Article
Engineering, Chemical
Suada Djukaj, Jiri Kolar, Robert Lehocky, Ales Zadrazil, Frantisek Stepanek
Summary: Dissolution testing is widely used to measure drug release rate and behavior. An optimization framework is proposed to design a PSD that results in a prescribed dissolution profile, reducing experimental time. The model shows good agreement between simulated and experimental data, indicating the framework's potential to determine the required PSD efficiently.
Article
Chemistry, Analytical
Yuxiao Wei, Isaac J. Pence, Anna Wiatrowski, Julia B. Slade, Conor L. Evans
Summary: Pharmaceutical development of solid-state formulations requires chemical imaging techniques to analyze the solid-state properties for ensuring drug efficacy and stability. Current chemical imaging techniques have high chemical and spatial resolution but lack the necessary measurement speed for pharmaceutical production and quality assurance processes. To address this issue, fast chemical imaging using stimulated Raman scattering can quantitatively analyze the degradation and distribution of drugs at a faster speed and higher resolution.
Article
Biochemistry & Molecular Biology
Chi Uyen Phan, Jie Shen, Kaxi Yu, Jianming Mao, Guping Tang
Summary: The study demonstrated that the needle-shaped crystal habit (ST-B) of sorafenib tosylate had a larger hydrophilic surface than the plate-shaped crystal habit (ST-A), resulting in a higher dissolution rate and a substantial enhancement of the in vivo pharmacokinetic performance of ST-B.
Article
Energy & Fuels
Shuaiwei Gu, Zhizhong Yang, Zhen Chen, Haiming Wang, Hanzi Liu, Wei Zhang, Changfu You
Summary: The utilization of low-grade limestone in wet flue gas desulfurization has shown promising results due to the higher dissolution rate and better desulfurization performance of finer LGL particles. Characterizations through XRD, SEM, EDS, and ICP-OES analyses revealed that smaller particles of LGL have higher desulfurization capacity and can greatly enhance gypsum crystal formation.
Article
Engineering, Chemical
Julia Marushka, Jana Brokesova, Chiazor Ugo Ogadah, Arash Kazemi, Jurjen Duintjer Tebbens, Zdenka Sklubalova
Summary: This study investigated the milling properties of 24 pharmaceutical excipients and identified ten excipients with acceptable milling performance. The effect of milling speed and time on particle size was evaluated using a circumscripted central composite design (CCD), and optimal milling conditions were established.
ADVANCED POWDER TECHNOLOGY
(2022)
Article
Energy & Fuels
Tehmeena Ahad, Amir Gull, Farooq Ahmad Masoodi, Dina S. Hussein, Jawaher Alkahtani
Summary: This research examined the influence of air inlet temperature and whey protein isolate (WPI) concentration on various parameters of ginger oleoresin powder produced by spray drying. Increasing WPI concentration and decreasing inlet temperature led to increased powder recovery and longer dissolving time. Water activity and encapsulation efficiency of ginger oleoresin microcapsules increased, while total phenolic content decreased with increasing WPI concentration. Lower encapsulation efficiency and higher total phenol content were observed at higher inlet temperatures. The encapsulated oleoresin samples exhibited smaller-sized particles that were tightly packed at higher inlet temperatures. Micrographs of the powdered sample showed a smooth morphology.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Environmental Sciences
Anindityo Patmonoaji, Yingxue Hu, Muhammad Nasir, Chunwei Zhang, Tetsuya Suekane
Summary: The study investigated dissolution mass transfer in porous media with different particle sizes and distributions using X-ray microcomputed tomography. It found that dissolution fingering has an effect on mass transfer coefficient, with a significant decrease observed when the porous media container diameter (Ly) is larger than the whole lambda. Validation experiments showed successful observation of dissolution fingers, with sizes comparable to theoretical predictions based on linear instability theory.
WATER RESOURCES RESEARCH
(2021)
Article
Environmental Sciences
Adrienne G. Donaghue, Erica R. McKenzie
Summary: The presence of dissolved organic matter (DOM) can impact metal sulfide (MeS) precipitation and mobility. Thiol containing ligands like cysteine can effectively stabilize MeS nanoparticles in both single and multi-metal systems. Metal sequestration into MeS solids follows solubility products, with the behavior varying in multi-metal systems due to different NP sizes and dissolved concentrations. MeS stabilization by cysteine is influenced by the CYS:S ratio and the presence of Ca2+, impacting particle aggregation and metal dissolution.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Medicinal
Nawaf Almotairi, Gamal M. Mahrous, Saleh Al-suwayeh, Mohsin Kazi
Summary: This study aimed to design and optimize the lornoxicam dispersible tablet formulation using the Quality by design approach, investigating the effect of critical factors on quality attributes and conducting drug-excipient interaction and accelerated stability studies.
Article
Pharmacology & Pharmacy
Ki-Young Huh, Se-jung Hwang, Sang-Yeob Park, Hye-Jung Lim, Mir-yung Jin, Jae-seong Oh, Kyung-Sang Yu, Jae-Yong Chung
Summary: The study evaluated the pharmacokinetic equivalence between SYO-1644 and Nexavar through a two-period trial, finding that a dose range between 120 and 125 mg of SYO-1644 achieved the highest proportion of bioequivalence.
Article
Environmental Sciences
Jonas Hedberg, Madeleine Eriksson, Amina Kesraoui, Alexander Noren, Inger Odnevall Wallinder
Summary: This study investigated the release of Ag NPs in artificial sweat and saliva, finding that smaller Ag NPs in mouth spray released more silver than those in skin cream. Significant particle agglomeration occurred in both sweat and saliva solutions. Normalizing silver dissolution with the geometric surface area showed promise for comparing dissolution behavior of different Ag NPs characteristics, but further research is needed for conclusive results.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Chu-Hsun Lu, Yu-Feng Huang, I-Ming Chu
Summary: In a recent study, oral mucolytic agent Sobrerol showed promise for treating multiple sclerosis. By developing sustained-release pellets, the frequency of administration and daily dose were successfully reduced, improving compliance and therapeutic efficacy.
Article
Pharmacology & Pharmacy
Elisa Toropainen, Sara J. Fraser-Miller, Dunja Novakovic, Eva M. Del Amo, Kati-Sisko Vellonen, Marika Ruponen, Tapani Viitala, Ossi Korhonen, Seppo Auriola, Laura Hellinen, Mika Reinisalo, Unni Tengvall, Stephanie Choi, Mohammad Absar, Clare Strachan, Arto Urtti
Summary: The study found that both particle size and viscosity significantly impact the absorption of drugs in ocular suspensions. Smaller particles facilitate drug absorption to deeper ocular tissues, while higher viscosity increases the overall drug absorption.
Article
Pharmacology & Pharmacy
Dora Csicsak, Rita Szollath, Szabina Kadar, Rita Ambrus, Csilla Bartos, Emese Balogh, Istvan Antal, Istvan Koteles, Petra Tozser, Vivien Bardos, Peter Horvath, Eniko Borbas, Krisztina Takacs-Novak, Balint Sinko, Gergely Volgyi
Summary: Particle size reduction is commonly used to improve drug formulation solubility and dissolution. This study investigated the effect of particle size, pH, biorelevant media and polymers on the solubility and dissolution of drug formulations using three model compounds. Micronization resulted in a faster dissolution without affecting drug equilibrium solubility, while nanonization improved equilibrium solubility but required appropriate excipient selection. PVPK-25 had an increasing effect on solubility and better inhibition of particle aggregation compared to PVA.
Article
Acoustics
Haoran Chu, Lanlan Chen, Dongfang Lu, Yuhua Wang, Xiayu Zheng
Summary: The study verified the potential of ultrasonic pretreatment in improving the floatability of spodumene with different size fractions. It was found that ultrasonic pretreatment significantly enhanced the floatability of coarse particles, but had no clear advantage over traditional methods for fine particles.
ULTRASONICS SONOCHEMISTRY
(2022)
Article
Plant Sciences
Ki-Taek Kim, Min-Hwan Kim, Ju-Hwan Park, Jae Younglee, Hyun-Jong Cho, In-Soo Yoon, Dae-Duk Kim
JOURNAL OF GINSENG RESEARCH
(2018)
Article
Pharmacology & Pharmacy
Shin Jung Park, Prakash Thapa, Hye-Jin Seo, Eun Seok Park, Seong Hoon Jeong
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2018)
Article
Engineering, Chemical
Prakash Thapa, Ritu Thapa, Du Hyung Choi, Seong Hoon Jeong
Article
Pharmacology & Pharmacy
Prakash Thapa, Du Hyung Choi, Min Soo Kim, Seong Hoon Jeong
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Review
Engineering, Chemical
Prakash Thapa, Julu Tripathi, Seong Hoon Jeong
Article
Pharmacology & Pharmacy
Daeun Jeon, Ki-Taek Kim, Min-Jun Baek, Dong Hyun Kim, Jae-Young Lee, Dae-Duk Kim
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2019)
Article
Biochemistry & Molecular Biology
Jeong-Jun Lee, Young-Min Han, Tae-Wan Kwon, Dong Hyun Kim, Han Sol Lee, Woo Jin Jung, Jina Kim, Sujin Kang, Sang Kyum Kim, Cheong-Weon Cho, Keong-Ryoon Lee, Dae-Duk Kim, Min Chul Park, Jae-Young Lee
Article
Medicine, Legal
Ji-Young Kim, Sunyeong Lee, Yongbum Kim, Eun Ju Jeong, In Hyun Lee, Min-Hee Son, Jae Young Lee, Sang Kyum Kim, Kyoung-Sik Moon
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2019)
Review
Pharmacology & Pharmacy
Julu Tripathi, Prakash Thapa, Ravi Maharjan, Seong Hoon Jeong
Review
Chemistry, Medicinal
Dong Hyun Kim, Han Sol Lee, Tae-Wan Kwon, Young-Min Han, Nae-Won Kang, Mee Yeon Lee, Dae-Duk Kim, Myeong Gyu Kim, Jae-Young Lee
ARCHIVES OF PHARMACAL RESEARCH
(2020)
Article
Nanoscience & Nanotechnology
Min-Jun Baek, Duy-Thuc Nguyen, Dahan Kim, So-Yeol Yoo, Sang Min Lee, Jae-Young Lee, Dae-Duk Kim
Summary: The study presents the design of a tailored structure for renal-clearable zwitterionic cyclodextrin for selective drug delivery in colorectal cancer. Twenty cyclodextrin derivatives were synthesized and screened for colloidal stability, resulting in five candidates that were evaluated for biodistribution and an optimized structure was identified. The optimized cyclodextrin demonstrated high tumour accumulation and improved antitumour efficacy in colorectal cancer models.
NATURE NANOTECHNOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Jae-Young Lee, Yae-Seul Lee, Dong Hyun Kim, Han Sol Lee, Bo Ram Yang, Myeong Gyu Kim
Summary: This study evaluated the use of social media in detecting new black box warnings, labeling changes, or withdrawals in advance. Results showed that social media could detect signals 3 months to 9 years before regulatory authorities take action. Challenges remain in using social media for pharmacovigilance, particularly in terms of coverage, data quality, and analytic processing. Further studies are needed to improve natural language processing and data mining on social media.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2021)
Article
Pharmacology & Pharmacy
Sung-Jin Kim, Young-Guk Na, Hong-Ki Lee, Hye-Jin Lee, Miao Wang, Hyun Wook Huh, Han-Sol Lee, Jae-Young Lee, Cheong-Weon Cho
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2020)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)