Article
Multidisciplinary Sciences
Tae Gun Kang, Kee Woong Kwon, Kyungsoo Kim, Insuk Lee, Myeong Joon Kim, Sang-Jun Ha, Sung Jae Shin
Summary: Viral coinfection can lead to immune complications or interference with immune responses to Mycobacterium tuberculosis (Mtb) infection. This study demonstrates that viral coinfection suppresses Mtb-specific T(H)1 response through type I IFN response to the infecting virus, exacerbating tuberculosis immunopathology.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Mohamad Mahjoor, Golnaz Mahmoudvand, Simin Farokhi, Alireza Shadab, Mojtaba Kashfi, Hamed Afkhami
Summary: The JAK/STAT signaling cascade plays a crucial role in regulating cell growth and differentiation, as well as immune responses and viral pathogenesis.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Immunology
Amos C. Lee, Yunjin Jeong, Sumin Lee, Haewook Jang, Allen Zheng, Sunghoon Kwon, John E. Repine
Summary: During the pandemic, IFN-beta has been identified as a potential prophylactic or early intervention for respiratory viral infections, providing an immediate intervention for new emerging viruses. IFN-beta prophylaxis has the potential to limit the spread and consequences of emerging respiratory viral infections in at-risk individuals while vaccines are being developed.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Virology
Jingwen Dai, Pingping Zhou, Su Li, Hua-Ji Qiu
Summary: Innate immunity plays critical roles in eliminating viral infections and maintaining tissue homeostasis. The crosstalk and interplay among signaling pathways are essential for regulating antiviral activity and homeostasis. NF-kappa B and inflammasome signaling have regulatory effects on IFN signaling, with several adaptors participating in the crosstalk between different pathways.
Review
Pharmacology & Pharmacy
Zhixing Niu, Guanyue Su, Tiantian Li, Hongchi Yu, Yang Shen, Demao Zhang, Xiaoheng Liu
Summary: This article reviews the role of BMPR1A in vascular calcification and the possible underlying molecular mechanisms. BMPR1A is considered a key molecule in the progression of vascular calcification, and its high expression leads to vascular calcification.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Polymer Science
Ruth Naomi, Pauzi Muhd Ridzuan, Hasnah Bahari
Summary: The review discusses the unique high biocompatibility of Collagen type I (Col-I) in human tissue and its widespread applications in various fields. It covers the structure, sources, synthesis, extraction methods, characteristics, applications, and biomarkers of Col-I, providing specific information on its availability over the past five years for researchers interested in collagen-based products for therapeutic purposes.
Review
Immunology
Betsy Yang, Kuender D. Yang
Summary: Different emerging viral infections have distinct pathogenic mechanisms, and providing guidance on early intervention and identification of fatal mechanisms is essential for reducing transmission and mortality rates.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Barbara N. Porto
Summary: The virome refers to the viral component of the microbiome, including all viruses that inhabit the human body. Despite previous limitations in accurately characterizing viruses, recent advancements in methods such as deep sequencing and metagenomics have allowed for a better understanding of the diverse viral species present in the human body.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Man Wang, Yuan Zhang, Chunmei Li, Wenguang Chang, Lei Zhang
Summary: The global health crisis caused by COVID-19 highlights the importance of competent immune responses and the disastrous consequences of immune dysregulation. The gut microbiota plays a vital role in immune homeostasis and the gut-lung crosstalk, and its disruption, known as gut dysbiosis, can contribute to COVID-19 progression. This review provides an overview of alterations in gut microbiota in COVID-19 patients and summarizes the bidirectional regulation between intestinal microbes and host immunity in the pathology of SARS-CoV-2.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Clinical Neurology
Mohammad Amin Habibi, Fatemeh Nezhad Shamohammadi, Taraneh Rajaei, Haideh Namdari, Mohammad Reza Pashaei, Hamid Farajifard, Sajjad Ahmadpour
Summary: Autoimmune diseases occur when the immune system fails to distinguish between self and non-self antigens. Factors such as genetics and environment contribute to the development of autoimmunity. While some studies suggest the causative role of viruses, others show their preventive effect in autoimmunity. This study reviews the current understanding of the immunopathogenesis of viruses in autoimmune diseases of the nervous system.
Review
Pharmacology & Pharmacy
Lize De Vlieger, Roosmarijn E. Vandenbroucke, Lien Van Hoecke
Summary: The article explores the impact of viral infection theory on Alzheimer's disease, with a focus on HSV-1 and SARS-CoV-2 viruses. By studying the potential involvement of extracellular vesicles in this process, it contributes to a more rational approach to potential treatment strategies for AD patients.
DRUG DISCOVERY TODAY
(2022)
Review
Cell Biology
Maximilian Hirschenberger, Victoria Hunszinger, Konstantin Maria Johannes Sparrer
Summary: Non-persistent viruses can cause post-acute sequelae (PAS) leading to persistent or new symptoms in patients after the acute phase. Immune dysregulation and chronic inflammation may play key roles in the development of PAS associated with non-persistent viral infections.
Review
Infectious Diseases
Mohammad-Javad Sanaei, Mahboobeh Nahid-Samiei, Milad Shahini Shams Abadi, Mohammad-Hassan Arjmand, Gordon A. Ferns, Davood Bashash, Ghorbanali Rahimian, Nader Bagheri
Summary: B-regs, a subset of B cells with immunosuppressive effects, produce regulatory cytokines like IL-10, TGF-beta, and IL-35, which limit host defense against pathogens and induce suppressive T-regs. High levels of B-regs are associated with viral and bacterial load, leading to poor vaccine responses and increased disease severity. B-regs also protect against hyperinflammatory responses in parasitic infections.
INFECTION GENETICS AND EVOLUTION
(2021)
Article
Multidisciplinary Sciences
Paola S. Apaolaza, Diana Balcacean, Jose Zapardiel-Gonzalo, Grace Nelson, Nataliya Lenchik, Pouria Akhbari, Ivan Gerling, Sarah J. Richardson, Teresa Rodriguez-Calvo
Summary: The study reveals the presence of IFN response markers in the islets of T1D patients, which may lead to inflammation and impair beta cell function. Therapeutic interventions targeting the elimination of persistent infections and reduction of inflammation are crucial for individuals with T1D.
Review
Virology
Kwang Il Jung, Savannah McKenna, Vijayamahantesh Vijayamahantesh, Ying He, Bumsuk Hahm
Summary: This article summarizes the role and response of type I interferons after virus infections, emphasizing their protective immune responses and potential negative effects such as inflammation and immune suppression.
Article
Immunology
Anne A. Gershon, David Brooks, Donald D. Stevenson, William K. Chin, Michael B. A. Oldstone, Michael D. Gershon
JOURNAL OF INFECTIOUS DISEASES
(2019)
Article
Oncology
Derek L. Clouthier, Scott C. Lien, S. Y. Cindy Yang, Linh T. Nguyen, Venkata S. K. Manem, Diana Gray, Michael Ryczko, Albiruni R. A. Razak, Jeremy Lewin, Stephanie Lheureux, Ilaria Colombo, Philippe L. Bedard, David Cescon, Anna Spreafico, Marcus O. Butler, Aaron R. Hansen, Raymond W. Jang, Sangeet Ghai, Ilan Weinreb, Valentin Sotov, Ramy Gadalla, Babak Noamani, Mengdi Guo, Sawako Elston, Amanda Giesler, Sevan Hakgor, Haiyan Jiang, Tracy McGaha, David G. Brooks, Benjamin Haibe-Kains, Trevor J. Pugh, Pamela S. Ohashi, Lillian L. Siu
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Review
Immunology
Sabelo Lukhele, Giselle M. Boukhaled, David G. Brooks
SEMINARS IN IMMUNOLOGY
(2019)
Article
Oncology
Ramy Gadalla, Babak Noamani, Bethany L. MacLeod, Russell J. Dickson, Mengdi Guo, Wenxi Xu, Sabelo Lukhele, Heidi J. Elsaesser, Albiruni R. Abdul Razak, Naoto Hirano, Tracy L. McGaha, Ben Wang, Marcus Butler, Cynthia J. Guidos, Pam S. Ohashi, Lillian L. Siu, David G. Brooks
FRONTIERS IN ONCOLOGY
(2019)
Article
Multidisciplinary Sciences
Heidi J. Elsaesser, Mahmood Mohtashami, Ivan Osokine, Laura M. Snell, Cameron R. Cunningham, Giselle M. Boukhaled, Dorian B. McGavern, Juan Carlos Zuniga-Pflucker, David G. Brooks
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Immunology
Marie Jo Halaby, Kebria Hezaveh, Sara Lamorte, M. Teresa Ciudad, Andreas Kloetgen, Bethany L. MacLeod, Mengdi Guo, Ankur Chakravarthy, Tiago Da Silva Medina, Stefano Ugel, Aristotelis Tsirigos, Vincenzo Bronte, David H. Munn, Trevor J. Pugh, Daniel D. De Carvalho, Marcus O. Butler, Pamela S. Ohashi, David G. Brooks, Tracy L. McGaha
SCIENCE IMMUNOLOGY
(2019)
Article
Immunology
Bethany L. Macleod, Heidi J. Elsaesser, Laura M. Snell, Russell J. Dickson, Mengdi Guo, Kebria Hezaveh, Wenxi Xu, Akash Kothari, Tracy L. McGaha, Cynthia J. Guidos, David G. Brooks
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Helen Loo Yau, Emma Bell, Ilias Ettayebi, Felipe Campos de Almeida, Giselle M. Boukhaled, Shu Yi Shen, David Allard, Beatriz Morancho, Sajid A. Marhon, Charles A. Ishak, Isabela M. Gonzaga, Tiago da Silva Medina, Rajat Singhania, Ankur Chakravarthy, Raymond Chen, Parinaz Mehdipour, Sandra Pommey, Christian Klein, Gustavo P. Amarante-Mendes, David Roulois, Joaquin Arribas, John Stagg, David G. Brooks, Daniel D. De Carvalho
Summary: The study demonstrates that DNA hypomethylating agents directly modulate the anti-tumor response and effector function of CD8(+) T cells, promoting tumor infiltration and suppressing growth. This effect is achieved through the regulation of T cell activation-related transcriptional networks, ultimately enhancing the immune response against tumors.
Article
Virology
David G. Brooks, Antoinette Tishon, Michael B. A. Oldstone, Dorian B. McGavern
Summary: During chronic viral infections, CD8 T cells can rapidly lose antiviral and immune-stimulatory functions and be physically deleted, but therapeutic strategies such as lowering viral replication and utilizing CD4 T cell help can prevent CD8 T cell deletion and enhance their diversity and function.
Article
Immunology
Laura M. Snell, Wenxi Xu, Diala Abd-Rabbo, Giselle Boukhaled, Mengdi Guo, Bethany L. Macleod, Heidi J. Elsaesser, Kebria Hezaveh, Nirmin Alsahafi, Sabelo Lukhele, Sara Nejat, Ramanandan Prabhakaran, Slava Epelman, Tracy L. McGaha, David G. Brooks
Summary: Inhibiting PD-1:PD-L1 signaling can restore the immune function of CD4(+) T cells in chronic infections and modulate the activation of T regulatory cells. This study demonstrates the heterogeneity of CD4(+) T cells in chronic viral infection and shows that PD-L1 blockade can enhance cytotoxic gene programs in antigen-specific T(H)1 cells.
Editorial Material
Immunology
Laura M. Snell
Summary: This study reveals a progenitor T cell subset that plays a crucial role in maintaining immune responses during chronic infection by generating effector and follicular helper T cells.
Article
Immunology
Sabelo Lukhele, Diala Abd Rabbo, Mengdi Guo, Jian Shen, Heidi J. Elsaesser, Rene Quevedo, Madeleine Carew, Ramy Gadalla, Laura M. Snell, Lawanya Mahesh, M. Teresa Ciudad, Bryan E. Snow, Annick You-Ten, Jillian Haight, Andrew Wakeham, Pamela S. Ohashi, Tak W. Mak, Weiguo Cui, Tracy L. McGaha, David G. Brooks
Summary: Type I and II interferons stimulate pro-inflammatory programs critical for immune activation, but also induce immune-suppressive feedback circuits that hinder cancer control. This study reveals that the transcription factor IRF2 plays a key role in redirecting interferon signals to suppress T cell responses and prevent T cell exhaustion within the tumor microenvironment, leading to improved tumor control and increased responsiveness to immune therapies.
Article
Medicine, Research & Experimental
Vyacheslav Palchevskiy, Ying Ving Xue, Rita Kern, Stephen S. Weigt, Ark L. Gregson, Sophie X. Song, Michael C. Fishbein, Cory M. Hogaboam, David M. Sayah, Joseph P. Lynch, Michael P. Keane, David G. Brooks, John A. Belperio