Article
Pharmacology & Pharmacy
Weijie Zhang, Zhongyue Zhang, Shitong Lou, Zhiwei Chang, Baohong Wen, Tao Zhang
Summary: This paper reports the synthesis of hyaluronic acid-stabilized Fe3O4 nanoparticles, which exhibit good colloidal stability and targeting ability, and demonstrate effectiveness as contrast agents for MRI in both in vitro and in vivo models.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Rujuan Wang, Haotong Yang, Abdur Rauf Khan, Xiaoye Yang, Jiangkang Xu, Jianbo Ji, Guangxi Zhai
Summary: Hyaluronic acid combined with cystamine to form nanoparticles showed improved uptake and drug release in tumor cells, indicating great potential for enhancing cancer treatment outcomes.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Xiyang Sun, Ye Xu, Qingkui Guo, Ning Wang, Bin Wu, Chen Zhu, Wen Zhao, Wenliang Qiang, Min Zheng
Summary: This study successfully constructed a targeted nanoprobe that can efficiently load the photosensitive drug ICG into lung cancer cells. The nanoprobe not only has excellent ICG loading and stability, but also improves the efficiency of thermal conversion and singlet oxygen generation, resulting in optimal photothermal/photodynamic therapy effects.
Article
Biochemistry & Molecular Biology
Hong Yu Yang, Jia Meng Du, Moon-Sun Jang, Xin Wang Mo, Xin Shun Sun, Doo Sung Lee, Jung Hee Lee, Yan Fu
Summary: EPNGs were successfully fabricated for CD44-targeted transport of cytochrome c through UV-triggered chemical cross-linking, showing stable and high protein encapsulation efficiency in blood circulation and rapid release in targeted tumor cells.
Article
Pharmacology & Pharmacy
Hagar I. Mohamed, Amal H. El-Kamel, Ghada O. Hammad, Lamia A. Heikal
Summary: This study formulated hyaluronic acid-coated bovine serum albumin nanoparticles loaded with flurbiprofen for the treatment of arthritis. The nanoparticles exhibited good physicochemical properties and demonstrated a promising therapeutic effect in both in-vitro and in-vivo studies.
Article
Pharmacology & Pharmacy
Zahra Jamshidi, Taraneh Sadat Zavvar, Mohammad Ramezani, Mona Alibolandi, Farzin Hadizadeh, Khalil Abnous, Seyed Mohammad Taghdisi
Summary: This study aimed to establish a new targeted and controlled release drug delivery system for the treatment of breast cancer by conjugating doxorubicin (DOX) with hyaluronic acid (HA). The results showed that the dual-targeted formulation exhibited significant advantages in terms of cellular uptake and cytotoxicity in positive cell lines, and demonstrated superior efficacy and minimal side effects in a mouse model.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Medicine, Research & Experimental
Wenguang Wang, Xingli Wang, Feng Tao, Kaiyuan Hu, Junying Zhang, Jinhui Wu, Linjun You, Weijun Zhao
Summary: In this study, O-2@PFC@FHA NPs were developed to deliver oxygen safely and specifically to tumors, thereby relieving tumor hypoxia. The combination of radiotherapy with O-2@PFC@FHA NPs resulted in almost threefold therapeutic improvement compared with radiotherapy alone, without causing obvious systemic toxicity.
MOLECULAR PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Dingcheng Zhu, Huijie Yan, Yaofeng Zhou, Leroy M. Nack, Junqiu Liu, Wolfgang J. Parak
Summary: The efficiency of delivering nanoparticles to targeted tissues, such as tumors, greatly affects their therapeutic and diagnostic effects. The size of nanoparticles is crucial in determining tissue penetration and retention. Nanoassemblies of larger nanoparticles are favorable for prolonged blood circulation and enhanced tumor accumulation. These nanoassemblies can dissociate at the target site and release smaller nanoparticles, benefiting their distribution and clearance. This review summarizes the design strategies and applications of stimuli-responsive disintegrable nanoassemblies in various fields.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Mostafa Zamani, Mozhgan Aghajanzadeh, Setare Jashnani, S. Shirin Shahangian, Farhad Shirini
Summary: In this project, various photosensitizers were prepared using different ratios of nickel, manganese, and iron. The efficiency of these photosensitizers were evaluated through multiple analyses, and the most suitable one was coated with hyaluronic acid to enhance biocompatibility and targeting ability. Riboflavin was also used as a chemical targeting agent to further improve the targeting ability. Spectroscopy and thermal analysis were used to determine the physical and chemical characteristics of the prepared nano-platform. In vitro and in vivo tests were conducted to determine its biocompatibility, and the results showed that the prepared nano-platform had great potential as a dual photo and chemo therapy agent for breast cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Qihang Ding, Ling Mei, Yu Liu, Shan Zhou, Lu Chen, Yuying Liang, Mingle Li, Hui Zhou, Chao Yin, Jong Seung Kim
Summary: Researchers constructed a D-A type-based NIR-II fluorophore with mitochondria targeting, which demonstrated both photothermal effect and photodynamic performance. They further fabricated nanodots with DSPE-mPEG for in vivo experiments, achieving strong NIR-II fluorescence tracing of tumors and impressive NIR-II image-guided photodynamic therapy and photothermal therapy.
CHEMICAL COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Prashant Kesharwani, Rahul Chadar, Afsana Sheikh, Waleed Y. Rizg, Awaji Y. Safhi
Summary: Cluster of differentiation 44 (CD44) is a cell surface glycoprotein overexpressed in various solid tumors. It plays a significant role in cell proliferation, cell-to-cell interaction, cellular migration, inflammation, and immune responses. Nanocarriers have been developed to target the CD44 receptor and improve the efficacy of chemotherapy. Hyaluronic acid (HA) also plays a crucial role in cancer therapy and interacts with CD44, providing a potential approach for targeted therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Eunkyeong Jung, Soonyoung Kwon, Nanhee Song, Nuri Kim, Hanui Jo, Manseok Yang, Sangjun Park, Chunho Kim, Dongwon Lee
Summary: Cancer cells possess antioxidants that hinder the effectiveness of photodynamic therapy (PDT). Additionally, upregulation of pro-angiogenic factors during PDT-induced hypoxia is another challenge. To overcome these obstacles, tumor targeted redox-regulating and antiangiogenic phototherapeutic nanoassemblies (tRAPs) were developed. tRAPs effectively depleted intracellular GSH and suppressed VEGF, enhancing the therapeutic outcomes of PDT.
Article
Medicine, Research & Experimental
Tingting Xiao, Wei Hu, Yu Fan, Mingwu Shen, Xiangyang Shi
Summary: The study developed a novel nanosystem integrated with macrophages for tumor therapy. By encapsulating hyaluronic acid nanogels with polypyrrole photothermal agent and anticancer drug doxorubicin, tumor homing and combination photothermo-chemotherapy were achieved. The results showed that the hybrid nanosystem has good targeting capability and enhanced antitumor therapy effect.
Article
Chemistry, Multidisciplinary
Hai-Yan Wang, Yan Zhang, Xing-Hui Ren, Xi-Wen He, Wen-You Li, Yu-Kui Zhang
Summary: In this study, a biocompatible, tumor-targeted nanoplatform (HIDSi(Gd)NPs@PDA-HA) based on HMONs was developed for accurate tumor-targeting and synergistic therapy. The nano-carrier promoted endocytosis in cancer cells, released DOX in response to tumor microenvironment, and utilized ICG for photothermal therapy, achieving multi-mode imaging-guided therapy. The results in tumor-bearing mice demonstrated excellent therapeutic efficacy, indicating the potential of this multifunctional nanomaterial for precise diagnosis and efficient treatment.
Article
Nanoscience & Nanotechnology
Ningning Song, Bo Li, Dandan Li, Yunwen Yan
Summary: In this study, a Zr-based metal-organic framework (MOF) modified with hyaluronic acid (HA) was developed for two-photon activated photodynamic therapy (PDT) in triple negative breast cancer (TNBC). The composite ZrTc@HA exhibited significant two-photon activity and excellent light-triggered reactive oxygen species generation ability. It can serve as a diagnostic probe for fluorescence imaging and a therapeutic agent for PDT, showing great potential for monotherapy and synergistic phototherapy in TNBC.
Article
Biochemistry & Molecular Biology
Song Yi Lee, Hyun-Jong Cho
Article
Pharmacology & Pharmacy
Sang Yeob Park, Zion Kang, Prakash Thapa, Yong Suk Jin, Joo Won Park, Hye Jung Lim, Jae Young Lee, Sa-Won Lee, Min-Hyo Seo, Min-Soo Kim, Seong Hoon Jeong
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Biochemistry & Molecular Biology
Jeong-Jun Lee, Young-Min Han, Tae-Wan Kwon, Dong Hyun Kim, Han Sol Lee, Woo Jin Jung, Jina Kim, Sujin Kang, Sang Kyum Kim, Cheong-Weon Cho, Keong-Ryoon Lee, Dae-Duk Kim, Min Chul Park, Jae-Young Lee
Article
Medicine, Legal
Ji-Young Kim, Sunyeong Lee, Yongbum Kim, Eun Ju Jeong, In Hyun Lee, Min-Hee Son, Jae Young Lee, Sang Kyum Kim, Kyoung-Sik Moon
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
JunHyung Lee, Abdolreza Hosseindoust, MinJu Kim, KwangYeol Kim, YoHan Choi, SeokHee Lee, SongYi Lee, HyunJong Cho, Wei Soo Kang, ByungJo Chae
BIOLOGICAL TRACE ELEMENT RESEARCH
(2020)
Review
Chemistry, Medicinal
Dong Hyun Kim, Han Sol Lee, Tae-Wan Kwon, Young-Min Han, Nae-Won Kang, Mee Yeon Lee, Dae-Duk Kim, Myeong Gyu Kim, Jae-Young Lee
ARCHIVES OF PHARMACAL RESEARCH
(2020)
Article
Pharmacology & Pharmacy
Chao-Feng Mu, Fude Cui, Yong-Mei Yin, Hyun-Jong Cho, Dae-Duk Kim
Article
Pharmacology & Pharmacy
Min-Hwan Kim, Ju-Hwan Park, Duy-Thuc Nguyen, Sungyun Kim, Da In Jeong, Hyun-Jong Cho, Dae-Duk Kim
Summary: An HAase inhibitor-incorporated hyaluronic acid hydrogel was designed to reduce toxicity risk and slow biodegradation rate in subcutaneous tissue. The hydrogel, formulated with Quercetin as an HAase inhibitor and quetiapine as a model drug, exhibited sustained drug release and improved pharmacokinetic parameters in rats following subcutaneous injection. All results supported the designed hydrogel as a biocompatible formulation for sustained drug delivery.
Article
Pharmacology & Pharmacy
Nae-Won Kang, So-Yeon Yoon, Sungho Kim, Na-Young Yu, Ju-Hwan Park, Jae-Young Lee, Hyun-Jong Cho, Dae-Duk Kim
Summary: The study developed a hybrid hydrogel containing microstructured lipid carriers and human serum albumin for sustained release of donepezil, which prolonged drug release and reduced initial plasma concentration in rats. The hydrogel exhibited good biocompatibility and therapeutic efficacy.
Article
Nanoscience & Nanotechnology
Min-Jun Baek, Duy-Thuc Nguyen, Dahan Kim, So-Yeol Yoo, Sang Min Lee, Jae-Young Lee, Dae-Duk Kim
Summary: The study presents the design of a tailored structure for renal-clearable zwitterionic cyclodextrin for selective drug delivery in colorectal cancer. Twenty cyclodextrin derivatives were synthesized and screened for colloidal stability, resulting in five candidates that were evaluated for biodistribution and an optimized structure was identified. The optimized cyclodextrin demonstrated high tumour accumulation and improved antitumour efficacy in colorectal cancer models.
NATURE NANOTECHNOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Jae-Young Lee, Yae-Seul Lee, Dong Hyun Kim, Han Sol Lee, Bo Ram Yang, Myeong Gyu Kim
Summary: This study evaluated the use of social media in detecting new black box warnings, labeling changes, or withdrawals in advance. Results showed that social media could detect signals 3 months to 9 years before regulatory authorities take action. Challenges remain in using social media for pharmacovigilance, particularly in terms of coverage, data quality, and analytic processing. Further studies are needed to improve natural language processing and data mining on social media.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2021)
Article
Pharmacology & Pharmacy
Sung-Jin Kim, Young-Guk Na, Hong-Ki Lee, Hye-Jin Lee, Miao Wang, Hyun Wook Huh, Han-Sol Lee, Jae-Young Lee, Cheong-Weon Cho
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2020)
Article
Materials Science, Biomaterials
Song Yi Lee, Eun-Hye Hong, Jae Young Jeong, Jaewon Cho, Ji-Hye Seo, Hyun-Jeong Ko, Hyun-Jong Cho
BIOMATERIALS SCIENCE
(2019)
Article
Agriculture, Dairy & Animal Science
JunHyung Lee, Abdolreza Hosseindoust, MinJu Kim, KwangYeol Kim, YoHan Choi, Joseph Moturi, ChangHyun Song, SongYi Lee, HyunJong Cho, ByungJo Chae
JOURNAL OF ANIMAL SCIENCE AND TECHNOLOGY
(2019)
Review
Pharmacology & Pharmacy
Hyun-Jong Cho
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2020)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.