Article
Cell Biology
Wenyuan G. Zhu, Jamie E. Hibbert, Kuan Hung Lin, Nathaniel D. Steinert, Jake L. Lemens, Kent W. Jorgenson, Sarah M. Newman, Dudley W. Lamming, Troy A. Hornberger
Summary: This study demonstrates that weight pulling can lead to increased muscle mass in mice and induce changes associated with long-term adaptations similar to those observed in humans, such as muscle fiber hypertrophy and myonuclear accretion.
Article
Cardiac & Cardiovascular Systems
Ningning Guo, Di Zheng, Jiaxin Sun, Jian Lv, Shun Wang, Yu Fang, Zhenyi Zhao, Sai Zeng, Qiuxiao Guo, Jingjing Tong, Zhihua Wang
Summary: Nap1l5 plays a crucial role in regulating protein synthesis and hypertrophy in cardiomyocytes, and its overexpression exacerbates hypertrophic effects. Knockdown of Nap1l5 reverses the transcriptional reprogramming associated with hypertrophy, highlighting its potential as a target for therapeutic interventions in cardiac hypertrophy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cell Biology
Kaitlin R. Morrison, William J. Smiles, Naomi X. Y. Ling, Ashfaqul Hoque, Gabrielle Shea, Kevin R. W. Ngoei, Dingyi Yu, Lisa Murray-Segal, John W. Scott, Sandra Galic, Bruce. E. Kemp, Janni Petersen, Jonathan S. Oakhill
Summary: AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin complex 1 (mTORC1) are metabolic kinases that co-ordinate nutrient supply with cell growth. This study reveals an α2-specific mechanism by which AMPK can be activated at lysosomes in the absence of changes in cellular energy. Loss of α2-S345 phosphorylation in endogenous AMPK fails to sustain cell growth under amino acid starvation conditions.
Article
Agriculture, Multidisciplinary
Dingding Zhang, Jingli Tao, Xuan Zhang, Xiangfei Ma, Chengyu Li, Hongmin Li, Weijian Li, Jie Chen, Honglin Liu
Summary: This study reveals the role of neoruscogenin in muscle growth by inhibiting MSTN maturation and promoting protein synthesis metabolism. It also shows its potential in repairing muscle injuries. These findings have important implications for the treatment of muscle disorders and the livestock industry.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Cell Biology
Haiyuan Mu, Ting Zhang, Ying Yang, Danru Zhang, Jie Gao, Junhong Li, Liang Yue, Dengfeng Gao, Bingbo Shi, Yue Han, Liang Zhong, Xinze Chen, Zhen-Bo Wang, Zhen Lin, Ming-Han Tong, Qing-Yuan Sun, Yun-Gui Yang, Jianyong Han
Summary: m(6)A modification plays essential roles in follicle development and oocyte growth, regulating oocyte meiosis by enhancing RNA stability.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Liang Wang, Taru Hilander, Xiaonan Liu, Hoi Ying Tsang, Ove Eriksson, Christopher B. Jackson, Markku Varjosalo, Hongxia Zhao
Summary: This study identifies GTPBP8 as a crucial factor in the assembly of the mitoribosomal large subunit (mt-LSU) and mitochondrial translation. Depletion of GTPBP8 leads to abnormal accumulation of mt-LSU and compromised mitochondrial function.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Immunology
Angela M. M. Gocher-Demske, Jian Cui, Andrea L. L. Szymczak-Workman, Kate M. M. Vignali, Julianna N. N. Latini, Gwen P. P. Pieklo, Jesse C. C. Kimball, Lyndsay Avery, Ellyse M. M. Cipolla, Brydie R. R. Huckestein, Lee Hedden, Marlies Meisel, John F. F. Alcorn, Lawrence P. P. Kane, Creg J. J. Workman, Dario A. A. Vignali
Summary: Unlike IL12, IFN gamma can induce a T helper 1-like state in regulatory T (T-reg) cells during viral infection in mice that suppresses effector T cell responses and memory formation.
Article
Cell Biology
Zhenbin Wang, Lei Zhang, Bing Li, Jiagui Song, Miao Yu, Jing Zhang, Ceshi Chen, Jun Zhan, Hongquan Zhang
Summary: This study reveals the importance of Kindlin-2 in myoepithelium in controlling the transition of luminal progenitors to alveolar cells during gestation. Kindlin-2 activates Stat3 and upregulates Dll1 to inhibit Notch signaling pathway, promoting the differentiation of luminal progenitors. Loss of Kindlin-2 reduces the proportion of matured alveolar cells. Inhibition of Notch1 with tangeretin restores the commitment ability of luminal progenitors in mice with Kindlin-2 depletion in myoepithelium.
CELL DEATH & DISEASE
(2023)
Article
Oncology
So-ichiro Fukada, Naoki Ito
Summary: Skeletal muscles have plasticity and can adapt to mechanical load induced by physical activity by increasing myofiber size and myonuclear number. Protein synthesis and MuSCs play important roles in this process. However, the signaling pathways promoting protein synthesis and the necessity of MuSCs in muscle hypertrophy are still controversial issues.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Immunology
Salida Mirzoeva, Yuchen Yang, Anna Klopot, Irina Budunova, Melissa A. Brown
Summary: REDD1 is an essential immune modulator that influences the initiation and effector phase of ACD disease by driving naive T cell activation and promoting immune cell trafficking in T cell-mediated skin inflammation.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jin Li, Tingting Yang, Haifei Tang, Zhao Sha, Rui Chen, Lei Chen, Yan Yu, Glenn C. Rowe, Saumya Das, Junjie Xiao
Summary: lncMAAT is identified as a common regulator of skeletal muscle atrophy, which is downregulated in multiple models and can ameliorate muscle atrophy by negatively regulating miR29b and positively regulating Mbnl1 expression. Overexpression of lncMAAT may represent a promising therapy for muscle atrophy induced by different stimuli.
Review
Immunology
Andres R. Munoz-Rojas, Diane Mathis
Summary: T-reg cells located in non-lymphoid tissues exhibit distinct transcriptomes, T cell receptor repertoires, and dependencies on growth factors which allow them to function effectively in their home tissue. These cells play crucial roles in tissue homeostasis, metabolism, tissue repair, and regulating the fate of non-lymphoid cell progenitors. Their specialized functions are influenced by transcriptional programs which differ based on the tissue environment, providing potential targets for precision immunotherapeutics.
NATURE REVIEWS IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Carlos Palma-Flores, Paola B. Zarate-Segura, J. Manuel Hernandez-Hernandez, Sergio de los Santos, Andrea S. Tejeda-Gomez, Luis Javier Cano-Martinez, Patricia Canto, Jorge Omar Garcia-Rebollar, Ramon M. Coral-Vazquez
Summary: This study demonstrates that (-)-epicatechin upregulates miRNAs involved in muscle adaptation, induces muscle hypertrophy, and increases the level of myogenic proteins.
Article
Plant Sciences
Muhammad Uzair, Haixin Long, Syed Adeel Zafar, Suyash B. Patil, Yan Chun, Lu Li, Jingjing Fang, Jinfeng Zhao, Lixiang Peng, Shoujiang Yuan, Xueyong Li
Summary: Leaf morphology is influenced by various factors and this study focused on the translational regulation of key factors involved in leaf development using a rice nal21 mutant as a model. The study revealed that RPS3A plays a crucial role in regulating translation of ARFs and WOX3A through uORFs, ultimately affecting leaf morphology and development.
Article
Gastroenterology & Hepatology
Bernhard Kloesch, Vivien Ionasz, Sumit Paliwal, Natascha Hruschka, Jaime Martinez de Villarreal, Rupert Ollinger, Sebastian Mueller, Hans Peter Dienes, Martin Schindl, Elisabeth S. Gruber, Judith Stift, Dietmar Herndler-Brandstetter, Gwen A. Lomberk, Barbara Seidler, Dieter Saur, Roland Rad, Raul A. Urrutia, Francisco X. Real, Paola Martinelli
Summary: The loss of GATA6 is identified as a necessary factor for the development of highly aggressive PDAC subtype, along with the concomitant loss of HNF1A and HNF4A. Deletion of Gata6 in mice significantly increases the metastatic rate of tumors, with a propensity for lung metastases.
Editorial Material
Neurosciences
Valentin Dablainville, Anthony M. J. Sanchez
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Review
Biochemistry & Molecular Biology
Robert Solsona, Laura Pavlin, Henri Bernardi, Anthony M. J. Sanchez
Summary: This investigation focuses on the mechanisms involved in the regulation of skeletal muscle mass, with an emphasis on proteosynthesis and new organelle production. The critical roles of the mammalian/mechanistic target of rapamycin complex 1 (mTORC1) pathway and its regulators are discussed, along with the importance of ribosome biogenesis, satellite cells involvement, myonuclear accretion, and epigenetic modifications related to protein synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Anastasiya Borsch, Daniel J. Ham, Nitish Mittal, Lionel A. Tintignac, Eugenia Migliavacca, Jerome N. Feige, Markus A. Ruegg, Mihaela Zavolan
Summary: This study utilized phenotypic measurements and RNA-Seq data from mice, rats, and humans to assess the relevance of rodent models for human muscle aging. The findings suggest that rodents can recapitulate some aspects of human sarcopenia, such as mitochondrial changes and inflammatory responses. Additionally, phenotypic measurements like muscle mass were found to be better indicators of muscle health than chronological age in aging-related molecular data analysis.
COMMUNICATIONS BIOLOGY
(2021)
Editorial Material
Neurosciences
Robert Solsona, Anthony M. J. Sanchez
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Sport Sciences
Fabio Borrani, Robert Solsona, Robin Candau, Thibaut Meline, Anthony M. J. Sanchez
Summary: This study examined the suitability of a model with exponential terms (Exp-Model) in elite short-track speed skaters. The findings suggest that Exp-Model may better describe training adaptations in elite short-track speed skaters than Imp-Model.
JOURNAL OF SPORTS SCIENCES
(2021)
Article
Physiology
Killian Salzmann, Anthony M. J. Sanchez, Fabio Borrani
Summary: This study found that applying different levels of blood flow restriction (BFR) during heavy cycling exercise can slow down the main phase time of VO2, increase the amplitude of the slow component, and accelerate the phase 3 amplitude of O-2 extraction kinetics. This suggests that using BFR in heavy exercise may shift the muscles to a more oxygen-dependent situation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Physiology
Robert Solsona, Hugues Berthelot, Fabio Borrani, Anthony M. J. Sanchez
Summary: The study found that sprint interval exercises (SIT) with gravity-induced blood flow restriction (G-BFR) led to lower mechanical, cardiorespiratory, and skeletal muscle oxygenation responses compared to other conditions. Training with BFR at 60% occlusive pressure (BFR60) resulted in higher blood accumulation in working muscles, potentially affecting cellular stress. Both hypoxia (HYP) and G-BFR induced local hypoxia, with G-BFR showing higher levels during both exercise bouts and recovery periods.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Food Science & Technology
Rim Nassar, Barbara Vernus, Gilles Carnac, Gilles Fouret, Benedicte Goustard, Francois Casas, Lionel Tintignac, Isabelle Cassar-Malek, Brigitte Picard, Iban Seiliez, Thomas Brioche, Christelle Koechlin-Ramonatxo, Christelle Bertrand-Gaday, Aline Hamade, Fadia Najjar, Beatrice Chabi, Anne Bonnieu
Summary: Myostatin deficiency leads to increased protein degradation in post-mortem muscle, primarily through enhanced calpain activity. Autophagy, ubiquitin-proteasome, and caspase systems are not upregulated in this process.
Article
Computer Science, Information Systems
Denis Maurel, Sandy Chery, Nicole Bidoit, Philippe Chatalic, Aziza Filali, Christine Froidevaux, Anne Poupon
Summary: G protein-coupled receptors (GPCRs) are membrane receptors that control cellular responses to signals. They are ideal targets for drug development, but only a small percentage of GPCRs are targeted by drugs due to a lack of knowledge about the cellular events triggered by these receptors. The ABLISS project aims to automatically build GPCRs networks by utilizing natural language processing to extract information from scientific papers. The extracted facts are stored in a relational database for later use.
Editorial Material
Neurosciences
Tom Normand-Gravier, Robert Solsona, Anthony M. J. Sanchez
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Physiology
Robert Solsona, Romeo Deriaz, Fabio Borrani, Anthony M. J. Sanchez
Summary: This study compared muscle deoxygenation and reoxygenation kinetics during a sprint interval protocol under four different modalities. It found that reoxygenation was delayed in the blood flow restriction condition, and reoxygenation was slower in the gravity-induced blood flow restriction condition.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Astrid Musnier, Thomas Bourquard, Amandine Vallet, Laetitia Mathias, Gilles Bruneau, Mohammed Akli Ayoub, Ophelie Travert, Yannick Corde, Nathalie Gallay, Thomas Boulo, Sandra Cortes, Herve Watier, Pascale Crepieux, Eric Reiter, Anne Poupon
Summary: Developing therapeutic antibodies is a complex and expensive process, and there is currently no computer simulation method to solve the problems involved. Researchers have found that by measuring the similarity between antibody CDRs (including structural features and sequence identity), they can identify antibody families that recognize similar epitopes and use this information to discover new antibodies for specific targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Margaux Giovanna, Robert Solsona, Anthony M. J. Sanchez, Fabio Borrani
Summary: Peak aerobic power, exercise duration, maximal accumulated oxygen deficit, and VO2 were improved after six RST sessions. However, combined hypoxic stress or partial BFR did not further increase peak aerobic power.
JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY
(2022)
Article
Biology
Marco S. Kaiser, Giulia Milan, Daniel J. Ham, Shuo Lin, Filippo Oliveri, Kathrin Chojnowska, Lionel A. Tintignac, Nitish Mittal, Christian E. Zimmerli, David J. Glass, Mihaela Zavolan, Markus A. Rueegg
Summary: Muscle size is regulated by the PI3K-PKB/Akt-mTORC1-FoxO pathway, which controls protein synthesis and breakdown. Paradoxically, while mTORC1 activity is necessary for muscle hypertrophy, its constant activation promotes protein breakdown through the UPS. This study highlights the importance of mTORC1-mediated PKB/Akt inhibition and the role of the UPS in muscle atrophy and proteome integrity.
COMMUNICATIONS BIOLOGY
(2022)
Article
Sport Sciences
Robert Solsona, Thibaut Meline, Fabio Borrani, Romeo Deriaz, Jerome Lacroix, Tom Normand-Gravier, Robin Candau, Sebastien Racinais, Anthony M. J. Sanchez
Summary: This study compared the effects of three different recovery methods in elite athletes and found that coldwater immersion may slightly impair performance outcomes compared to active recovery and hot-water immersion. More research is needed to confirm these findings.
JOURNAL OF SPORTS SCIENCES
(2023)