysis of robustness of dynamic response and signal transfer in insulin mediated PI3K/AKT pathway
- (2014) Shibin Mathew et al. COMPUTERS & CHEMICAL ENGINEERING
- The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation
- (2014) Alfredo Csibi et al. CURRENT BIOLOGY
- Signals Controlling Un-Differentiated States in Embryonic Stem and Cancer Cells: Role of the Phosphatidylinositol 3′ Kinase Pathway
- (2014) Daniel Voskas et al. JOURNAL OF CELLULAR PHYSIOLOGY
- A Methylation-Phosphorylation Switch Determines Sox2 Stability and Function in ESC Maintenance or Differentiation
- (2014) Lan Fang et al. MOLECULAR CELL
- Origins and implications of pluripotent stem cell variability and heterogeneity
- (2013) Patrick Cahan et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Activation of PDK-1 maintains mouse embryonic stem cell self-renewal in a PKB-dependent manner
- (2013) L S Ling et al. ONCOGENE
- Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies
- (2013) A. B. Hanker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Signaling interplay between transforming growth factor-β receptor and PI3K/AKT pathways in cancer
- (2013) Long Zhang et al. TRENDS IN BIOCHEMICAL SCIENCES
- PI3K/Akt1 signalling specifies foregut precursors by generating regionalized extra-cellular matrix
- (2013) S Nahuel Villegas et al. eLife
- Forcing Stem Cells to Behave: A Biophysical Perspective of the Cellular Microenvironment
- (2012) Yubing Sun et al. Annual Review of Biophysics
- Reconciling the different roles of Gsk3β in “naïve” and “primed” pluripotent stem cells
- (2012) Amar M. Singh et al. CELL CYCLE
- Signaling Network Crosstalk in Human Pluripotent Cells: A Smad2/3-Regulated Switch that Controls the Balance between Self-Renewal and Differentiation
- (2012) Amar M. Singh et al. Cell Stem Cell
- Signaling networks in human pluripotent stem cells
- (2012) Stephen Dalton CURRENT OPINION IN CELL BIOLOGY
- USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor
- (2012) Long Zhang et al. NATURE CELL BIOLOGY
- Active PI3K Pathway Causes an Invasive Phenotype Which Can Be Reversed or Promoted by Blocking the Pathway at Divergent Nodes
- (2012) Jeffrey J. Wallin et al. PLoS One
- Akt/PKB-Mediated Phosphorylation of Twist1 Promotes Tumor Metastasis via Mediating Cross-Talk between PI3K/Akt and TGF-β Signaling Axes
- (2012) Gongda Xue et al. Cancer Discovery
- Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast
- (2011) Christina Scheel et al. CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Sustained Activation of mTOR Pathway in Embryonic Neural Stem Cells Leads to Development of Tuberous Sclerosis Complex-Associated Lesions
- (2011) Laura Magri et al. Cell Stem Cell
- Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation
- (2011) Hideki Yamaguchi et al. JOURNAL OF CELL BIOLOGY
- Crosstalk in NF-κB signaling pathways
- (2011) Andrea Oeckinghaus et al. NATURE IMMUNOLOGY
- Chemically defined conditions for human iPSC derivation and culture
- (2011) Guokai Chen et al. NATURE METHODS
- Loss of Pten Causes Tumor Initiation Following Differentiation of Murine Pluripotent Stem Cells Due to Failed Repression of Nanog
- (2011) Anne G. Lindgren et al. PLoS One
- Phosphatase and Tensin Homolog Regulates the Pluripotent State and Lineage Fate Choice in Human Embryonic Stem Cells
- (2011) Jackelyn A. Alva et al. STEM CELLS
- The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
- (2011) Michelle C. Mendoza et al. TRENDS IN BIOCHEMICAL SCIENCES
- mTOR-Mediated Activation of p70 S6K Induces Differentiation of Pluripotent Human Embryonic Stem Cells
- (2010) Charles A. Easley et al. Cellular Reprogramming
- Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells
- (2010) Hideki Kobayashi et al. NATURE CELL BIOLOGY
- Inhibition of ERK1/2 prevents neural and mesendodermal differentiation and promotes human embryonic stem cell self-renewal
- (2010) Jie Na et al. Stem Cell Research
- Phosphorylation of Sox2 Cooperates in Reprogramming to Pluripotent Stem Cells
- (2010) Chul-Ho Jeong et al. STEM CELLS
- Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice
- (2009) M. G. Kharas et al. BLOOD
- mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging
- (2009) Rogerio M. Castilho et al. Cell Stem Cell
- Phosphorylation Dynamics during Early Differentiation of Human Embryonic Stem Cells
- (2009) Dennis Van Hoof et al. Cell Stem Cell
- Activin/Nodal signalling maintains pluripotency by controlling Nanog expression
- (2009) L. Vallier et al. DEVELOPMENT
- Distinct roles for isoforms of the catalytic subunit of class-IA PI3K in the regulation of behaviour of murine embryonic stem cells
- (2009) E. Kingham et al. JOURNAL OF CELL SCIENCE
- Subcellular Localization of Glycogen Synthase Kinase 3 Controls Embryonic Stem Cell Self-Renewal
- (2009) M. Bechard et al. MOLECULAR AND CELLULAR BIOLOGY
- mTOR supports long-term self-renewal and suppresses mesoderm and endoderm activities of human embryonic stem cells
- (2009) J. Zhou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Characterization of the Phosphoinositide 3-Kinase-Dependent Transcriptome in Murine Embryonic Stem Cells: Identification of Novel Regulators of Pluripotency
- (2009) Michael P. Storm et al. STEM CELLS
- Regulation of Mammary Stem/Progenitor Cells by PTEN/Akt/β-Catenin Signaling
- (2009) Hasan Korkaya et al. PLOS BIOLOGY
- SHIP is required for a functional hematopoietic stem cell niche
- (2008) A. L. Hazen et al. BLOOD
- Distinct Thresholds Govern Myc's Biological Output In Vivo
- (2008) Daniel J. Murphy et al. CANCER CELL
- NANOG Is a Direct Target of TGFβ/Activin-Mediated SMAD Signaling in Human ESCs
- (2008) Ren-He Xu et al. Cell Stem Cell
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started