Targeting Glutathione Metabolism: Partner in Crime in Anticancer Therapy

Erastin decreases radioresistance of NSCLC cells partially by inducing GPX4‑mediated ferroptosis

(2019) Xiaofen Pan et al.   Oncology Letters

A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity

(2019) Jennifer Yinuo Cao et al.   Cell Reports

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion

(2019) Isaac S. Harris et al.   Cell Metabolism

Targeting the Vulnerability of Glutathione Metabolism in ARID1A-Deficient Cancers

(2019) Hideaki Ogiwara et al.   CANCER CELL

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis

(2019) Mohamed Elgendy et al.   CANCER CELL

LKB1 and KEAP1/NRF2 pathways cooperatively promote metabolic reprogramming with enhanced glutamine dependence in KRAS-mutant lung adenocarcinoma

(2019) Ana Galan-Cobo et al.   CANCER RESEARCH

Oxidative Stress-Driven Autophagy acROSs Onset and Therapeutic Outcome in Hepatocellular Carcinoma

(2019) Fabio Ciccarone et al.   Oxidative Medicine and Cellular Longevity

Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis induction

(2018) Michael J. Kerins et al.   CANCER SCIENCE

Modulation of glutathione promotes apoptosis in triple-negative breast cancer cells

(2018) Tara Miran et al.   FASEB JOURNAL

The glutathione cycle: Glutathione metabolism beyond the γ-glutamyl cycle

(2018) Anand Kumar Bachhawat et al.   IUBMB LIFE

Glutathione metabolism in cancer progression and treatment resistance

(2018) Ankita Bansal et al.   JOURNAL OF CELL BIOLOGY

Ferroptosis-inducing agents enhance TRAIL-induced apoptosis through upregulation of death receptor 5

(2018) Young-Sun Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells

(2018) Shogo Okazaki et al.   Oncotarget

Rare Genetic Diseases with Defects in DNA Repair: Opportunities and Challenges in Orphan Drug Development for Targeted Cancer Therapy

(2018) Sonali Bhattacharjee et al.   Cancers

Glutathione compartmentalization and its role in glutathionylation and other regulatory processes of cellular pathways

(2018) Andrea Scirè et al.   BIOFACTORS

Inhibition of Thioredoxin/Thioredoxin Reductase Induces Synthetic Lethality in Lung Cancers with Compromised Glutathione Homeostasis

(2018) Xiang Yan et al.   CANCER RESEARCH

Reactive oxygen species and cancer paradox: To promote or to suppress?

(2017) Sehamuddin Galadari et al.   FREE RADICAL BIOLOGY AND MEDICINE

Synthetic lethality in DNA repair network: A novel avenue in targeted cancer therapy and combination therapeutics

(2017) Sonali Bhattacharjee et al.   IUBMB LIFE

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

(2017) Rodrigo Romero et al.   NATURE MEDICINE

Synthetic lethality and cancer

(2017) Nigel J. O'Neil et al.   NATURE REVIEWS GENETICS

Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death

(2017) Emarndeena H Cheteh et al.   Cell Death & Disease

Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation

(2017) David S. Liu et al.   Nature Communications

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

(2017) Volkan I Sayin et al.   eLife

A randomized, open-label, phase III trial of NOV-002 in combination with paclitaxel (P) and carboplatin (C) versus paclitaxel and carboplatin alone for the treatment of advanced non-small cell lung cancer (NSCLC).

(2017) P. Fidias et al.   JOURNAL OF CLINICAL ONCOLOGY

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

(2016) Federico Pietrocola et al.   CANCER CELL

Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

(2016) Stefano Di Biase et al.   CANCER CELL

Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer

(2016) Weimin Wang et al.   CELL

The role of glutathione reductase and related enzymes on cellular redox homoeostasis network

(2016) Narciso Couto et al.   FREE RADICAL BIOLOGY AND MEDICINE

ChaC2, an Enzyme for Slow Turnover of Cytosolic Glutathione

(2016) Amandeep Kaur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

(2016) Evan C. Lien et al.   NATURE CELL BIOLOGY

A Phase I New Approaches to Neuroblastoma Therapy Study of Buthionine Sulfoximine and Melphalan With Autologous Stem Cells for Recurrent/Refractory High-Risk Neuroblastoma

(2016) Judith G. Villablanca et al.   PEDIATRIC BLOOD & CANCER

Genetic Variations in Glutathione Pathway Genes Predict Cancer Recurrence in Patients Treated with Transurethral Resection and Bacillus Calmette–Guerin Instillation for Non-muscle Invasive Bladder Cancer

(2015) Hung-Lung Ke et al.   ANNALS OF SURGICAL ONCOLOGY

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

(2015) Isaac S. Harris et al.   CANCER CELL

Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element

(2015) Rebecca R. Crawford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype

(2015) Haiquan Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broad targeting of resistance to apoptosis in cancer

(2015) Ramzi M. Mohammad et al.   SEMINARS IN CANCER BIOLOGY

HNF1β drives glutathione (GSH) synthesis underlying intrinsic carboplatin resistance of ovarian clear cell carcinoma (OCCC)

(2015) Filipa Lopes-Coelho et al.   TUMOR BIOLOGY

Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death

(2015) Daniela Catanzaro et al.   Oncotarget

A review on hepatocyte nuclear factor-1beta and tumor

(2015) Dan-Dan Yu et al.   Cell and Bioscience

Antioxidant responses and cellular adjustments to oxidative stress

(2015) Cristina Espinosa-Diez et al.   Redox Biology

ROS-induced epithelial-mesenchymal transition in mammary epithelial cells is mediated by NF-κB-dependent activation of Snail

(2015) Magdalena A. Cichon et al.   Oncotarget

Multidrug Resistance Protein 1 (MRP1, ABCC1), a “Multitasking” ATP-binding Cassette (ABC) Transporter

(2014) Susan P. C. Cole   JOURNAL OF BIOLOGICAL CHEMISTRY

Fructose-1,6-bisphosphatase opposes renal carcinoma progression

(2014) Bo Li et al.   NATURE

Glutathione depletion sensitizes cisplatin- and temozolomide-resistant glioma cells in vitro and in vivo

(2014) C R R Rocha et al.   Cell Death & Disease

The glutathione synthesis inhibitor buthionine sulfoximine synergistically enhanced melphalan activity against preclinical models of multiple myeloma

(2014) A Tagde et al.   Blood Cancer Journal

ProteinS-glutathionylation: from current basics to targeted modifications

(2014) Doina Popov   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Glutathione: new roles in redox signaling for an old antioxidant

(2014) Katia Aquilano et al.   Frontiers in Pharmacology

Thioredoxins, Glutaredoxins, and Peroxiredoxins—Molecular Mechanisms and Health Significance: from Cofactors to Antioxidants to Redox Signaling

(2013) Eva-Maria Hanschmann et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione Efflux and Cell Death

(2012) Rodrigo Franco et al.   ANTIOXIDANTS & REDOX SIGNALING

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Glutathione participates in the modulation of starvation-induced autophagy in carcinoma cells

(2012) Enrico Desideri et al.   Autophagy

Glutathione transferases, regulators of cellular metabolism and physiology

(2012) Philip G. Board et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glutathione levels in human tumors

(2012) Michael P. Gamcsik et al.   BIOMARKERS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

A functional trinucleotide repeat polymorphism in the 5′-untranslated region of the glutathione biosynthetic gene GCLC is associated with increased risk for lung and aerodigestive tract cancers

(2012) Sailendra N. Nichenametla et al.   MOLECULAR CARCINOGENESIS

Phase 2 study of neoadjuvant treatment with NOV-002 in combination with doxorubicin and cyclophosphamide followed by docetaxel in patients with HER-2 negative clinical stage II–IIIc breast cancer

(2011) A. J. Montero et al.   BREAST CANCER RESEARCH AND TREATMENT

Enhancement of Carboplatin-Mediated Lung Cancer Cell Killing by Simultaneous Disruption of Glutathione and Thioredoxin Metabolism

(2011) M. A. Fath et al.   CLINICAL CANCER RESEARCH

Redox outside the Box: Linking Extracellular Redox Remodeling with Intracellular Redox Metabolism

(2011) Ruma Banerjee   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutathione in Cancer Cell Death

(2011) Angel L. Ortega et al.   Cancers

Genetic variation in glutathione metabolism and DNA repair genes predicts survival of small-cell lung cancer patients

(2010) Z. Sun et al.   ANNALS OF ONCOLOGY

Loss of Thioredoxin Reductase 1 Renders Tumors Highly Susceptible to Pharmacologic Glutathione Deprivation

(2010) P. K. Mandal et al.   CANCER RESEARCH

Regulation of Lung Cancer Cell Migration and Invasion by Reactive Oxygen Species and Caveolin-1

(2010) Sudjit Luanpitpong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of Sulfasalazine for the treatment of progressing malignant gliomas in adults

(2009) Pierre A Robe et al.   BMC CANCER

Pro-survival of estrogen receptor-negative breast cancer cells is regulated by a BLT2–reactive oxygen species-linked signaling pathway

(2009) Jung-A Choi et al.   CARCINOGENESIS

Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation

(2009) Yong Zhao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology

(2008) Nazzareno Ballatori et al.   MOLECULAR ASPECTS OF MEDICINE

Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy

(2008) L. Raffaghello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA