A network-based approach to identify deregulated pathways and drug effects in metabolic syndrome
出版年份 2019 全文链接
标题
A network-based approach to identify deregulated pathways and drug effects in metabolic syndrome
作者
关键词
-
出版物
Nature Communications
Volume 10, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-11-18
DOI
10.1038/s41467-019-13208-z
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Computational drug repositioning for rare diseases in the era of precision medicine
- (2018) Brian Delavan et al. DRUG DISCOVERY TODAY
- The development of Bruton's tyrosine kinase (BTK) inhibitors from 2012 to 2017: A mini-review
- (2018) Chengyuan Liang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation
- (2018) Eric R. Gamazon et al. NATURE GENETICS
- Network-based approach to prediction and population-based validation of in silico drug repurposing
- (2018) Feixiong Cheng et al. Nature Communications
- Drug repurposing: progress, challenges and recommendations
- (2018) Sudeep Pushpakom et al. NATURE REVIEWS DRUG DISCOVERY
- Systems biology–based drug repositioning identifies digoxin as a potential therapy for groups 3 and 4 medulloblastoma
- (2018) Lei Huang et al. Science Translational Medicine
- Molecular mechanisms underlying metabolic syndrome: the expanding role of the adipocyte
- (2017) Andrea Armani et al. FASEB JOURNAL
- Current role of the NLRP3 inflammasome on obesity and insulin resistance: A systematic review
- (2017) Jakeline Rheinheimer et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Network analyses identify liver‐specific targets for treating liver diseases
- (2017) Sunjae Lee et al. Molecular Systems Biology
- Genetic effects on gene expression across human tissues
- (2017) François Aguet et al. NATURE
- Current pharmacotherapy for obesity
- (2017) Gitanjali Srivastava et al. Nature Reviews Endocrinology
- Adapting to obesity with adipose tissue inflammation
- (2017) Shannon M. Reilly et al. Nature Reviews Endocrinology
- DrugBank 5.0: a major update to the DrugBank database for 2018
- (2017) David S Wishart et al. NUCLEIC ACIDS RESEARCH
- Bruton’s Tyrosine Kinase: An Emerging Key Player in Innate Immunity
- (2017) Alexander N. R. Weber et al. Frontiers in Immunology
- Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness
- (2017) Michiru Nishita et al. Scientific Reports
- Regulation of hepatic energy metabolism by the nuclear receptor PXR
- (2016) Jukka Hakkola et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Precision medicine, genomics and drug discovery: Table 1.
- (2016) Lon R. Cardon et al. HUMAN MOLECULAR GENETICS
- Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases
- (2016) Daniel Marbach et al. NATURE METHODS
- Targeting adipose tissue in the treatment of obesity-associated diabetes
- (2016) Christine M. Kusminski et al. NATURE REVIEWS DRUG DISCOVERY
- HIPPIE v2.0: enhancing meaningfulness and reliability of protein–protein interaction networks
- (2016) Gregorio Alanis-Lobato et al. NUCLEIC ACIDS RESEARCH
- Open Targets: a platform for therapeutic target identification and validation
- (2016) Gautier Koscielny et al. NUCLEIC ACIDS RESEARCH
- Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
- (2016) Maxim V. Kuleshov et al. NUCLEIC ACIDS RESEARCH
- DrugCentral: online drug compendium
- (2016) Oleg Ursu et al. NUCLEIC ACIDS RESEARCH
- The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)
- (2016) Jacqueline MacArthur et al. NUCLEIC ACIDS RESEARCH
- Network-based in silico drug efficacy screening
- (2016) Emre Guney et al. Nature Communications
- Impact of Obesity and Metabolic Syndrome on Immunity
- (2016) Catherine J Andersen et al. Advances in Nutrition
- Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics
- (2016) David Lamparter et al. PLoS Computational Biology
- The New Era of Drug Therapy for Obesity: The Evidence and the Expectations
- (2015) Ben J. Jones et al. DRUGS
- Integrative analysis of 111 reference human epigenomes
- (2015) Anshul Kundaje et al. NATURE
- The support of human genetic evidence for approved drug indications
- (2015) Matthew R Nelson et al. NATURE GENETICS
- Robust enumeration of cell subsets from tissue expression profiles
- (2015) Aaron M Newman et al. NATURE METHODS
- Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury
- (2015) Minako Ito et al. Nature Communications
- Drug target prioritization by perturbed gene expression and network information
- (2015) Zerrin Isik et al. Scientific Reports
- Gateways to the FANTOM5 promoter level mammalian expression atlas
- (2015) Marina Lizio et al. GENOME BIOLOGY
- T Cell–Derived IL-22 Amplifies IL-1β–Driven Inflammation in Human Adipose Tissue: Relevance to Obesity and Type 2 Diabetes
- (2014) Elise Dalmas et al. DIABETES
- Halogenated Bisphenol-A Analogs Act as Obesogens in Zebrafish Larvae (Danio rerio)
- (2014) Anne Riu et al. TOXICOLOGICAL SCIENCES
- Dietary cholesterol directly induces acute inflammasome-dependent intestinal inflammation
- (2014) Fränze Progatzky et al. Nature Communications
- B Lymphocytes in obesity-related adipose tissue inflammation and insulin resistance
- (2013) Daniel A. Winer et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus
- (2013) Stefan Kiechl et al. NATURE MEDICINE
- PubTator: a web-based text mining tool for assisting biocuration
- (2013) Chih-Hsuan Wei et al. NUCLEIC ACIDS RESEARCH
- Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
- (2012) Atsuhiko Ichimura et al. NATURE
- Use of genome-wide association studies for drug repositioning
- (2012) Philippe Sanseau et al. NATURE BIOTECHNOLOGY
- B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
- (2011) Daniel A Winer et al. NATURE MEDICINE
- Inflammasome is a central player in the induction of obesity and insulin resistance
- (2011) R. Stienstra et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish
- (2010) F. Ellett et al. BLOOD
- Common Inherited Variation in Mitochondrial Genes Is Not Enriched for Associations with Type 2 Diabetes or Related Glycemic Traits
- (2010) Ayellet V. Segrè et al. PLoS Genetics
- Harmonizing the Metabolic Syndrome
- (2009) K.G.M.M. Alberti et al. CIRCULATION
- Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis
- (2008) Richard Mark White et al. Cell Stem Cell
- The Immunological Genome Project: networks of gene expression in immune cells
- (2008) Tracy S P Heng et al. NATURE IMMUNOLOGY
- Metabolic syndrome: from epidemiology to systems biology
- (2008) Aldons J. Lusis et al. NATURE REVIEWS GENETICS
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