Targeting the Oncogenic p53 Mutants in Colorectal Cancer and Other Solid Tumors

JQ-1 Inhibits Colon Cancer Proliferation via Suppressing Wnt/β-Catenin Signaling and miR-21

(2018) Yan Zhang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The relationship between the PD-1/PD-L1 pathway and DNA mismatch repair in cervical cancer and its clinical significance

(2018) Yang-chun Feng et al.   Cancer Management and Research

Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion

(2018) Ramona Schulz-Heddergott et al.   CANCER CELL

Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mutant p53 targeting by the low molecular weight compound STIMA-1

(2017) Nicole Zache et al.   Molecular Oncology

Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation

(2017) M Nakayama et al.   ONCOGENE

Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling

(2017) Homa Rahnamoun et al.   Nature Communications

Dual SIRT1 expression patterns strongly suggests its bivalent role in human breast cancer

(2017) Khaldoun Rifaï et al.   Oncotarget

MiR-590-3p regulates osteogenic differentiation of human mesenchymal stem cells by regulating APC gene

(2016) Siyuan Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epigenetic blockade of neoplastic transformation by bromodomain and extra-terminal (BET) domain protein inhibitor JQ-1

(2016) Chengyue Zhang et al.   BIOCHEMICAL PHARMACOLOGY

A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas

(2016) Alice Soragni et al.   CANCER CELL

Design and synthesis of a C7-aryl piperlongumine derivative with potent antimicrotubule and mutant p53-reactivating properties

(2016) Surendra R. Punganuru et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

TP53Variations in Human Cancers: New Lessons from the IARC TP53 Database and Genomics Data

(2016) Liacine Bouaoun et al.   HUMAN MUTATION

Colorectal cancer is a leading cause of cancer incidence and mortality among adults younger than 50 years in the USA: a SEER-based analysis with comparison to other young-onset cancers

(2016) Abhishek Bhandari et al.   JOURNAL OF INVESTIGATIVE MEDICINE

2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells

(2016) Matthias R. Bauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer therapeutic approach based on conformational stabilization of mutant p53 protein by small peptides

(2016) Perry Tal et al.   Oncotarget

COTI-2, a novel small molecule that is active against multiple human cancer cell lines in vitro and in vivo

(2016) Kowthar Y. Salim et al.   Oncotarget

Mutant p53 (p53-R248Q) functions as an oncogene in promoting endometrial cancer by up-regulating REGγ

(2015) Huihui Wang et al.   CANCER LETTERS

Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53

(2015) Shengliang Zhang et al.   CANCER RESEARCH

Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis

(2015) Masatsugu Hiraki et al.   CHEMISTRY & BIOLOGY

YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins

(2015) Silvia Di Agostino et al.   EMBO REPORTS

Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulateVEGFR2in breast cancer cells

(2015) Neil T. Pfister et al.   GENES & DEVELOPMENT

Mutant p53 Promotes Tumor Cell Malignancy by Both Positive and Negative Regulation of the Transforming Growth Factor β (TGF-β) Pathway

(2015) Lei Ji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment

(2015) E. M. Alexandrova et al.   NATURE

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

(2015) Jiajun Zhu et al.   NATURE

p53mutations in colorectal cancer- molecular pathogenesis and pharmacological reactivation

(2015) Xiao-Lan Li   WORLD JOURNAL OF GASTROENTEROLOGY

Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities

(2015) Madhusudhan Kollareddy et al.   Nature Communications

Targeting Oncogenic Mutant p53 for Cancer Therapy

(2015) Alejandro Parrales et al.   Frontiers in Oncology

A Novel PTEN/Mutant p53/c-Myc/Bcl-XL Axis Mediates Context-Dependent Oncogenic Effects of PTEN with Implications for Cancer Prognosis and Therapy

(2015) Xiaoping Huang et al.   NEOPLASIA

Gain-of-function of mutant p53: mutant p53 enhances cancer progression by inhibiting KLF17 expression in invasive breast carcinoma cells

(2014) Amjad Ali et al.   CANCER LETTERS

p53 as a target for the treatment of cancer

(2014) Michael J. Duffy et al.   CANCER TREATMENT REVIEWS

Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

(2014) Susann Weissmueller et al.   CELL

Mutant p53–associated myosin-X upregulation promotes breast cancer invasion and metastasis

(2014) Antti Arjonen et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

A mutant p53/let-7i-axis-regulated gene network drives cell migration, invasion and metastasis

(2014) M Subramanian et al.   ONCOGENE

Arsenic Trioxide Reactivates Proteasome-Dependent Degradation of Mutant p53 Protein in Cancer Cells in Part via Enhanced Expression of Pirh2 E3 Ligase

(2014) Wensheng Yan et al.   PLoS One

Unequal prognostic potentials of p53 gain-of-function mutations in human cancers associate with drug-metabolizing activity

(2014) J Xu et al.   Cell Death & Disease

Heat-shock factor 1 both positively and negatively affects cellular clonogenic growth depending on p53 status

(2013) Chau H. Nguyen et al.   BIOCHEMICAL JOURNAL

Degradation of NF-κB, p53 and other regulatory redox-sensitive proteins by thiol-conjugating and -nitrosylating drugs in human tumor cells

(2013) Ameya Paranjpe et al.   CARCINOGENESIS

Chaperone-mediated autophagy degrades mutant p53

(2013) H. Vakifahmetoglu-Norberg et al.   GENES & DEVELOPMENT

Mutant p53 Regulates Dicer through p63-dependent and -independent Mechanisms to Promote an Invasive Phenotype

(2013) Patricia A. J. Muller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small molecule induced reactivation of mutant p53 in cancer cells

(2013) Xiangrui Liu et al.   NUCLEIC ACIDS RESEARCH

Differential regulation of the REGγ–proteasome pathway by p53/TGF-β signalling and mutant p53 in cancer cells

(2013) Amjad Ali et al.   Nature Communications

Allele specific gain-of-function activity of p53 mutants in lung cancer cells

(2012) Catherine A. Vaughan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Potential tumorigenic programs associated with TP53 mutation status reveal role of VEGF pathway

(2012) H Joshi et al.   BRITISH JOURNAL OF CANCER

Allele-Specific p53 Mutant Reactivation

(2012) Xin Yu et al.   CANCER CELL

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Molecular Pathways: Targeting Mdm2 and Mdm4 in Cancer Therapy

(2012) Q. Li et al.   CLINICAL CANCER RESEARCH

Mutant p53R273Hattenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species

(2012) Eyal Kalo et al.   JOURNAL OF CELL SCIENCE

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

R280T mutation of p53 gene promotes proliferation of human glioma cells through GSK-3β/PTEN pathway

(2012) Chenli Lin et al.   NEUROSCIENCE LETTERS

Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion

(2012) P A J Muller et al.   ONCOGENE

Mutant p53 gain-of-function induces epithelial–mesenchymal transition through modulation of the miR-130b–ZEB1 axis

(2012) P Dong et al.   ONCOGENE

A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer

(2011) Javier E. Girardini et al.   CANCER CELL

Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migration

(2011) W.Andrew Yeudall et al.   CARCINOGENESIS

Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs

(2011) Rosa Puca et al.   CELL CYCLE

SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis

(2011) D Li et al.   CELL DEATH AND DIFFERENTIATION

PRIMA-1Met/APR-246 Induces Apoptosis and Tumor Growth Delay in Small Cell Lung Cancer Expressing Mutant p53

(2011) R. Zandi et al.   CLINICAL CANCER RESEARCH

Mutant p53 Protein Is Targeted by Arsenic for Degradation and Plays a Role in Arsenic-mediated Growth Suppression

(2011) Wensheng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TopBP1 Mediates Mutant p53 Gain of Function through NF-Y and p63/p73

(2011) K. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells

(2011) D. Li et al.   MOLECULAR CANCER RESEARCH

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

Mutant p53-induced Up-regulation of Mitogen-activated Protein Kinase Kinase 3 Contributes to Gain of Function

(2010) Aymone Gurtner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SCH529074, a Small Molecule Activator of Mutant p53, Which Binds p53 DNA Binding Domain (DBD), Restores Growth-suppressive Function to Mutant p53 and Interrupts HDM2-mediated Ubiquitination of Wild Type p53

(2010) Mark Demma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gambogic acid-induced degradation of mutant p53 is mediated by proteasome and related to CHIP

(2010) Jia Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

(2010) S. Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilization of mutant p53 via alkylation of cysteines and effects on DNA binding

(2010) Joel L. Kaar et al.   PROTEIN SCIENCE

PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

(2009) Jeremy M.R. Lambert et al.   CANCER CELL

Mutant p53 Drives Invasion by Promoting Integrin Recycling

(2009) Patricia A.J. Muller et al.   CELL

A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

(2009) Maddalena Adorno et al.   CELL

Identification of GRO1 as a Critical Determinant for Mutant p53 Gain of Function

(2009) Wensheng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis

(2009) Giulia Fontemaggi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53

(2009) S. Sur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 hot-spot mutants increase tumor vascularization via ROS-mediated activation of the HIF1/VEGF-A pathway

(2008) N.V. Khromova et al.   CANCER LETTERS

A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis

(2008) L Weinmann et al.   CELL DEATH AND DIFFERENTIATION

Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway

(2008) J. E. Kravchenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted rescue of a destabilized mutant of p53 by an in silico screened drug

(2008) F. M. Boeckler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA