期刊
MOLECULAR AND CELLULAR NEUROSCIENCE
卷 84, 期 -, 页码 11-28出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mcn.2017.03.008
关键词
Neuronal polarity; Feedback loops; Signaling; Cytoskeleton; Axonal growth
资金
- International Foundation for Research in Paraplegia (IRP)
- Wings for Life
- German Research Foundation (DFG)
- German Center for Neurodegenerative Diseases (DZNE)
Neuronal polarization establishes distinct molecular structures to generate a single axon and multiple dendrites. Studies over the past years indicate that this efficient separation is brought about by a network of feedback loops. Axonal growth seems to play a major role in fueling those feedback loops and thereby stabilizing neuronal polarity. Indeed, various effectors involved in feedback loops are pivotal for axonal growth by ultimately acting on the actin and microtubule cytoskeleton. These effectors have key roles in interconnecting actin and microtubule dynamics - a mechanism crucial to commanding the growth of axons. We propose a model connecting signaling with cytoskeletal dynamics and neurite growth to better describe the underlying processes involved in neuronal polarization. We will discuss the current views on feedback loops and highlight the current limits of our understanding. (C) 2017 The Authors. Published by Elsevier Inc.
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