Aspirin enhances cisplatin sensitivity of resistant non-small cell lung carcinoma stem-like cells by targeting mTOR-Akt axis to repress migration

Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2

(2019) Serena Lucotti et al.   JOURNAL OF CLINICAL INVESTIGATION

A juxtacrine/paracrine loop between C-Kit and stem cell factor promotes cancer stem cell survival in epithelial ovarian cancer

(2019) Elena Laura Mazzoldi et al.   Cell Death & Disease

Macrophage migration inhibitory factor promotes tumor aggressiveness of esophageal squamous cell carcinoma via activation of Akt and inactivation of GSK3β

(2018) Rui-Min Liu et al.   CANCER LETTERS

MET/SMAD3/SNAIL circuit mediated by miR-323a-3p is involved in regulating epithelial–mesenchymal transition progression in bladder cancer

(2017) Jiangfeng Li et al.   Cell Death & Disease

Aspirin inhibits epithelial-to-mesenchymal transition and migration of oncogenic K-ras-expressing non-small cell lung carcinoma cells by down-regulating E-cadherin repressor Slug

(2016) Poulami Khan et al.   BMC CANCER

Aspirin Suppresses the Acquisition of Chemoresistance in Breast Cancer by Disrupting an NFκB–IL6 Signaling Axis Responsible for the Generation of Cancer Stem Cells

(2016) Shilpi Saha et al.   CANCER RESEARCH

CXCR4 is involved in CD133-induced EMT in non-small cell lung cancer

(2016) Zhenbo Tu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Non-migratory tumorigenic intrinsic cancer stem cells ensure breast cancer metastasis by generation of CXCR4+ migrating cancer stem cells

(2016) S Mukherjee et al.   ONCOGENE

Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition

(2016) F Mateo et al.   ONCOGENE

Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

(2016) Evelyne Beerling et al.   Cell Reports

Phosphoinositide dependent protein kinase 1 is required for exercise-induced cardiac hypertrophy but not the associated mitochondrial adaptations

(2015) Junghyun Noh et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

USP44+ Cancer Stem Cell Subclones Contribute to Breast Cancer Aggressiveness by Promoting Vasculogenic Mimicry

(2015) T. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Mithramycin A sensitizes therapy-resistant breast cancer stem cells toward genotoxic drug doxorubicin

(2015) Shilpi Saha et al.   Translational Research

Blocking the epithelial-to-mesenchymal transition pathway abrogates resistance to anti-folate chemotherapy in lung cancer

(2015) S-Q Liang et al.   Cell Death & Disease

Transcriptomic analysis of pancreatic cancer cells in response to metformin and aspirin: an implication of synergy

(2015) Wen Yue et al.   Scientific Reports

Rap2B promotes proliferation, migration and invasion of human breast cancer through calcium-related ERK1/2 signaling pathway

(2015) Jiehui Di et al.   Scientific Reports

Inhibition of glycogen synthase kinase-3 beta induces apoptosis and mitotic catastrophe by disrupting centrosome regulation in cancer cells

(2015) Yuki Yoshino et al.   Scientific Reports

Restoration of p53/miR-34a regulatory axis decreases survival advantage and ensures Bax-dependent apoptosis of non-small cell lung carcinoma cells

(2014) Samik Chakraborty et al.   FEBS LETTERS

Nuclear Matrix Protein SMAR1 Represses c-Fos-mediated HPV18 E6 Transcription through Alteration of Chromatin Histone Deacetylation

(2014) Samik Chakraborty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Epithelial to Mesenchymal Transition by E-cadherin Up-regulation via Repression of Slug Transcription and Inhibition of E-cadherin Degradation

(2014) Arghya Adhikary et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GSK3β Overexpression Indicates Poor Prognosis and Its Inhibition Reduces Cell Proliferation and Survival of Non-Small Cell Lung Cancer Cells

(2014) Jing Zeng et al.   PLoS One

Akt Signaling Leads to Stem Cell Activation and Promotes Tumor Development in Epidermis

(2014) Carmen Segrelles et al.   STEM CELLS

Aspirin inhibits cell viability and mTOR downstream signaling in gastroenteropancreatic and bronchopulmonary neuroendocrine tumor cells

(2014) Matilde Spampatti   WORLD JOURNAL OF GASTROENTEROLOGY

ROS-PIASγ cross talk channelizes ATM signaling from resistance to apoptosis during chemosensitization of resistant tumors

(2014) S Mohanty et al.   Cell Death & Disease

Curcumin inhibits breast cancer stem cell migration by amplifying the E-cadherin/β-catenin negative feedback loop

(2014) Shravanti Mukherjee et al.   Stem Cell Research & Therapy

Regulation of Wnt/β-catenin signaling by posttranslational modifications

(2014) Chenxi Gao et al.   Cell and Bioscience

Nuclear reprogramming of luminal-like breast cancer cells generates Sox2-overexpressing cancer stem-like cellular states harboring transcriptional activation of the mTOR pathway

(2013) BRUNA COROMINAS-FAJA et al.   CELL CYCLE

Glycogen synthase kinase-3 beta regulates Snail and β-catenin expression during Fas-induced epithelial–mesenchymal transition in gastrointestinal cancer

(2013) Haoxuan Zheng et al.   EUROPEAN JOURNAL OF CANCER

E-cadherin-integrin crosstalk in cancer invasion and metastasis

(2013) M. Canel et al.   JOURNAL OF CELL SCIENCE

DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival

(2013) Ying Tu et al.   Molecular Cancer

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells

(2013) M. A. Nieto   SCIENCE

Deficient DNA Damage Signaling Leads to Chemoresistance to Cisplatin in Oral Cancer

(2012) L. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression

(2012) Z.-Q. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells

(2011) Alan Serrels et al.   INTERNATIONAL JOURNAL OF CANCER

mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets

(2011) Samantha F. Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Curcumin Enhances the Efficacy of Chemotherapy by Tailoring p65NFκB-p300 Cross-talk in Favor of p53-p300 in Breast Cancer

(2011) Gouri Sankar Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanical Regulation of Glycogen Synthase Kinase 3β (GSK3β) in Mesenchymal Stem Cells Is Dependent on Akt Protein Serine 473 Phosphorylation via mTORC2 Protein

(2011) Natasha Case et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient mTOR Inhibition Facilitates Continuous Growth of Liver Tumors by Modulating the Maintenance of CD133+ Cell Populations

(2011) Zhaojuan Yang et al.   PLoS One

Chemotherapy, chemoresistance and the changing treatment landscape for NSCLC

(2010) Alex Chang   LUNG CANCER

Crosstalk Between the PI3K/mTOR and MEK/ERK Pathways Involved in the Maintenance of Self-Renewal and Tumorigenicity of Glioblastoma Stem-Like Cells

(2010) Jun Sunayama et al.   STEM CELLS

Inhibition of mTOR restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteins

(2008) Medhi Wangpaichitr et al.   EUROPEAN JOURNAL OF PHARMACOLOGY