Quantitative Spatial Analysis of Metabolic Heterogeneity Across in vivo and in vitro Tumor Models

Cellular Metabolic Heterogeneity In Vivo Is Recapitulated in Tumor Organoids

(2019) Joe T. Sharick et al.   NEOPLASIA

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Sharing and reusing cell image data

(2018) Assaf Zaritsky   MOLECULAR BIOLOGY OF THE CELL

Protein-bound NAD(P)H Lifetime is Sensitive to Multiple Fates of Glucose Carbon

(2018) Joe T. Sharick et al.   Scientific Reports

Mapping metabolic changes by noninvasive, multiparametric, high-resolution imaging using endogenous contrast

(2018) Zhiyi Liu et al.   Science Advances

NADH Autofluorescence-A Marker on its Way to Boost Bioenergetic Research

(2018) Patrick M. Schaefer et al.   CYTOMETRY PART A

A Growing Toolbox to Image Gene Expression in Single Cells: Sensitive Approaches for Demanding Challenges

(2018) Xavier Pichon et al.   MOLECULAR CELL

Quantitative imaging of cancer in the postgenomic era: Radio(geno)mics, deep learning, and habitats

(2018) Sandy Napel et al.   CANCER

Autofluorescence lifetime imaging of cellular metabolism: Sensitivity toward cell density, pH, intracellular, and intercellular heterogeneity

(2018) Jenu V. Chacko et al.   CYTOMETRY PART A

Head and neck cancer organoids established by modification of the CTOS method can be used to predict in vivo drug sensitivity

(2018) Noriaki Tanaka et al.   ORAL ONCOLOGY

Organotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations

(2018) Jose M. Ayuso et al.   EBioMedicine

The Influence of Metabolism on Drug Response in Cancer

(2018) Esther A. Zaal et al.   Frontiers in Oncology

Autofluorescence imaging identifies tumor cell-cycle status on a single-cell level

(2017) Tiffany M. Heaster et al.   Journal of Biophotonics

Mechanisms and clinical implications of tumor heterogeneity and convergence on recurrent phenotypes

(2017) Jasmine A. McQuerry et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

(2017) Moritz Schütte et al.   Nature Communications

Biologically Relevant Heterogeneity: Metrics and Practical Insights

(2017) Albert Gough et al.   SLAS Discovery

Three-Dimensional Cell Cultures in Drug Discovery and Development

(2017) Ye Fang et al.   SLAS Discovery

Metabolic Imaging of Head and Neck Cancer Organoids

(2017) Amy T. Shah et al.   PLoS One

Spatial Autocorrelation in Mass Spectrometry Imaging

(2016) Alberto Cassese et al.   ANALYTICAL CHEMISTRY

A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo

(2016) Christopher G. Hubert et al.   CANCER RESEARCH

Correlating two-photon excited fluorescence imaging of breast cancer cellular redox state with seahorse flux analysis of normalized cellular oxygen consumption

(2016) Jue Hou et al.   JOURNAL OF BIOMEDICAL OPTICS

Imaging metabolic heterogeneity in cancer

(2016) Debanti Sengupta et al.   Molecular Cancer

Imagining the future of bioimage analysis

(2016) Erik Meijering et al.   NATURE BIOTECHNOLOGY

Role of the tumor microenvironment in tumor progression and the clinical applications (Review)

(2016) YAO YUAN et al.   ONCOLOGY REPORTS

Spatial Heterogeneity in the Tumor Microenvironment

(2016) Yinyin Yuan   Cold Spring Harbor Perspectives in Medicine

Mapping spatial heterogeneity in the tumor microenvironment: a new era for digital pathology

(2015) Andreas Heindl et al.   LABORATORY INVESTIGATION

Optical metabolic imaging quantifies heterogeneous cell populations

(2015) Alex J. Walsh et al.   Biomedical Optics Express

In Vivo Autofluorescence Imaging of Tumor Heterogeneity in Response to Treatment

(2015) Amy T. Shah et al.   NEOPLASIA

Quantitative Optical Imaging of Primary Tumor Organoid Metabolism Predicts Drug Response in Breast Cancer

(2014) A. J. Walsh et al.   CANCER RESEARCH

In Vitro and In Vivo Models for Analysis of Resistance to Anticancer Molecular Therapies

(2014) Roberta Rosa et al.   CURRENT MEDICINAL CHEMISTRY

Metabolic Reprogramming of Macrophages

(2014) Alex J. Freemerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Expression Analyses at the Single Cell Level

(2014) Masae Ohno et al.   MOLECULES

Fast Segmentation of Stained Nuclei in Terabyte-Scale, Time Resolved 3D Microscopy Image Stacks

(2014) Johannes Stegmaier et al.   PLoS One

Clustering by fast search and find of density peaks

(2014) A. Rodriguez et al.   SCIENCE

Separating NADH and NADPH fluorescence in live cells and tissues using FLIM

(2014) Thomas S. Blacker et al.   Nature Communications

Inference of Tumor Evolution during Chemotherapy by Computational Modeling and In Situ Analysis of Genetic and Phenotypic Cellular Diversity

(2014) Vanessa Almendro et al.   Cell Reports

Analysis and Interpretation of Imaging Mass Spectrometry Data by Clustering Mass-to-Charge Images According to Their Spatial Similarity

(2013) Theodore Alexandrov et al.   ANALYTICAL CHEMISTRY

Optical Metabolic Imaging Identifies Glycolytic Levels, Subtypes, and Early-Treatment Response in Breast Cancer

(2013) A. J. Walsh et al.   CANCER RESEARCH

Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer

(2013) Gabriela Bindea et al.   IMMUNITY

Spatial organization of dendritic cells within tumor draining lymph nodes impacts clinical outcome in breast cancer patients

(2013) Andrew Y Chang et al.   Journal of Translational Medicine

Quantitative metabolic imaging using endogenous fluorescence to detect stem cell differentiation

(2013) Kyle P. Quinn et al.   Scientific Reports

Characterizing the metabolic heterogeneity in human breast cancer xenografts by 3D high resolution fluorescence imaging

(2013) He N Xu et al.   SpringerPlus

Optical Imaging Using Endogenous Contrast to Assess Metabolic State

(2012) Irene Georgakoudi et al.   Annual Review of Biomedical Engineering

Combat or surveillance? Evaluation of the heterogeneous inflammatory breast cancer microenvironment

(2012) Juliane M Krüger et al.   JOURNAL OF PATHOLOGY

Annotated high-throughput microscopy image sets for validation

(2012) Vebjorn Ljosa et al.   NATURE METHODS

Genetically Engineered Cancer Models, But Not Xenografts, Faithfully Predict Anticancer Drug Exposure in Melanoma Tumors

(2012) A. J. Combest et al.   ONCOLOGIST

Quantitative Image Analysis of Cellular Heterogeneity in Breast Tumors Complements Genomic Profiling

(2012) Y. Yuan et al.   Science Translational Medicine

Revisiting Guerry’s data: Introducing spatial constraints in multivariate analysis

(2011) Stéphane Dray et al.   Annals of Applied Statistics

Metabolic alterations in cancer cells and therapeutic implications

(2011) Naima Hammoudi et al.   Chinese Journal of Cancer

Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies

(2010) Ahmed A Heikal   Biomarkers in Medicine

The Epidermal Growth Factor Receptor Antibody Cetuximab Induces Autophagy in Cancer Cells by Downregulating HIF-1  and Bcl-2 and Activating the Beclin 1/hVps34 Complex

(2010) X. Li et al.   CANCER RESEARCH

Quantitative, Architectural Analysis of Immune Cell Subsets in Tumor-Draining Lymph Nodes from Breast Cancer Patients and Healthy Lymph Nodes

(2010) A. Francesca Setiadi et al.   PLoS One

Epithelial-to-mesenchymal transition and c-myc expression are the determinants of cetuximab-induced enhancement of squamous cell carcinoma radioresponse

(2010) Ira Skvortsova et al.   RADIOTHERAPY AND ONCOLOGY

Tumor heterogeneity: Causes and consequences

(2009) Andriy Marusyk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Revealing cryptic spatial patterns in genetic variability by a new multivariate method

(2008) T Jombart et al.   HEREDITY