Molecular basis for the P450-catalyzed C–N bond formation in indolactam biosynthesis

11-Step Total Synthesis of Teleocidins B-1–B-4

(2019) Hugh Nakamura et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes

(2019) F. Peter Guengerich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation and Cleavage of C–C Bonds by Enzymatic Oxidation–Reduction Reactions

(2018) F. Peter Guengerich et al.   CHEMICAL REVIEWS

Biosynthetic studies on teleocidins in Streptomyces

(2018) Ikuro Abe   JOURNAL OF ANTIBIOTICS

Unprecedented Cyclization Catalyzed by a Cytochrome P450 in Benzastatin Biosynthesis

(2018) Hayama Tsutsumi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases

(2018) Lukas Reisky et al.   Nature Chemical Biology

CASTp 3.0: computed atlas of surface topography of proteins

(2018) Wei Tian et al.   NUCLEIC ACIDS RESEARCH

Substrate-induced conformational change in cytochrome P450 OleP

(2018) Giacomo Parisi et al.   FASEB JOURNAL

Design of catalysts for site-selective and enantioselective functionalization of non-activated primary C–H bonds

(2018) Kuangbiao Liao et al.   Nature Chemistry

Binding of Distinct Substrate Conformations Enables Hydroxylation of Remote Sites in Thaxtomin D by Cytochrome P450 TxtC

(2018) Lona M. Alkhalaf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural analysis of SgvP involved in carbon-sulfur bond formation during griseoviridin biosynthesis

(2017) Qin Li et al.   FEBS LETTERS

Expansion of chemical space for natural products by uncommon P450 reactions

(2017) Xingwang Zhang et al.   NATURAL PRODUCT REPORTS

Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function

(2017) Jeffrey D. Rudolf et al.   NATURAL PRODUCT REPORTS

Oxidative Cyclization in Natural Product Biosynthesis

(2016) Man-Cheng Tang et al.   CHEMICAL REVIEWS

Copper(II)-Mediated Intermolecular C(sp2)–H Amination of Benzamides with Electron-Rich Anilines

(2016) Bijaya Kumar Singh et al.   JOURNAL OF ORGANIC CHEMISTRY

P450-Mediated Coupling of Indole Fragments To Forge Communesin and Unnatural Isomers

(2016) Hsiao-Ching Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of a regioselectivity switch in nitrating P450s guided by molecular dynamics simulations and Markov models

(2016) Sheel C. Dodani et al.   Nature Chemistry

Dali server update

(2016) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4

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Manipulation of prenylation reactions by structure-based engineering of bacterial indolactam prenyltransferases

(2016) Takahiro Mori et al.   Nature Communications

Evolution of C–H Bond Functionalization from Methane to Methodology

(2015) John F. Hartwig   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The stability of nitrogen-centered radicals

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Biological Matching of Chemical Reactivity: Pairing Indole Nucleophilicity with Electrophilic Isoprenoids

(2014) Christopher T. Walsh   ACS Chemical Biology

Heme Enzyme Structure and Function

(2014) Thomas L. Poulos   CHEMICAL REVIEWS

Expanding P450 catalytic reaction space through evolution and engineering

(2014) John A McIntosh et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Structure-Function Analyses of Cytochrome P450revI Involved in Reveromycin A Biosynthesis and Evaluation of the Biological Activity of Its Substrate, Reveromycin T

(2014) Shunji Takahashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Methyltransferase Initiates Terpene Cyclization in Teleocidin B Biosynthesis

(2014) Takayoshi Awakawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Overcoming the limitations of directed C–H functionalizations of heterocycles

(2014) Yue-Jin Liu et al.   NATURE

Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo

(2013) John A. McIntosh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

(2012) Junichiro Yamaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Diversity of P450 enzymes in the biosynthesis of natural products

(2012) Larissa M. Podust et al.   NATURAL PRODUCT REPORTS

Cytochrome P450–catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis

(2012) Sarah M Barry et al.   Nature Chemical Biology

Crystal Structures of CO and NO Adducts of MauG in Complex with Pre-Methylamine Dehydrogenase: Implications for the Mechanism of Dioxygen Activation

(2011) Erik T. Yukl et al.   BIOCHEMISTRY

C–H Functionalization in organic synthesis

(2011) Huw M. L. Davies et al.   CHEMICAL SOCIETY REVIEWS

C–H functionalization logic in total synthesis

(2011) Will R. Gutekunst et al.   CHEMICAL SOCIETY REVIEWS

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

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Annulated Diketopiperazines from Dipeptides or Schöllkopf Reagents via Tandem Cyclization−Intramolecular N-Arylation

(2010) Hwan Jung Lim et al.   ORGANIC LETTERS

Enzymatic Production of (−)-Indolactam V by LtxB, a Cytochrome P450 Monooxygenase

(2009) Minh U. Huynh et al.   JOURNAL OF NATURAL PRODUCTS

A small molecule that directs differentiation of human ESCs into the pancreatic lineage

(2009) Shuibing Chen et al.   Nature Chemical Biology

Residence Time of Receptor−Ligand Complexes and Its Effect on Biological Function

(2008) Peter J. Tummino et al.   BIOCHEMISTRY

Flexibility of Human Cytochromes P450: Molecular Dynamics Reveals Differences between CYPs 3A4, 2C9, and 2A6, which Correlate with Their Substrate Preferences

(2008) Josef Skopalík et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Carbon–heteroatom bond formation catalysed by organometallic complexes

(2008) John F. Hartwig   NATURE

Catalytic C–H functionalization by metal carbenoid and nitrenoid insertion

(2008) Huw M. L. Davies et al.   NATURE