Structural Insight into IAPP-Derived Amyloid Inhibitors and Their Mechanism of Action

Designed Macrocyclic Peptides as Nanomolar Amyloid Inhibitors Based on Minimal Recognition Elements

(2018) Anna Spanopoulou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transthyretin Mimetics as Anti-β-Amyloid Agents: A Comparison of Peptide and Protein Approaches

(2018) Kayla M. Pate et al.   ChemMedChem

Key aromatic/hydrophobic amino acids controlling a cross-amyloid peptide interaction versus amyloid self-assembly

(2017) Maria Bakou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sulindac Sulfide Induces the Formation of Large Oligomeric Aggregates of the Alzheimer’s Disease Amyloid-β Peptide Which Exhibit Reduced Neurotoxicity

(2016) Elke Prade et al.   BIOCHEMISTRY

Phase separation in biology; functional organization of a higher order

(2016) Diana M. Mitrea et al.   Cell Communication and Signaling

Metadynamic metainference: Enhanced sampling of the metainference ensemble using metadynamics

(2016) Massimiliano Bonomi et al.   Scientific Reports

A Hot-Segment-Based Approach for the Design of Cross-Amyloid Interaction Surface Mimics as Inhibitors of Amyloid Self-Assembly

(2015) Erika Andreetto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure-Free Validation of Residual Dipolar Coupling and Paramagnetic Relaxation Enhancement Measurements of Disordered Proteins

(2015) Francisco N. Newby et al.   BIOCHEMISTRY

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

(2015) Amandine Molliex et al.   CELL

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

Structural Mechanism of the Interaction of Alzheimer Disease Aβ Fibrils with the Non-steroidal Anti-inflammatory Drug (NSAID) Sulindac Sulfide

(2015) Elke Prade et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

(2015) Yuan Lin et al.   MOLECULAR CELL

Preclinical Validation of the Heparin-Reactive Peptide p5+14 as a Molecular Imaging Agent for Visceral Amyloidosis

(2015) Jonathan Wall et al.   MOLECULES

The inverted free energy landscape of an intrinsically disordered peptide by simulations and experiments

(2015) Daniele Granata et al.   Scientific Reports

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

In Vitro and Mechanistic Studies of an Antiamyloidogenic Self-Assembled Cyclic d,l-α-Peptide Architecture

(2013) Michal Richman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Asymmetric Dimer as the Basic Subunit in Alzheimer’s Disease Amyloid β Fibrils

(2012) Juan Miguel Lopez del Amo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Bacterial toxininhibitors based on multivalent scaffolds

(2012) Thomas R. Branson et al.   CHEMICAL SOCIETY REVIEWS

Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity

(2012) Pin-Nan Cheng et al.   Nature Chemistry

Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes

(2011) C. P. Brangwynne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Hot Regions of the Aβ-IAPP Interaction Interface as High-Affinity Binding Sites in both Cross- and Self-Association

(2010) Erika Andreetto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Kinetics of Amyloid β Monomer-to-Oligomer Exchange by NMR Relaxation

(2010) Nicolas L. Fawzi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Peptide Hairpin Inhibitor of Amyloid β-Protein Oligomerization and Fibrillogenesis

(2009) Ghiam Yamin et al.   BIOCHEMISTRY

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

(2009) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

CanN-methylated amino acids serve as substitutes for prolines in conformational design of cyclic pentapeptides?

(2008) Burkhardt Laufer et al.   JOURNAL OF PEPTIDE SCIENCE

Small-molecule aggregates inhibit amyloid polymerization

(2008) Brian Y Feng et al.   Nature Chemical Biology

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA