Exploring the Interface between Inflammatory and Therapeutic Glucocorticoid Induced Bone and Muscle Loss

Glucocorticoid receptor in stromal cells is essential for glucocorticoid-mediated suppression of inflammation in arthritis

(2018) Mascha Koenen et al.   ANNALS OF THE RHEUMATIC DISEASES

11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis

(2018) R.S. Hardy et al.   JOURNAL OF AUTOIMMUNITY

The role of microRNAs in glucocorticoid action

(2018) Sally A. Clayton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pre-treatment with Pamidronate Improves Bone Mechanical Properties in Mdx Mice Treated with Glucocorticoids

(2018) Jinghan Chen et al.   CALCIFIED TISSUE INTERNATIONAL

New Insights in Glucocorticoid Receptor Signaling—More Than Just a Ligand-Binding Receptor

(2017) Karin Scheschowitsch et al.   Frontiers in Endocrinology

Defining conditions where long-term glucocorticoid treatment has an acceptably low level of harm to facilitate implementation of existing recommendations: viewpoints from an EULAR task force

(2016) Cindy Strehl et al.   ANNALS OF THE RHEUMATIC DISEASES

11β-Hydroxysteroid dehydrogenase type 1 within muscle protects against the adverse effects of local inflammation

(2016) Rowan S Hardy et al.   JOURNAL OF PATHOLOGY

Inflammation induced loss of skeletal muscle

(2015) Priya Londhe et al.   BONE

Insulin-like growth factor-1 (IGF-1) promotes myoblast proliferation and skeletal muscle growth of embryonic chickens via the PI3K/Akt signalling pathway

(2015) Minli Yu et al.   CELL BIOLOGY INTERNATIONAL

Tbx6, Mesp-b and Ripply1 regulate the onset of skeletal myogenesis in zebrafish

(2015) S. E. Windner et al.   DEVELOPMENT

Inflammatory Markers and Risk of Hip Fracture in Older White Women: The Study of Osteoporotic Fractures

(2014) Kamil E Barbour et al.   JOURNAL OF BONE AND MINERAL RESEARCH

11 -HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess

(2014) S. A. Morgan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding Coupling between Bone Resorption and Formation

(2013) Thomas L. Andersen et al.   AMERICAN JOURNAL OF PATHOLOGY

High dickkopf-1 levels in sera and leukocytes from children with 21-hydroxylase deficiency on chronic glucocorticoid treatment

(2013) Giacomina Brunetti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

11β-Hydroxysteroid Dehydrogenase 1: Translational and Therapeutic Aspects

(2013) Laura L. Gathercole et al.   ENDOCRINE REVIEWS

IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro

(2013) Shoichi Kaneshiro et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting

(2012) Sudarsanareddy Lokireddy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Role of IGF-I and the TNFα/NF-κB pathway in the induction of muscle atrogenes by acute inflammation

(2012) O. Schakman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inflammatory regulation of glucocorticoid metabolism in mesenchymal stromal cells

(2012) Mohammad M. Ahasan et al.   ARTHRITIS AND RHEUMATISM

Corticosteroids and β2-agonists upregulate mitogen-activated protein kinase phosphatase 1: in vitro mechanisms

(2012) M Manetsch et al.   BRITISH JOURNAL OF PHARMACOLOGY

Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy

(2012) Rita A. Hanna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory markers and the risk of hip fracture: The women's health initiative

(2012) Kamil E Barbour et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

(2012) Lingling Xian et al.   NATURE MEDICINE

Recognizing and treating secondary osteoporosis

(2012) Karen Walker-Bone   Nature Reviews Rheumatology

Plasma and Muscle Myostatin in Relation to Type 2 Diabetes

(2012) Claus Brandt et al.   PLoS One

Effects of an 11β-hydroxysteroid dehydrogenase type 1 inhibitor, MK-0916, in patients with type 2 diabetes mellitus and metabolic syndrome

(2011) P. U. Feig et al.   DIABETES OBESITY & METABOLISM

11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice

(2011) Agnes E. Coutinho et al.   ENDOCRINOLOGY

Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease

(2011) Liping Zhang et al.   FASEB JOURNAL

Muscle actin is polyubiquitinylated in vitro and in vivo and targeted for breakdown by the E3 ligase MuRF1

(2011) Cécile Polge et al.   FASEB JOURNAL

Apoptotic osteocytes regulate osteoclast precursor recruitment and differentiation in vitro

(2011) Saja A. Al-Dujaili et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models

(2011) Stefano Schiaffino et al.   Skeletal Muscle

Glucocorticoids Suppress Bone Formation by Attenuating Osteoblast Differentiation via the Monomeric Glucocorticoid Receptor

(2010) Alexander Rauch et al.   Cell Metabolism

The 11- -Hydroxysteroid Dehydrogenase Type 1 Inhibitor INCB13739 Improves Hyperglycemia in Patients With Type 2 Diabetes Inadequately Controlled by Metformin Monotherapy

(2010) J. Rosenstock et al.   DIABETES CARE

Autophagy in skeletal muscle

(2010) Marco Sandri   FEBS LETTERS

Sepsis increases the expression and activity of the transcription factor Forkhead Box O 1 (FOXO1) in skeletal muscle by a glucocorticoid-dependent mechanism

(2010) Ira J. Smith et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The spectrum of celiac disease: epidemiology, clinical aspects and treatment

(2010) Greetje J. Tack et al.   Nature Reviews Gastroenterology & Hepatology

The Translation Regulatory Subunit eIF3f Controls the Kinase-Dependent mTOR Signaling Required for Muscle Differentiation and Hypertrophy in Mouse

(2010) Alfredo Csibi et al.   PLoS One

Dendritic processes of osteocytes are mechanotransducers that induce the opening of hemichannels

(2010) S. Burra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The science of muscle hypertrophy: making dietary protein count

(2010) Stuart M. Phillips   PROCEEDINGS OF THE NUTRITION SOCIETY

The Mechanism of Mineralization and the Role of Alkaline Phosphatase in Health and Disease

(2010) Hideo Orimo   JOURNAL OF NIPPON MEDICAL SCHOOL

Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids: implications for inflammation associated bone loss

(2009) K. Kaur et al.   ANNALS OF THE RHEUMATIC DISEASES

A novel T cell cytokine, secreted osteoclastogenic factor of activated T cells, induces osteoclast formation in a RANKL-independent manner

(2009) Leonard Rifas et al.   ARTHRITIS AND RHEUMATISM

Biphasic Glucocorticoid-Dependent Regulation of Wnt Expression and Its Inhibitors in Mature Osteoblastic Cells

(2009) Wendy Mak et al.   CALCIFIED TISSUE INTERNATIONAL

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation

(2009) Shenhav Cohen et al.   JOURNAL OF CELL BIOLOGY

Osteoclastogenesis in Children with 21-Hydroxylase Deficiency on Long-Term Glucocorticoid Therapy: The Role of Receptor Activator of Nuclear Factor-κB Ligand/Osteoprotegerin Imbalance

(2009) Maria Felicia Faienza et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Bone loss in inflammatory disorders

(2009) R Hardy et al.   JOURNAL OF ENDOCRINOLOGY

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

(2009) Yi Tang et al.   NATURE MEDICINE

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of Atrogin-1/MAFbx Mediated MyoD Proteolysis Prevents Skeletal Muscle Atrophy In Vivo

(2009) Julie Lagirand-Cantaloube et al.   PLoS One

Correlates of osteoporosis in chronic obstructive pulmonary disease: An underestimated systemic component

(2009) Lidwien Graat-Verboom et al.   RESPIRATORY MEDICINE

Bone mineral density in rheumatoid arthritis patients 1 year after adalimumab therapy: arrest of bone loss

(2008) C A Wijbrandts et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-6 Directly Inhibits Osteoclast Differentiation by Suppressing Receptor Activator of NF-κB Signaling Pathways

(2008) Fumio Yoshitake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atp6v0d2 Is an Essential Component of the Osteoclast-Specific Proton Pump That Mediates Extracellular Acidification in Bone Resorption

(2008) Haiping Wu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Circulating Levels of Inflammatory Markers Predict Change in Bone Mineral Density and Resorption in Older Adults: A Longitudinal Study

(2008) Changhai Ding et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

Changes in bone mineral density in patients with recent onset, active rheumatoid arthritis

(2007) M Guler-Yuksel et al.   ANNALS OF THE RHEUMATIC DISEASES

How corticosteroids control inflammation: Quintiles Prize Lecture 2005

(2006) Peter J Barnes   BRITISH JOURNAL OF PHARMACOLOGY