Brain Ischemia/Reperfusion Injury and Mitochondrial Complex I Damage

Redox-dependent loss of flavin by mitochondrial complex I in brain ischemia/reperfusion injury

(2019) Anna Stepanova et al.   ANTIOXIDANTS & REDOX SIGNALING

Clinical validation of blood/brain glutamate grabbing in acute ischemic stroke

(2018) Andrés da Silva-Candal et al.   ANNALS OF NEUROLOGY

Attenuation of oxidative damage by targeting mitochondrial complex I in neonatal hypoxic-ischemic brain injury

(2018) Minso Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Deactivation of mitochondrial complex I after hypoxia–ischemia in the immature brain

(2018) Anna Stepanova et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mitochondrial complex I in the post-ischemic heart reperfusion-mediated oxidative injury and protein cysteine sulfonation

(2018) Patrick T. Kang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states

(2018) Ahmed-Noor A. Agip et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Critical Role of Flavin and Glutathione in Complex I–Mediated Bioenergetic Failure in Brain Ischemia/Reperfusion Injury

(2018) Anja Kahl et al.   STROKE

Structure of the Deactive State of Mammalian Respiratory Complex I

(2018) James N. Blaza et al.   STRUCTURE

Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states

(2018) Ahmed-Noor A. Agip et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The dependence of brain mitochondria reactive oxygen species production on oxygen level is linear, except when inhibited by antimycin A

(2018) Anna Stepanova et al.   JOURNAL OF NEUROCHEMISTRY

Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps

(2018) Alfredo Cabrera-Orefice et al.   Nature Communications

Cryo-EM structure of respiratory complex I at work

(2018) Kristian Parey et al.   eLife

Reverse electron transfer results in a loss of flavin from mitochondrial complex I: Potential mechanism for brain ischemia reperfusion injury

(2017) Anna Stepanova et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Krebs cycle metabolites and preferential succinate oxidation following neonatal hypoxic-ischemic brain injury in mice

(2017) Prateek V Sahni et al.   PEDIATRIC RESEARCH

Mitochondrial complex I deactivation is related to superoxide production in acute hypoxia

(2017) Pablo Hernansanz-Agustín et al.   Redox Biology

Reversible FMN dissociation from Escherichia coli respiratory complex I

(2016) Peter J. Holt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Ischemic A/D transition of mitochondrial complex I and its role in ROS generation

(2016) Stefan Dröse et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Differential susceptibility of mitochondrial complex II to inhibition by oxaloacetate in brain and heart

(2016) Anna Stepanova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The architecture of respiratory supercomplexes

(2016) James A. Letts et al.   NATURE

Structure of mammalian respiratory complex I

(2016) Jiapeng Zhu et al.   NATURE

Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes

(2016) Irene Lopez-Fabuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Inhibition of Deactivated Mitochondrial Complex I by Biguanides

(2015) Satoshi Matsuzaki et al.   BIOCHEMISTRY

Effect of monovalent cations on the kinetics of hypoxic conformational change of mitochondrial complex I

(2015) Anna Stepanova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mechanistic insight from the crystal structure of mitochondrial complex I

(2015) V. Zickermann et al.   SCIENCE

Characterisation of the active/de-active transition of mitochondrial complex I

(2014) Marion Babot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

ND3, ND1 and 39kDa subunits are more exposed in the de-active form of bovine mitochondrial complex I

(2014) Marion Babot et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

PET Imaging of Ischemia-Induced Impairment of Mitochondrial Complex I Function in Monkey Brain

(2014) Hideo Tsukada et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Fatty Acids in Energy Metabolism of the Central Nervous System

(2014) Alexander Panov et al.   Biomed Research International

Mitochondrial reactive oxygen species: A double edged sword in ischemia/reperfusion vs preconditioning

(2014) Theodore Kalogeris et al.   Redox Biology

Mitochondrial Complex I

(2013) Judy Hirst   Annual Review of Biochemistry

Conformational Change of Mitochondrial Complex I Increases ROS Sensitivity During Ischemia

(2013) Natalia Gorenkova et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular mechanism and physiological role of active–deactive transition of mitochondrial complex I

(2013) Marion Babot et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Conformation-specific crosslinking of mitochondrial complex I

(2013) Margherita Ciano et al.   FEBS LETTERS

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

(2013) Edward T Chouchani et al.   NATURE MEDICINE

Intrapartum-related neonatal encephalopathy incidence and impairment at regional and global levels for 2010 with trends from 1990

(2013) Anne CC Lee et al.   PEDIATRIC RESEARCH

Sites of reactive oxygen species generation by mitochondria oxidizing different substrates

(2013) Casey L. Quinlan et al.   Redox Biology

The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues

(2012) Tomáš Mráček et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Circulation : Clinical Summaries

(2012)   CIRCULATION

The Deactive Form of Respiratory Complex I from Mammalian Mitochondria Is a Na+/H+Antiporter

(2012) Philippa G. Roberts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Oxygen Free Radicals Originating from Mitochondrial Complex I Contribute to Oxidative Brain Injury Following Hypoxia-Ischemia in Neonatal Mice

(2012) Z. V. Niatsetskaya et al.   JOURNAL OF NEUROSCIENCE

The role of mitochondrial OXPHOS dysfunction in the development of neurologic diseases

(2012) M.E. Breuer et al.   NEUROBIOLOGY OF DISEASE

Monogenic Mitochondrial Disorders

(2012) Werner J.H. Koopman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Updated Neuronal Scaling Rules for the Brains of Glires (Rodents/Lagomorphs)

(2011) Suzana Herculano-Houzel et al.   BRAIN BEHAVIOR AND EVOLUTION

Mitochondrial complex I: A central regulator of the aging process

(2011) Rhoda Stefanatos et al.   CELL CYCLE

Superoxide Is Produced by the Reduced Flavin in Mitochondrial Complex I

(2011) Kenneth R. Pryde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The electron transfer flavoprotein: Ubiquinone oxidoreductases

(2010) Nicholas J. Watmough et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Metabolomic Analyses of Plasma Reveals New Insights into Asphyxia and Resuscitation in Pigs

(2010) Rønnaug Solberg et al.   PLoS One

Mitochondria, oxidative metabolism and cell death in stroke

(2009) Neil R. Sims et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Lack of Oxygen Deactivates Mitochondrial Complex I

(2009) Alexander Galkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury

(2009) T. A. Prime et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the Mitochondrial ND3 Subunit as a Structural Component Involved in the Active/Deactive Enzyme Transition of Respiratory Complex I

(2008) Alexander Galkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bioenergetics of cerebral ischemia: A cellular perspective

(2008) Leif Hertz   NEUROPHARMACOLOGY