期刊
CURRENT MEDICINAL CHEMISTRY
卷 21, 期 14, 页码 1595-1606出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/09298673113209990226
关键词
Anticancer molecular therapies; tumour; molecular modelling
资金
- Associazione Italiana per la Ricerca sul Cancro (AIRC) [MFAG-11473]
- POR Campania
- SEMM (Scuola Europea di Medicina Molecolare)
The efficacy of classical and molecular therapies in cancer is hampered by the occurrence of primary (intrinsic) and secondary (acquired) refractoriness of tumours to selected therapeutic regimens. Nevertheless, the increased knowledge of the genetic, molecular and metabolic mechanisms underlying cancer results in the generation of a correspondingly increasing number of druggable targets and molecular drugs. Thus, a current challenge in molecular oncology and medicinal chemistry is to cope with the increased need for modelling, both in cellular and animal systems, the genetic assets associated to cancer resistance to drugs. In this review, we summarize the current strategies for generation and analysis of in vitro and in vivo models, which may reveal useful to extract information on the molecular basis of intrinsic and acquired resistance to anticancer molecular agents.
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