6-Shogaol Inhibits Advanced Glycation End-Products-Induced IL-6 and ICAM-1 Expression by Regulating Oxidative Responses in Human Gingival Fibroblasts

Beneficial effects of 6-shogaol on hyperglycemia, islet morphology and apoptosis in some tissues of streptozotocin-induced diabetic mice

(2019) Jun-Koo Yi et al.   Diabetology & Metabolic Syndrome

Advanced glycation end-products disrupt human endothelial cells redox homeostasis: new insights into reactive oxygen species production

(2019) Anthony Dobi et al.   FREE RADICAL RESEARCH

6-Shogaol ameliorates diabetic nephropathy through anti-inflammatory, hyperlipidemic, anti-oxidative activity in db/db mice

(2018) Yun Xu et al.   BIOMEDICINE & PHARMACOTHERAPY

Oxidative stress and cardiovascular disease: new insights

(2018) Pasquale Pignatelli et al.   Kardiologia Polska

Anti-neuroinflammatory Effects of 12-Dehydrogingerdione in LPS-Activated Microglia through Inhibiting Akt/IKK/NF-κB Pathway and Activating Nrf-2/HO-1 Pathway

(2018) Dong Zhao et al.   Biomolecules & Therapeutics

Advanced glycation end‐products induce oxidative stress through the Sirt1/Nrf2 axis by interacting with the receptor of AGEs under diabetic conditions

(2018) Xiao‐Jun Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Additive Capacity of [6]-Shogaol and Epicatechin To Trap Methylglyoxal

(2017) Qiju Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oral Delivery of Nanoparticles Loaded With Ginger Active Compound, 6-Shogaol, Attenuates Ulcerative Colitis and Promotes Wound Healing in a Murine Model of Ulcerative Colitis

(2017) Mingzhen Zhang et al.   Journal of Crohns & Colitis

Advanced glycation end-products increase IL-6 and ICAM-1 expression via RAGE, MAPK and NF-κB pathways in human gingival fibroblasts

(2017) K. Nonaka et al.   JOURNAL OF PERIODONTAL RESEARCH

Comparative suppressing effects of black and green teas on the formation of advanced glycation end products (AGEs) and AGE-induced oxidative stress

(2017) P. Ramlagan et al.   Food & Function

Oxidative Stress and Antioxidant System in Periodontitis

(2017) Yue Wang et al.   Frontiers in Physiology

Pathways that Regulate ROS Scavenging Enzymes, and Their Role in Defense Against Tissue Destruction in Periodontitis

(2017) Hiroyuki Kanzaki et al.   Frontiers in Physiology

Resveratrol prevents alveolar bone loss in an experimental rat model of periodontitis

(2016) Govinda Bhattarai et al.   Acta Biomaterialia

6-shogaol attenuates H2O2-induced oxidative stress via upregulation of Nrf2-mediated γ-glutamylcysteine synthetase and heme oxygenase expression in HepG2 cells

(2016) Jin-Kyoung Kim et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Porphyromonas gingivalis-induced production of reactive oxygen species, tumor necrosis factor-α, interleukin-6, CXCL8 and CCL2 by neutrophils from localized aggressive periodontitis and healthy donors: modulating actions of red blood cells and resolvin E1

(2016) C. Damgaard et al.   JOURNAL OF PERIODONTAL RESEARCH

Bioactive compounds isolated from apple, tea, and ginger protect against dicarbonyl induced stress in cultured human retinal epithelial cells

(2016) Chethan Sampath et al.   PHYTOMEDICINE

6-Shogaol, an active compound of ginger, alleviates allergic dermatitis-like skin lesions via cytokine inhibition by activating the Nrf2 pathway

(2016) Gunhyuk Park et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Evaluation of the efficacy of a polyherbal mouthwash containing Zingiber officinale, Rosmarinus officinalis and Calendula officinalis extracts in patients with gingivitis: A randomized double-blind placebo-controlled trial

(2016) Saman Mahyari et al.   Complementary Therapies in Clinical Practice

Bioactive Ginger Constituents Alleviate Protein Glycation by Trapping Methylglyoxal

(2015) Yingdong Zhu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Gingerols and shogaols: Important nutraceutical principles from ginger

(2015) Ruchi Badoni Semwal et al.   PHYTOCHEMISTRY

6-Shogaol exerts anti-proliferative and pro-apoptotic effects through the modulation of STAT3 and MAPKs signaling pathways

(2015) Sung-Moo Kim et al.   MOLECULAR CARCINOGENESIS

Ginger Compound [6]-Shogaol and Its Cysteine-Conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo

(2014) Huadong Chen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Glycosaminoglycan Degradation by Selected Reactive Oxygen Species

(2013) Beate Fuchs et al.   ANTIOXIDANTS & REDOX SIGNALING

Sirt1 resists advanced glycation end products-induced expressions of fibronectin and TGF-β1 by activating the Nrf2/ARE pathway in glomerular mesangial cells

(2013) Kaipeng Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The anti-inflammation effect of Moutan Cortex on advanced glycation end products-induced rat mesangial cells dysfunction and High-glucose–fat diet and streptozotocin-induced diabetic nephropathy rats

(2013) Ming-hua Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Advanced Glycation End Products Induce Human Corneal Epithelial Cells Apoptosis through Generation of Reactive Oxygen Species and Activation of JNK and p38 MAPK Pathways

(2013) Long Shi et al.   PLoS One

Gingival advanced glycation end-products in diabetes mellitus-associated chronic periodontitis: an immunohistochemical study

(2012) A. Zizzi et al.   JOURNAL OF PERIODONTAL RESEARCH

6-Shogaol-Rich Extract from Ginger Up-Regulates the Antioxidant Defense Systems in Cells and Mice

(2012) Min-Ji Bak et al.   MOLECULES

Heme Oxygenase-1, Oxidation, Inflammation, and Atherosclerosis

(2012) Jesus A. Araujo et al.   Frontiers in Pharmacology

Attenuation of Liver Pro-Inflammatory Responses by Zingiber officinale via Inhibition of NF-kappa B Activation in High-Fat Diet-Fed Rats

(2011) Xiao-Hong Li et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Matrix Metalloproteinase-1 of Gingival Fibroblasts Influenced by Advanced Glycation End Products (AGEs) and Their Association With Receptor for AGEs and Nuclear Factor-κB in Gingival Connective Tissue

(2011) Shaojie Yu et al.   JOURNAL OF PERIODONTOLOGY

Ischemic kidney injury and mechanisms of tissue repair

(2011) Marwa El Sabbahy et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation

(2010) H Ling et al.   BRITISH JOURNAL OF PHARMACOLOGY

Induction of HO-1 and redox signaling in endothelial cells by advanced glycation end products: A role for Nrf2 in vascular protection in diabetes

(2010) M. He et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Periodontal Disease Mechanisms: Reactive oxygen species: a potential role in the pathogenesis of periodontal diseases

(2010) RJ Waddington et al.   ORAL DISEASES

Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol

(2009) Swarnalatha Dugasani et al.   JOURNAL OF ETHNOPHARMACOLOGY

Comparative Effects of Two Gingerol-ContainingZingiber officinaleExtracts on Experimental Rheumatoid Arthritis⊥

(2009) Janet L. Funk et al.   JOURNAL OF NATURAL PRODUCTS

Advanced Glycation End Products Inhibit the Expression of Collagens Type I and III by Human Gingival Fibroblasts

(2009) Lei Ren et al.   JOURNAL OF PERIODONTOLOGY

Hepatocyte growth factor prevents advanced glycation end products-induced injury and oxidative stress through a PI3K/Akt-dependent pathway in human endothelial cells

(2009) Yi-Jun Zhou et al.   LIFE SCIENCES

The Role of Advanced Glycation End Products in Progression and Complications of Diabetes

(2008) Su-Yen Goh et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteria

(2008) Miri Park et al.   PHYTOTHERAPY RESEARCH