Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1

Flow Cytometric Analysis of Myeloid Cells in Human Blood, Bronchoalveolar Lavage, and Lung Tissues

(2016) Yen-Rei A. Yu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Enhanced Innate Inflammation Induced by Anti-BTLA Antibody in Dual Insult Model of Hemorrhagic Shock/Sepsis

(2016) Tingting Cheng et al.   SHOCK

Up-regulation of Programmed Cell Death 1 Ligand 1 on Neutrophils May Be Involved in Sepsis-induced Immunosuppression

(2015) Jia-Feng Wang et al.   ANESTHESIOLOGY

Acute-Phase Deaths from Murine Polymicrobial Sepsis Are Characterized by Innate Immune Suppression Rather Than Exhaustion

(2015) Evan L. Chiswick et al.   JOURNAL OF IMMUNOLOGY

Marked alterations of neutrophil functions during sepsis-induced immunosuppression

(2015) Julie Demaret et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Myeloid-Derived Suppressor Cells and Therapeutic Strategies in Cancer

(2015) Hiroshi Katoh et al.   MEDIATORS OF INFLAMMATION

Social networking of human neutrophils within the immune system

(2014) P. Scapini et al.   BLOOD

Circulating Immature Granulocytes With T-Cell Killing Functions Predict Sepsis Deterioration*

(2014) Estelle Guérin et al.   CRITICAL CARE MEDICINE

Complexity and challenges in defining myeloid-derived suppressor cells

(2014) Vera Damuzzo et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis

(2014) Albert Dahdah et al.   JOURNAL OF CLINICAL INVESTIGATION

Cross-Linking of B7-H1 on EBV-Transformed B Cells Induces Apoptosis through Reactive Oxygen Species Production, JNK Signaling Activation, and fasL Expression

(2014) Y. S. Kim et al.   JOURNAL OF IMMUNOLOGY

A high frequency of MDSCs in sepsis patients, with the granulocytic subtype dominating in gram-positive cases

(2014) Helena Janols et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The new normal: immunomodulatory agents against sepsis immune suppression

(2014) Noelle A. Hutchins et al.   TRENDS IN MOLECULAR MEDICINE

Immune Suppression by Neutrophils in HIV-1 Infection: Role of PD-L1/PD-1 Pathway

(2014) Nathan L. Bowers et al.   PLoS Pathogens

The Multifaceted Functions of Neutrophils

(2013) Tanya N. Mayadas et al.   Annual Review of Pathology-Mechanisms of Disease

Immune suppression by neutrophils and granulocytic myeloid-derived suppressor cells: similarities and differences

(2013) Janesh Pillay et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Innate Immune Functions of Immature Neutrophils in Patients With Sepsis and Severe Systemic Inflammatory Response Syndrome*

(2013) Geneviève Drifte et al.   CRITICAL CARE MEDICINE

Identification of B7-H1 as a Novel Mediator of the Innate Immune/Proinflammatory Response as well as a Possible Myeloid Cell Prognostic Biomarker in Sepsis

(2013) X. Huang et al.   JOURNAL OF IMMUNOLOGY

Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach

(2013) Richard S Hotchkiss et al.   LANCET INFECTIOUS DISEASES

Severe Sepsis and Septic Shock

(2013) Derek C. Angus et al.   NEW ENGLAND JOURNAL OF MEDICINE

The changing immune system in sepsis

(2013) Jonathan S Boomer et al.   Virulence

Myeloid-derived suppressor cells in sepsis: friend or foe?

(2012) Alex G. Cuenca et al.   INTENSIVE CARE MEDICINE

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Interleukin-7 Ameliorates Immune Dysfunction and Improves Survival in a 2-Hit Model of Fungal Sepsis

(2012) Jacqueline Unsinger et al.   JOURNAL OF INFECTIOUS DISEASES

Programmed Death 1 Expression as a Marker for Immune and Physiological Dysfunction in the Critically Ill Surgical Patient

(2012) Sean F. Monaghan et al.   SHOCK

Generation of Nitric Oxide and Reactive Oxygen Species by Neutrophils and Monocytes From Septic Patients and Association With Outcomes

(2012) Sidnéia Sousa Santos et al.   SHOCK

Mechanisms of Indirect Acute Lung Injury

(2011) Sean F. Monaghan et al.   ANNALS OF SURGERY

Myeloid derived suppressor cells in human diseases

(2011) Tim F. Greten et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

(2011) Jonathan S. Boomer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The PD-1/PD-L1 (B7-H1) Pathway in Chronic Infection-Induced Cytotoxic T Lymphocyte Exhaustion

(2011) Kimberly A. Hofmeyer et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1

(2011) Janesh Pillay et al.   JOURNAL OF CLINICAL INVESTIGATION

Unknown

(2011) Alex Cuenca et al.   MOLECULAR MEDICINE

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Characterization and Modulation of the Immunosuppressive Phase of Sepsis

(2010) J. T. Muenzer et al.   INFECTION AND IMMUNITY

IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis

(2010) J. Unsinger et al.   JOURNAL OF IMMUNOLOGY

The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria

(2008) B. O. Fabriek et al.   BLOOD