Article
Chemistry, Organic
Dajana Barisic, Mario Pajic, Ivan Halasz, Darko Babic, Manda Curic
Summary: This study describes the direct and selective mechanochemical halogenation of C-H bonds in unsymmetrically substituted azobenzenes using N-halosuccinimides as the halogen source in a ball mill. The reaction occurs in the absence or presence of PdII catalysts depending on the azobenzene substrate used. In situ Raman spectroscopy, ex situ NMR spectroscopy, and PXRD analysis were used to gain insight into the reaction dynamics and characterization of the products. The different 4,4'-substituents of azobenzene were found to have a strong influence on the halogenation time and mechanism.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Materials Science, Biomaterials
Jean Felix Mukerabigwi, Yu Han, Nannan Lu, Wendong Ke, Yuheng Wang, Qinghao Zhou, Fathelrahman Mohammed, Alhadi Ibrahim, Bin Zheng, Zhishen Ge
Summary: Novel strategy utilizing vesicular nanoreactors for simultaneous cisplatin delivery and H2O2 generation can overcome drug resistance in lung cancer cells, enhancing therapeutic efficacy without obvious toxic side effects.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Review
Biochemistry & Molecular Biology
David Schweer, J. Robert McCorkle, Jurgen Rohr, Oleg V. Tsodikov, Frederick Ueland, Jill Kolesar
Summary: Ovarian cancer is a highly deadly malignancy with poor outcomes in cases of platinum-based chemotherapy resistance, highlighting the importance of novel therapeutic approaches. Recent advancements in semisynthetic methods have led to mithramycin analogs with improved pharmacological properties that show potential in treating platinum-resistant ovarian cancer by inhibiting the activity of the transcription factor Sp1.
Article
Biochemistry & Molecular Biology
Mariafrancesca Hyeraci, Laura Agnarelli, Luca Labella, Fabio Marchetti, Maria Luisa Di Paolo, Simona Samaritani, Lisa Dalla Via
Summary: Resistance to cisplatin limits its usefulness as an anticancer drug. This study describes the synthesis and characterization of two new platinum complexes and demonstrates their potential in overcoming cisplatin resistance in cancer cells. The complexes exhibited poor ability to platinate DNA but showed significant intracellular accumulation. Mechanistic studies revealed their ability to inhibit DNA relaxation and activate the apoptotic pathway. Comparison with related complexes provides insights into the resistance phenotype.
Article
Chemistry, Multidisciplinary
Kai Xiong, Cheng Ouyang, Jiaqi Liu, Johannes Karges, Xinlin Lin, Xiang Chen, Yu Chen, Jian Wan, Liangnian Ji, Hui Chao
Summary: This study developed highly potent G-quadruplex stabilizers, which can maintain their efficacy even under crowded cellular conditions. The stabilizers were encapsulated in DNA cages to enhance sub-cellular localization and provide cancer selectivity. The resulting nanomaterials efficiently inhibit telomerase activity in drug-resistant cancer cells and induce cell death.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Pharmacology & Pharmacy
Patricia Fernandez de Larrinoa, Jordan Parmentier, Antoine Kichler, Thierry Achard, Monique Dontenwill, Christel Herold-Mende, Sylvie Fournel, Benoit Frisch, Beatrice Heurtault, Stephane Bellemin-Laponnaz
Summary: A novel series of platinum(II) complexes modified with the mitochondria targeting group triphenylphosphonium were synthesized, which showed significantly higher anticancer activity on cancer stem cell line compared to oxaliplatin. Mechanistic studies revealed that these complexes altered mitochondrial function and induced atypical cell death.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Thermodynamics
Svetla Todinova, Biliana Nikolova, Ivan Iliev, Severina Semkova, Sashka Krumova, Stefka G. Taneva
Summary: This study examines and compares the effects of two anticancer drugs on different breast cancer and normal cell lines, revealing distinct responses to drug treatment. The thermal behavior and viability of cancer cells are significantly altered by the drugs, suggesting changes in protein conformation and cellular structures.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Oncology
Francesca Ricci, Alessandro Corbelli, Roberta Affatato, Rosaria Chila, Michela Chiappa, Laura Brunelli, Robert Fruscio, Roberta Pastorelli, Fabio Fiordaliso, Giovanna Damia
Summary: Our study found that acquisition of DDP resistance is associated with morphological alterations in mitochondria, despite the lack of dysregulation in the studied genes/proteins that could explain the observed differences.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Oncology
Glenn F. Van Wigcheren, Nienke De Haas, Tom A. Mulder, Sophie K. Horrevorts, Martine Bloemendal, Simone Hins-Debree, Yumeng Mao, Rolf Kiessling, Carla M. L. van Herpen, Georgina Florez-Grau, Stanleyson V. Hato, I. Jolanda M. De Vries
Summary: Research has shown that platinum-based chemotherapeutics can interfere with the development of suppressive M-MDSCs, potentially synergizing with cancer immunotherapy to reduce immune suppression and enhance treatment response.
Article
Biochemistry & Molecular Biology
Kevin P. Gillespie, Ross Pirnie, Clementina Mesaros, Ian A. Blair
Summary: It has been found that cisplatin treatment can induce secretion of HMGB1 from human non-small cell lung cancer cells, while carboplatin cannot. This secretion is dose-dependent and regulated by nuclear exportin 1. Additionally, the secreted HMGB1 after cisplatin treatment is mainly in the fully reduced form.
Article
Nanoscience & Nanotechnology
Mengjun Zhang, Haodi Yue, Xin Huang, Jialin Wang, Zengbei Li, Xinjie Deng
Summary: This study demonstrates the anti-tumor effects of polyethylenimine-caged platinum nanoclusters on cisplatin-resistant ovarian cancer cells, inhibiting proliferation and migration while promoting apoptosis. The study also validates the role of these nanoclusters in regulating autophagy through the PI3K-AKT-mTOR signaling pathway. These findings suggest the promising potential of platinum nanoclusters as a novel chemotherapeutic agent for cisplatin-resistant ovarian cancer.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Haiyan Xu, Lanping Hu, Guanghua Zhu, Yueping Zhu, Yang Wang, Zheng-Guang Wu, You Zi, Weichun Huang
Summary: A simple and practical method for synthesizing aromatic halides has been developed using the Lewis base DABCO as a catalyst. This method proceeds conveniently and efficiently at ambient conditions, providing the desired products in good to excellent yields and selectivity.
Article
Biochemistry & Molecular Biology
Young Joo Lee, Sung Wook Kim, Min Hyung Jung, Young Sun Kim, Kyung Sook Kim, Dong Soo Suh, Ki Hyung Kim, Eun Ha Choi, Jongmin Kim, Byung Su Kwon
Summary: Ovarian cancer stem-like cells (CSCs) are sensitive to plasma-activated medium (PAM) treatment, which inhibits CSC traits and exhibits synergistic cytotoxicity with cisplatin (CDDP). This study suggests that PAM could be a promising intraperitoneal chemotherapy for ovarian cancer, enhancing antitumor efficacy and reducing side effects.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Inorganic & Nuclear
Yuewen Sun, Enmao Yin, Yehong Tan, Tao Yang, Dongfan Song, Suxing Jin, Zijian Guo, Xiaoyong Wang
Summary: Platinum-based anticancer drug DCP can effectively induce immunogenic cell death, stimulating the antitumor immune response and increasing cytotoxicity to cancer cells.
DALTON TRANSACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Mohamed A. El-Atawy, Mai S. Alsubaie, Mohammed L. Alazmi, Ezzat A. Hamed, Demiana H. Hanna, Hoda A. Ahmed, Alaa Z. Omar
Summary: "The preparation of N,N-diarylurea and N,N-diarylthiourea derivatives successfully revealed their therapeutic effects on human MCF-7 cancer cells. Among them, Diarylthiourea (compound 4) showed the highest efficacy with the most effective IC50 value (338.33±1.52 μM) and no cytotoxic effects on normal human lung cells (wi38 cells)."
Article
Chemistry, Inorganic & Nuclear
Shu Chen, Ka-Yan Ng, Qiyuan Zhou, Houzong Yao, Zhiqin Deng, Man-Kit Tse, Guangyu Zhu
Summary: This study synthesized six mono-carbonated Pt(iv) complexes with axial carbonate ligands of various electron-withdrawing abilities, and prepared corresponding mono-carboxylated analogues as references to investigate the differences in hydrolysis and reduction rates. It was found that mono-carbonated Pt(iv) complexes are less stable and reduced faster compared to mono-carboxylated ones, and the hydrolysis and reduction profiles depend on both the electron-withdrawing ability of the carbonates and the nature of the opposite axial ligands.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Physical
Di Zhang, Jie Zou, Weilong Chen, Shek-Man Yiu, Man-Kit Tse, Jingdong Luo, Alex K-Y Jen
Summary: This study reports the synthesis and analysis of structure-property relationship of dipolar heptamethines containing a strong electron acceptor. The results show that these compounds have lower electro-optic activities but better chemical and thermal stability and higher synthetic efficacy. By fine-tuning the structure and properties of the molecules, larger nonlinear optical effects have been achieved in photonic devices.
CHEMISTRY OF MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Chi-Fung Yeung, Sik-Him Tang, Zhe Yang, Tsun-Yin Li, Ka-Kit Li, Yuen-Man Chan, Hau-Lam Shek, Kai-Wa Io, King-Ting Tam, Shek-Man Yiu, Man-Kit Tse, Chun-Yuen Wong
Summary: In this study, several ruthenium complexes were synthesized and evaluated for their potential as anticancer agents.
Article
Chemistry, Inorganic & Nuclear
Hau -Lam Shek, King -Ting Tam, Shek-Man Yiu, Man-Kit Tse, Robert H. Morris, Chun-Yuen Wong
Summary: Osmafuran complexes were prepared from reactions between dichloro-Os(II) complexes and allenols in alcoholic solvents. Structural analysis revealed a rearrangement mechanism of allenolates and theoretical calculations supported the proposed mechanism. The osmafurans synthesized in this study did not follow common metal-allene reaction patterns.
Article
Chemistry, Inorganic & Nuclear
Yanpeng Liu, Houzong Yao, Man-Kit Tse, Shu Chen, Shek-Man Yiu, Guangyu Zhu
Summary: By designing and synthesizing a Pt(IV) monotrifluoromethyl complex, we have increased its reactivity and discovered its ability to react with phosphates via the S(N)2 nucleophilic substitution pathway, which is different from traditional Pt(II) drugs. This complex exhibits cytotoxicity in human ovarian cancer cells and may serve as a potential new anticancer agent.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Chen Cao, Ji-Hua Tan, Ze-Lin Zhu, Jiu-Dong Lin, Hong-Ji Tan, Huan Chen, Yi Yuan, Man-Kit Tse, Wen-Cheng Chen, Chun-Sing Lee
Summary: By intramolecular cyclization in a carbonyl/N resonant core (QAO), a deep-blue emitter (CZ2CO) with a peak wavelength of 440 nm and an ultranarrow spectral FWHM of 16 nm (0.10 eV) was developed. CZ2CO exhibits excellent performance that complies with the BT.2020 standard. Additionally, a hyper-fluorescent device based on CZ2CO achieves a high maximum external quantum efficiency (EQE(max)) of 25.6% and maintains an EQE of 22.4% at a practical brightness of 1000 cd m(-2).
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Libei Huang, Le Cheng, Tinghao Ma, Jun-Jie Zhang, Haikun Wu, Jianjun Su, Yun Song, He Zhu, Qi Liu, Minghui Zhu, Zhiyuan Zeng, Qiyuan He, Man-Kit Tse, Deng-tao Yang, Boris I. Yakobson, Ben Zhong Tang, Yang Ren, Ruquan Ye
Summary: Amorphous graphene synthesized by laser induction is shown to efficiently electrocatalyze the reduction of nitrate to ammonia, with high conversion efficiency and production rate. This method has significant potential for the on-demand synthesis of ammonia in agriculture and pharmaceutical industries, resulting in increased yields and survival rates for plant cultivation.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Qiyuan Zhou, Shu Chen, Zoufeng Xu, Gongyuan Liu, Shuyuan Zhang, Zhigang Wang, Man-Kit Tse, Shek-Man Yiu, Guangyu Zhu
Summary: This study reports the synthesis of Pt-IV complexes bearing axial pyridines through ligand exchange reactions. It was discovered that these axial pyridines can be quickly released after reduction, indicating their potential as axial leaving groups. Two multitargeted Pt-IV prodrugs containing bioactive pyridinyl ligands, a PARP inhibitor and an EGFR tyrosine kinase inhibitor, were successfully obtained using this method. These conjugates show great potential for overcoming drug resistance, with the latter inhibiting the growth of Pt-resistant tumor in vivo. This research expands the synthetic methods for Pt-IV prodrugs and increases the range of bioactive axial ligands that can be conjugated to a Pt-IV center.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Hau-Lam Shek, Chi-Fung Yeung, Lai-Hon Chung, Man-Kit Tse, Shek-Man Yiu, Chun-Yuen Wong
Summary: Systematic investigation of the reactions between cis-[M(dppm)(2)Cl-2] (M=Ru/Os; dppm=1,1-bis(diphenylphosphino)methane) and pyridine/quinoline substituted homopropargylic alcohols revealed diverse Ru(II)/Os(II)-induced alkyne activation pathways. At lower temperatures, alkynes cyclized on M via a non-vinylidene pathway, forming alkenyl intermediates that further metallacyclized to give metallapyrroloindolizines. Conversely, at higher temperatures, alkyne cyclization on M occurred via a vinylidene pathway, resulting in cyclic oxacarbene complexes. A rare decyclization mechanism was observed during the transformation of a metallacyclization-resistant alkenyl complex into a cyclic oxacarbene complex. DFT calculations confirmed the experimental findings. Overall, these results provide insights into controlling alkyne activation pathways and offer new strategies for preparing metalated heterocyclic and metallacyclic complexes.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Multidisciplinary Sciences
Gongyuan Liu, Yachao Zhang, Houzong Yao, Zhiqin Deng, Shu Chen, Yue Wang, Wang Peng, Guohan Sun, Man-Kit Tse, Xianfeng Chen, Jianbo Yue, Yung-Kang Peng, Lidai Wang, Guangyu Zhu
Summary: In this work, cyaninplatin, a Pt(IV) anticancer prodrug, is introduced, which can be activated by ultrasound. The sono-activation of cyaninplatin leads to strengthened mitochondrial DNA damage and cell killing efficiency, along with overcoming drug resistance. This study demonstrates the practical utility of ultrasound in activating Pt(IV) anticancer prodrugs for the eradication of deep tumor lesions.
Article
Chemistry, Physical
Yelan Xiao, Yecheng Leng, Xinxin Lu, Shun-Cheung Cheng, Hao Huang, Man-Kit Tse, Jiechun Liang, Wenguang Tu, Chi-Chiu Ko, Xi Zhu, Lu Wang, Yong Zhou, Yingfang Yao, Zhigang Zou
Summary: Photocatalytic radical fluoroalkylation is an important method to prepare organofluorine compounds. This study introduces a cost-effective and recyclable heterogeneous photocatalysis using cyano-modified graphitic carbon nitride as the photocatalyst. The photocatalytic process is attributed to the long-lived triplet excited states and the strong interaction between the catalyst and substrate. Moreover, the catalyst shows high performance, wide reaction scope, and can be easily recovered and reused for multiple catalytic cycles.
JOURNAL OF CATALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Jana Kasparkova, Hana Kostrhunova, Vojtech Novohradsky, Lili Ma, Guangyu Zhu, Elena R. Milaeva, Alexender A. Shtill, Robin Vinck, Gilles Gasser, Viktor Brabec, Alexey A. Nazarov
Summary: This study investigated the mechanism of action of a Pt(IV) complex 2 with two axial lonidamine ligands, which selectively inhibit aerobic glycolysis. Compared to the parent Pt(II) complex, the presence of two lonidamine ligands increased the antiproliferative activity of complex 2, influenced its cell cycle profile and mechanism of cell death. In 3D cell culture, complex 2 exhibited exceptional antiproliferative activity.
Article
Chemistry, Multidisciplinary
Zhiqin Deng, Cai Li, Shu Chen, Qiyuan Zhou, Zoufeng Xu, Zhigang Wang, Houzong Yao, Hajime Hirao, Guangyu Zhu
Summary: Selective activation of prodrugs at diseased tissue through bioorthogonal catalysis using Pt(iv) complexes with internal photoswitches shows promise for precision cancer treatment. These complexes exhibit significantly increased photoconversion efficiency and photocytotoxicity compared to conventional platforms, demonstrating potential for highly effective prodrugs in medical applications.
Article
Chemistry, Physical
Yelan Xiao, Yuen-Kiu Chun, Shun-Cheung Cheng, Chi-On Ng, Man-Kit Tse, Ngai-Yu Lei, Ruoyang Liu, Chi-Chiu Ko
Summary: This study successfully prepared perfluoroalkyl amides and esters through photoredox catalysis, investigating the effects and mechanisms of different photocatalysts, and conducting detailed experimental and computational analyses.
CATALYSIS SCIENCE & TECHNOLOGY
(2021)