Editorial Material
Cell Biology
Cansu Karabiyik, David C. Rubinsztein
Summary: During glucose starvation, activation of AMPK, ULK1, and PIKFYVE kinases via a non-canonical signaling pathway leads to the formation of autophagosomes containing PtdIns5P, increasing autophagy flux and facilitating the clearance of autophagy substrates.
Article
Plant Sciences
Tae Jin Kim, Do Hyeon Pyun, Myeong Jun Kim, Ji Hoon Jeong, A. M. Abd El-Aty, Tae Woo Jung
Summary: In this study, Compound K (CK) was found to prevent lipid-induced skeletal muscle apoptosis via AMPK/autophagy-mediated attenuation of ER stress and induction of myoblast differentiation. Therefore, CK may be suggested as a potential therapeutic approach for treating muscle-wasting conditions associated with obesity.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Cell & Tissue Engineering
T. J. Park, S. Y. Park, W. Cho, H. Oh, H. J. Lee, A. M. Abd El- Aty, C. Bayram, J. H. Jeong, T. W. Jung
Summary: This study reveals that DEL-1 can suppress inflammation and ER stress in tenocytes, thereby attenuating tenocyte apoptosis through AMPK/autophagy-mediated signaling.
BONE & JOINT RESEARCH
(2022)
Article
Cell Biology
Laszlo Sos, Eva Garabuczi, Tibor Saghy, Gabor Mocsar, Zsuzsa Szondy
Summary: It is suggested by the research that obesity may be partially attributable to impaired efferocytosis induced by increased uptake of circulating saturated fatty acids by macrophages. Palmitate inhibits the phagocytic function of macrophages, while AMP-activated protein kinase activators can relieve this inhibition.
Review
Cell Biology
Yuyao Feng, Ying Chen, Xiaoyong Wu, Junye Chen, Qingyan Zhou, Bao Liu, Liqin Zhang, Cong Yi
Summary: Macroautophagy/autophagy plays a crucial role in cell survival and maintaining cellular energy homeostasis during starvation or energy stress. Further investigation is needed to understand the specific substrates degraded by autophagy during glucose or energy deprivation and the diverse roles and mechanisms during varying durations of energy starvation.
Article
Cell Biology
Mengmeng Chen, Yushan Fu, Xu Wang, Ruitong Wu, Dongmei Su, Nan Zhou, Yanhua Qi
Summary: The senescence of lens epithelial cells (LECs) is a major factor leading to age-related cataract (ARC). This study aimed to investigate the mechanism of ARC formation and explore the anti-aging effect of metformin (MET) on ARC. The results showed that MET effectively alleviated the senescence of LECs and the formation of ARC probably through inactivation of the AMPK pathway and augmentation of autophagy.
CELL DEATH DISCOVERY
(2022)
Article
Pharmacology & Pharmacy
Ping Wang, Chun Guang Li, Xian Zhou, Shuzhe Ding
Summary: Overexpression of TFEB can improve palmitate-induced insulin resistance by enhancing autophagy and upregulating AMPK activity, thereby increasing intracellular glucose uptake and consumption.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Wenying Chen, Fengting Huang, Jing Huang, Yuanhua Li, Juanfei Peng, Yanyan Zhuang, Xianxian Huang, Liting Lu, Zhe Zhu, Shineng Zhang
Summary: This study revealed that SLC45A4 inhibits autophagy via the AMPK/ULK1 axis in TP53 mutant PDA, suggesting it may serve as a promising biomarker and therapeutic target in TP53 mutant PDA.
JOURNAL OF GENE MEDICINE
(2021)
Article
Neurosciences
Pinzhong Chen, Xiaohui Chen, Honghong Zhang, Jianghu Chen, Mingxue Lin, Haitao Qian, Fei Gao, Yisheng Chen, Cansheng Gong, Xiaochun Zheng, Ting Zheng
Summary: This study demonstrated that Dexmedetomidine can regulate autophagy via the AMPK/mTOR pathway to improve high glucose-induced neurotoxicity. It provided neuroprotection and suggested a potential role of Dexmedetomidine in treating postoperative cognitive dysfunction in diabetic patients.
NEUROMOLECULAR MEDICINE
(2023)
Article
Cell Biology
Shi Li, Banzhan Ruan, Zhi Wang, Jianling Xia, Qi Lin, Ruoting Xu, Hua Zhu, Zhixian Yu
Summary: Glucose dysregulation inhibits autophagy and promotes cancer development in bladder cancer. Patients with Type 2 diabetes and bladder cancer have a poorer tumor grade and stage. The expression of YAP1, TAZ, and AMPK is negatively regulated under high glucose conditions.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Min-Woo Song, Wenhao Cui, Chang-Gun Lee, Rihua Cui, Young Ho Son, Young Ha Kim, Yujin Kim, Hae Jin Kim, Sung-E. Choi, Yup Kang, Tae Ho Kim, Ja Young Jeon, Kwan-Woo Lee
Summary: This study investigates the molecular mechanisms of empagliflozin (EMPA), an SGLT2 inhibitor, in mitigating palmitate (PA)-induced cardiomyocyte injury and finds that EMPA significantly attenuates PA-induced impairments and enhances fatty acid oxidation. This study reveals a novel mechanism of EMPA's protective effects against PA-induced cardiomyocyte injury and provides new therapeutic insights.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Qiushi Xu, Yunhui Fan, Juan J. Loor, Yusheng Liang, Xudong Sun, Hongdou Jia, Chenxu Zhao, Chuang Xu
Summary: The study investigated the role of AMPK in adipose tissue of ketotic cows, showing that AMPK can reduce oxidative stress in bovine adipocytes by regulating antioxidant responses and autophagy processes.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Cell Biology
Wenxian Wu, Xiaojing Wang, Yadong Sun, Niklas Berleth, Jana Deitersen, David Schluetermann, Fabian Stuhldreier, Nora Wallot-Hieke, Maria Jose Mendiburo, Jan Cox, Christoph Peter, Ann Kathrin Bergmann, Bjoern Stork
Summary: This study identified RIPK3 as an AMPK-activating kinase, establishing a direct link between the kinases regulating autophagy and necroptosis.Activation of AMPK by RIPK3 leads to phosphorylation of autophagy-regulating proteins ULK1 and BECN1, while TNF-induced necroptosis blocks lysosomal degradation of autophagosomes. Dysregulation of SNARE complexes, including reduced levels of full-length STX17, was observed upon TNF treatment.
Article
Immunology
Songqi Liu, Wenjin Guo, Yuxi Jia, Bojian Ye, Shu Liu, Shoupeng Fu, Juxiong Liu, Guiqiu Hu
Summary: Menthol has been found to alleviate the inflammatory response in BMECs by activating the AMPK/ULK1/Nrf-2/autophagy pathway, and inhibit the expression of inflammatory factors induced by lipopolysaccharide.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Hong-Yue Lai, Hsin-Hwa Tsai, Chia-Jui Yen, Liang-Yi Hung, Ching-Chieh Yang, Chung-Han Ho, Hsin-Yin Liang, Feng-Wei Chen, Chien-Feng Li, Ju-Ming Wang
Summary: This study found that HCC patients receiving sorafenib with HBV were at higher risk of mortality, and high EGFR expression was linked to HBV-induced sorafenib resistance. Additionally, AMPK/CEBPD-activated autophagy could be a potent strategy for improving the efficacy of sorafenib in HCC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Karen A. Weikel, Jose M. Cacicedo, Neil B. Ruderman, Yasuo Ido
BIOSCIENCE REPORTS
(2016)
Review
Endocrinology & Metabolism
Karen A. Weikel, Neil B. Ruderman, Jose M. Cacicedo
METABOLISM-CLINICAL AND EXPERIMENTAL
(2016)
Article
Cell Biology
Tomoaki Uchiki, Karen A. Weikel, Wangwang Jiao, Fu Shang, Andrea Caceres, Dorota Pawlak, James T. Handa, Michael Brownlee, Ram Nagaraj, Allen Taylor
Article
Agriculture, Multidisciplinary
James A. Joseph, Barbara Shukitt-Hale, Gregory J. Brewer, Karen A. Weikel, Wilhelmina Kalt, Derek R. Fisher
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2010)
Review
Biochemistry & Molecular Biology
Karen A. Weikel, Chung-Jung Chiu, Allen Taylor
MOLECULAR ASPECTS OF MEDICINE
(2012)
Review
Nutrition & Dietetics
Karen A. Weikel, Caren Garber, Alyssa Baburins, Allen Taylor
Article
Multidisciplinary Sciences
Yasuo Ido, Albert Duranton, Fan Lan, Karen A. Weikel, Lionel Breton, Neil B. Ruderman
Review
Nutrition & Dietetics
Molly Schleicher, Karen Weikel, Caren Garber, Allen Taylor
Article
Ophthalmology
Karen A. Weikel, Paul FitzGerald, Fu Shang, M. Andrea Caceres, Qingning Bian, James T. Handa, Alan W. Stitt, Allen Taylor
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2012)