Rewiring carbon metabolism in yeast for high level production of aromatic chemicals

Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0

(2019) Laurent Heirendt et al.   Nature Protocols

Heterologous phosphoketolase expression redirects flux towards acetate, perturbs sugar phosphate pools and increases respiratory demand in Saccharomyces cerevisiae

(2019) Alexandra Bergman et al.   Microbial Cell Factories

BRENDA in 2019: a European ELIXIR core data resource

(2018) Lisa Jeske et al.   NUCLEIC ACIDS RESEARCH

Production of plant metabolites with applications in the food industry using engineered microorganisms

(2018) Nicolai Kallscheuer et al.   CURRENT OPINION IN BIOTECHNOLOGY

Multilevel engineering of the upstream module of aromatic amino acid biosynthesis in Saccharomyces cerevisiae for high production of polymer and drug precursors

(2017) Miguel Suástegui et al.   METABOLIC ENGINEERING

Systematic testing of enzyme perturbation sensitivities via graded dCas9 modulation in Saccharomyces cerevisiae

(2017) Matthew Deaner et al.   METABOLIC ENGINEERING

Improving the phenotype predictions of a yeast genome‐scale metabolic model by incorporating enzymatic constraints

(2017) Benjamín J Sánchez et al.   Molecular Systems Biology

Accelerating the semisynthesis of alkaloid-based drugs through metabolic engineering

(2017) Amy M Ehrenworth et al.   Nature Chemical Biology

Rapid and Efficient CRISPR/Cas9-Based Mating-Type Switching of Saccharomyces cerevisiae

(2017) Ze-Xiong Xie et al.   G3-Genes Genomes Genetics

Microbial production of natural and non-natural flavonoids: Pathway engineering, directed evolution and systems/synthetic biology

(2016) Ramesh Prasad Pandey et al.   BIOTECHNOLOGY ADVANCES

Investigating strain dependency in the production of aromatic compounds inSaccharomyces cerevisiae

(2016) Miguel Suástegui et al.   BIOTECHNOLOGY AND BIOENGINEERING

Engineering the shikimate pathway for biosynthesis of molecules with pharmaceutical activities in E. coli

(2016) Ming Jiang et al.   CURRENT OPINION IN BIOTECHNOLOGY

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Rewriting yeast central carbon metabolism for industrial isoprenoid production

(2016) Adam L. Meadows et al.   NATURE

Functional expression and evaluation of heterologous phosphoketolases in Saccharomyces cerevisiae

(2016) Alexandra Bergman et al.   AMB Express

Highly Active and Specific Tyrosine Ammonia-Lyases from Diverse Origins Enable Enhanced Production of Aromatic Compounds in Bacteria and Saccharomyces cerevisiae

(2015) Christian Bille Jendresen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Construction of lycopene-overproducing Saccharomyces cerevisiae by combining directed evolution and metabolic engineering

(2015) Wenping Xie et al.   METABOLIC ENGINEERING

Establishment of a yeast platform strain for production of p- coumaric acid through metabolic engineering of aromatic amino acid biosynthesis

(2015) Angelica Rodriguez et al.   METABOLIC ENGINEERING

De novo production of resveratrol from glucose or ethanol by engineered Saccharomyces cerevisiae

(2015) Mingji Li et al.   METABOLIC ENGINEERING

An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose

(2015) William C DeLoache et al.   Nature Chemical Biology

De novo production of the plant-derived alkaloid strictosidine in yeast

(2015) Stephanie Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complete biosynthesis of opioids in yeast

(2015) S. Galanie et al.   SCIENCE

CRISPRdirect: software for designing CRISPR/Cas guide RNA with reduced off-target sites

(2014) Yuki Naito et al.   BIOINFORMATICS

Metabolomic and13C-metabolic flux analysis of a xylose-consumingSaccharomyces cerevisiaestrain expressing xylose isomerase

(2014) Thomas M. Wasylenko et al.   BIOTECHNOLOGY AND BIOENGINEERING

Promoters maintain their relative activity levels under different growth conditions

(2013) L. Keren et al.   Molecular Systems Biology

Controlling promoter strength and regulation inSaccharomyces cerevisiaeusing synthetic hybrid promoters

(2012) John Blazeck et al.   BIOTECHNOLOGY AND BIOENGINEERING

Modular Pathway Engineering of Diterpenoid Synthases and the Mevalonic Acid Pathway for Miltiradiene Production

(2012) Yongjin J. Zhou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Microbial production of indolylglucosinolate through engineering of a multi-gene pathway in a versatile yeast expression platform

(2012) Michael Dalgaard Mikkelsen et al.   METABOLIC ENGINEERING

Metabolic engineering of muconic acid production in Saccharomyces cerevisiae

(2012) Kathleen A. Curran et al.   METABOLIC ENGINEERING

De novo production of the flavonoid naringenin in engineered Saccharomyces cerevisiae

(2012) Frank Koopman et al.   Microbial Cell Factories

Scheffersomyces stipitis: a comparative systems biology study with the Crabtree positive yeast Saccharomyces cerevisiae

(2012) Marta Papini et al.   Microbial Cell Factories

Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

(2012) P. J. Westfall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advancing secondary metabolite biosynthesis in yeast with synthetic biology tools

(2011) Michael S. Siddiqui et al.   FEMS YEAST RESEARCH

Improved vanillin production in baker's yeast through in silico design

(2010) Ana Brochado et al.   Microbial Cell Factories

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Integrated multilaboratory systems biology reveals differences in protein metabolism between two reference yeast strains

(2010) André B. Canelas et al.   Nature Communications

Quantitative Evaluation of Intracellular Metabolite Extraction Techniques for Yeast Metabolomics

(2009) André B. Canelas et al.   ANALYTICAL CHEMISTRY

Metabolic engineering for plant natural product biosynthesis in microbes

(2008) Joseph A Chemler et al.   CURRENT OPINION IN BIOTECHNOLOGY

Alleviation of feedback inhibition in Saccharomyces cerevisiae aromatic amino acid biosynthesis: Quantification of metabolic impact

(2008) M.A.H. Luttik et al.   METABOLIC ENGINEERING