TLR7 and TLR8 activate distinct pathways in monocytes during RNA virus infection

Immune Consequences of in vitro Infection of Human Peripheral Blood Leukocytes with Vesicular Stomatitis Virus

(2018) Tomasz Tomczyk et al.   Journal of Innate Immunity

The MEK1/2-ERK Pathway Inhibits Type I IFN Production in Plasmacytoid Dendritic Cells

(2018) Vaclav Janovec et al.   Frontiers in Immunology

Coxsackievirus-B4E2 can infect monocytes and macrophages in vitro and in vivo

(2018) M.A. Benkahla et al.   VIROLOGY

Differential and Overlapping Immune Programs Regulated by IRF3 and IRF5 in Plasmacytoid Dendritic Cells

(2018) Kwan T. Chow et al.   JOURNAL OF IMMUNOLOGY

Viral dependence on cellular ion channels – an emerging anti-viral target?

(2017) Samantha Hover et al.   JOURNAL OF GENERAL VIROLOGY

Human Monocyte Subsets Are Transcriptionally and Functionally Altered in Aging in Response to Pattern Recognition Receptor Agonists

(2017) Talibah U. Metcalf et al.   JOURNAL OF IMMUNOLOGY

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

FOSL1 Inhibits Type I Interferon Responses to Malaria and Viral Infections by Blocking TBK1 and TRAF3/TRIF Interactions

(2017) Baowei Cai et al.   mBio

Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer

(2017) Changwen Ning et al.   Oncotarget

The Fos-Related Antigen 1–JUNB/Activator Protein 1 Transcription Complex, a Downstream Target of Signal Transducer and Activator of Transcription 3, Induces T Helper 17 Differentiation and Promotes Experimental Autoimmune Arthritis

(2017) Young-Mee Moon et al.   Frontiers in Immunology

CD14+CD16+ monocytes are the main target of Zika virus infection in peripheral blood mononuclear cells in a paediatric study in Nicaragua

(2017) Daniela Michlmayr et al.   Nature Microbiology

The cGAS-STING Defense Pathway and Its Counteraction by Viruses

(2016) Zhe Ma et al.   Cell Host & Microbe

TLR7 Engagement on Dendritic Cells Enhances Autoreactive Th17 Responses via Activation of ERK

(2016) Qing Xiao et al.   JOURNAL OF IMMUNOLOGY

Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease

(2016) P. S. Pillai et al.   SCIENCE

Monocytes of Patients with Type 1 Diabetes Harbour Enterovirus RNA

(2015) Enagnon Kazali Alidjinou et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Biology of IL-27 and its Role in the Host Immunity against Mycobacterium Tuberculosis

(2015) Abualgasim Elgaili Abdalla et al.   International Journal of Biological Sciences

TLR8 Senses Bacterial RNA in Human Monocytes and Plays a Nonredundant Role for Recognition ofStreptococcus pyogenes

(2015) Tatjana Eigenbrod et al.   JOURNAL OF IMMUNOLOGY

TLR8 SensesStaphylococcus aureusRNA in Human Primary Monocytes and Macrophages and Induces IFN-β Production via a TAK1–IKKβ–IRF5 Signaling Pathway

(2015) Bjarte Bergstrøm et al.   JOURNAL OF IMMUNOLOGY

TLR8, but not TLR7, induces the priming of the NADPH oxidase activation in human neutrophils

(2015) Karama Makni-Maalej et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Human T Cell Leukemia Virus Type 1 Infection of the Three Monocyte Subsets Contributes to Viral Burden in Humans

(2015) Maria Fernanda de Castro-Amarante et al.   JOURNAL OF VIROLOGY

An efficient siRNA-mediated gene silencing in primary human monocytes, dendritic cells and macrophages

(2014) Anthony Troegeler et al.   IMMUNOLOGY AND CELL BIOLOGY

TLR7 induces anergy in human CD4+ T cells

(2014) Margarita Dominguez-Villar et al.   NATURE IMMUNOLOGY

HIV and HCV Activate the Inflammasome in Monocytes and Macrophages via Endosomal Toll-Like Receptors without Induction of Type 1 Interferon

(2014) Michael A. Chattergoon et al.   PLoS Pathogens

Modulation of TLR 3, 7 and 8 Expressions in HCV Genotype 3 Infected Individuals: Potential Correlations of Pathogenesis and Spontaneous Clearance

(2014) Rushna Firdaus et al.   Biomed Research International

Toll-like receptors in systemic lupus erythematosus: potential for personalized treatment

(2014) Teja Celhar et al.   Frontiers in Pharmacology

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Inhibitory effect of resveratrol dimerized derivatives on nitric oxide production in lipopolysaccharide-induced RAW 264.7 cells

(2013) Chen Zhong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Xestospongin C induces monocytic differentiation of HL60 cells through activation of the ERK pathway

(2013) Dong-Oh Moon et al.   FOOD AND CHEMICAL TOXICOLOGY

A Virological View of Innate Immune Recognition

(2012) Akiko Iwasaki   Annual Review of Microbiology

Viral infection triggers rapid differentiation of human blood monocytes into dendritic cells

(2012) W. Hou et al.   BLOOD

Toll-like receptors, signaling adapters and regulation of the pro-inflammatory response by PI3K

(2012) Ty Dale Troutman et al.   CELL CYCLE

TLR8: the forgotten relative revindicated

(2012) Jorge L Cervantes et al.   Cellular & Molecular Immunology

Toll-Like Receptor 7 Protects From Atherosclerosis by Constraining “Inflammatory” Macrophage Activation

(2012) Maria Salagianni et al.   CIRCULATION

Sensing of RNA Viruses: a Review of Innate Immune Receptors Involved in Recognizing RNA Virus Invasion

(2012) S. Jensen et al.   JOURNAL OF VIROLOGY

A Cell Permeable Peptide Inhibitor of NFAT Inhibits Macrophage Cytokine Expression and Ameliorates Experimental Colitis

(2012) Houda Z. Elloumi et al.   PLoS One

Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets

(2011) K. L. Wong et al.   BLOOD

Effects of Expression of Transcriptional Factor AP-1 FOSL1 Gene on Psoriatic Process

(2011) V. V. Sobolev et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

Control of Type I Interferon-induced Cell Death by Orai1-mediated Calcium Entry in T Cells

(2011) Chanyu Yue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional Suppression of IL-27 Production by Mycobacterium tuberculosis-Activated p38 MAPK via Inhibition of AP-1 Binding

(2011) J. Zhang et al.   JOURNAL OF IMMUNOLOGY

Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt

(2011) T. D. Troutman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phagosomal signaling byBorrelia burgdorferiin human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-β

(2011) Jorge L. Cervantes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nomenclature of monocytes and dendritic cells in blood

(2010) L. Ziegler-Heitbrock et al.   BLOOD

AP-1 — The Jun proteins: Oncogenes or tumor suppressors in disguise?

(2010) Eitan Shaulian   CELLULAR SIGNALLING

Indirect Inhibition of Toll-like Receptor and Type I Interferon Responses by ITAM-Coupled Receptors and Integrins

(2010) Lu Wang et al.   IMMUNITY

Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors

(2010) Jérôme Cros et al.   IMMUNITY

Active Infection of Human Blood Monocytes by Chikungunya Virus Triggers an Innate Immune Response

(2010) Z. Her et al.   JOURNAL OF IMMUNOLOGY

The Inducible Costimulator (ICOS) Is Critical for the Development of Human TH17 Cells

(2010) C. M. Paulos et al.   Science Translational Medicine

IPS-1 Is Essential for the Control of West Nile Virus Infection and Immunity

(2010) Mehul S. Suthar et al.   PLoS Pathogens

Toll-like receptor expression and responsiveness are increased in viraemic HIV-1 infection

(2009) Richard T Lester et al.   AIDS

TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN

(2009) J. Di Domizio et al.   BLOOD

Viral calciomics: Interplays between Ca2+ and virus

(2009) Yubin Zhou et al.   CELL CALCIUM

JNK inhibitor SP600125 promotes the formation of polymerized tubulin, leading to G2/M phase arrest, endoreduplication, and delayed apoptosis

(2009) Dong-Oh Moon et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

TLR7 and TLR8 ligands and antiphospholipid antibodies show synergistic effects on the induction of IL-1β and caspase-1 in monocytes and dendritic cells

(2009) Julia Hurst et al.   IMMUNOBIOLOGY

Fra-1 negatively regulates lipopolysaccharide-mediated inflammatory responses

(2009) H. Morishita et al.   INTERNATIONAL IMMUNOLOGY

AP-1 Activated by Toll-like Receptors Regulates Expression of IL-23 p19

(2009) Weicheng Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Abscisic Acid Released by Human Monocytes Activates Monocytes and Vascular Smooth Muscle Cell Responses Involved in Atherogenesis

(2009) Mirko Magnone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Plasmacytoid Dendritic Cells Support Th17 Cell Effector Function in Response to TLR7 Ligation

(2009) C.-F. Yu et al.   JOURNAL OF IMMUNOLOGY

TLR7 and TLR8 agonists trigger different signaling pathways for human dendritic cell maturation

(2009) A. Larange et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Induction of IFN-β and the Innate Antiviral Response in Myeloid Cells Occurs through an IPS-1-Dependent Signal That Does Not Require IRF-3 and IRF-7

(2009) Stephane Daffis et al.   PLoS Pathogens

Monocyte-Mediated Defense Against Microbial Pathogens

(2008) Natalya V. Serbina et al.   Annual Review of Immunology

Genome-wide analysis displays marked induction of EBI3/IL-27B in IL-18-activated AML-derived KG1 cells: Critical role of two κB binding sites in the human EBI3 promotor

(2008) Marco A. Poleganov et al.   MOLECULAR IMMUNOLOGY

TLR7 and TLR8 as targets in cancer therapy

(2008) M P Schön et al.   ONCOGENE