Investigations of the Kinetics and Mechanism of Reduction of a Carboplatin Pt(IV) Prodrug by the Major Small-Molecule Reductants in Human Plasma

Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?

(2019) Reece G. Kenny et al.   CHEMICAL REVIEWS

Antitumor Platinium(IV) Prodrugs: A Systematic Computational Exploration of Their Reduction Mechanism by l-Ascorbic Acid

(2019) Eslam Dabbish et al.   INORGANIC CHEMISTRY

Structure elucidation and quantification of the reduction products of anticancer Pt(iv) prodrugs by electrochemistry/mass spectrometry (EC-MS)

(2018) L. M. Frensemeier et al.   ANALYST

Reduction of ormaplatin by an extended series of thiols unravels a remarkable correlation

(2018) Jingran Dong et al.   DALTON TRANSACTIONS

The impact of whole human blood on the kinetic inertness of platinum(iv) prodrugs – an HPLC-ICP-MS study

(2018) Sarah Theiner et al.   DALTON TRANSACTIONS

The side effects of platinum-based chemotherapy drugs: a review for chemists

(2018) Rabbab Oun et al.   DALTON TRANSACTIONS

Anticancer metallodrugs: where is the next cisplatin?

(2018) Muhammad Hanif et al.   Future Medicinal Chemistry

Redox Potentials for Tetraplatin, Satraplatin, Its Derivatives, and Ascorbic Acid: A Computational Study

(2018) Filip Šebesta et al.   INORGANIC CHEMISTRY

Effective platinum(IV) prodrugs conjugated with lonidamine as a functional group working on the mitochondria

(2018) Hong Chen et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A study on platinum(iv) species containing an estrogen receptor modulator to reverse tamoxifen resistance of breast cancer

(2018) Weiwei Hu et al.   Metallomics

Recent progress in polymer-based platinum drug delivery systems

(2018) Haihua Xiao et al.   PROGRESS IN POLYMER SCIENCE

Triple action Pt(iv) derivatives of cisplatin: a new class of potent anticancer agents that overcome resistance

(2018) Emanuele Petruzzella et al.   Chemical Science

Reduction of a platinum(iv) prodrug model by sulfur containing biological reductants: computational mechanistic elucidation

(2018) Antony Chipman et al.   CHEMICAL COMMUNICATIONS

Chlorambucil-conjugated platinum(IV) prodrugs to treat triple-negative breast cancer in vitro and in vivo

(2018) Zhong-Ying Ma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Kinetics and mechanism for reduction of Pt(IV) anticancer model compounds by Se-methyl L-selenocysteine. Comparison with L-selenomethionine

(2018) Chunli Liu et al.   JOURNAL OF MOLECULAR LIQUIDS

Platinum(IV) Prodrugs - A Step Closer to Ehrlich's Vision?

(2017) Reece G. Kenny et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Reduction of Cisplatin and Carboplatin Pt(IV) Prodrugs by Homocysteine: Kinetic and Mechanistic Investigations

(2017) Hongwu Tian et al.   INTERNATIONAL JOURNAL OF CHEMICAL KINETICS

Glycosylated Platinum(IV) Complexes as Substrates for Glucose Transporters (GLUTs) and Organic Cation Transporters (OCTs) Exhibited Cancer Targeting and Human Serum Albumin Binding Properties for Drug Delivery

(2017) Jing Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo

(2017) Josef Mayr et al.   Chemical Science

Reactivity of the glutathione species towards the reduction of ormaplatin (or tetraplatin)

(2016) Jingran Dong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Unique Use of Alkylation for Chemo-Redox Activity by a PtIV Prodrug

(2016) Rakesh K. Pathak et al.   CHEMISTRY-A EUROPEAN JOURNAL

Reduction of ormaplatin and cis-diamminetetrachloroplatinum(iv) by ascorbic acid and dominant thiols in human plasma: kinetic and mechanistic analyses

(2016) Jingran Dong et al.   DALTON TRANSACTIONS

Platinum complexes as light promoted anticancer agents: a redefined strategy for controlled activation

(2016) Koushambi Mitra   DALTON TRANSACTIONS

Halogenated PtIVComplexes fromN-Halosuccinimide Oxidation of PtIIAntitumor Drugs: Synthesis, Mechanistic Investigation, and Cytotoxicity

(2016) Zoufeng Xu et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

The molecular shape and the field similarities as criteria to interpret SAR studies for fragment-based design of platinum(IV) anticancer agents. Correlation of physicochemical properties with cytotoxicity

(2016) Julia Lorenzo et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Activation of Platinum(IV) Prodrugs by Cytochrome c and Characterization of the Protein Binding Sites

(2016) Alessia Lasorsa et al.   MOLECULAR PHARMACEUTICS

Oxidative halogenation of cisplatin and carboplatin: synthesis, spectroscopy, and crystal and molecular structures of Pt(iv) prodrugs

(2015) Timothy C. Johnstone et al.   DALTON TRANSACTIONS

Influence of reducing agents on the cytotoxic activity of platinum(iv) complexes: induction of G2/M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines

(2015) Verena Pichler et al.   Metallomics

A simple method for plasma total vitamin C analysis suitable for routine clinical laboratory use

(2015) Line Robitaille et al.   Nutrition Journal

The thiol pool in human plasma: The central contribution of albumin to redox processes

(2013) Lucía Turell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterization of the reaction products, kinetics and mechanism of oxidation of the drug captopril by platinum(iv) complexes

(2013) Shuying Huo et al.   RSC Advances

Dependence of the Reduction Products of Platinum(IV) Prodrugs upon the Configuration of the Substrate, Bulk of the Carrier Ligands, and Nature of the Reducing Agent

(2012) Marilù Sinisi et al.   INORGANIC CHEMISTRY

Platinum-Induced Ototoxicity in Children: A Consensus Review on Mechanisms, Predisposition, and Protection, Including a New International Society of Pediatric Oncology Boston Ototoxicity Scale

(2012) Penelope R. Brock et al.   JOURNAL OF CLINICAL ONCOLOGY

Quantitative measurement of the reduction of platinum(iv) complexes using X-ray absorption near-edge spectroscopy (XANES)

(2012) Matthew D. Hall et al.   Metallomics

Pt(iv) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate

(2011) Jenny Z. Zhang et al.   CHEMICAL COMMUNICATIONS

Reduction of Cisplatin-Induced Nephrotoxicity in Vivo by Selenomethionine: The Effect on Cisplatin–DNA Adducts

(2011) Daniel García Sar et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Clinical and pharmacokinetic evaluation of satraplatin

(2011) Gury Doshi et al.   Expert Opinion on Drug Metabolism & Toxicology

The status of platinum anticancer drugs in the clinic and in clinical trials

(2010) Nial J. Wheate et al.   DALTON TRANSACTIONS

The Rational Design of Anticancer Platinum Complexes: The Importance of the Structure-Activity Relationship

(2009) Angel Montana et al.   CURRENT MEDICINAL CHEMISTRY

Kinetics and Mechanism of the Oxidation of Ascorbic Acid in Aqueous Solutions by atrans-Dioxoruthenium(VI) Complex

(2008) Yi-Ning Wang et al.   INORGANIC CHEMISTRY