Human cytochrome P450 enzymes bind drugs and other substrates mainly through conformational-selection modes

Rolapitant Is a Reversible Inhibitor of CYP2D6

(2019) Sarah M. Glass et al.   DRUG METABOLISM AND DISPOSITION

Conformational selection dominates binding of steroids to human cytochrome P450 17A1

(2019) F. Peter Guengerich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation and Cleavage of C–C Bonds by Enzymatic Oxidation–Reduction Reactions

(2018) F. Peter Guengerich et al.   CHEMICAL REVIEWS

Substrate-induced conformational change in cytochrome P450 OleP

(2018) Giacomo Parisi et al.   FASEB JOURNAL

Structures of human cytochrome P450 1A1 with bergamottin and erlotinib reveal active-site modifications for binding of diverse ligands

(2018) Aaron G. Bart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate-Dependent Allosteric Regulation in Cytochrome P450cam (CYP101A1)

(2018) Alec H. Follmer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanisms of Cytochrome P450-Catalyzed Oxidations

(2018) F. Peter Guengerich   ACS Catalysis

Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1

(2017) Eric Gonzalez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human mitochondrial cytochrome P450 27C1 is localized in skin and preferentially desaturatestrans-retinol to 3,4-dehydroretinol

(2017) Kevin M. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detection of substrate-dependent conformational changes in the P450 fold by nuclear magnetic resonance

(2016) Allison M. Colthart et al.   Scientific Reports

Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase

(2015) Pradeep S. Pallan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Based Inhibitor Design for Evaluation of a CYP3A4 Pharmacophore Model

(2015) Parminder Kaur et al.   JOURNAL OF MEDICINAL CHEMISTRY

Kinetic Analysis of Lauric Acid Hydroxylation by Human Cytochrome P450 4A11

(2014) Donghak Kim et al.   BIOCHEMISTRY

Distinguishing induced fit from conformational selection

(2014) Stefano Gianni et al.   BIOPHYSICAL CHEMISTRY

Survey of Human Oxidoreductases and Cytochrome P450 Enzymes Involved in the Metabolism of Xenobiotic and Natural Chemicals

(2014) Slobodan Rendic et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Human Cytochrome P450 17A1 Conformational Selection

(2014) D. Fernando Estrada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pivotal role of P450–P450 interactions in CYP3A4 allostery: the case of α-naphthoflavone

(2013) Dmitri R. Davydov et al.   BIOCHEMICAL JOURNAL

Essential role of conformational selection in ligand binding

(2013) Austin D. Vogt et al.   BIOPHYSICAL CHEMISTRY

Human Cytochrome P450 1A1 Structure and Utility in Understanding Drug and Xenobiotic Metabolism

(2013) Agnes A. Walsh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for Effector Control and Redox Partner Recognition in Cytochrome P450

(2013) S. Tripathi et al.   SCIENCE

Solution Structural Ensembles of Substrate-Free Cytochrome P450cam

(2012) Eliana K. Asciutto et al.   BIOCHEMISTRY

Conformational Selection or Induced Fit? A Critical Appraisal of the Kinetic Mechanism

(2012) Austin D. Vogt et al.   BIOCHEMISTRY

Type II Ligands as Chemical Auxiliaries To Favor Enzymatic Transformations by P450 2E1

(2012) Amélie Ménard et al.   CHEMBIOCHEM

Structural and Mechanistic Insights into the Interaction of Cytochrome P4503A4 with Bromoergocryptine, a Type I Ligand

(2011) Irina F. Sevrioukova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytochrome P450 Is Present in Both Ferrous and Ferric Forms in the Resting State within IntactEscherichia coliand Hepatocytes

(2011) Wayne A. Johnston et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The effects of type II binding on metabolic stability and binding affinity in cytochrome P450 CYP3A4

(2010) Chi-Chi Peng et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

P450cam Visits an Open Conformation in the Absence of Substrate,

(2010) Young-Tae Lee et al.   BIOCHEMISTRY

From Induced Fit to Conformational Selection: A Continuum of Binding Mechanism Controlled by the Timescale of Conformational Transitions

(2010) Huan-Xiang Zhou   BIOPHYSICAL JOURNAL

Human Cytochrome P450 2E1 Structures with Fatty Acid Analogs Reveal a Previously Unobserved Binding Mode

(2010) Patrick R. Porubsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetic Analysis of the Three-step Steroid Aromatase Reaction of Human Cytochrome P450 19A1

(2010) Christal D. Sohl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir

(2010) I. F. Sevrioukova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elucidation of Functions of Human Cytochrome P450 Enzymes: Identification of Endogenous Substrates in Tissue Extracts Using Metabolomic and Isotopic Labeling Approaches

(2009) Zhongmei Tang et al.   ANALYTICAL CHEMISTRY

Fundamental Aspects of Protein−Protein Association Kinetics

(2009) G. Schreiber et al.   CHEMICAL REVIEWS

Investigating the Structural Plasticity of a Cytochrome P450

(2009) Carmelinda Savino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for androgen specificity and oestrogen synthesis in human aromatase

(2009) Debashis Ghosh et al.   NATURE

Conformational selection or induced fit: A flux description of reaction mechanism

(2009) G. G. Hammes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate binding to cytochromes P450

(2008) Emre M. Isin et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

FitSpace Explorer: An algorithm to evaluate multidimensional parameter space in fitting kinetic data

(2008) Kenneth A. Johnson et al.   ANALYTICAL BIOCHEMISTRY

Global Kinetic Explorer: A new computer program for dynamic simulation and fitting of kinetic data

(2008) Kenneth A. Johnson et al.   ANALYTICAL BIOCHEMISTRY

Free-Energy Landscape of Enzyme Catalysis†

(2008) Stephen J. Benkovic et al.   BIOCHEMISTRY

Cooperativity in Oxidation Reactions Catalyzed by Cytochrome P450 1A2

(2008) Christal D. Sohl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of Human Cytochrome P-450 2E1

(2008) Patrick R. Porubsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ligand-Induced Conformational Heterogeneity of Cytochrome P450 CYP119 Identified by 2D NMR Spectroscopy with the Unnatural Amino Acid13C-p-Methoxyphenylalanine

(2008) Jed N. Lampe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY