Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation

Suppressing TGF  Signaling in Regenerating Epithelia in an Inflammatory Microenvironment Is Sufficient to Cause Invasive Intestinal Cancer

(2015) H. Oshima et al.   CANCER RESEARCH

Gut stem cells, a story of snails, flies and mice

(2015) M. Amoyel   EMBO JOURNAL

Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulateVEGFR2in breast cancer cells

(2015) Neil T. Pfister et al.   GENES & DEVELOPMENT

Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment

(2015) E. M. Alexandrova et al.   NATURE

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

(2015) Jiajun Zhu et al.   NATURE

Toward recreating colon cancer in human organoids

(2015) Ameen A Salahudeen et al.   NATURE MEDICINE

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

(2014) Patricia A.J. Muller et al.   CANCER CELL

Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling

(2014) Susann Weissmueller et al.   CELL

A combination of Wnt and growth factor signaling induces Arl4c expression to form epithelial tubular structures

(2014) S. Matsumoto et al.   EMBO JOURNAL

Mutant p53 Reprograms TNF Signaling in Cancer Cells through Interaction with the Tumor Suppressor DAB2IP

(2014) Giulio Di Minin et al.   MOLECULAR CELL

A cell-intrinsic role for TLR2–MYD88 in intestinal and breast epithelia and oncogenesis

(2014) Ferenc A. Scheeren et al.   NATURE CELL BIOLOGY

Arl4c expression in colorectal and lung cancers promotes tumorigenesis and may represent a novel therapeutic target

(2014) S Fujii et al.   ONCOGENE

Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer

(2013) Tomer Cooks et al.   CANCER CELL

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State

(2012) Wenjun Guo et al.   CELL

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

(2012) Sarah Schwitalla et al.   CELL

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion

(2012) P A J Muller et al.   ONCOGENE

SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis

(2011) D Li et al.   CELL DEATH AND DIFFERENTIATION

Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells

(2011) D. Li et al.   MOLECULAR CANCER RESEARCH

p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma

(2010) Brendan Doyle et al.   JOURNAL OF PATHOLOGY

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

Mutant p53 Drives Invasion by Promoting Integrin Recycling

(2009) Patricia A.J. Muller et al.   CELL

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

(2009) J. P. Morton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA