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Oncology
Chuntao Li, Bo Chen, Junxia Zhang, Jingxuan Yang, Muzi Guo, Yu Ren, Zhijun Zhou, Kar-Ming Fung, Min Li, Liyang Zhang, Zhixiong Liu
Summary: SEM1 is highly expressed in gliomas and correlated with malignant features and poor prognosis. SEM1 plays a critical role in the proliferation, apoptosis, invasion, and migration of glioma cells through regulating the PI3K-Akt pathway. The SEM1 malignant regulatory network shows significant importance for the prognosis and treatment of gliomas.
Article
Cell Biology
Huanhuan Deng, Leihong Deng, Haichao Chao, Zhaojun Yu, Jianbiao Huang, Zhen Song, Lifen Peng, Tao Zeng
Summary: Bladder cancer (BLCA) is a common cancer with high mortality ranking 9th. The relationship between autophagy and epithelial to mesenchymal transition (EMT) in BLCA is poorly understood. This study identified the autophagy-related gene RAB14 and demonstrated its promotion of EMT, migration, and invasion in bladder cancer cells through the Akt-associated autophagic pathway. Knocking down RAB14 inhibited EMT and autophagy in T24 cells, and RAB14 levels were positively correlated with key autophagy genes LC3B and Beclin1. These findings suggest the potential role of RAB14 in BLCA progression.
CELL DEATH DISCOVERY
(2023)
Article
Cell Biology
Xuehui Wang, Hongming Song, Lin Fang, Tianqi Wu
Summary: In this study, it was found that circPRKCI, derived from the PRKCI gene, was highly expressed in TNBC and could promote the proliferation and migration of TNBC by regulating the WBP2 and PI3K/AKT signaling pathway, providing a new avenue for TNBC therapy.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Jianxin Xu, Xuejiao Fang, Luye Long, Sixuan Wang, Shihan Qian, Jianxin Lyu
Summary: This study found that HMGA2 is highly expressed in TNBC cells, and downregulation of HMGA2 inhibits the migration and invasion of TNBC, as well as tumor metastasis in vivo, through suppression of EMT and the Hippo-YAP pathway.
CANCER BIOLOGY & THERAPY
(2021)
Article
Medicine, General & Internal
Wen Shi, Yan Zheng, Shuai Luo, Xiaofeng Li, Yilong Zhang, Xiaoming Meng, Cheng Huang, Jun Li
Summary: METTL3 plays a crucial role in rheumatoid arthritis by promoting FLS activation and inflammatory response via the NF-kappa B signaling pathway.
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Xin Shen, Lingxia Li, Yuanyuan He, Xiaohui Lv, Jiajia Ma
Summary: Raddeanin A inhibits proliferation, invasion, and migration while promoting apoptosis of cervical cancer cells through the miR-224-3p/Slit2/Robo1 signaling pathway.
Article
Pathology
Jie Zhang, Sujie Zhang, Xiaoyan Li, Fan Zhang, Lei Zhao
Summary: The study revealed that HOXB5 expression is increased in breast cancer and positively correlated with tumor size, TNM stage, and lymph node metastasis. The oncogenic function of HOXB5 in breast cancer is mediated through the activation of the wnt/beta-catenin pathway.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Medicine, Research & Experimental
Tianshui Sun, Fangfang Bi, Zhuonan Liu, Qing Yang
Summary: In ovarian cancer patients, TMEM119 is overexpressed and associated with poor survival. Experimental results indicate TMEM119 promotes proliferation, invasion, and migration of ovarian cancer cells. Additionally, TMEM119 may exert oncogenic effects by regulating PDGFRB expression and activating the PI3K/AKT signaling pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Jiangtao Yu, Xiaoli Hu, Xiuxiu Chen, Qiangyong Zhou, Qi Jiang, Zhengzheng Shi, Haiyan Zhu
Summary: CNOT7 plays an important role in biological processes and has potential for treating malignant tumors. This study aimed to investigate the functions and mechanism of CNOT7 in ovarian cancer. Results showed that CNOT7 overexpression in A2780 and SKOV3 cells could be partially or completely eliminated by treatment with the AKT inhibitor LY294002.
Article
Cell Biology
Xiangchan Hou, Le Tang, Xiayu Li, Fang Xiong, Yongzhen Mo, Xianjie Jiang, Xiangying Deng, Miao Peng, Pan Wu, Mengyao Zhao, Jiawei Ouyang, Lei Shi, Yi He, Qijia Yan, Shanshan Zhang, Zhaojian Gong, Guiyuan Li, Zhaoyang Zeng, Fuyan Wang, Can Guo, Wei Xiong
Summary: Breast cancer is the most common malignant tumor in women, with KCNK6 being significantly overexpressed in breast cancer cells and promoting their proliferation, invasion, and migration abilities. Targeting KCNK6 may offer a novel therapeutic strategy for breast cancer treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Rui Zhao, Yuzhen Ge, Yongjun Gong, Bo Li, Benli Xiao, Shi Zuo
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide. This study found that low expression of NAP1L5 in HCC was associated with shorter survival and disease-free survival. NAP1L5 inhibited the proliferation, migration, and invasion of hepatoma cells, and induced apoptosis. It also inhibited the growth and metastasis of HCC cells in vivo. Mechanistically, NAP1L5 regulated the PI3K/AKT/mTOR signaling pathway by controlling MYH9 to affect the occurrence and development of HCC. NAP1L5 may be a potential target for liver cancer treatment.
Article
Oncology
Tianying Cai, Junjie Bai, Peng Tan, Zhiwei Huang, Chen Liu, Ziming Wu, Yonglang Cheng, Tongxi Li, Yifan Chen, Jian Ruan, Lin Gao, Yichao Du, Wenguang Fu
Summary: The expression of actin-interacting protein zyxin (ZYX) is significantly higher in hepatocellular carcinoma (HCC) tissues compared to normal liver tissues. Overexpression of ZYX enhances the proliferation, migration, and invasion of HCC cells, while its knockdown has the opposite effects. ZYX promotes HCC progression by activating the AKT/mTOR signaling pathway, suggesting that it could be a potential therapeutic target.
Article
Oncology
Weitao Yao, Jingyu Hou, Guoqing Liu, Fangxing Wu, Qiang Yan, Liangyu Guo, Chuchu Wang
Summary: The study found that CBR3-AS1 is highly expressed in osteosarcoma cells and promotes the stemness and EMT of these cells, as well as tumor growth.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Oncology
Xian-Yi Bao, Ming Sun, Ting-Ting Peng, Dong-Mei Han
Summary: TRIB3 acts as an oncogene in retinoblastoma, promoting cell proliferation and invasion through activation of the AKT/mTOR signaling pathway. Targeting TRIB3 may hold promise for the diagnosis and treatment of RB.
Article
Biochemistry & Molecular Biology
Jiayao Qu, Jia Li, Yaming Zhang, Rongzhang He, Xiangting Liu, Ke Gong, Lili Duan, Weihao Luo, Zheng Hu, Gengsheng Wang, Chenglai Xia, Dixian Luo
Summary: Elevated expression of AKR1B10 in breast cancer tissues was associated with lymph node metastasis, tumor size, Ki67 expression, and p53 expression, while inversely correlated with overall and disease-free survival rates. AKR1B10 promotes proliferation, migration, and invasion of breast cancer cells via the PI3K/AKT/NF-kappa B signaling pathway, indicating its potential as a prognostic indicator and therapeutic target in breast cancer.
CELL AND BIOSCIENCE
(2021)