PYCR1 interference inhibits cell growth and survival via c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathway in hepatocellular cancer

The Proline Cycle As a Potential Cancer Therapy Target

(2018) John J. Tanner et al.   BIOCHEMISTRY

Molecular therapies and precision medicine for hepatocellular carcinoma

(2018) Josep M. Llovet et al.   Nature Reviews Clinical Oncology

Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance

(2017) Melania Gaggini et al.   HEPATOLOGY

Knockdown of PYCR1 inhibits cell proliferation and colony formation via cell cycle arrest and apoptosis in prostate cancer

(2017) Tengyue Zeng et al.   MEDICAL ONCOLOGY

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

(2017) Orianne Olivares et al.   Nature Communications

Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

(2017) Ilaria Elia et al.   Nature Communications

JNK at the crossroad of obesity, insulin resistance, and cell stress response

(2017) Giovanni Solinas et al.   Molecular Metabolism

Proline Metabolism in Cell Regulation and Cancer Biology: Recent Advances and Hypotheses

(2017) James M. Phang   ANTIOXIDANTS & REDOX SIGNALING

MiR-103 regulates hepatocellular carcinoma growth by targeting AKAP12

(2016) Wei Xia et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

(2016) Cholsoon Jang et al.   NATURE MEDICINE

Survival Benefit of Exercise Differs by Tumor IRS1 Expression Status in Colorectal Cancer

(2015) Akiko Hanyuda et al.   ANNALS OF SURGICAL ONCOLOGY

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(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Proline biosynthesis augments tumor cell growth and aerobic glycolysis: involvement of pyridine nucleotides

(2015) Wei Liu et al.   Scientific Reports

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(2014) Cristina Bosetti et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

The clinical management of hepatocellular carcinoma in the United States, Europe, and Asia: A comprehensive and evidence-based comparison and review

(2014) Zhi Ven Fong et al.   CANCER

JNK signalling in cancer: in need of new, smarter therapeutic targets

(2013) Concetta Bubici et al.   BRITISH JOURNAL OF PHARMACOLOGY

IRS1 is highly expressed in localized breast tumors and regulates the sensitivity of breast cancer cells to chemotherapy, while IRS2 is highly expressed in invasive breast tumors

(2013) Holly A. Porter et al.   CANCER LETTERS

Bridging epigenetics and metabolism

(2013) James M. Phang et al.   Epigenetics

Insulin resistance and cancer: the role of insulin and IGFs

(2012) Sefirin Djiogue et al.   ENDOCRINE-RELATED CANCER

A Liver Full of JNK: Signaling in Regulation of Cell Function and Disease Pathogenesis, and Clinical Approaches

(2012) Ekihiro Seki et al.   GASTROENTEROLOGY

Insulin resistance: A significant risk factor of endometrial cancer

(2012) Nan Mu et al.   GYNECOLOGIC ONCOLOGY

The soybean peptide aglycin regulates glucose homeostasis in type 2 diabetic mice via IR/IRS1 pathway

(2012) Jingli Lu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

(2012) W. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin resistance and the metabolism of branched-chain amino acids in humans

(2011) María M. Adeva et al.   AMINO ACIDS

Resistin Promotes Cardiac Hypertrophy via the AMP-activated Protein Kinase/Mammalian Target of Rapamycin (AMPK/mTOR) and c-Jun N-terminal Kinase/Insulin Receptor Substrate 1 (JNK/IRS1) Pathways

(2011) Soojeong Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men

(2010) E. S. Tai et al.   DIABETOLOGIA

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Insulin and JNK: optimizing metabolic homeostasis and lifespan

(2009) Jason Karpac et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM