A piperidinol-containing molecule is active against Mycobacterium tuberculosis by inhibiting the mycolic acid flippase activity of MmpL3
出版年份 2019 全文链接
标题
A piperidinol-containing molecule is active against Mycobacterium tuberculosis by inhibiting the mycolic acid flippase activity of MmpL3
作者
关键词
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出版物
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 294, Issue 46, Pages 17512-17523
出版商
American Society for Biochemistry & Molecular Biology (ASBMB)
发表日期
2019-09-28
DOI
10.1074/jbc.ra119.010135
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Direct Inhibition of MmpL3 by Novel Antitubercular Compounds
- (2019) Wei Li et al. ACS Infectious Diseases
- Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target
- (2019) Bing Zhang et al. CELL
- MmpL3 is a lipid transporter that binds trehalose monomycolate and phosphatidylethanolamine
- (2019) Chih-Chia Su et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- HC2091 Kills Mycobacterium tuberculosis by Targeting the MmpL3 Mycolic Acid Transporter
- (2018) Huiqing Zheng et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Cyclipostins and cyclophostin analogs inhibit the antigen 85C fromMycobacterium tuberculosisbothin vitroandin vivo
- (2018) Albertus Viljoen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MmpL3 as a Target for the Treatment of Drug-Resistant Nontuberculous Mycobacterial Infections
- (2018) Wei Li et al. Frontiers in Microbiology
- Novel Acetamide Indirectly Targets Mycobacterial Transporter MmpL3 by Proton Motive Force Disruption
- (2018) Annanya Shetty et al. Frontiers in Microbiology
- Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus Infections
- (2017) Alan P. Kozikowski et al. JOURNAL OF MEDICINAL CHEMISTRY
- New structural classes of antituberculosis agents
- (2017) Vajinder Kumar et al. MEDICINAL RESEARCH REVIEWS
- The diverse family of MmpL transporters in mycobacteria: from regulation to antimicrobial developments
- (2017) Albertus Viljoen et al. MOLECULAR MICROBIOLOGY
- MmpL3 is the flippase for mycolic acids in mycobacteria
- (2017) Zhujun Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Controlling Extra- and Intramacrophagic Mycobacterium abscessus by Targeting Mycolic Acid Transport
- (2017) Albertus Viljoen et al. Frontiers in Cellular and Infection Microbiology
- The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis
- (2017) Keertan Dheda et al. Lancet Respiratory Medicine
- Essentiality of mmpL3 and impact of its silencing on Mycobacterium tuberculosis gene expression
- (2017) Giulia Degiacomi et al. Scientific Reports
- Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3
- (2016) Wei Li et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- MmpL3 Inhibitors: Diverse Chemical Scaffolds Inhibit the Same Target
- (2016) Giovanna Poce et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- A new piperidinol derivative targeting mycolic acid transport inMycobacterium abscessus
- (2016) Christian Dupont et al. MOLECULAR MICROBIOLOGY
- Diphenylether-Modified 1,2-Diamines with Improved Drug Properties for Development against Mycobacterium tuberculosis
- (2016) Marie H. Foss et al. ACS Infectious Diseases
- THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria
- (2016) Jonathan A. G. Cox et al. Nature Microbiology
- Lipid transport in Mycobacterium tuberculosis and its implications in virulence and drug development
- (2015) Rebeca Bailo et al. BIOCHEMICAL PHARMACOLOGY
- Mycolic acids: deciphering and targeting the Achilles' heel of the tubercle bacillus
- (2015) Vijayashankar Nataraj et al. MOLECULAR MICROBIOLOGY
- Insights into the smooth-to-rough transitioning in Mycobacterium bolletii unravels a functional Tyr residue conserved in all mycobacterial MmpL family members
- (2015) Audrey Bernut et al. MOLECULAR MICROBIOLOGY
- The Phyre2 web portal for protein modeling, prediction and analysis
- (2015) Lawrence A Kelley et al. Nature Protocols
- Antiinfectives targeting enzymes and the proton motive force
- (2015) Xinxin Feng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Novel Insights into the Mechanism of Inhibition of MmpL3, a Target of Multiple Pharmacophores in Mycobacterium tuberculosis
- (2014) Wei Li et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Multitarget Drug Discovery for Tuberculosis and Other Infectious Diseases
- (2014) Kai Li et al. JOURNAL OF MEDICINAL CHEMISTRY
- Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis
- (2013) Lluís Ballell et al. ChemMedChem
- Tetrahydropyrazolo[1,5-a]Pyrimidine-3-Carboxamide and N-Benzyl-6′,7′-Dihydrospiro[Piperidine-4,4′-Thieno[3,2-c]Pyran] Analogues with Bactericidal Efficacy against Mycobacterium tuberculosis Targeting MmpL3
- (2013) Modesto J. Remuiñán et al. PLoS One
- Indolcarboxamide Is a Preclinical Candidate for Treating Multidrug-Resistant Tuberculosis
- (2013) S. P. S. Rao et al. Science Translational Medicine
- Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen
- (2013) Lorenza Favrot et al. Nature Communications
- Indoleamides are active against drug-resistant Mycobacterium tuberculosis
- (2013) Shichun Lun et al. Nature Communications
- SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis
- (2012) Kapil Tahlan et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- MmpL Genes Are Associated with Mycolic Acid Metabolism in Mycobacteria and Corynebacteria
- (2012) Cristian Varela et al. CHEMISTRY & BIOLOGY
- Probing the Mycobacterial Trehalome with Bioorthogonal Chemistry
- (2012) Benjamin M. Swarts et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane
- (2012) Anna E Grzegorzewicz et al. Nature Chemical Biology
- MmpL3 Is the Cellular Target of the Antitubercular Pyrrole Derivative BM212
- (2011) Valentina La Rosa et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
- (2009) Oleg Trott et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
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