Cofilin, a Master Node Regulating Cytoskeletal Pathogenesis in Alzheimer’s Disease

Tauopathy: A common mechanism for neurodegeneration and Brain Aging

(2019) Pampa Saha et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Microtubule control of functional architecture in neurons

(2019) Michael T Kelliher et al.   CURRENT OPINION IN NEUROBIOLOGY

Amyloid fibrils induce dysfunction of hippocampal glutamatergic silent synapses

(2018) Bihua Bie et al.   HIPPOCAMPUS

Brain ischemic insult induces cofilin rod formation leading to synaptic dysfunction in neurons

(2018) Liang Shu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microtubule dynamics: an interplay of biochemistry and mechanics

(2018) Gary J. Brouhard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microtubules and Microtubule-Associated Proteins

(2018) Holly V. Goodson et al.   Cold Spring Harbor Perspectives in Biology

Fibrillar Amyloid-β1-42 Modifies Actin Organization Affecting the Cofilin Phosphorylation State: A Role for Rac1/cdc42 Effector Proteins and the Slingshot Phosphatase

(2018) Ariadna Mendoza-Naranjo et al.   JOURNAL OF ALZHEIMERS DISEASE

Cofilin Rods and Aggregates Concur with Tau Pathology and the Development of Alzheimer's Disease

(2018) Tasnim Rahman et al.   JOURNAL OF ALZHEIMERS DISEASE

Synaptotoxicity in Alzheimer's Disease Involved a Dysregulation of Actin Cytoskeleton Dynamics through Cofilin 1 Phosphorylation

(2018) Travis Rush et al.   JOURNAL OF NEUROSCIENCE

An Integrated Cytoskeletal Model of Neurite Outgrowth

(2018) Kyle E. Miller et al.   Frontiers in Cellular Neuroscience

Regulation of actin dynamics by PI(4,5)P2 in cell migration and endocytosis

(2018) Yosuke Senju et al.   CURRENT OPINION IN CELL BIOLOGY

Axodendritic sorting and pathological missorting of Tau are isoform-specific and determined by axon initial segment architecture

(2017) Hans Zempel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rho GTPase signaling complexes in cell migration and invasion

(2017) Campbell D. Lawson et al.   JOURNAL OF CELL BIOLOGY

Actin-based growth cone motility and guidance

(2017) Omotola F. Omotade et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neuronal polarization: From spatiotemporal signaling to cytoskeletal dynamics

(2017) Max Schelski et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Actin Waves: Origin of Cell Polarization and Migration?

(2017) Naoyuki Inagaki et al.   TRENDS IN CELL BIOLOGY

Moonlighting Motors: Kinesin, Dynein, and Cell Polarity

(2017) Wen Lu et al.   TRENDS IN CELL BIOLOGY

Dendritic Actin Cytoskeleton: Structure, Functions, and Regulations

(2017) Anja Konietzny et al.   Frontiers in Cellular Neuroscience

Neurofilaments and Neurofilament Proteins in Health and Disease

(2017) Aidong Yuan et al.   Cold Spring Harbor Perspectives in Biology

Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission

(2017) Katharina Rehklau et al.   Cell Death & Disease

Cofilin-mediated Neuronal Apoptosis via p53 Translocation and PLD1 Regulation

(2017) Tian Liu et al.   Scientific Reports

Actin dynamics and cofilin-actin rods in alzheimer disease

(2016) James R. Bamburg et al.   Cytoskeleton

Binding Sites for Amyloid-β Oligomers and Synaptic Toxicity

(2016) Levi M. Smith et al.   Cold Spring Harbor Perspectives in Medicine

Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity

(2016) Kanae Ando et al.   PLoS Genetics

TAR DNA-binding protein 43 and pathological subtype of Alzheimer's disease impact clinical features

(2015) Keith A. Josephs et al.   ANNALS OF NEUROLOGY

Erratum: Slingshot-Cofilin activation mediates mitochondrial and synaptic dysfunction via Aβ ligation to β1-integrin conformers

(2015) J A Woo et al.   CELL DEATH AND DIFFERENTIATION

ADF/cofilin: a crucial regulator of synapse physiology and behavior

(2015) Marco B. Rust   CELLULAR AND MOLECULAR LIFE SCIENCES

Coordinating Neuronal Actin–Microtubule Dynamics

(2015) Charlotte H. Coles et al.   CURRENT BIOLOGY

Coronin Enhances Actin Filament Severing by Recruiting Cofilin to Filament Sides and Altering F-Actin Conformation

(2015) Mouna A. Mikati et al.   JOURNAL OF MOLECULAR BIOLOGY

Configuration-specific immunotherapy targeting cis pThr231-Pro232 tau for Alzheimer disease

(2015) Jing-Zhang Wang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

RanBP9 at the intersection between cofilin and Aβ pathologies: rescue of neurodegenerative changes by RanBP9 reduction

(2015) J A Woo et al.   Cell Death & Disease

Inactivation of brain Cofilin-1 by age, Alzheimer's disease and γ-secretase

(2014) Eugenio Barone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Aip1 Destabilizes Cofilin-Saturated Actin Filaments by Severing and Accelerating Monomer Dissociation from Ends

(2014) Ambika V. Nadkarni et al.   CURRENT BIOLOGY

Aβ Selectively Impairs mGluR7 Modulation of NMDA Signaling in Basal Forebrain Cholinergic Neurons: Implication in Alzheimer's Disease

(2014) Zhenglin Gu et al.   JOURNAL OF NEUROSCIENCE

Aβ Influences Cytoskeletal Signaling Cascades with Consequences to Alzheimer’s Disease

(2014) Ana Gabriela Henriques et al.   MOLECULAR NEUROBIOLOGY

RanBP9 overexpression reduces dendritic arbor and spine density

(2014) H. Wang et al.   NEUROSCIENCE

Amyloid-β and Proinflammatory Cytokines Utilize a Prion Protein-Dependent Pathway to Activate NADPH Oxidase and Induce Cofilin-Actin Rods in Hippocampal Neurons

(2014) Keifer P. Walsh et al.   PLoS One

Cellular prion protein: A co-receptor mediating neuronal cofilin-actin rod formation induced by β-amyloid and proinflammatory cytokines

(2014) Keifer P Walsh et al.   Prion

PAK Inactivation Impairs Social Recognition in 3xTg-AD Mice without Increasing Brain Deposition of Tau and A 

(2013) D. Arsenault et al.   JOURNAL OF NEUROSCIENCE

Human LilrB2 Is a  -Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer's Model

(2013) T. Kim et al.   SCIENCE

Presenilins and  -Secretase: Structure, Function, and Role in Alzheimer Disease

(2013) B. De Strooper et al.   Cold Spring Harbor Perspectives in Medicine

Alzheimer Disease in 2020

(2013) D. M. Holtzman et al.   Cold Spring Harbor Perspectives in Medicine

Pivotal role of the RanBP9-cofilin pathway in Aβ-induced apoptosis and neurodegeneration

(2012) J A Woo et al.   CELL DEATH AND DIFFERENTIATION

β-Arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology

(2012) Xiaosong Liu et al.   CELL RESEARCH

Multiple roles for the actin cytoskeleton during regulated exocytosis

(2012) Natalie Porat-Shliom et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Axonal degeneration in Alzheimer's disease: When signaling abnormalities meet the axonal transport system

(2012) Nicholas M. Kanaan et al.   EXPERIMENTAL NEUROLOGY

Neuronal receptors as targets for the action of amyloid-beta protein (Aβ) in the brain

(2012) Aarti N. Patel et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Incorporation of Cofilin into Rods Depends on Disulfide Intermolecular Bonds: Implications for Actin Regulation and Neurodegenerative Disease

(2012) B. W. Bernstein et al.   JOURNAL OF NEUROSCIENCE

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease

(2012) Amantha Thathiah et al.   NATURE MEDICINE

Cofilin under control of  -arrestin-2 in NMDA-dependent dendritic spine plasticity, long-term depression (LTD), and learning

(2012) C. G. Pontrello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Life at the Leading Edge

(2011) Anne J. Ridley   CELL

Tau Protein Is Required for Amyloid  -Induced Impairment of Hippocampal Long-Term Potentiation

(2011) O. A. Shipton et al.   JOURNAL OF NEUROSCIENCE

Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation

(2011) Richard C Davis et al.   Molecular Neurodegeneration

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Interface between Cytoskeletal Aberrations and Mitochondrial Dysfunction in Alzheimer's Disease and Related Disorders

(2011) David E. Kang et al.   Experimental Neurobiology

ADF/Cofilin-Actin Rods in Neurodegenerative Diseases

(2010) J.R. Bamburg et al.   Current Alzheimer Research

β-Arrestins Scaffold Cofilin with Chronophin to Direct Localized Actin Filament Severing and Membrane Protrusions Downstream of Protease-activated Receptor-2

(2010) Maria Zoudilova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overlapping and distinct functions for cofilin, coronin and Aip1 in actin dynamics in vivo

(2010) M.-C. Lin et al.   JOURNAL OF CELL SCIENCE

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

ADF/Cofilin: a functional node in cell biology

(2010) Barbara W. Bernstein et al.   TRENDS IN CELL BIOLOGY

The E693Δ Mutation in Amyloid Precursor Protein Increases Intracellular Accumulation of Amyloid β Oligomers and Causes Endoplasmic Reticulum Stress-Induced Apoptosis in Cultured Cells

(2009) Kazuchika Nishitsuji et al.   AMERICAN JOURNAL OF PATHOLOGY

A fragment of the scaffolding protein RanBP9 is increased in Alzheimer’s disease brains and strongly potentiates amyloid-β peptide generation

(2009) Madepalli K. Lakshmana et al.   FASEB JOURNAL

Novel Role of RanBP9 in BACE1 Processing of Amyloid Precursor Protein and Amyloid β Peptide Generation

(2009) Madepalli K. Lakshmana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activated Actin-Depolymerizing Factor/Cofilin Sequesters Phosphorylated Microtubule-Associated Protein during the Assembly of Alzheimer-Like Neuritic Cytoskeletal Striations

(2009) I. T. Whiteman et al.   JOURNAL OF NEUROSCIENCE

Unbalancing the Phosphatidylinositol-4,5-bisphosphate–Cofilin Interaction Impairs Cell Steering

(2009) Shirley Leyman et al.   MOLECULAR BIOLOGY OF THE CELL

Reactive Oxygen Species Regulate a Slingshot-Cofilin Activation Pathway

(2009) Jun-Sub Kim et al.   MOLECULAR BIOLOGY OF THE CELL

The role of tau in neurodegeneration

(2009) Tania F Gendron et al.   Molecular Neurodegeneration

Oxidant-induced apoptosis is mediated by oxidation of the actin-regulatory protein cofilin

(2009) Fábio Klamt et al.   NATURE CELL BIOLOGY

Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot

(2009) Tim Eiseler et al.   NATURE CELL BIOLOGY

Cytoskeletal pathologies of Alzheimer disease

(2009) James R. Bamburg et al.   CELL MOTILITY AND THE CYTOSKELETON

A new amyloid β variant favoring oligomerization in Alzheimer's-type dementia

(2008) Takami Tomiyama et al.   ANNALS OF NEUROLOGY

Role of Axonal Transport in Neurodegenerative Diseases

(2008) Kurt J. De Vos et al.   Annual Review of Neuroscience

Chronophin Mediates an ATP-Sensing Mechanism for Cofilin Dephosphorylation and Neuronal Cofilin-Actin Rod Formation

(2008) Timothy Y. Huang et al.   DEVELOPMENTAL CELL

Structural Classification of Toxic Amyloid Oligomers

(2008) Charles G. Glabe   JOURNAL OF BIOLOGICAL CHEMISTRY

Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers

(2008) Hao Yuan Kueh et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial shuttling of CAP1 promotes actin- and cofilin-dependent apoptosis

(2008) C. Wang et al.   JOURNAL OF CELL SCIENCE

Microtubules in Dendritic Spine Development

(2008) J. Gu et al.   JOURNAL OF NEUROSCIENCE