SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity

Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease

(2018) Mario Masarone et al.   Oxidative Medicine and Cellular Longevity

Canonical and non-canonical mechanisms of Nrf2 activation

(2018) Carlos Alfredo Silva-Islas et al.   PHARMACOLOGICAL RESEARCH

Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy

(2017) Rhianna C. Laker et al.   Nature Communications

p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer

(2016) Angeles Duran et al.   CANCER CELL

p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer

(2016) Koji Taniguchi et al.   FEBS LETTERS

Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis

(2016) Da Hyun Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

p62 improves AD-like pathology by increasing autophagy

(2016) A Caccamo et al.   MOLECULAR PSYCHIATRY

Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies

(2016) Giovanni Musso et al.   NATURE REVIEWS DRUG DISCOVERY

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming

(2016) Tetsuya Saito et al.   Nature Communications

Concerted action of p62 and Nrf2 protects cells from palmitic acid-induced lipotoxicity

(2015) Jeong Su Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

Proteasome Dysfunction Activates Autophagy and the Keap1-Nrf2 Pathway

(2014) Shun Kageyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ASPP2 attenuates triglycerides to protect against hepatocyte injury by reducing autophagy in a cell and mouse model of non-alcoholic fatty liver disease

(2014) Fang Xie et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

(2014) Á González-Rodríguez et al.   Cell Death & Disease

Metabolic Characterization of Hepatocellular Carcinoma Using Nontargeted Tissue Metabolomics

(2013) Q. Huang et al.   CANCER RESEARCH

Deficiency of p62/Sequestosome 1 Causes Hyperphagia Due to Leptin Resistance in the Brain

(2013) H. Harada et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Maintenance of Metabolic Homeostasis by Sestrin2 and Sestrin3

(2012) Jun Hee Lee et al.   Cell Metabolism

Sestrins Activate Nrf2 by Promoting p62-Dependent Autophagic Degradation of Keap1 and Prevent Oxidative Liver Damage

(2012) Soo Han Bae et al.   Cell Metabolism

Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials

(2012) G. Musso et al.   DIABETOLOGIA

Assurance of mitochondrial integrity and mammalian longevity by the p62–Keap1–Nrf2–Nqo1 cascade

(2012) Jeongho Kwon et al.   EMBO REPORTS

TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation

(2012) Manohar Pilli et al.   IMMUNITY

Induction of Autophagy by Palmitic Acid via Protein Kinase C-mediated Signaling Pathway Independent of mTOR (Mammalian Target of Rapamycin)

(2012) Shi Hao Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62/SQSTM1/A170: Physiology and pathology

(2012) Masaaki Komatsu et al.   PHARMACOLOGICAL RESEARCH

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

(2011) Dan Egan et al.   Autophagy

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

(2011) Keiko Taguchi et al.   GENES TO CELLS

Death Receptor 5 Signaling Promotes Hepatocyte Lipoapoptosis

(2011) Sophie C. Cazanave et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

(2011) Eisuke Itakura et al.   JOURNAL OF CELL BIOLOGY

Lipotoxicity in NASH

(2011) Michael Fuchs et al.   JOURNAL OF HEPATOLOGY

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

(2011) Gen Matsumoto et al.   MOLECULAR CELL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Autophagy in nonalcoholic steatohepatitis

(2011) Muhammad Amir et al.   Expert Review of Gastroenterology & Hepatology

Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview

(2010) Ken Itoh et al.   ANTIOXIDANTS & REDOX SIGNALING

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Preparation of fatty acid methyl esters for gas-liquid chromatography

(2009) Ken'ichi Ichihara et al.   JOURNAL OF LIPID RESEARCH

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL