Neuromedin U suppresses insulin secretion by triggering mitochondrial dysfunction and endoplasmic reticulum stress in pancreatic β‐cells

The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent

(2019) Israa Mohammad Al-Amily et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets

(2018) Patricio Atanes et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Etiology of type 2 diabetes and Alzheimer's disease: Exploring the mitochondria

(2018) Talisa K. Silzer et al.   MITOCHONDRION

The role of endoplasmic reticulum-mitochondria contact sites in the control of glucose homeostasis: an update

(2018) Jennifer Rieusset   Cell Death & Disease

Neuromedin U Does Not Act as a Decretin in Rats

(2018) Rune Ehrenreich Kuhre et al.   Cell Metabolism

Preserving Insulin Secretion in Diabetes by Inhibiting VDAC1 Overexpression and Surface Translocation in β Cells

(2018) Enming Zhang et al.   Cell Metabolism

Keratins regulate β-cell mitochondrial morphology, motility, and homeostasis

(2017) Jonas S. G. Silvander et al.   FASEB JOURNAL

Neuromedin U is upregulated by Snail at early stages of EMT in HT29 colon cancer cells

(2016) Patrycja Przygodzka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells

(2016) Jing Wang et al.   CELLULAR SIGNALLING

Physiological roles of the mitochondrial permeability transition pore

(2016) Nelli Mnatsakanyan et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Suppression of Insulin Production and Secretion by a Decretin Hormone

(2015) Ronald W. Alfa et al.   Cell Metabolism

Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

(2015) David M. Blodgett et al.   DIABETES

Calcium release channel RyR2 regulates insulin release and glucose homeostasis

(2015) Gaetano Santulli et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes

(2015) Sumaira Z Hasnain et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Mitochondrial regulation of β-cell function: Maintaining the momentum for insulin release

(2015) Brett A. Kaufman et al.   MOLECULAR ASPECTS OF MEDICINE

Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion

(2015) Talitha van der Meulen et al.   NATURE MEDICINE

Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance andβ-Cell Dysfunction

(2015) Kevin Noel Keane et al.   Oxidative Medicine and Cellular Longevity

Endoplasmic Reticulum Stress and Oxidative Stress in Cell Fate Decision and Human Disease

(2014) Stewart Siyan Cao et al.   ANTIOXIDANTS & REDOX SIGNALING

Lipotoxicity in the Pancreatic Beta Cell: Not Just Survival and Function, but Proliferation as Well?

(2014) Rohit B. Sharma et al.   Current Diabetes Reports

Adipose tissue mitochondrial dysfunction triggers a lipodystrophic syndrome with insulin resistance, hepatosteatosis, and cardiovascular complications

(2014) Cecile Vernochet et al.   FASEB JOURNAL

Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic  -cell function in diabetes

(2014) A. Hoshino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death

(2013) Jaeseok Han et al.   NATURE CELL BIOLOGY

An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans

(2013) Stefan Amisten et al.   PHARMACOLOGY & THERAPEUTICS

Endoplasmic Reticulum Stress and Type 2 Diabetes

(2012) Sung Hoon Back et al.   Annual Review of Biochemistry

Neuroendocrine regulatory peptide-2 stimulates glucose-induced insulin secretion in vivo and in vitro

(2012) Abu Saleh Md. Moin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autocrine regulation of insulin secretion

(2012) M. Braun et al.   DIABETES OBESITY & METABOLISM

Reactive oxygen and nitrogen species generation, antioxidant defenses, and β-cell function: a critical role for amino acids

(2012) P Newsholme et al.   JOURNAL OF ENDOCRINOLOGY

Mitochondrial dysfunction in pancreatic β cells

(2012) Sachin Supale et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Effects of Peripherally Administered Neuromedin U on Energy and Glucose Homeostasis

(2011) Andrea M. Peier et al.   ENDOCRINOLOGY

Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle

(2011) H.-F. Jheng et al.   MOLECULAR AND CELLULAR BIOLOGY

The Role of Mitochondria in the Pathogenesis of Type 2 Diabetes

(2010) Mary-Elizabeth Patti et al.   ENDOCRINE REVIEWS

Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S

(2009) JD Mitchell et al.   BRITISH JOURNAL OF PHARMACOLOGY

Insights into the critical role of NADPH oxidase(s) in the normal and dysregulated pancreatic beta cell

(2009) P. Newsholme et al.   DIABETOLOGIA

Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular system

(2008) J. D. Mitchell et al.   CARDIOVASCULAR RESEARCH

Roles of IP3R and RyR Ca2+ Channels in Endoplasmic Reticulum Stress and  -Cell Death

(2008) D. S. Luciani et al.   DIABETES

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE